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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NDUFV3 (ImmuneEditome ID:4731)

1. Gene summary of enriched editing regions for NDUFV3

check button Gene summary
Gene informationGene symbol

NDUFV3

Gene ID

4731

GeneSynonymsCI-10k|CI-9KD
GeneCytomap

21q22.3

GeneTypeprotein-coding
GeneDescriptionNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial|NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa|NADH-ubiquinone oxidoreductase 9 kD subunit|NADH-ubiquinone oxidoreductase 9 kDa subunit|NADH-ubiquinone oxidoreductase flavoprotein 3, 10kD|complex I 10kDa subunit|complex I, mitochondrial respiratory chain, 10-kD subunit|complex I-9kD|mitochondrial NADH oxidoreductase-like protein|renal carcinoma antigen NY-REN-4
GeneModificationdate20230329
UniprotIDP56181
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr21:42882459-42883177:+ENST00000460259.1ENSG00000160194.16NDUFV3ncRNA_intronicAluSq2,AluSz6,AluSx1chr21:42882459-42883177:+.alignment
chr21:42895141-42895613:+ENST00000460259.1ENSG00000160194.16NDUFV3ncRNA_intronicAluSx,AluSzchr21:42895141-42895613:+.alignment
chr21:42895141-42895613:+ENST00000460740.1ENSG00000160194.16NDUFV3ncRNA_intronicAluSx,AluSzchr21:42895141-42895613:+.alignment
chr21:42898311-42898631:+ENST00000460259.1ENSG00000160194.16NDUFV3ncRNA_intronicAluJo,AluJrchr21:42898311-42898631:+.alignment
chr21:42898311-42898631:+ENST00000460740.1ENSG00000160194.16NDUFV3ncRNA_intronicAluJo,AluJrchr21:42898311-42898631:+.alignment
chr21:42909116-42913097:+ENST00000340344.4ENSG00000160194.16NDUFV3UTR3AluYk3,(AATATG)n,AluY,AluSx1,AluSp,(T)n,AluJb,AluSx3,AluSz,AluSq2,L2achr21:42909116-42913097:+.alignment


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2. Tumor-specific enriched editing regions for NDUFV3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr21:42909116-42913097:+BRCAEER5.0639e-07image
ENSG00000160194.16,NDUFV3BRCAEAG3.3531e-07image
chr21:42909116-42913097:+COADEER3.0665e-02image
ENSG00000160194.16,NDUFV3COADEAG2.7001e-02image
chr21:42909116-42913097:+KIRPEER8.0403e-05image
ENSG00000160194.16,NDUFV3KIRPEAG7.6721e-05image
chr21:42909116-42913097:+LUADEER9.1295e-03image
ENSG00000160194.16,NDUFV3LUADEAG9.5712e-03image
chr21:42909116-42913097:+LUSCEER5.1516e-03image
ENSG00000160194.16,NDUFV3LUSCEAG5.0294e-03image
chr21:42909116-42913097:+PRADEER5.0322e-03image
ENSG00000160194.16,NDUFV3PRADEAG5.0294e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr21:42898311-42898631:+OVCliEER1.8930e-032.1071e-030.4895image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr21:42909116-42913097:+UVMEER7.2403e-033.2602e-027.7460e-04image
ENSG00000160194.16,NDUFV3UVMEAG7.2403e-033.2602e-027.7460e-04image

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3. Enriched editing regions and immune related genes for NDUFV3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr21:42909116-42913097:+STADEERENSG00000129968,ABHD17A0.36002.7818e-081.2567e-140.4057imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr21:42909116-42913097:+DLBCEERENSG00000152284,TCF7L10.66261.5261e-021.0634e-040.5872imageNNTCF7L1Macrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr21:42909116-42913097:+DLBCEERENSG00000152270,PDE3B0.63372.1682e-025.1142e-040.5368imageNNPDE3BMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr21:42909116-42913097:+DLBCEERENSG00000144837,PLA1A0.64862.1898e-021.4157e-060.6931imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr21:42909116-42913097:+DLBCEERENSG00000188868,ZNF563-0.62332.9703e-024.4886e-03-0.4510imageNNNAPlasma_cellsGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr21:42909116-42913097:+DLBCEERENSG00000116574,RHOU0.57793.2537e-024.7923e-040.5391imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr21:42909116-42913097:+DLBCEERENSG00000202441,RNY4P100.60793.6512e-023.4782e-030.4623imageNNNAMast_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr21:42909116-42913097:+DLBCEERENSG00000152422,XRCC4-0.58513.7063e-023.7077e-03-0.4595imageNNXRCC4T_cells_follicular_helperGSVA_HALLMARK_DNA_REPAIR
chr21:42909116-42913097:+DLBCEERENSG00000261269,RP11-389C8.20.58094.0016e-021.9680e-030.4862imageNNNAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr21:42909116-42913097:+DLBCEERENSG00000099949,LZTR10.59794.0664e-021.2153e-040.5832imageNNNAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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4. Enriched editing regions and immune related splicing for NDUFV3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000160194.16,NDUFV3
ESCAEAGIRENSG00000063978.11chr42512386:2512390:2512437:25125970.32356.0922e-033.6954e-070.4410imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANeutrophilsGSVA_HALLMARK_GLYCOLYSIS
ENSG00000160194.16,NDUFV3
ESCAEAGIRENSG00000132694.14chr1156937248:156937496:156939547:1569396510.34271.7800e-021.8975e-070.4001imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184ARHGEF11Dendritic_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr21:42909116-42913097:+
ESCAEERIRENSG00000063978.11chr42512386:2512390:2512437:25125970.31318.9817e-038.6690e-070.4298imageNNNANeutrophilsGSVA_HALLMARK_GLYCOLYSIS
chr21:42909116-42913097:+
ESCAEERIRENSG00000132694.14chr1156937248:156937496:156939547:1569396510.32872.5555e-021.6814e-070.4029imageNNARHGEF11Dendritic_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000160194.16,NDUFV3
THYMEAGIRENSG00000157873.13chr12561800:2561957:2562864:25628960.38417.0975e-032.7305e-060.4266imageNAUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX42;DGCR8;EIF4A3;FAM120A;FBL;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP7;LIN28B;LSM11;NONO;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;XRN2TNFRSF14Mast_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000160194.16,NDUFV3
THYMEAGIRENSG00000099840.9chr192097928:2098127:2098286:20983340.37208.7466e-039.3759e-060.4035imageNBCCIP;BUD13;CSTF2T;DDX42;EIF4A3;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPK;HNRNPL;HNRNPM;HNRNPU;KHSRP;LIN28;LIN28A;LSM11;NONO;PCBP2;PRPF8;RANGAP1;RBFOX2;RTCB;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184NAMast_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000160194.16,NDUFV3
THYMEAGMEXENSG00000183889.8chr1616333834:16333884:16335860:16335992:16336051:16336137:16337393:163375260.41901.4642e-033.0593e-060.4300imageNADAR;BUD13;ELAVL1;FUS;HNRNPA1;HNRNPC;IGF2BP2;IGF2BP3;NUMA1;SRSF1;SRSF10;SRSF3;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;YTHDF1NAGSVA_HALLMARK_COMPLEMENT
ENSG00000160194.16,NDUFV3
THYMEAGA3ENSG00000006007.7chr1619521703:19522123:19517013:19517185:19517013:195171890.28684.1057e-022.4232e-050.4249imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM27;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000160194.16,NDUFV3
THYMEAGMEXENSG00000134574.7chr1147234572:47234672:47234756:47234876:47235279:47235412:47237836:472380010.39404.3034e-031.0037e-060.4412imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr21:42909116-42913097:+
THYMEERIRENSG00000122566.16chr726189926:26190460:26191055:261911280.40553.4135e-037.9885e-070.4430imageNNNANeutrophilsGSVA_HALLMARK_KRAS_SIGNALING_DN

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5. Enriched editing regions and immune infiltration for NDUFV3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr21:42909116-42913097:+BLCAEERDendritic_cells_resting1.5991e-02-0.1260image
ENSG00000160194.16,NDUFV3BLCAEAGDendritic_cells_resting1.5744e-02-0.1263image
chr21:42909116-42913097:+BRCAEERB_cells_memory1.8502e-020.0724image
ENSG00000160194.16,NDUFV3BRCAEAGT_cells_CD4_memory_resting3.0378e-020.0665image
chr21:42909116-42913097:+CHOLEERB_cells_naive8.1969e-040.5698image
ENSG00000160194.16,NDUFV3CHOLEAGB_cells_naive8.1969e-040.5698image
chr21:42909116-42913097:+DLBCEERNK_cells_resting3.7331e-030.4592image
ENSG00000160194.16,NDUFV3DLBCEAGNK_cells_resting3.7331e-030.4592image
chr21:42909116-42913097:+ESCAEERT_cells_CD4_naive3.2552e-030.2334image
ENSG00000160194.16,NDUFV3ESCAEAGT_cells_CD4_naive4.1316e-030.2270image
chr21:42909116-42913097:+GBMEEREosinophils3.0213e-020.1704image
ENSG00000160194.16,NDUFV3GBMEAGEosinophils3.0841e-020.1697image
chr21:42909116-42913097:+HNSCEERB_cells_naive1.9874e-02-0.1161image
ENSG00000160194.16,NDUFV3HNSCEAGB_cells_naive1.9862e-02-0.1161image
chr21:42909116-42913097:+KICHEEREosinophils3.7506e-070.5933image
ENSG00000160194.16,NDUFV3KICHEAGEosinophils3.6964e-070.5935image
chr21:42909116-42913097:+KIRCEERT_cells_CD4_memory_activated3.2990e-040.1864image
ENSG00000160194.16,NDUFV3KIRCEAGT_cells_CD4_memory_activated3.4951e-040.1856image
chr21:42909116-42913097:+LAMLEERDendritic_cells_activated3.8899e-020.1793image
ENSG00000160194.16,NDUFV3LAMLEAGT_cells_CD4_memory_activated2.9143e-020.1892image
chr21:42909116-42913097:+LGGEERT_cells_CD4_memory_resting1.0107e-02-0.1118image
ENSG00000160194.16,NDUFV3LGGEAGT_cells_CD4_memory_resting1.0120e-02-0.1118image
chr21:42909116-42913097:+LUADEERT_cells_regulatory_(Tregs)2.6001e-020.1044image
ENSG00000160194.16,NDUFV3LUADEAGT_cells_regulatory_(Tregs)2.7942e-020.1029image
chr21:42909116-42913097:+LUSCEERT_cells_gamma_delta3.9529e-040.1738image
ENSG00000160194.16,NDUFV3LUSCEAGT_cells_gamma_delta3.9681e-040.1737image
chr21:42882459-42883177:+OVEERB_cells_memory1.4575e-030.6242image
chr21:42898311-42898631:+OVEERT_cells_gamma_delta1.3659e-070.8141image
chr21:42909116-42913097:+OVEERT_cells_CD82.3693e-020.1333image
ENSG00000160194.16,NDUFV3OVEAGT_cells_CD82.5904e-020.1313image
chr21:42909116-42913097:+PCPGEERMacrophages_M03.3108e-02-0.1607image
ENSG00000160194.16,NDUFV3PCPGEAGMacrophages_M03.3108e-02-0.1607image
chr21:42909116-42913097:+PRADEERT_cells_CD83.1500e-030.1319image
ENSG00000160194.16,NDUFV3PRADEAGT_cells_CD82.9907e-030.1326image
chr21:42909116-42913097:+READEERB_cells_naive3.8057e-030.3200image
ENSG00000160194.16,NDUFV3READEAGB_cells_naive3.8057e-030.3200image
chr21:42909116-42913097:+SARCEERT_cells_CD4_memory_activated1.2326e-070.3353image
ENSG00000160194.16,NDUFV3SARCEAGT_cells_CD4_memory_activated1.2307e-070.3353image
chr21:42909116-42913097:+SKCMEERMacrophages_M21.0738e-02-0.1214image
ENSG00000160194.16,NDUFV3SKCMEAGMacrophages_M21.0891e-02-0.1211image
chr21:42898311-42898631:+STADEERT_cells_CD4_memory_activated3.6788e-030.4336image
chr21:42909116-42913097:+STADEEREosinophils4.7880e-05-0.2209image
ENSG00000160194.16,NDUFV3STADEAGEosinophils6.5283e-05-0.2164image
chr21:42909116-42913097:+THCAEERT_cells_CD4_memory_resting2.9796e-020.0970image
ENSG00000160194.16,NDUFV3THCAEAGT_cells_CD4_memory_resting2.9892e-020.0969image
chr21:42909116-42913097:+THYMEERT_cells_CD84.4043e-03-0.2649image
ENSG00000160194.16,NDUFV3THYMEAGT_cells_CD84.3988e-03-0.2649image
chr21:42909116-42913097:+UCECEERT_cells_CD4_memory_resting4.6145e-020.1560image
chr21:42909116-42913097:+UCSEERMacrophages_M04.6809e-020.2770image
ENSG00000160194.16,NDUFV3UCSEAGMacrophages_M13.8113e-020.2884image


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6. Enriched editing regions and immune gene sets for NDUFV3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000160194.16,NDUFV3ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.1156e-02-0.3060image
chr21:42909116-42913097:+ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.1191e-02-0.3059image
chr21:42909116-42913097:+BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER7.5112e-05-0.1214image
ENSG00000160194.16,NDUFV3BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.4198e-04-0.1046image
chr21:42909116-42913097:+CESCGSVA_HALLMARK_PEROXISOMEEER4.5342e-03-0.1745image
ENSG00000160194.16,NDUFV3CESCGSVA_HALLMARK_PEROXISOMEEAG3.9409e-03-0.1772image
ENSG00000160194.16,NDUFV3COADGSVA_HALLMARK_SPERMATOGENESISEAG4.1065e-02-0.1394image
ENSG00000160194.16,NDUFV3DLBCGSVA_HALLMARK_DNA_REPAIREAG1.8161e-02-0.3813image
chr21:42909116-42913097:+DLBCGSVA_HALLMARK_DNA_REPAIREER1.8161e-02-0.3813image
chr21:42898311-42898631:+ESCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.9442e-02-0.4047image
chr21:42909116-42913097:+ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER4.6689e-04-0.2760image
ENSG00000160194.16,NDUFV3ESCAGSVA_HALLMARK_MYC_TARGETS_V2EAG2.8111e-04-0.2852image
chr21:42909116-42913097:+GBMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.4272e-020.1922image
ENSG00000160194.16,NDUFV3GBMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.3349e-020.1940image
ENSG00000160194.16,NDUFV3HNSCGSVA_HALLMARK_UV_RESPONSE_UPEAG9.8285e-03-0.1286image
chr21:42909116-42913097:+HNSCGSVA_HALLMARK_UV_RESPONSE_UPEER9.7546e-03-0.1288image
chr21:42909116-42913097:+KIRCGSVA_HALLMARK_BILE_ACID_METABOLISMEER9.8709e-03-0.1345image
ENSG00000160194.16,NDUFV3KIRCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.4938e-03-0.1352image
chr21:42909116-42913097:+KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.0252e-02-0.1554image
ENSG00000160194.16,NDUFV3KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.1131e-02-0.1537image
ENSG00000160194.16,NDUFV3LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG5.4386e-05-0.1747image
chr21:42909116-42913097:+LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.4358e-05-0.1747image
ENSG00000160194.16,NDUFV3LUADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.2964e-03-0.1502image
chr21:42909116-42913097:+LUADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.6630e-03-0.1470image
chr21:42909116-42913097:+LUSCGSVA_HALLMARK_NOTCH_SIGNALINGEER2.7278e-02-0.1088image
ENSG00000160194.16,NDUFV3LUSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.6981e-02-0.1090image
chr21:42882459-42883177:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.7542e-02-0.4360image
ENSG00000160194.16,NDUFV3OVGSVA_HALLMARK_DNA_REPAIREAG2.0786e-030.1807image
chr21:42898311-42898631:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.7710e-030.5294image
chr21:42909116-42913097:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.2563e-030.1793image
ENSG00000160194.16,NDUFV3PAADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.8881e-020.1909image
chr21:42909116-42913097:+PAADGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.8881e-020.1909image
ENSG00000160194.16,NDUFV3PCPGGSVA_HALLMARK_MYC_TARGETS_V2EAG3.8243e-02-0.1564image
chr21:42909116-42913097:+PCPGGSVA_HALLMARK_MYC_TARGETS_V2EER3.8243e-02-0.1564image
ENSG00000160194.16,NDUFV3PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2722e-02-0.1115image
chr21:42909116-42913097:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2715e-02-0.1115image
chr21:42909116-42913097:+READGSVA_HALLMARK_PEROXISOMEEER4.1061e-020.2290image
ENSG00000160194.16,NDUFV3READGSVA_HALLMARK_PEROXISOMEEAG4.1061e-020.2290image
ENSG00000160194.16,NDUFV3SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG5.2337e-030.1808image
chr21:42909116-42913097:+SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER5.2438e-030.1808image
ENSG00000160194.16,NDUFV3SKCMGSVA_HALLMARK_HEME_METABOLISMEAG1.5205e-04-0.1794image
chr21:42909116-42913097:+SKCMGSVA_HALLMARK_HEME_METABOLISMEER1.5365e-04-0.1793image
ENSG00000160194.16,NDUFV3STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.7395e-040.1933image
chr21:42909116-42913097:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.3997e-040.1886image
chr21:42909116-42913097:+TGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER5.2676e-03-0.2260image
ENSG00000160194.16,NDUFV3TGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.9747e-03-0.2267image
ENSG00000160194.16,NDUFV3THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.4960e-030.1301image
chr21:42909116-42913097:+THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.3509e-030.1307image
ENSG00000160194.16,NDUFV3THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.2784e-030.2830image
chr21:42909116-42913097:+THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2823e-030.2830image
ENSG00000160194.16,NDUFV3UCECGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.7601e-020.1852image
chr21:42909116-42913097:+UCECGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.8548e-020.1837image
chr21:42909116-42913097:+UVMGSVA_HALLMARK_NOTCH_SIGNALINGEER3.9171e-020.2387image
ENSG00000160194.16,NDUFV3UVMGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.9171e-020.2387image


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7. Enriched editing regions and drugs for NDUFV3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000160194.16,NDUFV3ACCAICAREAG9.1201e-04-0.3931image
chr21:42909116-42913097:+ACCAICAREER9.5059e-04-0.3919image
ENSG00000160194.16,NDUFV3BLCABryostatin.1EAG1.6012e-02-0.1260image
chr21:42909116-42913097:+BLCABryostatin.1EER1.5174e-02-0.1270image
ENSG00000160194.16,NDUFV3BRCAAZD.0530EAG3.5804e-03-0.0894image
chr21:42909116-42913097:+BRCAAZD.0530EER3.3649e-03-0.0901image
ENSG00000160194.16,NDUFV3CESCCHIR.99021EAG3.3424e-03-0.1803image
chr21:42909116-42913097:+CESCCHIR.99021EER3.4359e-03-0.1798image
ENSG00000160194.16,NDUFV3CHOLBI.D1870EAG3.5965e-020.3781image
chr21:42909116-42913097:+CHOLBI.D1870EER3.5965e-020.3781image
ENSG00000160194.16,NDUFV3DLBCATRAEAG2.2699e-02-0.3688image
chr21:42909116-42913097:+DLBCATRAEER2.2699e-02-0.3688image
chr21:42898311-42898631:+ESCAABT.263EER2.5195e-02-0.4150image
ENSG00000160194.16,NDUFV3ESCAAP.24534EAG1.3047e-02-0.1971image
chr21:42909116-42913097:+ESCAAP.24534EER1.7335e-02-0.1897image
ENSG00000160194.16,NDUFV3GBMGSK269962AEAG1.2886e-03-0.2508image
chr21:42909116-42913097:+GBMGSK269962AEER1.3181e-03-0.2503image
ENSG00000160194.16,NDUFV3HNSCAZD6244EAG2.7662e-030.1491image
chr21:42909116-42913097:+HNSCAZD6244EER2.7538e-030.1491image
chr21:42909116-42913097:+KICHCMKEER7.7592e-030.3351image
ENSG00000160194.16,NDUFV3KICHCMKEAG7.6815e-030.3355image
ENSG00000160194.16,NDUFV3KIRCBI.D1870EAG5.8562e-06-0.2340image
chr21:42909116-42913097:+KIRCBI.D1870EER6.3588e-06-0.2332image
ENSG00000160194.16,NDUFV3KIRPMidostaurinEAG5.2318e-030.1689image
chr21:42909116-42913097:+KIRPMidostaurinEER5.9323e-030.1664image
ENSG00000160194.16,NDUFV3LAMLJNK.Inhibitor.VIIIEAG2.7972e-020.1906image
chr21:42909116-42913097:+LAMLA.770041EER4.9510e-02-0.1707image
ENSG00000160194.16,NDUFV3LGGCHIR.99021EAG2.5384e-05-0.1822image
chr21:42909116-42913097:+LGGCHIR.99021EER2.5340e-05-0.1822image
ENSG00000160194.16,NDUFV3LUADAG.014699EAG2.8055e-03-0.1396image
chr21:42909116-42913097:+LUADAG.014699EER3.1533e-03-0.1381image
ENSG00000160194.16,NDUFV3LUSCAMG.706EAG5.5982e-03-0.1363image
chr21:42909116-42913097:+LUSCAMG.706EER5.5437e-03-0.1364image
chr21:42909116-42913097:+OVMG.132EER1.0158e-03-0.1930image
chr21:42898311-42898631:+OVAG.014699EER3.9809e-020.3907image
chr21:42882459-42883177:+OVMethotrexateEER1.2856e-020.5103image
ENSG00000160194.16,NDUFV3OVMG.132EAG8.8664e-04-0.1952image
ENSG00000160194.16,NDUFV3PCPGJNK.Inhibitor.VIIIEAG2.2015e-02-0.1726image
chr21:42909116-42913097:+PCPGJNK.Inhibitor.VIIIEER2.2015e-02-0.1726image
chr21:42909116-42913097:+PRADEpothilone.BEER8.6476e-040.1487image
ENSG00000160194.16,NDUFV3PRADEpothilone.BEAG8.7810e-040.1485image
ENSG00000160194.16,NDUFV3READBMS.754807EAG4.3682e-030.3155image
chr21:42909116-42913097:+READBMS.754807EER4.3682e-030.3155image
ENSG00000160194.16,NDUFV3SARCLFM.A13EAG2.8476e-03-0.1930image
chr21:42909116-42913097:+SARCLFM.A13EER2.8436e-03-0.1930image
ENSG00000160194.16,NDUFV3SKCMA.443654EAG6.3734e-04-0.1620image
chr21:42909116-42913097:+SKCMA.443654EER6.3793e-04-0.1620image
chr21:42898311-42898631:+STADEtoposideEER3.2601e-02-0.3265image
chr21:42909116-42913097:+STADAZD6244EER2.7309e-06-0.2538image
ENSG00000160194.16,NDUFV3STADAZD6244EAG3.5498e-05-0.2239image
chr21:42909116-42913097:+TGCTFTI.277EER1.3181e-020.2013image
ENSG00000160194.16,NDUFV3TGCTFTI.277EAG1.3381e-020.2002image
chr21:42909116-42913097:+THCAJNK.Inhibitor.VIIIEER1.8342e-02-0.1054image
ENSG00000160194.16,NDUFV3THCAJNK.Inhibitor.VIIIEAG1.7833e-02-0.1058image
ENSG00000160194.16,NDUFV3THYMJNK.Inhibitor.VIIIEAG5.4208e-06-0.4114image
chr21:42909116-42913097:+THYMJNK.Inhibitor.VIIIEER5.4425e-06-0.4114image
ENSG00000160194.16,NDUFV3UCECABT.263EAG1.5845e-02-0.1881image
chr21:42909116-42913097:+UCECImatinibEER1.1400e-02-0.1971image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr21:42909116-42913097:+ENST00000340344.4P56181DB00157NADHSmallMoleculeDrug
chr21:42909116-42913097:+ENST00000340344.4P56181DB09270UbidecarenoneSmallMoleculeDrug