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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ATXN3 (ImmuneEditome ID:4287)

1. Gene summary of enriched editing regions for ATXN3

check button Gene summary
Gene informationGene symbol

ATXN3

Gene ID

4287

GeneSynonymsAT3|ATX3|JOS|MJD|MJD1|SCA3
GeneCytomap

14q32.12

GeneTypeprotein-coding
GeneDescriptionataxin-3|Machado-Joseph disease protein 1|josephin|olivopontocerebellar ataxia 3|spinocerebellar ataxia type 3 protein
GeneModificationdate20230329
UniprotIDP54252;D6R9I5;D3VVP3;G3V4F4;G3V4B1;G3V526;A0A0A0MS38;G3V5H3;A0A2R8Y888;A0A2R8Y3X7;G3V4U9;G3V390;G3V2G2;F5H211;G3V3A6;C9JQV6;G3V4F5;E9PJN5;G3V3T6;G3V2G1;G3V3T0;G3V328;G3V3R7;G3V3S5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:92051776-92052041:-ENST00000558190.4ENSG00000066427.20ATXN3UTR3AluSgchr14:92051776-92052041:-.alignment
chr14:92053556-92054167:-ENST00000558190.4ENSG00000066427.20ATXN3UTR3AluSg,AluJo,MER41A,MLT1Jchr14:92053556-92054167:-.alignment
chr14:92059515-92062223:-ENST00000526245.1ENSG00000066427.20ATXN3ncRNA_intronicAluSg4,AluSq2,AluSz,(AT)n,AluSx1chr14:92059515-92062223:-.alignment
chr14:92065434-92067583:-ENST00000526245.1ENSG00000066427.20ATXN3ncRNA_intronicAluSx1,L1MDa,AluSc8,SVA_A,L1MD2,AluSz,FLAM_C,AluSxchr14:92065434-92067583:-.alignment
chr14:92068680-92069693:-ENST00000526245.1ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx1,AluSp,L1MDa,AluSq2chr14:92068680-92069693:-.alignment
chr14:92075212-92075466:-ENST00000526245.1ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000553287.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000553309.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000553498.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000553686.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000554040.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000554214.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000554491.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000555958.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000556339.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92075212-92075466:-ENST00000556644.4ENSG00000066427.20ATXN3ncRNA_intronicAluSq2chr14:92075212-92075466:-.alignment
chr14:92090982-92091873:-ENST00000511362.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000526245.1ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000553287.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000553309.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000553498.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000553686.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000554040.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000554214.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000554491.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000555958.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000556339.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment
chr14:92090982-92091873:-ENST00000556644.4ENSG00000066427.20ATXN3ncRNA_intronicL1ME1,AluSx,AluJo,FLAM_Cchr14:92090982-92091873:-.alignment


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2. Tumor-specific enriched editing regions for ATXN3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr14:92059515-92062223:-BRCAEER2.1229e-04image
ENSG00000066427.20,ATXN3BRCAEAG1.0647e-04image
chr14:92059515-92062223:-LUSCEER6.4314e-04image
ENSG00000066427.20,ATXN3LUSCEAG4.7383e-04image
chr14:92059515-92062223:-UCECEER1.8747e-02image
ENSG00000066427.20,ATXN3UCECEAG1.2276e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000066427.20,ATXN3UVMCliEAG3.6209e-023.6209e-020.4593image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr14:92059515-92062223:-BRCAEER3.0825e-023.7314e-029.6312e+00image
chr14:92068680-92069693:-ESCAEER3.5327e-023.9784e-027.5600e-08image

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3. Enriched editing regions and immune related genes for ATXN3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:92059515-92062223:-THYMEERENSG00000143797,MBOAT2-0.44973.4394e-042.5273e-05-0.4137imageNHNRNPLNAT_cells_CD4_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92059515-92062223:-THYMEERENSG00000179833,SERTAD2-0.42707.8472e-044.3701e-05-0.4025imageNHNRNPLNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr14:92059515-92062223:-THYMEERENSG00000147383,NSDHL0.41798.8037e-049.9731e-070.4730imageNHNRNPLNAT_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92059515-92062223:-THYMEERENSG00000272447,RP11-182L21.6-0.41789.9051e-049.4174e-06-0.4330imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92059515-92062223:-THYMEERENSG00000183161,FANCF-0.41451.2448e-032.0533e-05-0.4179imageNHNRNPLFANCFT_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr14:92059515-92062223:-THYMEERENSG00000133114,GPALPP1-0.40001.9289e-032.3543e-05-0.4152imageNHNRNPLNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr14:92059515-92062223:-THYMEERENSG00000185825,BCAP310.39082.1090e-032.0415e-050.4180imageNNBCAP31T_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr14:92059515-92062223:-THYMEERENSG00000152795,HNRNPDL-0.39382.2986e-032.2492e-05-0.4161imageNHNRNPLNAT_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr14:92059515-92062223:-THYMEERENSG00000125629,INSIG2-0.39222.4189e-033.2693e-05-0.4085imageNHNRNPLNAT_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr14:92059515-92062223:-THYMEERENSG00000189266,PNRC2-0.37802.8424e-033.2519e-05-0.4086imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

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4. Enriched editing regions and immune related splicing for ATXN3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000066427.20,ATXN3
THYMEAGA3ENSG00000153283.8chr3111624332:111624404:111637198:111637261:111637195:111637261-0.36274.8083e-034.6273e-06-0.4898imageNADAR;CELF2;CNBP;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPL;IGF2BP2;IGF2BP3;LIN28B;MSI2;NOP56;NOP58;PTBP1;SRSF1;SRSF7;SRSF9;TAF15;TROVE2;U2AF2;UPF1CD96Macrophages_M1GSVA_HALLMARK_SPERMATOGENESIS
chr14:92059515-92062223:-
THYMEERA5ENSG00000002933.3chr7150804826:150804936:150804361:150804485:150804361:150804719-0.23643.3070e-023.8130e-05-0.4808imageNNNAB_cells_naiveGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr14:92059515-92062223:-
THYMEERIRENSG00000141140.12chr1736495632:36496406:36499074:36499160-0.31684.1684e-021.0334e-05-0.4419imageNNNANK_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92059515-92062223:-
THYMEERIRENSG00000012822.11chr1253711118:53712846:53713099:53713203-0.31363.1709e-022.7701e-06-0.5083imageNHNRNPLNANK_cells_restingGSVA_HALLMARK_GLYCOLYSIS
chr14:92059515-92062223:-
THYMEERESENSG00000116237.11chr16233508:6233643:6234404:6234511:6234885:62349700.30404.3641e-021.9919e-040.4117imageNHNRNPLNANK_cells_restingGSVA_HALLMARK_GLYCOLYSIS
ENSG00000066427.20,ATXN3
THYMEAGIRENSG00000141140.12chr1736495632:36496406:36499074:36499160-0.32582.7183e-024.0526e-06-0.4574imageNNNANK_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr14:92059515-92062223:-
THYMEERESENSG00000241258.2chr766127703:66127740:66130743:66130842:66134279:661343740.31352.2622e-022.4210e-040.4118imageNHNRNPLNAGSVA_HALLMARK_HEME_METABOLISM
ENSG00000066427.20,ATXN3
THYMEAGIRENSG00000012822.11chr1253711118:53712846:53713099:53713203-0.30123.8644e-024.1686e-06-0.5004imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NANK_cells_restingGSVA_HALLMARK_GLYCOLYSIS
chr14:92059515-92062223:-
THYMEERA5ENSG00000186973.6chr143156205:43156279:43152827:43152979:43152827:43152931-0.35474.9976e-037.2642e-05-0.4531imageNHNRNPLNAT_cells_CD4_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000066427.20,ATXN3
THYMEAGA5ENSG00000141140.12chr1736496184:36496406:36499074:36499160:36498265:364991600.31844.1487e-021.9747e-060.4614imageNNNAMacrophages_M1GSVA_HALLMARK_XENOBIOTIC_METABOLISM

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5. Enriched editing regions and immune infiltration for ATXN3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000066427.20,ATXN3ACCEAGMacrophages_M05.5969e-030.5824image
chr14:92059515-92062223:-BLCAEERB_cells_memory3.0956e-030.2072image
ENSG00000066427.20,ATXN3BLCAEAGB_cells_memory3.6754e-030.2025image
chr14:92059515-92062223:-BRCAEERNK_cells_activated2.7015e-030.1083image
ENSG00000066427.20,ATXN3BRCAEAGNK_cells_activated4.4538e-030.1025image
ENSG00000066427.20,ATXN3CESCEAGT_cells_gamma_delta3.1589e-020.1536image
chr14:92059515-92062223:-COADEERT_cells_follicular_helper7.3260e-030.3201image
ENSG00000066427.20,ATXN3COADEAGMast_cells_activated1.6566e-030.3667image
ENSG00000066427.20,ATXN3ESCAEAGMast_cells_activated4.2654e-020.1630image
chr14:92059515-92062223:-HNSCEERT_cells_CD4_memory_resting2.3053e-02-0.1449image
ENSG00000066427.20,ATXN3HNSCEAGT_cells_CD4_memory_resting3.4800e-02-0.1344image
chr14:92059515-92062223:-KIRCEERNeutrophils1.1442e-030.2046image
ENSG00000066427.20,ATXN3KIRCEAGNeutrophils2.0932e-030.1930image
chr14:92059515-92062223:-KIRPEEREosinophils2.0616e-040.3816image
ENSG00000066427.20,ATXN3KIRPEAGEosinophils6.4798e-040.3455image
chr14:92059515-92062223:-LAMLEERNK_cells_resting2.2391e-02-0.2405image
chr14:92068680-92069693:-LAMLEERNeutrophils1.1603e-02-0.3321image
chr14:92090982-92091873:-LAMLEERPlasma_cells4.8967e-03-0.4362image
ENSG00000066427.20,ATXN3LAMLEAGT_cells_CD4_memory_activated5.5687e-040.3033image
chr14:92059515-92062223:-LGGEERT_cells_follicular_helper1.0033e-02-0.1826image
ENSG00000066427.20,ATXN3LGGEAGT_cells_follicular_helper1.7457e-02-0.1651image
chr14:92059515-92062223:-LIHCEERT_cells_CD4_memory_activated1.8538e-030.3348image
ENSG00000066427.20,ATXN3LIHCEAGT_cells_CD82.3127e-030.3208image
chr14:92059515-92062223:-LUADEERMacrophages_M29.6896e-04-0.2261image
ENSG00000066427.20,ATXN3LUADEAGMacrophages_M22.3025e-03-0.2078image
chr14:92059515-92062223:-LUSCEERMacrophages_M22.2855e-02-0.1605image
ENSG00000066427.20,ATXN3LUSCEAGNeutrophils2.6711e-020.1551image
chr14:92059515-92062223:-OVEERNeutrophils2.3015e-02-0.1505image
ENSG00000066427.20,ATXN3OVEAGT_cells_gamma_delta2.7468e-040.2367image
chr14:92059515-92062223:-PCPGEEREosinophils7.9454e-040.3792image
ENSG00000066427.20,ATXN3PCPGEAGEosinophils8.2230e-040.3758image
ENSG00000066427.20,ATXN3PRADEAGT_cells_gamma_delta1.8946e-020.1211image
chr14:92059515-92062223:-SARCEERNeutrophils1.5818e-030.2704image
ENSG00000066427.20,ATXN3SARCEAGNeutrophils4.1761e-030.2424image
chr14:92059515-92062223:-SKCMEERT_cells_gamma_delta1.5493e-020.1948image
ENSG00000066427.20,ATXN3SKCMEAGT_cells_gamma_delta1.4674e-020.1957image
chr14:92051776-92052041:-STADEERPlasma_cells3.0701e-020.4328image
chr14:92059515-92062223:-TGCTEERB_cells_memory1.5427e-030.3422image
ENSG00000066427.20,ATXN3TGCTEAGB_cells_memory1.8148e-030.3374image
chr14:92059515-92062223:-THCAEERMacrophages_M21.3187e-03-0.1682image
ENSG00000066427.20,ATXN3THCAEAGMacrophages_M22.3252e-03-0.1579image
chr14:92059515-92062223:-THYMEERT_cells_gamma_delta3.2769e-030.2957image
ENSG00000066427.20,ATXN3THYMEAGT_cells_gamma_delta3.0931e-030.2902image


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6. Enriched editing regions and immune gene sets for ATXN3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000066427.20,ATXN3ACCGSVA_HALLMARK_MYC_TARGETS_V1EAG6.3339e-030.5755image
ENSG00000066427.20,ATXN3BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.1680e-02-0.1505image
chr14:92059515-92062223:-BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEER3.0847e-02-0.1520image
ENSG00000066427.20,ATXN3BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.3521e-100.2205image
chr14:92059515-92062223:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3262e-120.2499image
ENSG00000066427.20,ATXN3CESCGSVA_HALLMARK_G2M_CHECKPOINTEAG1.0076e-04-0.2742image
chr14:92059515-92062223:-CESCGSVA_HALLMARK_E2F_TARGETSEER5.2254e-04-0.2468image
chr14:92059515-92062223:-COADGSVA_HALLMARK_G2M_CHECKPOINTEER6.2956e-030.3258image
ENSG00000066427.20,ATXN3COADGSVA_HALLMARK_HEME_METABOLISMEAG1.6398e-03-0.3671image
chr14:92059515-92062223:-ESCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.9037e-020.1687image
ENSG00000066427.20,ATXN3GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.5852e-020.3102image
chr14:92059515-92062223:-GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.6857e-030.4103image
chr14:92059515-92062223:-HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEER5.7968e-04-0.2179image
ENSG00000066427.20,ATXN3HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.7047e-03-0.1986image
chr14:92059515-92062223:-KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.2251e-02-0.1445image
ENSG00000066427.20,ATXN3KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.1081e-02-0.1598image
chr14:92068680-92069693:-LAMLGSVA_HALLMARK_KRAS_SIGNALING_UPEER2.1655e-020.3037image
ENSG00000066427.20,ATXN3LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.9707e-02-0.1366image
ENSG00000066427.20,ATXN3LIHCGSVA_HALLMARK_HEME_METABOLISMEAG5.5133e-03-0.2935image
ENSG00000066427.20,ATXN3LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5835e-020.1527image
chr14:92059515-92062223:-LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.8992e-020.1618image
ENSG00000066427.20,ATXN3LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.6669e-030.2093image
chr14:92059515-92062223:-LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5936e-030.2213image
chr14:92059515-92062223:-OVGSVA_HALLMARK_TGF_BETA_SIGNALINGEER9.1301e-05-0.2562image
chr14:92068680-92069693:-OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.2013e-030.4785image
ENSG00000066427.20,ATXN3OVGSVA_HALLMARK_HEME_METABOLISMEAG1.7902e-05-0.2776image
ENSG00000066427.20,ATXN3PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.9679e-020.2281image
chr14:92059515-92062223:-PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.6032e-020.2546image
chr14:92059515-92062223:-PCPGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.3425e-030.3258image
ENSG00000066427.20,ATXN3PCPGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG7.0308e-030.3068image
ENSG00000066427.20,ATXN3PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.4213e-050.2162image
chr14:92059515-92062223:-PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.3624e-060.2438image
chr14:92059515-92062223:-SARCGSVA_HALLMARK_GLYCOLYSISEER9.9123e-030.2221image
ENSG00000066427.20,ATXN3SARCGSVA_HALLMARK_GLYCOLYSISEAG1.3878e-020.2090image
chr14:92059515-92062223:-SKCMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER8.5522e-030.2112image
ENSG00000066427.20,ATXN3SKCMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.0829e-020.2042image
chr14:92059515-92062223:-STADGSVA_HALLMARK_SPERMATOGENESISEER1.0535e-020.1575image
chr14:92090982-92091873:-STADGSVA_HALLMARK_G2M_CHECKPOINTEER4.8791e-030.3617image
chr14:92068680-92069693:-STADGSVA_HALLMARK_MYC_TARGETS_V1EER1.9255e-020.3206image
ENSG00000066427.20,ATXN3STADGSVA_HALLMARK_UV_RESPONSE_DNEAG4.2568e-02-0.1217image
chr14:92051776-92052041:-STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.7025e-020.4727image
chr14:92059515-92062223:-TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.5267e-02-0.2315image
chr14:92059515-92062223:-THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.7922e-020.1156image
ENSG00000066427.20,ATXN3THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.9949e-020.1020image
chr14:92059515-92062223:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER3.9106e-03-0.2904image
ENSG00000066427.20,ATXN3THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG9.8423e-030.2545image
ENSG00000066427.20,ATXN3UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.8204e-02-0.2603image
chr14:92059515-92062223:-UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER1.7186e-02-0.2709image


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7. Enriched editing regions and drugs for ATXN3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000066427.20,ATXN3ACCCCT018159EAG6.6828e-03-0.5725image
ENSG00000066427.20,ATXN3BLCAFH535EAG2.5354e-030.2103image
chr14:92059515-92062223:-BLCAAZD.2281EER2.0567e-03-0.2156image
chr14:92059515-92062223:-BRCAA.770041EER6.7067e-07-0.1788image
ENSG00000066427.20,ATXN3BRCAA.770041EAG2.7194e-06-0.1684image
ENSG00000066427.20,ATXN3CESCBAY.61.3606EAG1.1478e-040.2720image
chr14:92059515-92062223:-CESCBAY.61.3606EER5.2573e-040.2467image
ENSG00000066427.20,ATXN3COADAZ628EAG1.9218e-040.4286image
chr14:92059515-92062223:-COADGDC0941EER4.6506e-020.2405image
ENSG00000066427.20,ATXN3ESCAABT.263EAG2.3926e-020.1819image
chr14:92059515-92062223:-ESCAABT.263EER5.4992e-030.2264image
ENSG00000066427.20,ATXN3GBMBortezomibEAG7.9296e-03-0.3397image
chr14:92059515-92062223:-GBMGNF.2EER5.5731e-03-0.3657image
chr14:92059515-92062223:-HNSCAZD6482EER2.4242e-050.2657image
ENSG00000066427.20,ATXN3HNSCMetforminEAG4.5883e-04-0.2213image
ENSG00000066427.20,ATXN3KIRCAS601245EAG1.1298e-020.1594image
chr14:92059515-92062223:-KIRCAS601245EER1.1323e-020.1599image
chr14:92059515-92062223:-KIRPBicalutamideEER1.8594e-03-0.3237image
ENSG00000066427.20,ATXN3KIRPBryostatin.1EAG5.8854e-04-0.3480image
chr14:92090982-92091873:-LAMLAZD.2281EER2.5649e-020.3526image
chr14:92059515-92062223:-LAMLErlotinibEER3.8990e-03-0.3013image
ENSG00000066427.20,ATXN3LAMLDocetaxelEAG9.4355e-030.2304image
chr14:92068680-92069693:-LAMLBX.795EER2.6032e-02-0.2947image
ENSG00000066427.20,ATXN3LIHCAZD6482EAG3.2201e-040.3747image
chr14:92059515-92062223:-LUADAZD.2281EER1.5668e-02-0.1682image
ENSG00000066427.20,ATXN3LUADAZD.2281EAG1.3571e-02-0.1705image
ENSG00000066427.20,ATXN3LUSCJW.7.52.1EAG3.6945e-03-0.2024image
chr14:92059515-92062223:-LUSCJW.7.52.1EER3.4855e-03-0.2051image
chr14:92059515-92062223:-OVEmbelinEER8.3086e-060.2904image
chr14:92068680-92069693:-OVCGP.60474EER1.0848e-03-0.5360image
ENSG00000066427.20,ATXN3OVAZD6482EAG4.9016e-060.2955image
ENSG00000066427.20,ATXN3PAADBMS.754807EAG1.3779e-03-0.3340image
chr14:92059515-92062223:-PAADBMS.754807EER4.4834e-04-0.3663image
chr14:92059515-92062223:-PCPGLenalidomideEER1.2632e-020.2867image
ENSG00000066427.20,ATXN3PCPGIPA.3EAG1.4917e-020.2783image
ENSG00000066427.20,ATXN3PRADDMOGEAG5.2365e-060.2328image
chr14:92059515-92062223:-PRADDMOGEER2.7032e-040.1893image
ENSG00000066427.20,ATXN3READCCT007093EAG3.4583e-030.5837image
chr14:92059515-92062223:-SARCDocetaxelEER1.1566e-04-0.3269image
ENSG00000066427.20,ATXN3SARCDocetaxelEAG2.2133e-04-0.3095image
chr14:92059515-92062223:-SKCMBAY.61.3606EER3.4206e-020.1708image
ENSG00000066427.20,ATXN3STADEpothilone.BEAG5.7291e-050.2389image
chr14:92068680-92069693:-STADAMG.706EER3.6915e-04-0.4712image
chr14:92090982-92091873:-STADCytarabineEER9.4982e-04-0.4192image
chr14:92059515-92062223:-STADBIBW2992EER4.8163e-03-0.1743image
ENSG00000066427.20,ATXN3TGCTBMS.754807EAG1.0862e-02-0.2783image
chr14:92059515-92062223:-TGCTBMS.754807EER7.6689e-03-0.2907image
chr14:92059515-92062223:-THCAGefitinibEER7.9063e-03-0.1394image
ENSG00000066427.20,ATXN3THCAGefitinibEAG1.4086e-02-0.1275image
chr14:92059515-92062223:-THYMEmbelinEER3.4233e-050.4076image
ENSG00000066427.20,ATXN3THYMEtoposideEAG8.5005e-040.3253image
chr14:92059515-92062223:-UCECJNK.9LEER4.2079e-050.4490image
ENSG00000066427.20,ATXN3UCECAZD6244EAG1.0763e-03-0.3568image
ENSG00000066427.20,ATXN3UVMAZD8055EAG2.8131e-020.4787image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType