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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ABCC1 (ImmuneEditome ID:4363)

1. Gene summary of enriched editing regions for ABCC1

check button Gene summary
Gene informationGene symbol

ABCC1

Gene ID

4363

GeneSynonymsABC29|ABCC|DFNA77|GS-X|MRP|MRP1
GeneCytomap

16p13.11

GeneTypeprotein-coding
GeneDescriptionmultidrug resistance-associated protein 1|ATP-binding cassette transporter variant ABCC1delta-ex13|ATP-binding cassette transporter variant ABCC1delta-ex13&14|ATP-binding cassette transporter variant ABCC1delta-ex25|ATP-binding cassette transporter variant ABCC1delta-ex25&26|ATP-binding cassette, sub-family C (CFTR/MRP), member 1|LTC4 transporter|glutathione S-conjugate export pump|glutathione-S-conjugate-translocating ATPase ABCC1|leukotriene C(4) transporter
GeneModificationdate20230517
UniprotIDA0A0A0MS99;P33527;A0A7I2V2E0;A0A7I2V4C6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:15953193-15954321:+ENST00000399408.5ENSG00000103222.17ABCC1intronicAluSx,AluSz,MIRchr16:15953193-15954321:+.alignment
chr16:15953193-15954321:+ENST00000399410.6ENSG00000103222.17ABCC1intronicAluSx,AluSz,MIRchr16:15953193-15954321:+.alignment
chr16:16021453-16021619:+ENST00000574224.1ENSG00000103222.17ABCC1ncRNA_intronicAluSx1chr16:16021453-16021619:+.alignment
chr16:16035883-16037032:+ENST00000399410.6ENSG00000103222.17ABCC1exonicAluSx1,MIRc,AluJochr16:16035883-16037032:+.alignment
chr16:16035883-16037032:+ENST00000572882.2ENSG00000103222.17ABCC1exonicAluSx1,MIRc,AluJochr16:16035883-16037032:+.alignment
chr16:16048814-16050897:+ENST00000574224.1ENSG00000103222.17ABCC1ncRNA_intronicAluSz6,AluSx,AluJr,MLT1K,AluSpchr16:16048814-16050897:+.alignment
chr16:16053332-16054124:+ENST00000574224.1ENSG00000103222.17ABCC1ncRNA_intronicAluSx1,AluJb,FLAM_Cchr16:16053332-16054124:+.alignment
chr16:16056535-16057328:+ENST00000574224.1ENSG00000103222.17ABCC1ncRNA_exonicAluSx,AluSz6,Charlie10a,L2achr16:16056535-16057328:+.alignment
chr16:16059605-16060927:+ENST00000399408.5ENSG00000103222.17ABCC1intronicAluSz,AluSz6,MER58B,AluSx1,MIR3chr16:16059605-16060927:+.alignment
chr16:16059605-16060927:+ENST00000399410.6ENSG00000103222.17ABCC1intronicAluSz,AluSz6,MER58B,AluSx1,MIR3chr16:16059605-16060927:+.alignment
chr16:16059605-16060927:+ENST00000572882.2ENSG00000103222.17ABCC1intronicAluSz,AluSz6,MER58B,AluSx1,MIR3chr16:16059605-16060927:+.alignment
chr16:16075390-16075532:+ENST00000399408.5ENSG00000103222.17ABCC1intronicAluSz6chr16:16075390-16075532:+.alignment
chr16:16075390-16075532:+ENST00000399410.6ENSG00000103222.17ABCC1intronicAluSz6chr16:16075390-16075532:+.alignment
chr16:16075390-16075532:+ENST00000572882.2ENSG00000103222.17ABCC1intronicAluSz6chr16:16075390-16075532:+.alignment
chr16:16088898-16089850:+ENST00000575422.4ENSG00000103222.17ABCC1ncRNA_intronicAluJr,AluSz,MER58B,AluSqchr16:16088898-16089850:+.alignment
chr16:16113448-16114469:+ENST00000574761.1ENSG00000103222.17ABCC1ncRNA_intronicAluJb,(ATT)n,MER3,MER1B,MIR,AluSx1chr16:16113448-16114469:+.alignment
chr16:16126434-16127510:+ENST00000399408.5ENSG00000103222.17ABCC1intronicAluJb,MER113,AluSx1,MIR,MIR3chr16:16126434-16127510:+.alignment
chr16:16126434-16127510:+ENST00000399410.6ENSG00000103222.17ABCC1intronicAluJb,MER113,AluSx1,MIR,MIR3chr16:16126434-16127510:+.alignment
chr16:16126434-16127510:+ENST00000572882.2ENSG00000103222.17ABCC1intronicAluJb,MER113,AluSx1,MIR,MIR3chr16:16126434-16127510:+.alignment
chr16:16128736-16129821:+ENST00000399408.5ENSG00000103222.17ABCC1intronicAluSx1,MIRb,AluJbchr16:16128736-16129821:+.alignment
chr16:16128736-16129821:+ENST00000399410.6ENSG00000103222.17ABCC1intronicAluSx1,MIRb,AluJbchr16:16128736-16129821:+.alignment
chr16:16128736-16129821:+ENST00000572882.2ENSG00000103222.17ABCC1intronicAluSx1,MIRb,AluJbchr16:16128736-16129821:+.alignment
chr16:16138800-16140741:+ENST00000399408.5ENSG00000103222.17ABCC1intronicAluJb,AluSx,L2a,MER58A,ORSLchr16:16138800-16140741:+.alignment
chr16:16138800-16140741:+ENST00000399410.6ENSG00000103222.17ABCC1intronicAluJb,AluSx,L2a,MER58A,ORSLchr16:16138800-16140741:+.alignment
chr16:16138800-16140741:+ENST00000572882.2ENSG00000103222.17ABCC1intronicAluJb,AluSx,L2a,MER58A,ORSLchr16:16138800-16140741:+.alignment


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2. Tumor-specific enriched editing regions for ABCC1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr16:16056535-16057328:+ESCACliEER4.4253e-021.1195e-02-0.5544image
ENSG00000103222.17,ABCC1KIRCPathEAG4.6519e-028.5962e-030.2740image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr16:16138800-16140741:+KIRCEER2.3239e-023.5288e-028.3274e+02image

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3. Enriched editing regions and immune related genes for ABCC1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr16:16138800-16140741:+LAMLEERENSG00000099284,H2AFY2-0.50413.1605e-038.2388e-06-0.4144imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;ELAVL1;FBL;FMR1;IGF2BP1;IGF2BP2;IGF2BP3;NOP58;PRPF8;RBFOX2;SND1;TRA2A;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_TGF_BETA_SIGNALING
chr16:16138800-16140741:+LAMLEERENSG00000234882,EIF3EP1-0.40363.3543e-021.6069e-05-0.4021imageNNNAEosinophilsGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr16:16138800-16140741:+LAMLEERENSG00000099284,H2AFY2-0.50413.1605e-038.2388e-06-0.4144imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;ELAVL1;FBL;FMR1;IGF2BP1;IGF2BP2;IGF2BP3;NOP58;PRPF8;RBFOX2;SND1;TRA2A;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_TGF_BETA_SIGNALING
chr16:16138800-16140741:+LAMLEERENSG00000234882,EIF3EP1-0.40363.3543e-021.6069e-05-0.4021imageNNNAEosinophilsGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr16:16138800-16140741:+LAMLEERENSG00000099284,H2AFY2-0.50413.1605e-038.2388e-06-0.4144imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;ELAVL1;FBL;FMR1;IGF2BP1;IGF2BP2;IGF2BP3;NOP58;PRPF8;RBFOX2;SND1;TRA2A;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_TGF_BETA_SIGNALING
chr16:16138800-16140741:+LAMLEERENSG00000234882,EIF3EP1-0.40363.3543e-021.6069e-05-0.4021imageNNNAEosinophilsGSVA_HALLMARK_IL2_STAT5_SIGNALING

More results



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4. Enriched editing regions and immune related splicing for ABCC1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ABCC1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr16:16053332-16054124:+ESCAEERMonocytes1.9123e-02-0.2756image
chr16:16056535-16057328:+ESCAEERMacrophages_M22.0768e-02-0.2885image
chr16:16088898-16089850:+ESCAEERT_cells_regulatory_(Tregs)1.6655e-020.4486image
chr16:16126434-16127510:+ESCAEERNeutrophils3.7703e-020.3298image
ENSG00000103222.17,ABCC1ESCAEAGMonocytes2.5138e-02-0.1995image
ENSG00000103222.17,ABCC1HNSCEAGT_cells_CD4_memory_resting3.0562e-02-0.3302image
ENSG00000103222.17,ABCC1KIRCEAGT_cells_regulatory_(Tregs)1.6231e-030.4116image
chr16:16048814-16050897:+LAMLEERMacrophages_M14.2205e-020.4269image
chr16:16138800-16140741:+LAMLEEREosinophils4.6150e-03-0.2706image
ENSG00000103222.17,ABCC1LAMLEAGEosinophils3.8043e-05-0.3467image
chr16:16138800-16140741:+LUSCEERT_cells_gamma_delta1.2040e-020.2267image
ENSG00000103222.17,ABCC1LUSCEAGT_cells_gamma_delta2.3333e-040.2924image
ENSG00000103222.17,ABCC1PRADEAGDendritic_cells_activated3.1349e-020.3112image
chr16:15953193-15954321:+STADEERMacrophages_M14.8039e-020.2462image
chr16:16053332-16054124:+STADEERB_cells_naive1.1388e-02-0.2765image
chr16:16056535-16057328:+STADEERMacrophages_M01.1665e-020.2724image
chr16:16138800-16140741:+STADEERMacrophages_M22.1373e-020.3098image
ENSG00000103222.17,ABCC1STADEAGMast_cells_activated4.6321e-030.2051image
ENSG00000103222.17,ABCC1UCECEAGT_cells_CD4_memory_activated2.6440e-020.4524image


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6. Enriched editing regions and immune gene sets for ABCC1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000103222.17,ABCC1CESCGSVA_HALLMARK_COAGULATIONEAG4.4540e-020.3575image
chr16:16138800-16140741:+ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.2559e-020.2729image
chr16:16126434-16127510:+ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER1.7479e-020.3739image
ENSG00000103222.17,ABCC1ESCAGSVA_HALLMARK_COMPLEMENTEAG2.5469e-020.1990image
chr16:16053332-16054124:+ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEER7.1705e-030.3143image
chr16:16048814-16050897:+ESCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.4256e-020.2665image
ENSG00000103222.17,ABCC1HNSCGSVA_HALLMARK_HEME_METABOLISMEAG4.4185e-02-0.3084image
ENSG00000103222.17,ABCC1KIRCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7176e-020.2952image
chr16:16075390-16075532:+LAMLGSVA_HALLMARK_GLYCOLYSISEER2.3260e-030.4574image
chr16:16138800-16140741:+LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEER5.8236e-030.2637image
ENSG00000103222.17,ABCC1LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.6394e-030.2486image
ENSG00000103222.17,ABCC1LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.4834e-030.4103image
ENSG00000103222.17,ABCC1LUSCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.9637e-040.2957image
chr16:16138800-16140741:+LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.1725e-030.2750image
ENSG00000103222.17,ABCC1OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0133e-020.3604image
chr16:16056535-16057328:+OVGSVA_HALLMARK_HYPOXIAEER1.1807e-020.5384image
ENSG00000103222.17,ABCC1PRADGSVA_HALLMARK_APICAL_SURFACEEAG2.9856e-02-0.3138image
ENSG00000103222.17,ABCC1STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG9.3118e-040.2389image
chr16:16053332-16054124:+STADGSVA_HALLMARK_COAGULATIONEER3.6176e-020.2303image
chr16:16048814-16050897:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER1.9449e-040.3236image
chr16:16138800-16140741:+STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6700e-030.4142image
chr16:15953193-15954321:+STADGSVA_HALLMARK_MTORC1_SIGNALINGEER3.7455e-030.3547image
chr16:16056535-16057328:+STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.8699e-02-0.2546image


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7. Enriched editing regions and drugs for ABCC1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000103222.17,ABCC1BLCAATRAEAG2.0058e-020.3914image
ENSG00000103222.17,ABCC1BRCALapatinibEAG1.1034e-02-0.3839image
ENSG00000103222.17,ABCC1CESCCMKEAG8.7744e-03-0.4556image
chr16:16138800-16140741:+ESCABMS.708163EER2.8166e-04-0.3887image
chr16:16088898-16089850:+ESCAGW.441756EER2.4495e-020.4241image
chr16:16056535-16057328:+ESCACMKEER3.1643e-02-0.2689image
chr16:16126434-16127510:+ESCACCT007093EER3.6918e-030.4486image
ENSG00000103222.17,ABCC1ESCABexaroteneEAG4.1080e-03-0.2540image
chr16:16053332-16054124:+ESCAGW843682XEER9.0976e-040.3826image
chr16:16048814-16050897:+ESCAGW843682XEER7.2057e-040.3618image
ENSG00000103222.17,ABCC1HNSCMethotrexateEAG2.4690e-030.4499image
ENSG00000103222.17,ABCC1KIRCGSK269962AEAG8.5494e-04-0.4331image
chr16:16075390-16075532:+LAMLBI.D1870EER5.1343e-03-0.4240image
chr16:16048814-16050897:+LAMLGDC.0449EER2.5877e-050.7600image
chr16:16138800-16140741:+LAMLAZD8055EER3.5658e-040.3374image
ENSG00000103222.17,ABCC1LAMLAZD7762EAG2.9819e-04-0.3066image
ENSG00000103222.17,ABCC1LUADAxitinibEAG2.0600e-020.3695image
ENSG00000103222.17,ABCC1LUSCCCT018159EAG7.4308e-03-0.2149image
chr16:16138800-16140741:+LUSCCyclopamineEER9.1477e-03-0.2351image
ENSG00000103222.17,ABCC1OVMG.132EAG9.7167e-04-0.4524image
chr16:16056535-16057328:+OVCI.1040EER1.5145e-02-0.5223image
ENSG00000103222.17,ABCC1PRADCCT018159EAG3.6842e-020.3022image
ENSG00000103222.17,ABCC1STADBIRB.0796EAG3.3610e-02-0.1546image
chr16:16048814-16050897:+STADBMS.708163EER3.7945e-030.2541image
chr16:16138800-16140741:+STADMidostaurinEER8.4947e-03-0.3515image
chr16:15953193-15954321:+STADGW.441756EER1.2447e-02-0.3084image
chr16:16056535-16057328:+STADBMS.708163EER2.9191e-030.3190image
ENSG00000103222.17,ABCC1UCECBMS.754807EAG3.2225e-03-0.5760image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr16:15953193-15954321:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:15953193-15954321:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug
chr16:16035883-16037032:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:16035883-16037032:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug
chr16:16059605-16060927:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:16059605-16060927:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug
chr16:16075390-16075532:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:16075390-16075532:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug
chr16:16126434-16127510:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:16126434-16127510:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug
chr16:16128736-16129821:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:16128736-16129821:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug
chr16:16138800-16140741:+ENST00000399410.6P33527DB01138SulfinpyrazoneSmallMoleculeDrug
chr16:16138800-16140741:+ENST00000399410.6P33527DB06176RomidepsinSmallMoleculeDrug