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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ASL (ImmuneEditome ID:435)

1. Gene summary of enriched editing regions for ASL

check button Gene summary
Gene informationGene symbol

ASL

Gene ID

435

GeneSynonymsASAL
GeneCytomap

7q11.21

GeneTypeprotein-coding
GeneDescriptionargininosuccinate lyase|argininosuccinase|arginosuccinase
GeneModificationdate20230329
UniprotIDP04424;A0A024RDL8;F8W943;A0A5F9ZI35;A0A5F9ZHC6;A0A0S2Z316;A0A5F9ZHM8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:66078681-66081586:+ENST00000487982.4ENSG00000126522.15ASLncRNA_intronicAluYf1,AluY,AluSx1,MIR,AluSx,AluJo,(CCCTCTG)n,AluScchr7:66078681-66081586:+.alignment
chr7:66078681-66081586:+ENST00000496336.1ENSG00000126522.15ASLncRNA_intronicAluYf1,AluY,AluSx1,MIR,AluSx,AluJo,(CCCTCTG)n,AluScchr7:66078681-66081586:+.alignment
chr7:66083474-66086082:+ENST00000487982.4ENSG00000126522.15ASLncRNA_intronicAluY,AluSq,L1MB8,AluJr,AluSx,AluSz6chr7:66083474-66086082:+.alignment
chr7:66090028-66091405:+ENST00000464970.1ENSG00000126522.15ASLncRNA_intronicAluSz,L1MC5,AluJo,AluJr,(TAAAT)n,MER5Achr7:66090028-66091405:+.alignment
chr7:66090028-66091405:+ENST00000488343.1ENSG00000126522.15ASLncRNA_intronicAluSz,L1MC5,AluJo,AluJr,(TAAAT)n,MER5Achr7:66090028-66091405:+.alignment
chr7:66090028-66091405:+ENST00000493708.4ENSG00000126522.15ASLncRNA_intronicAluSz,L1MC5,AluJo,AluJr,(TAAAT)n,MER5Achr7:66090028-66091405:+.alignment
chr7:66093192-66098342:+ENST00000304874.12ENSG00000126522.15ASLUTR3MER5A,AluY,MLT1D,AluSx1,(AATA)n,Tigger1,AluSz,AluSq2,AluSg4,MADE1,AluJr,FLAM_C,AluSx,AluSq10chr7:66093192-66098342:+.alignment


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2. Tumor-specific enriched editing regions for ASL


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ASL


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for ASL


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ASL


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr7:66078681-66081586:+ESCAEERNeutrophils2.5790e-020.3033image
chr7:66083474-66086082:+ESCAEERMacrophages_M04.5977e-020.2411image
chr7:66090028-66091405:+ESCAEERDendritic_cells_activated1.6904e-02-0.4193image
chr7:66093192-66098342:+ESCAEERT_cells_CD81.0253e-020.3050image
ENSG00000126522.15,ASLLAMLEAGMast_cells_activated1.5503e-030.5524image
chr7:66078681-66081586:+LIHCEERNeutrophils1.4965e-020.2712image
chr7:66093192-66098342:+LIHCEERNeutrophils2.2687e-020.3842image
ENSG00000126522.15,ASLLIHCEAGNeutrophils2.6491e-020.2155image
ENSG00000126522.15,ASLLUADEAGMacrophages_M11.6487e-020.3311image
chr7:66083474-66086082:+OVEERT_cells_CD81.2085e-020.3248image
chr7:66093192-66098342:+OVEERMast_cells_activated4.0587e-020.2139image
ENSG00000126522.15,ASLOVEAGT_cells_CD81.2845e-030.3697image
chr7:66083474-66086082:+STADEERT_cells_gamma_delta1.4982e-030.2247image
chr7:66093192-66098342:+STADEERT_cells_CD4_memory_activated4.3407e-030.2152image
ENSG00000126522.15,ASLSTADEAGNK_cells_activated9.8008e-030.1707image


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6. Enriched editing regions and immune gene sets for ASL


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000126522.15,ASLBRCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.4497e-020.3155image
ENSG00000126522.15,ASLESCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG8.3598e-030.2985image
chr7:66090028-66091405:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.2287e-020.3793image
chr7:66078681-66081586:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.1884e-020.3400image
chr7:66083474-66086082:+ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER3.8749e-030.3433image
chr7:66093192-66098342:+ESCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER5.7311e-030.3270image
ENSG00000126522.15,ASLLIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.8955e-030.2714image
chr7:66078681-66081586:+LIHCGSVA_HALLMARK_HYPOXIAEER5.5608e-030.3073image
chr7:66083474-66086082:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER1.4640e-02-0.2755image
chr7:66093192-66098342:+LIHCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER9.5681e-030.4319image
ENSG00000126522.15,ASLLUADGSVA_HALLMARK_APICAL_JUNCTIONEAG1.5834e-030.4272image
ENSG00000126522.15,ASLOVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.6029e-02-0.2458image
chr7:66083474-66086082:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER6.5122e-04-0.4312image
chr7:66093192-66098342:+OVGSVA_HALLMARK_DNA_REPAIREER3.1470e-030.3047image
ENSG00000126522.15,ASLSTADGSVA_HALLMARK_APOPTOSISEAG1.0889e-030.2150image
chr7:66078681-66081586:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER9.0728e-040.2567image
chr7:66083474-66086082:+STADGSVA_HALLMARK_P53_PATHWAYEER9.4403e-050.2746image
chr7:66093192-66098342:+STADGSVA_HALLMARK_HYPOXIAEER2.4578e-040.2746image


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7. Enriched editing regions and drugs for ASL


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000126522.15,ASLBRCAEHT.1864EAG2.5824e-020.3479image
ENSG00000126522.15,ASLESCAAZ628EAG8.1743e-03-0.2994image
chr7:66090028-66091405:+ESCAGDC0941EER4.2249e-02-0.3612image
chr7:66078681-66081586:+ESCAGSK269962AEER1.8829e-02-0.3187image
chr7:66083474-66086082:+ESCAAZD.2281EER1.1712e-03-0.3828image
chr7:66093192-66098342:+ESCACamptothecinEER5.5913e-03-0.3279image
ENSG00000126522.15,ASLLAMLGefitinibEAG5.9739e-03-0.4901image
ENSG00000126522.15,ASLLIHCGNF.2EAG5.5411e-06-0.4252image
chr7:66078681-66081586:+LIHCMetforminEER1.5381e-020.2701image
chr7:66083474-66086082:+LIHCAICAREER3.5960e-040.3939image
chr7:66093192-66098342:+LIHCMetforminEER1.9994e-020.3916image
ENSG00000126522.15,ASLLUADBryostatin.1EAG3.2974e-03-0.4001image
ENSG00000126522.15,ASLOVBosutinibEAG3.4933e-04-0.4072image
chr7:66083474-66086082:+OVCHIR.99021EER3.3513e-040.4512image
chr7:66093192-66098342:+OVBexaroteneEER1.2105e-030.3323image
ENSG00000126522.15,ASLSTADAMG.706EAG5.2632e-04-0.2278image
chr7:66090028-66091405:+STADEHT.1864EER8.1430e-03-0.2976image
chr7:66078681-66081586:+STADElesclomolEER2.7906e-03-0.2320image
chr7:66083474-66086082:+STADBleomycinEER1.1967e-06-0.3379image
chr7:66093192-66098342:+STADBortezomibEER6.0932e-04-0.2573image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType