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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TMEM41B (ImmuneEditome ID:440026)

1. Gene summary of enriched editing regions for TMEM41B

check button Gene summary
Gene informationGene symbol

TMEM41B

Gene ID

440026

GeneSynonyms-
GeneCytomap

11p15.4

GeneTypeprotein-coding
GeneDescriptiontransmembrane protein 41B|protein stasimon|stasimon
GeneModificationdate20230517
UniprotIDQ5BJD5;E9PJ42
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:9282084-9282363:-ENST00000524543.4ENSG00000166471.9TMEM41BUTR3AluSxchr11:9282084-9282363:-.alignment
chr11:9282084-9282363:-ENST00000528080.4ENSG00000166471.9TMEM41BUTR3AluSxchr11:9282084-9282363:-.alignment
chr11:9288989-9294461:-ENST00000299596.7ENSG00000166471.9TMEM41BintronicAluSx,AluJo,AluSz6,AluSg7,AluSc,AluJr,AluJb,L1MC5a,(AC)n,L1PA6,L1MC5,A-rich,AluSc8,(ATA)n,AluYc,AluSq,AluSp,L1M3chr11:9288989-9294461:-.alignment
chr11:9288989-9294461:-ENST00000524543.4ENSG00000166471.9TMEM41BintronicAluSx,AluJo,AluSz6,AluSg7,AluSc,AluJr,AluJb,L1MC5a,(AC)n,L1PA6,L1MC5,A-rich,AluSc8,(ATA)n,AluYc,AluSq,AluSp,L1M3chr11:9288989-9294461:-.alignment
chr11:9288989-9294461:-ENST00000527813.4ENSG00000166471.9TMEM41BintronicAluSx,AluJo,AluSz6,AluSg7,AluSc,AluJr,AluJb,L1MC5a,(AC)n,L1PA6,L1MC5,A-rich,AluSc8,(ATA)n,AluYc,AluSq,AluSp,L1M3chr11:9288989-9294461:-.alignment
chr11:9288989-9294461:-ENST00000528080.4ENSG00000166471.9TMEM41BintronicAluSx,AluJo,AluSz6,AluSg7,AluSc,AluJr,AluJb,L1MC5a,(AC)n,L1PA6,L1MC5,A-rich,AluSc8,(ATA)n,AluYc,AluSq,AluSp,L1M3chr11:9288989-9294461:-.alignment
chr11:9288989-9294461:-ENST00000611268.3ENSG00000166471.9TMEM41BintronicAluSx,AluJo,AluSz6,AluSg7,AluSc,AluJr,AluJb,L1MC5a,(AC)n,L1PA6,L1MC5,A-rich,AluSc8,(ATA)n,AluYc,AluSq,AluSp,L1M3chr11:9288989-9294461:-.alignment
chr11:9303724-9303954:-ENST00000299596.7ENSG00000166471.9TMEM41BintronicAluSxchr11:9303724-9303954:-.alignment
chr11:9303724-9303954:-ENST00000524543.4ENSG00000166471.9TMEM41BintronicAluSxchr11:9303724-9303954:-.alignment
chr11:9303724-9303954:-ENST00000527813.4ENSG00000166471.9TMEM41BintronicAluSxchr11:9303724-9303954:-.alignment
chr11:9303724-9303954:-ENST00000528080.4ENSG00000166471.9TMEM41BintronicAluSxchr11:9303724-9303954:-.alignment
chr11:9303724-9303954:-ENST00000533723.1ENSG00000166471.9TMEM41BintronicAluSxchr11:9303724-9303954:-.alignment
chr11:9303724-9303954:-ENST00000611268.3ENSG00000166471.9TMEM41BintronicAluSxchr11:9303724-9303954:-.alignment
chr11:9308194-9309172:-ENST00000299596.7ENSG00000166471.9TMEM41BintronicAluSp,AluSzchr11:9308194-9309172:-.alignment
chr11:9308194-9309172:-ENST00000524543.4ENSG00000166471.9TMEM41BintronicAluSp,AluSzchr11:9308194-9309172:-.alignment
chr11:9308194-9309172:-ENST00000527813.4ENSG00000166471.9TMEM41BintronicAluSp,AluSzchr11:9308194-9309172:-.alignment
chr11:9308194-9309172:-ENST00000528080.4ENSG00000166471.9TMEM41BintronicAluSp,AluSzchr11:9308194-9309172:-.alignment
chr11:9308194-9309172:-ENST00000533723.1ENSG00000166471.9TMEM41BintronicAluSp,AluSzchr11:9308194-9309172:-.alignment
chr11:9308194-9309172:-ENST00000611268.3ENSG00000166471.9TMEM41BintronicAluSp,AluSzchr11:9308194-9309172:-.alignment


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2. Tumor-specific enriched editing regions for TMEM41B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000166471.9,TMEM41BESCAPathEAG6.6865e-032.2430e-020.2328image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for TMEM41B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for TMEM41B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for TMEM41B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000166471.9,TMEM41BBLCAEAGMonocytes1.5194e-02-0.4464image
chr11:9288989-9294461:-BRCAEERMacrophages_M19.6407e-040.2420image
ENSG00000166471.9,TMEM41BBRCAEAGMacrophages_M12.4697e-030.2134image
chr11:9288989-9294461:-COADEERT_cells_follicular_helper3.5671e-020.3072image
ENSG00000166471.9,TMEM41BCOADEAGT_cells_follicular_helper3.0615e-020.3157image
chr11:9288989-9294461:-ESCAEERT_cells_follicular_helper2.2828e-020.2275image
ENSG00000166471.9,TMEM41BKIRCEAGPlasma_cells2.4723e-02-0.3547image
chr11:9288989-9294461:-LAMLEERNeutrophils7.3585e-030.2777image
ENSG00000166471.9,TMEM41BLAMLEAGNeutrophils1.1363e-020.2587image
ENSG00000166471.9,TMEM41BLGGEAGPlasma_cells3.0409e-020.3664image
chr11:9288989-9294461:-LUADEERNK_cells_activated1.3112e-02-0.2130image
ENSG00000166471.9,TMEM41BLUADEAGNK_cells_activated1.1510e-03-0.2720image
chr11:9288989-9294461:-OVEERT_cells_regulatory_(Tregs)1.4896e-020.3777image
ENSG00000166471.9,TMEM41BPRADEAGT_cells_CD83.9980e-020.4514image
chr11:9288989-9294461:-STADEERT_cells_CD4_memory_activated1.1468e-030.2510image
ENSG00000166471.9,TMEM41BSTADEAGT_cells_CD4_memory_activated1.6786e-030.2265image


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6. Enriched editing regions and immune gene sets for TMEM41B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr11:9288989-9294461:-STADEER1.1230e-020.19693.5571e-020.16381.6269e-020.18683.6923e-020.1626image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000166471.9,TMEM41BBRCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.0583e-020.1808image
chr11:9288989-9294461:-BRCAGSVA_HALLMARK_COAGULATIONEER1.2153e-020.1850image
ENSG00000166471.9,TMEM41BCOADGSVA_HALLMARK_UV_RESPONSE_UPEAG5.1120e-030.4018image
chr11:9288989-9294461:-COADGSVA_HALLMARK_P53_PATHWAYEER5.3653e-030.3998image
ENSG00000166471.9,TMEM41BESCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.2012e-03-0.2549image
ENSG00000166471.9,TMEM41BKIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.3564e-02-0.3872image
chr11:9288989-9294461:-LAMLGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.7771e-050.4031image
ENSG00000166471.9,TMEM41BLAMLGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.3033e-040.3607image
ENSG00000166471.9,TMEM41BLGGGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.9900e-02-0.3674image
chr11:9288989-9294461:-LUADGSVA_HALLMARK_APICAL_SURFACEEER1.6814e-050.3612image
ENSG00000166471.9,TMEM41BLUADGSVA_HALLMARK_APICAL_SURFACEEAG2.3644e-050.3491image
ENSG00000166471.9,TMEM41BPRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.3709e-020.4649image
chr11:9303724-9303954:-STADGSVA_HALLMARK_ANGIOGENESISEER3.9102e-020.4427image
chr11:9288989-9294461:-STADGSVA_HALLMARK_ANGIOGENESISEER7.5483e-030.2073image


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7. Enriched editing regions and drugs for TMEM41B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000166471.9,TMEM41BBLCACI.1040EAG3.9075e-020.3852image
ENSG00000166471.9,TMEM41BBRCAAZD8055EAG9.0375e-03-0.1846image
chr11:9288989-9294461:-BRCABMS.509744EER4.1078e-04-0.2585image
ENSG00000166471.9,TMEM41BCOADAKT.inhibitor.VIIIEAG1.3597e-030.4537image
chr11:9288989-9294461:-COADAKT.inhibitor.VIIIEER1.3296e-030.4545image
ENSG00000166471.9,TMEM41BESCACHIR.99021EAG1.3863e-030.3012image
chr11:9288989-9294461:-ESCABMS.754807EER2.9050e-040.3550image
ENSG00000166471.9,TMEM41BKIRCLapatinibEAG1.7620e-02-0.3734image
chr11:9288989-9294461:-LAMLCI.1040EER2.4039e-03-0.3127image
ENSG00000166471.9,TMEM41BLAMLJNK.9LEAG1.2375e-02-0.2557image
ENSG00000166471.9,TMEM41BLGGGW.441756EAG6.3701e-04-0.5490image
chr11:9288989-9294461:-LUADABT.888EER1.9281e-020.2012image
ENSG00000166471.9,TMEM41BLUADGDC0941EAG8.5078e-03-0.2216image
chr11:9288989-9294461:-LUSCDocetaxelEER1.1950e-02-0.2505image
ENSG00000166471.9,TMEM41BLUSCDocetaxelEAG1.5373e-02-0.2394image
chr11:9288989-9294461:-OVBryostatin.1EER1.5694e-020.3750image
ENSG00000166471.9,TMEM41BOVErlotinibEAG1.4056e-020.3355image
ENSG00000166471.9,TMEM41BPRADAZD.2281EAG3.2876e-030.6105image
ENSG00000166471.9,TMEM41BSTADAZD6482EAG9.3507e-03-0.1881image
chr11:9288989-9294461:-STADMidostaurinEER1.4533e-02-0.1900image
ENSG00000166471.9,TMEM41BTHCADMOGEAG8.7806e-030.4556image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType