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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NASP (ImmuneEditome ID:4678)

1. Gene summary of enriched editing regions for NASP

check button Gene summary
Gene informationGene symbol

NASP

Gene ID

4678

GeneSynonymsFLB7527|HMDRA1|PRO1999
GeneCytomap

1p34.1

GeneTypeprotein-coding
GeneDescriptionnuclear autoantigenic sperm protein|NASP histone chaperone|histone H1-binding protein|nuclear autoantigenic sperm protein (histone-binding)
GeneModificationdate20230409
UniprotIDE9PAU3;E9PKR5;P49321;Q5T626;E9PJQ2;E9PPQ8;E9PNB5;E9PRH9;E9PI86;E9PQG5;E9PPR5;Q5T624
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:45593298-45593489:+ENST00000464190.5ENSG00000132780.15NASPncRNA_intronicAluSx1chr1:45593298-45593489:+.alignment
chr1:45593298-45593489:+ENST00000534101.1ENSG00000132780.15NASPncRNA_intronicAluSx1chr1:45593298-45593489:+.alignment
chr1:45609897-45611681:+ENST00000481782.1ENSG00000132780.15NASPncRNA_exonicAluJo,AluSx,AluSx4,AluSc8,MIRchr1:45609897-45611681:+.alignment
chr1:45609897-45611681:+ENST00000530073.4ENSG00000132780.15NASPncRNA_exonicAluJo,AluSx,AluSx4,AluSc8,MIRchr1:45609897-45611681:+.alignment


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2. Tumor-specific enriched editing regions for NASP


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:45609897-45611681:+BRCAEER1.1109e-02image
ENSG00000132780.15,NASPBRCAEAG1.4365e-02image
chr1:45609897-45611681:+LUSCEER9.6007e-04image
ENSG00000132780.15,NASPLUSCEAG1.5358e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000132780.15,NASPESCACliEAG4.0649e-024.5836e-03-0.4107image
chr1:45609897-45611681:+ESCACliEER3.9093e-024.4439e-03-0.4120image
chr1:45609897-45611681:+TGCTCliEER1.6409e-029.4028e-030.3354image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for NASP


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:45609897-45611681:+GBMEERENSG00000240970,RPL23AP64-0.55391.0222e-077.7477e-10-0.4935imageNNNANeutrophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000254428,RP11-110I1.11-0.51819.9619e-079.1554e-10-0.4916imageNNNAT_cells_follicular_helperGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000240053,LY6G5B-0.48138.5490e-061.1788e-08-0.4619imageNAUH;DGCR8;DKC1;ELAVL1;HNRNPC;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2LY6G5BT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000272153,RP1-286D6.5-0.48258.7921e-062.7731e-08-0.4513imageNNNAMacrophages_M2GSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000230415,RP5-902P8.10-0.47501.2593e-051.5222e-08-0.4588imageNDGCR8;HNRNPC;NOP58;U2AF1;U2AF2NAT_cells_CD8GSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000279382,RP11-449J21.3-0.47521.2863e-051.3867e-08-0.4599imageNDKC1NAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000203761,MSTO2P-0.47201.5745e-051.3259e-08-0.4605imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000204149,AGAP6-0.46951.5788e-057.7354e-08-0.4381imageNDKC1;ELAVL1;HNRNPC;HNRNPD;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAMonocytesGSVA_HALLMARK_PEROXISOME
chr1:45609897-45611681:+GBMEERENSG00000183426,NPIPA1-0.46821.7323e-052.0397e-07-0.4250imageNAUH;ELAVL1;ELAVL3;HNRNPC;KHSRP;NOP58;PTBP1;U2AF1;U2AF2NAMonocytesGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000207741,MIR590-0.45941.7993e-052.7985e-08-0.4512imageNNNANeutrophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000240970,RPL23AP64-0.55391.0222e-077.7477e-10-0.4935imageNNNANeutrophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000254428,RP11-110I1.11-0.51819.9619e-079.1554e-10-0.4916imageNNNAT_cells_follicular_helperGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000240053,LY6G5B-0.48138.5490e-061.1788e-08-0.4619imageNAUH;DGCR8;DKC1;ELAVL1;HNRNPC;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2LY6G5BT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000272153,RP1-286D6.5-0.48258.7921e-062.7731e-08-0.4513imageNNNAMacrophages_M2GSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000230415,RP5-902P8.10-0.47501.2593e-051.5222e-08-0.4588imageNDGCR8;HNRNPC;NOP58;U2AF1;U2AF2NAT_cells_CD8GSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000279382,RP11-449J21.3-0.47521.2863e-051.3867e-08-0.4599imageNDKC1NAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+GBMEERENSG00000203761,MSTO2P-0.47201.5745e-051.3259e-08-0.4605imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000204149,AGAP6-0.46951.5788e-057.7354e-08-0.4381imageNDKC1;ELAVL1;HNRNPC;HNRNPD;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAMonocytesGSVA_HALLMARK_PEROXISOME
chr1:45609897-45611681:+GBMEERENSG00000183426,NPIPA1-0.46821.7323e-052.0397e-07-0.4250imageNAUH;ELAVL1;ELAVL3;HNRNPC;KHSRP;NOP58;PTBP1;U2AF1;U2AF2NAMonocytesGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+GBMEERENSG00000207741,MIR590-0.45941.7993e-052.7985e-08-0.4512imageNNNANeutrophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

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4. Enriched editing regions and immune related splicing for NASP


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:45609897-45611681:+
GBMEERIRENSG00000112592.8chr6170569611:170569779:170571409:170571504-0.44003.7290e-042.7693e-07-0.4236imageNDGCR8;DKC1;ELAVL1;ELAVL3;HNRNPC;HNRNPD;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NANeutrophilsGSVA_HALLMARK_PEROXISOME
chr1:45609897-45611681:+
GBMEERIRENSG00000130023.11chr6169766637:169766667:169768102:169768171-0.42855.8610e-044.6825e-08-0.4491imageNAUH;DGCR8;DKC1;ELAVL1;ELAVL3;HNRNPC;HNRNPD;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NANK_cells_restingGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+
GBMEERIRENSG00000204628.7chr5181236908:181237042:181237224:181237263-0.41601.3447e-032.3725e-07-0.4243imageNAUH;DGCR8;DKC1;ELAVL1;ELAVL3;HNRNPC;HNRNPD;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2GNB2L1T_cells_CD4_memory_activatedGSVA_HALLMARK_ADIPOGENESIS
ENSG00000132780.15,NASP
GBMEAGIRENSG00000129197.10chr175425945:5426082:5426235:5426299-0.51781.6208e-051.0882e-09-0.4897imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:45609897-45611681:+
GBMEERIRENSG00000198276.9chr2063945804:63945975:63946160:63946267-0.47301.1993e-045.8653e-09-0.4719imageNAUH;DGCR8;DKC1;ELAVL1;HNRNPC;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+
GBMEERIRENSG00000143933.12chr247172413:47172459:47176440:47176511-0.45252.3078e-041.6754e-09-0.4929imageNAUH;DGCR8;DKC1;ELAVL1;ELAVL3;HNRNPC;HNRNPD;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr1:45609897-45611681:+
GBMEERIRENSG00000165661.11chr9136206332:136209275:136211263:136211452-0.41383.7346e-049.5262e-09-0.4821imageNAUH;DGCR8;DKC1;ELAVL1;ELAVL3;HNRNPC;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr1:45609897-45611681:+
GBMEERIRENSG00000140365.11chr1575338984:75339104:75339263:75339344-0.40562.2579e-033.1523e-07-0.4190imageNAUH;DGCR8;DKC1;ELAVL1;HNRNPC;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAT_cells_follicular_helperGSVA_HALLMARK_PEROXISOME
chr1:45609897-45611681:+
GBMEERIRENSG00000005302.13chrX11763779:11763938:11765466:11765646-0.42509.1130e-045.6161e-07-0.4135imageNAUH;DGCR8;DKC1;ELAVL1;ELAVL3;HNRNPC;KHSRP;NOP58;PTBP1;RANGAP1;U2AF1;U2AF2NAT_cells_follicular_helperGSVA_HALLMARK_PEROXISOME
ENSG00000132780.15,NASP
GBMEAGIRENSG00000140104.9chr14104988942:104989088:104991490:104991620-0.40169.9248e-043.0808e-07-0.4325imageNACIN1;AUH;BUD13;CNBP;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA2B1;HNRNPC;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LIN28;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SMNDC1;SRSF1;TAF15;TNRC6A;TROVE2;U2AF2;UPF1;ZNF184NANeutrophilsGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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5. Enriched editing regions and immune infiltration for NASP


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:45609897-45611681:+BRCAEERT_cells_CD81.0645e-02-0.1028image
ENSG00000132780.15,NASPBRCAEAGT_cells_CD89.0917e-03-0.1050image
chr1:45609897-45611681:+CESCEERNK_cells_activated1.2398e-020.1731image
ENSG00000132780.15,NASPCESCEAGNK_cells_activated1.8192e-020.1632image
chr1:45609897-45611681:+COADEERDendritic_cells_activated1.7629e-020.2200image
ENSG00000132780.15,NASPCOADEAGDendritic_cells_activated2.2990e-020.2101image
chr1:45609897-45611681:+ESCAEERT_cells_regulatory_(Tregs)6.9795e-03-0.2287image
ENSG00000132780.15,NASPESCAEAGT_cells_regulatory_(Tregs)6.7215e-03-0.2297image
chr1:45609897-45611681:+GBMEERMacrophages_M22.3034e-040.3086image
ENSG00000132780.15,NASPGBMEAGMacrophages_M22.7819e-040.3048image
chr1:45609897-45611681:+KIRCEERMacrophages_M22.2491e-02-0.1601image
ENSG00000132780.15,NASPKIRCEAGDendritic_cells_activated1.7693e-020.1659image
chr1:45609897-45611681:+KIRPEEREosinophils1.6081e-020.2414image
ENSG00000132780.15,NASPKIRPEAGEosinophils1.6081e-020.2414image
chr1:45609897-45611681:+LAMLEERDendritic_cells_activated3.3714e-02-0.1796image
ENSG00000132780.15,NASPLAMLEAGDendritic_cells_activated2.0713e-02-0.1954image
chr1:45609897-45611681:+LGGEERMacrophages_M02.5635e-02-0.1059image
ENSG00000132780.15,NASPLGGEAGMacrophages_M09.1383e-03-0.1234image
chr1:45609897-45611681:+LUADEERDendritic_cells_activated4.8669e-030.1712image
ENSG00000132780.15,NASPLUADEAGDendritic_cells_activated4.8133e-030.1714image
chr1:45609897-45611681:+LUSCEERMacrophages_M11.9901e-020.1463image
ENSG00000132780.15,NASPLUSCEAGMacrophages_M13.5136e-020.1320image
chr1:45609897-45611681:+OVEERMast_cells_resting3.3434e-02-0.1462image
ENSG00000132780.15,NASPOVEAGMast_cells_resting3.4300e-02-0.1454image
chr1:45609897-45611681:+PAADEERT_cells_CD86.0817e-03-0.3561image
ENSG00000132780.15,NASPPAADEAGT_cells_CD86.0817e-03-0.3561image
chr1:45609897-45611681:+PRADEERB_cells_naive2.0519e-02-0.2439image
ENSG00000132780.15,NASPPRADEAGB_cells_naive2.0567e-02-0.2438image
chr1:45609897-45611681:+READEERMacrophages_M03.4581e-020.3808image
ENSG00000132780.15,NASPREADEAGMacrophages_M03.1430e-020.3871image
ENSG00000132780.15,NASPSARCEAGT_cells_CD82.3510e-02-0.2220image
chr1:45609897-45611681:+SKCMEERT_cells_CD4_memory_resting1.8984e-020.1658image
ENSG00000132780.15,NASPSKCMEAGT_cells_CD4_memory_resting1.8725e-020.1661image
chr1:45609897-45611681:+STADEERB_cells_memory1.5684e-02-0.1575image
ENSG00000132780.15,NASPSTADEAGB_cells_memory9.4938e-03-0.1664image
chr1:45609897-45611681:+THYMEERT_cells_gamma_delta1.6372e-020.3347image
ENSG00000132780.15,NASPTHYMEAGT_cells_gamma_delta1.6372e-020.3347image
chr1:45609897-45611681:+UCSEERT_cells_follicular_helper1.5386e-02-0.4989image
ENSG00000132780.15,NASPUCSEAGT_cells_follicular_helper1.5386e-02-0.4989image


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6. Enriched editing regions and immune gene sets for NASP


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr1:45609897-45611681:+BLCAGSVA_HALLMARK_HYPOXIAEER1.8242e-030.2699image
ENSG00000132780.15,NASPBLCAGSVA_HALLMARK_HYPOXIAEAG3.8721e-030.2498image
ENSG00000132780.15,NASPBRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.0287e-030.1241image
chr1:45609897-45611681:+BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.4756e-030.1217image
ENSG00000132780.15,NASPCESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.6934e-02-0.1376image
chr1:45609897-45611681:+CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.2597e-02-0.1727image
chr1:45609897-45611681:+COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.7196e-02-0.1847image
ENSG00000132780.15,NASPESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.8279e-040.3044image
chr1:45609897-45611681:+ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.6554e-040.2991image
ENSG00000132780.15,NASPGBMGSVA_HALLMARK_ADIPOGENESISEAG5.7991e-060.3752image
chr1:45609897-45611681:+GBMGSVA_HALLMARK_ADIPOGENESISEER5.9372e-060.3748image
ENSG00000132780.15,NASPKIRCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.9629e-040.2417image
chr1:45609897-45611681:+KIRCGSVA_HALLMARK_MYC_TARGETS_V2EER8.9087e-050.2715image
chr1:45609897-45611681:+KIRPGSVA_HALLMARK_P53_PATHWAYEER4.7087e-030.2818image
ENSG00000132780.15,NASPKIRPGSVA_HALLMARK_P53_PATHWAYEAG4.7087e-030.2818image
chr1:45609897-45611681:+LAMLGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.5839e-020.1884image
ENSG00000132780.15,NASPLAMLGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.1435e-020.2132image
chr1:45609897-45611681:+LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.3744e-100.2905image
ENSG00000132780.15,NASPLGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG5.8017e-090.2716image
ENSG00000132780.15,NASPLIHCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.8956e-030.4371image
chr1:45609897-45611681:+LIHCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.8956e-030.4371image
chr1:45609897-45611681:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER6.2110e-030.1664image
ENSG00000132780.15,NASPLUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG6.9033e-030.1644image
ENSG00000132780.15,NASPLUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.0261e-040.2307image
chr1:45609897-45611681:+LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER7.8254e-050.2457image
chr1:45609897-45611681:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1365e-030.2220image
ENSG00000132780.15,NASPOVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.1382e-030.2220image
ENSG00000132780.15,NASPPAADGSVA_HALLMARK_PROTEIN_SECRETIONEAG9.7126e-030.3369image
chr1:45609897-45611681:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER9.7126e-030.3369image
ENSG00000132780.15,NASPPRADGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.7641e-02-0.2094image
chr1:45609897-45611681:+PRADGSVA_HALLMARK_NOTCH_SIGNALINGEER4.6985e-02-0.2100image
chr1:45609897-45611681:+SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.1237e-050.4179image
ENSG00000132780.15,NASPSARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.3847e-050.4121image
chr1:45609897-45611681:+SKCMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.1062e-020.1793image
ENSG00000132780.15,NASPSKCMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.0713e-020.1801image
ENSG00000132780.15,NASPSTADGSVA_HALLMARK_HYPOXIAEAG1.7360e-060.3018image
chr1:45609897-45611681:+STADGSVA_HALLMARK_HYPOXIAEER2.4009e-050.2718image
ENSG00000132780.15,NASPTGCTGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.5411e-040.3335image
chr1:45609897-45611681:+TGCTGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.2444e-040.3502image
ENSG00000132780.15,NASPTHYMGSVA_HALLMARK_G2M_CHECKPOINTEAG8.3137e-03-0.3657image
chr1:45609897-45611681:+THYMGSVA_HALLMARK_G2M_CHECKPOINTEER8.3137e-03-0.3657image
chr1:45609897-45611681:+UCSGSVA_HALLMARK_DNA_REPAIREER9.2541e-030.5302image
ENSG00000132780.15,NASPUCSGSVA_HALLMARK_DNA_REPAIREAG9.2541e-030.5302image


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7. Enriched editing regions and drugs for NASP


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr1:45609897-45611681:+BLCAA.770041EER3.0170e-02-0.1895image
ENSG00000132780.15,NASPBLCADasatinibEAG3.0707e-02-0.1882image
chr1:45609897-45611681:+BRCAIPA.3EER4.0291e-020.0827image
ENSG00000132780.15,NASPBRCAIPA.3EAG2.7724e-020.0888image
chr1:45609897-45611681:+CESCBMS.509744EER6.5072e-03-0.1881image
ENSG00000132780.15,NASPCESCAZD6244EAG1.7072e-02-0.1648image
chr1:45609897-45611681:+COADKU.55933EER4.8927e-020.1833image
ENSG00000132780.15,NASPCOADKU.55933EAG3.6227e-020.1939image
chr1:45609897-45611681:+ESCAA.770041EER4.5207e-05-0.3399image
ENSG00000132780.15,NASPESCAA.770041EAG5.4037e-05-0.3367image
chr1:45609897-45611681:+GBMBortezomibEER9.9930e-04-0.2771image
ENSG00000132780.15,NASPGBMBortezomibEAG9.4189e-04-0.2785image
chr1:45609897-45611681:+HNSCFTI.277EER2.7217e-02-0.2231image
ENSG00000132780.15,NASPHNSCFTI.277EAG2.7217e-02-0.2231image
ENSG00000132780.15,NASPKIRCJNK.9LEAG5.4756e-070.3422image
chr1:45609897-45611681:+KIRCDMOGEER2.9574e-040.2515image
ENSG00000132780.15,NASPKIRPAKT.inhibitor.VIIIEAG5.3432e-03-0.2780image
chr1:45609897-45611681:+KIRPAKT.inhibitor.VIIIEER5.3432e-03-0.2780image
chr1:45609897-45611681:+LAMLBryostatin.1EER9.0322e-030.2199image
ENSG00000132780.15,NASPLAMLBryostatin.1EAG2.2317e-020.1930image
chr1:45609897-45611681:+LGGJNK.Inhibitor.VIIIEER3.2235e-070.2396image
ENSG00000132780.15,NASPLGGJNK.Inhibitor.VIIIEAG1.2400e-060.2275image
ENSG00000132780.15,NASPLIHCIPA.3EAG2.8481e-020.3164image
chr1:45609897-45611681:+LIHCIPA.3EER2.8481e-020.3164image
ENSG00000132780.15,NASPLUADABT.263EAG3.1299e-030.1802image
chr1:45609897-45611681:+LUADABT.263EER2.7559e-030.1825image
chr1:45609897-45611681:+LUSCDocetaxelEER4.3896e-05-0.2539image
ENSG00000132780.15,NASPLUSCEpothilone.BEAG1.2571e-04-0.2378image
chr1:45609897-45611681:+MESOGemcitabineEER1.7777e-02-0.4298image
ENSG00000132780.15,NASPMESOGemcitabineEAG1.7777e-02-0.4298image
chr1:45609897-45611681:+OVBMS.509744EER1.7833e-05-0.2900image
ENSG00000132780.15,NASPOVBMS.509744EAG2.4611e-05-0.2854image
ENSG00000132780.15,NASPPAADBMS.509744EAG8.1083e-030.3444image
chr1:45609897-45611681:+PAADBMS.509744EER8.1083e-030.3444image
chr1:45609897-45611681:+PRADAICAREER2.5373e-020.2356image
ENSG00000132780.15,NASPPRADAICAREAG2.5202e-020.2359image
ENSG00000132780.15,NASPSARCBicalutamideEAG9.5663e-04-0.3192image
chr1:45609897-45611681:+SARCBicalutamideEER1.7367e-03-0.3049image
chr1:45609897-45611681:+SKCMGefitinibEER2.8991e-030.2101image
ENSG00000132780.15,NASPSKCMGefitinibEAG2.7660e-030.2111image
ENSG00000132780.15,NASPSTADDocetaxelEAG3.1373e-03-0.1892image
chr1:45609897-45611681:+STADDocetaxelEER3.3562e-04-0.2320image
ENSG00000132780.15,NASPTGCTAZ628EAG5.7456e-03-0.2550image
chr1:45609897-45611681:+TGCTAZ628EER5.1823e-03-0.2590image
chr1:45609897-45611681:+THCAGemcitabineEER2.6843e-02-0.1845image
ENSG00000132780.15,NASPTHCAErlotinibEAG1.8781e-02-0.1936image
chr1:45609897-45611681:+THYMEpothilone.BEER9.4693e-050.5192image
ENSG00000132780.15,NASPTHYMEpothilone.BEAG9.4693e-050.5192image
ENSG00000132780.15,NASPUCECMethotrexateEAG2.9172e-020.2917image
chr1:45609897-45611681:+UCECMethotrexateEER4.6695e-020.2694image
chr1:45609897-45611681:+UCSDocetaxelEER1.3386e-03-0.6279image
ENSG00000132780.15,NASPUCSDocetaxelEAG1.3386e-03-0.6279image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType