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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NDUFB1 (ImmuneEditome ID:4707)

1. Gene summary of enriched editing regions for NDUFB1

check button Gene summary
Gene informationGene symbol

NDUFB1

Gene ID

4707

GeneSynonymsCI-MNLL|CI-SGDH|MNLL
GeneCytomap

14q32.12

GeneTypeprotein-coding
GeneDescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1|NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa|NADH-ubiquinone oxidoreductase MNLL subunit|complex I MNLL subunit|complex I-MNLL
GeneModificationdate20230329
UniprotIDO75438;A0A024R6G6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:92116423-92116656:-ENST00000553666.1ENSG00000183648.8NDUFB1ncRNA_intronicAluSzchr14:92116423-92116656:-.alignment
chr14:92117714-92121189:-ENST00000553666.1ENSG00000183648.8NDUFB1ncRNA_exonicAluSz,AluSq2,AluSg,FAM,AluJr,AluSz6,MIR,Tigger4b,AluSpchr14:92117714-92121189:-.alignment
chr14:92117714-92121189:-ENST00000556555.1ENSG00000183648.8NDUFB1ncRNA_exonicAluSz,AluSq2,AluSg,FAM,AluJr,AluSz6,MIR,Tigger4b,AluSpchr14:92117714-92121189:-.alignment


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2. Tumor-specific enriched editing regions for NDUFB1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr14:92117714-92121189:-COADEER3.5892e-08image
ENSG00000183648.8,NDUFB1COADEAG3.5892e-08image
chr14:92117714-92121189:-LUSCEER2.0616e-02image
ENSG00000183648.8,NDUFB1LUSCEAG2.0712e-02image
chr14:92117714-92121189:-PRADEER4.6411e-02image
ENSG00000183648.8,NDUFB1PRADEAG4.5643e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr14:92117714-92121189:-LUSCPathEER4.4129e-023.4323e-020.1052image
ENSG00000183648.8,NDUFB1LUSCPathEAG4.5840e-023.4894e-020.1049image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for NDUFB1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:92117714-92121189:-LUADEERENSG00000234420,ZNF37BP0.47483.1483e-191.1298e-180.4256imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000165494,PCF110.47393.4244e-193.9015e-200.4415imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000169045,HNRNPH10.47237.7611e-193.6952e-190.4310imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000268087,CTC-429P9.20.46202.2647e-182.0991e-180.4225imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
chr14:92117714-92121189:-LUADEERENSG00000184863,RBM330.45442.7870e-172.5791e-180.4215imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000147162,OGT0.44853.5670e-171.3815e-160.4011imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92117714-92121189:-LUADEERENSG00000132424,PNISR0.45183.5895e-174.2174e-170.4074imageNDKC1;HNRNPL;PTBP1NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000273096,RP3-508I15.200.44834.6066e-172.3048e-190.4332imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000100201,DDX170.44699.5919e-175.9983e-190.4286imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000109920,FNBP40.44511.0107e-162.9437e-180.4208imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_naiveGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000234420,ZNF37BP0.47483.1483e-191.1298e-180.4256imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000165494,PCF110.47393.4244e-193.9015e-200.4415imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000169045,HNRNPH10.47237.7611e-193.6952e-190.4310imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000268087,CTC-429P9.20.46202.2647e-182.0991e-180.4225imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
chr14:92117714-92121189:-LUADEERENSG00000184863,RBM330.45442.7870e-172.5791e-180.4215imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000147162,OGT0.44853.5670e-171.3815e-160.4011imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92117714-92121189:-LUADEERENSG00000132424,PNISR0.45183.5895e-174.2174e-170.4074imageNDKC1;HNRNPL;PTBP1NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000273096,RP3-508I15.200.44834.6066e-172.3048e-190.4332imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr14:92117714-92121189:-LUADEERENSG00000100201,DDX170.44699.5919e-175.9983e-190.4286imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr14:92117714-92121189:-LUADEERENSG00000109920,FNBP40.44511.0107e-162.9437e-180.4208imageNDKC1;HNRNPL;PTBP1NAT_cells_CD4_naiveGSVA_HALLMARK_ADIPOGENESIS

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4. Enriched editing regions and immune related splicing for NDUFB1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000183648.8,NDUFB1
ESCAEAGA3ENSG00000187079.10chr1112864837:12864900:12879707:12879842:12878888:12879842-0.30531.7050e-026.5679e-06-0.4048imageNACIN1;AIFM1;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZC3H7B;ZNF184NAMast_cells_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000183648.8,NDUFB1
ESCAEAGESENSG00000187079.10chr1112864837:12864900:12878888:12878900:12879707:128798420.31161.1542e-022.8056e-060.4210imageNACIN1;AIFM1;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZC3H7B;ZNF184NAMast_cells_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000183648.8,NDUFB1
ESCAEAGA3ENSG00000122966.9chr12119712177:119712347:119710539:119710620:119710539:119711093-0.31604.0833e-023.0061e-08-0.4362imageNACIN1;AIFM1;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7B;ZNF184NAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr14:92117714-92121189:-
ESCAEERA3ENSG00000187079.10chr1112864837:12864900:12879707:12879842:12878888:12879842-0.30521.4434e-026.9466e-06-0.4038imageNDKC1;HNRNPL;PTBP1NAMast_cells_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr14:92117714-92121189:-
ESCAEERESENSG00000187079.10chr1112864837:12864900:12878888:12878900:12879707:128798420.31159.8591e-032.9614e-060.4201imageNDKC1;HNRNPL;PTBP1NAMast_cells_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr14:92117714-92121189:-
ESCAEERA3ENSG00000122966.9chr12119712177:119712347:119710539:119710620:119710539:119711093-0.31723.2921e-022.8786e-08-0.4367imageNDKC1;HNRNPL;PTBP1NAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000183648.8,NDUFB1
GBMEAGIRENSG00000165802.15chr9137452464:137452819:137453061:137453171-0.14504.0641e-021.1512e-05-0.4014imageNACIN1;AIFM1;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NANK_cells_activated
chr14:92117714-92121189:-
GBMEERIRENSG00000165802.15chr9137452464:137452819:137453061:137453171-0.14503.5135e-021.1504e-05-0.4014imageNPTBP1NANK_cells_activated
chr14:92117714-92121189:-
KIRPEERIRENSG00000070610.10chr935736865:35737447:35737747:357379390.25327.6520e-038.9766e-110.4004imageNHNRNPL;PTBP1NAMacrophages_M2GSVA_HALLMARK_FATTY_ACID_METABOLISM
chr14:92117714-92121189:-
KIRPEERIRENSG00000081870.7chr153921560:53921767:53923903:539239470.32976.1752e-052.7505e-110.4104imageNDKC1;HNRNPL;PTBP1HSPB11Mast_cells_restingGSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for NDUFB1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:92117714-92121189:-ACCEERT_cells_CD4_memory_resting9.5789e-03-0.3167image
ENSG00000183648.8,NDUFB1ACCEAGT_cells_CD4_memory_resting9.0536e-03-0.3189image
chr14:92117714-92121189:-BRCAEERB_cells_naive4.3884e-030.0949image
ENSG00000183648.8,NDUFB1BRCAEAGB_cells_naive4.2518e-030.0952image
chr14:92117714-92121189:-CESCEERT_cells_CD4_memory_resting1.0439e-020.1539image
ENSG00000183648.8,NDUFB1CESCEAGT_cells_CD4_memory_resting1.0051e-020.1547image
chr14:92117714-92121189:-CHOLEERT_cells_gamma_delta3.6771e-020.3766image
ENSG00000183648.8,NDUFB1CHOLEAGT_cells_gamma_delta3.5399e-020.3792image
chr14:92117714-92121189:-COADEERNeutrophils3.0747e-020.1653image
ENSG00000183648.8,NDUFB1COADEAGNeutrophils3.0747e-020.1653image
chr14:92117714-92121189:-ESCAEERMacrophages_M21.9114e-020.1905image
ENSG00000183648.8,NDUFB1ESCAEAGMacrophages_M22.0055e-020.1891image
chr14:92117714-92121189:-GBMEERMast_cells_resting4.6147e-020.1584image
ENSG00000183648.8,NDUFB1GBMEAGMast_cells_resting4.6198e-020.1584image
chr14:92117714-92121189:-HNSCEERMacrophages_M13.0884e-02-0.1317image
ENSG00000183648.8,NDUFB1HNSCEAGMacrophages_M13.0884e-02-0.1317image
chr14:92117714-92121189:-KIRPEERMast_cells_resting2.2102e-040.2348image
ENSG00000183648.8,NDUFB1KIRPEAGMast_cells_resting2.1605e-040.2352image
chr14:92117714-92121189:-LAMLEERMast_cells_activated2.3599e-02-0.2763image
ENSG00000183648.8,NDUFB1LAMLEAGMast_cells_activated2.3599e-02-0.2763image
chr14:92117714-92121189:-LGGEERMacrophages_M11.2090e-03-0.1458image
ENSG00000183648.8,NDUFB1LGGEAGMacrophages_M11.1882e-03-0.1460image
chr14:92117714-92121189:-LUADEERT_cells_CD4_memory_resting4.5520e-070.2515image
ENSG00000183648.8,NDUFB1LUADEAGT_cells_CD4_memory_resting4.1431e-070.2523image
chr14:92117714-92121189:-LUSCEERT_cells_regulatory_(Tregs)4.6585e-020.0990image
ENSG00000183648.8,NDUFB1LUSCEAGT_cells_regulatory_(Tregs)4.3571e-020.1003image
chr14:92117714-92121189:-MESOEERDendritic_cells_resting3.6336e-050.4787image
ENSG00000183648.8,NDUFB1MESOEAGDendritic_cells_resting3.6336e-050.4787image
chr14:92117714-92121189:-OVEERMacrophages_M04.7291e-030.1660image
ENSG00000183648.8,NDUFB1OVEAGMacrophages_M04.9536e-030.1652image
chr14:92117714-92121189:-PAADEERDendritic_cells_resting4.8785e-03-0.2272image
ENSG00000183648.8,NDUFB1PAADEAGDendritic_cells_resting4.8785e-03-0.2272image
chr14:92117714-92121189:-PCPGEERT_cells_gamma_delta2.0947e-02-0.1802image
ENSG00000183648.8,NDUFB1PCPGEAGT_cells_gamma_delta2.0910e-02-0.1803image
chr14:92117714-92121189:-PRADEERB_cells_memory2.2149e-02-0.1154image
ENSG00000183648.8,NDUFB1PRADEAGB_cells_memory2.2601e-02-0.1144image
chr14:92117714-92121189:-READEERNK_cells_resting3.1269e-020.2738image
ENSG00000183648.8,NDUFB1READEAGNK_cells_resting3.1269e-020.2738image
chr14:92117714-92121189:-SARCEERB_cells_naive2.5021e-030.2132image
ENSG00000183648.8,NDUFB1SARCEAGB_cells_naive2.4610e-030.2135image
chr14:92117714-92121189:-STADEERMonocytes6.1327e-03-0.1497image
ENSG00000183648.8,NDUFB1STADEAGMonocytes5.8247e-03-0.1506image
chr14:92117714-92121189:-TGCTEERT_cells_follicular_helper6.3841e-03-0.2337image
ENSG00000183648.8,NDUFB1TGCTEAGT_cells_follicular_helper6.9941e-03-0.2311image
chr14:92117714-92121189:-THCAEERB_cells_memory3.3002e-020.0990image
ENSG00000183648.8,NDUFB1THCAEAGB_cells_memory3.2853e-020.0991image
chr14:92117714-92121189:-THYMEERT_cells_regulatory_(Tregs)2.2705e-03-0.2844image
ENSG00000183648.8,NDUFB1THYMEAGT_cells_regulatory_(Tregs)2.8377e-03-0.2783image
chr14:92117714-92121189:-UCECEERNeutrophils1.0315e-030.2628image
ENSG00000183648.8,NDUFB1UCECEAGNeutrophils8.8486e-040.2661image
chr14:92117714-92121189:-UCSEERMast_cells_activated1.3732e-020.3774image
ENSG00000183648.8,NDUFB1UCSEAGMast_cells_activated1.3677e-020.3776image


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6. Enriched editing regions and immune gene sets for NDUFB1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr14:92117714-92121189:-UCECEER8.7323e-04-0.26641.2564e-02-0.20142.7949e-02-0.17774.0522e-02-0.1658image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr14:92117714-92121189:-BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.1661e-03-0.1613image
ENSG00000183648.8,NDUFB1BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.9467e-03-0.1622image
chr14:92117714-92121189:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9787e-04-0.1238image
ENSG00000183648.8,NDUFB1BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6445e-04-0.1253image
chr14:92117714-92121189:-CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.3946e-03-0.1758image
ENSG00000183648.8,NDUFB1CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.8182e-03-0.1736image
ENSG00000183648.8,NDUFB1CHOLGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.2679e-02-0.4425image
chr14:92117714-92121189:-CHOLGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.2488e-02-0.4434image
ENSG00000183648.8,NDUFB1COADGSVA_HALLMARK_DNA_REPAIREAG2.8254e-04-0.2743image
chr14:92117714-92121189:-COADGSVA_HALLMARK_DNA_REPAIREER2.8254e-04-0.2743image
ENSG00000183648.8,NDUFB1DLBCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.2790e-02-0.3517image
chr14:92117714-92121189:-DLBCGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.0001e-02-0.3392image
chr14:92117714-92121189:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER8.3816e-050.3145image
ENSG00000183648.8,NDUFB1ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG8.3826e-050.3145image
ENSG00000183648.8,NDUFB1GBMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG9.5290e-03-0.2050image
chr14:92117714-92121189:-GBMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER9.5389e-03-0.2050image
chr14:92117714-92121189:-HNSCGSVA_HALLMARK_UV_RESPONSE_UPEER1.0845e-03-0.1982image
ENSG00000183648.8,NDUFB1HNSCGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0845e-03-0.1982image
ENSG00000183648.8,NDUFB1KICHGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.2024e-02-0.3122image
chr14:92117714-92121189:-KICHGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.2005e-02-0.3123image
ENSG00000183648.8,NDUFB1KIRCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.3761e-06-0.2454image
chr14:92117714-92121189:-KIRCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.3763e-06-0.2454image
ENSG00000183648.8,NDUFB1KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG8.5491e-06-0.2812image
chr14:92117714-92121189:-KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.8882e-06-0.2840image
chr14:92117714-92121189:-LGGGSVA_HALLMARK_ADIPOGENESISEER7.0182e-05-0.1786image
ENSG00000183648.8,NDUFB1LGGGSVA_HALLMARK_ADIPOGENESISEAG7.1954e-05-0.1784image
ENSG00000183648.8,NDUFB1LIHCGSVA_HALLMARK_HEME_METABOLISMEAG1.3836e-02-0.1511image
chr14:92117714-92121189:-LIHCGSVA_HALLMARK_HEME_METABOLISMEER1.3840e-02-0.1511image
ENSG00000183648.8,NDUFB1LUADGSVA_HALLMARK_ADIPOGENESISEAG1.7333e-19-0.4346image
chr14:92117714-92121189:-LUADGSVA_HALLMARK_ADIPOGENESISEER1.4830e-19-0.4353image
ENSG00000183648.8,NDUFB1LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.7979e-04-0.1796image
chr14:92117714-92121189:-LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.8017e-04-0.1796image
ENSG00000183648.8,NDUFB1MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.9041e-05-0.4935image
chr14:92117714-92121189:-MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9041e-05-0.4935image
ENSG00000183648.8,NDUFB1OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.9969e-030.1814image
chr14:92117714-92121189:-OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.8882e-030.1824image
ENSG00000183648.8,NDUFB1PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.1395e-04-0.2960image
chr14:92117714-92121189:-PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.1395e-04-0.2960image
ENSG00000183648.8,NDUFB1PCPGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG9.5269e-03-0.2019image
chr14:92117714-92121189:-PCPGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER9.4382e-03-0.2021image
chr14:92117714-92121189:-PRADGSVA_HALLMARK_NOTCH_SIGNALINGEER8.1207e-04-0.1682image
ENSG00000183648.8,NDUFB1PRADGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.0449e-03-0.1639image
chr14:92117714-92121189:-READGSVA_HALLMARK_UV_RESPONSE_UPEER1.8148e-03-0.3883image
ENSG00000183648.8,NDUFB1READGSVA_HALLMARK_UV_RESPONSE_UPEAG1.8148e-03-0.3883image
ENSG00000183648.8,NDUFB1SARCGSVA_HALLMARK_DNA_REPAIREAG3.7310e-03-0.2047image
chr14:92117714-92121189:-SARCGSVA_HALLMARK_DNA_REPAIREER3.5689e-03-0.2056image
ENSG00000183648.8,NDUFB1SKCMGSVA_HALLMARK_ADIPOGENESISEAG1.0672e-07-0.2854image
chr14:92117714-92121189:-SKCMGSVA_HALLMARK_ADIPOGENESISEER1.0706e-07-0.2854image
chr14:92117714-92121189:-TGCTGSVA_HALLMARK_UV_RESPONSE_DNEER4.0310e-040.3002image
ENSG00000183648.8,NDUFB1TGCTGSVA_HALLMARK_UV_RESPONSE_DNEAG4.1873e-040.2994image
ENSG00000183648.8,NDUFB1THCAGSVA_HALLMARK_ADIPOGENESISEAG5.2772e-07-0.2303image
chr14:92117714-92121189:-THCAGSVA_HALLMARK_ADIPOGENESISEER5.7946e-07-0.2295image
ENSG00000183648.8,NDUFB1THYMGSVA_HALLMARK_MYC_TARGETS_V1EAG5.7642e-04-0.3189image
chr14:92117714-92121189:-THYMGSVA_HALLMARK_MYC_TARGETS_V1EER6.6037e-04-0.3156image
ENSG00000183648.8,NDUFB1UCECGSVA_HALLMARK_DNA_REPAIREAG2.5606e-07-0.4022image
chr14:92117714-92121189:-UCECGSVA_HALLMARK_DNA_REPAIREER7.4391e-08-0.4183image
chr14:92117714-92121189:-UCSGSVA_HALLMARK_ADIPOGENESISEER1.6535e-02-0.3679image
ENSG00000183648.8,NDUFB1UCSGSVA_HALLMARK_ADIPOGENESISEAG1.6447e-02-0.3682image


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7. Enriched editing regions and drugs for NDUFB1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr14:92117714-92121189:-ACCJW.7.52.1EER2.6750e-02-0.2727image
ENSG00000183648.8,NDUFB1ACCJW.7.52.1EAG2.5513e-02-0.2749image
chr14:92117714-92121189:-BLCABI.D1870EER8.7893e-030.1476image
ENSG00000183648.8,NDUFB1BLCABI.D1870EAG8.8068e-030.1476image
chr14:92117714-92121189:-BRCAAS601245EER1.1307e-03-0.1084image
ENSG00000183648.8,NDUFB1BRCAAS601245EAG7.0865e-04-0.1127image
chr14:92117714-92121189:-CESCGW843682XEER6.2353e-030.1643image
ENSG00000183648.8,NDUFB1CESCGW843682XEAG6.2644e-030.1642image
chr14:92117714-92121189:-CHOLAZD.0530EER3.1746e-02-0.3865image
ENSG00000183648.8,NDUFB1CHOLAZD.0530EAG2.9467e-02-0.3914image
ENSG00000183648.8,NDUFB1COADCCT007093EAG8.4718e-05-0.2960image
chr14:92117714-92121189:-COADCCT007093EER8.4718e-05-0.2960image
ENSG00000183648.8,NDUFB1DLBCGSK.650394EAG1.7961e-02-0.3870image
chr14:92117714-92121189:-DLBCGSK.650394EER1.9122e-02-0.3835image
ENSG00000183648.8,NDUFB1ESCAGSK269962AEAG3.8128e-05-0.3285image
chr14:92117714-92121189:-ESCAGSK269962AEER4.0557e-05-0.3275image
ENSG00000183648.8,NDUFB1GBMATRAEAG8.5772e-03-0.2078image
chr14:92117714-92121189:-GBMATRAEER8.5683e-03-0.2078image
chr14:92117714-92121189:-HNSCErlotinibEER7.1759e-03-0.1639image
ENSG00000183648.8,NDUFB1HNSCErlotinibEAG7.1759e-03-0.1639image
chr14:92117714-92121189:-KICHJNJ.26854165EER2.9282e-030.3661image
ENSG00000183648.8,NDUFB1KICHJNJ.26854165EAG2.9255e-030.3661image
chr14:92117714-92121189:-KIRCAZD.2281EER2.2186e-04-0.1987image
ENSG00000183648.8,NDUFB1KIRCAZD.2281EAG2.2183e-04-0.1987image
ENSG00000183648.8,NDUFB1KIRPBryostatin.1EAG8.7857e-060.2808image
chr14:92117714-92121189:-KIRPBryostatin.1EER1.2311e-050.2764image
chr14:92117714-92121189:-LAMLEmbelinEER1.4370e-02-0.2978image
ENSG00000183648.8,NDUFB1LAMLEmbelinEAG1.4370e-02-0.2978image
ENSG00000183648.8,NDUFB1LGGA.443654EAG2.5817e-040.1644image
chr14:92117714-92121189:-LGGA.443654EER2.4999e-040.1647image
ENSG00000183648.8,NDUFB1LIHCAZD.2281EAG1.4473e-02-0.1515image
chr14:92117714-92121189:-LIHCAZD.2281EER1.4473e-02-0.1515image
ENSG00000183648.8,NDUFB1LUADLenalidomideEAG1.2081e-10-0.3177image
chr14:92117714-92121189:-LUADLenalidomideEER1.1087e-10-0.3183image
ENSG00000183648.8,NDUFB1LUSCAZD6482EAG6.5424e-06-0.2219image
chr14:92117714-92121189:-LUSCAZD6482EER6.9645e-06-0.2213image
ENSG00000183648.8,NDUFB1MESOCCT007093EAG2.5111e-04-0.4302image
chr14:92117714-92121189:-MESOCCT007093EER2.5111e-04-0.4302image
chr14:92117714-92121189:-OVImatinibEER5.2877e-03-0.1639image
ENSG00000183648.8,NDUFB1OVImatinibEAG5.5189e-03-0.1631image
chr14:92117714-92121189:-PAADIPA.3EER1.0169e-02-0.2150image
ENSG00000183648.8,NDUFB1PAADIPA.3EAG1.0169e-02-0.2150image
chr14:92117714-92121189:-PCPGLenalidomideEER8.7509e-03-0.2041image
ENSG00000183648.8,NDUFB1PCPGLenalidomideEAG8.7689e-03-0.2041image
chr14:92117714-92121189:-PRADBX.795EER2.5801e-020.1124image
ENSG00000183648.8,NDUFB1PRADDasatinibEAG3.2671e-020.1083image
chr14:92117714-92121189:-READDocetaxelEER1.3673e-040.4657image
ENSG00000183648.8,NDUFB1READDocetaxelEAG1.3673e-040.4657image
chr14:92117714-92121189:-SARCGDC.0449EER1.2504e-040.2686image
ENSG00000183648.8,NDUFB1SARCGDC.0449EAG1.3482e-040.2674image
ENSG00000183648.8,NDUFB1SKCMMG.132EAG2.7208e-030.1638image
chr14:92117714-92121189:-SKCMMG.132EER2.7273e-030.1637image
chr14:92117714-92121189:-STADJNJ.26854165EER3.6395e-030.1589image
ENSG00000183648.8,NDUFB1STADJNJ.26854165EAG3.6502e-030.1589image
chr14:92117714-92121189:-TGCTAZD6482EER1.0065e-04-0.3284image
ENSG00000183648.8,NDUFB1TGCTAZD6482EAG1.0391e-04-0.3278image
chr14:92117714-92121189:-THCAAP.24534EER6.2139e-07-0.2289image
ENSG00000183648.8,NDUFB1THCAAP.24534EAG4.9961e-07-0.2308image
chr14:92117714-92121189:-THYMLFM.A13EER5.9822e-05-0.3683image
ENSG00000183648.8,NDUFB1THYMLFM.A13EAG5.4304e-05-0.3702image
ENSG00000183648.8,NDUFB1UCECDocetaxelEAG5.1581e-060.3591image
chr14:92117714-92121189:-UCECDocetaxelEER4.1907e-060.3623image
chr14:92117714-92121189:-UCSBMS.708163EER1.6399e-020.3683image
ENSG00000183648.8,NDUFB1UCSBMS.708163EAG1.4566e-020.3744image
ENSG00000183648.8,NDUFB1UVMBX.795EAG4.0759e-02-0.2719image
chr14:92117714-92121189:-UVMBX.795EER4.0759e-02-0.2719image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType