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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MDM4 (ImmuneEditome ID:4194)

1. Gene summary of enriched editing regions for MDM4

check button Gene summary
Gene informationGene symbol

MDM4

Gene ID

4194

GeneSynonymsBMFS6|HDMX|MDMX|MRP1
GeneCytomap

1q32.1

GeneTypeprotein-coding
GeneDescriptionprotein Mdm4|MDM4, p53 regulator|MDM4-related protein 1|Mdm4 p53 binding protein homolog|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdmx
GeneModificationdate20230329
UniprotIDO15151;Q68DC0;A0A087WZ58;A0A087WTR9;Q5T0Y4;Q5T0Y2;A0A087WUE3;Q5T0Y3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:204534494-204536271:+ENST00000463049.4ENSG00000198625.11MDM4ncRNA_intronicAluY,AluSz,AluSg4,L1MC4a,AluJbchr1:204534494-204536271:+.alignment
chr1:204534494-204536271:+ENST00000470908.4ENSG00000198625.11MDM4ncRNA_intronicAluY,AluSz,AluSg4,L1MC4a,AluJbchr1:204534494-204536271:+.alignment
chr1:204534494-204536271:+ENST00000471783.1ENSG00000198625.11MDM4ncRNA_intronicAluY,AluSz,AluSg4,L1MC4a,AluJbchr1:204534494-204536271:+.alignment
chr1:204550350-204553184:+ENST00000463049.4ENSG00000198625.11MDM4ncRNA_exonicAluJo,AluJb,AluJr4,(T)n,MER30,AluSq2,AluSg,Charlie2a,AluSpchr1:204550350-204553184:+.alignment
chr1:204555235-204557725:+ENST00000367182.6ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment
chr1:204555235-204557725:+ENST00000367183.6ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment
chr1:204555235-204557725:+ENST00000391947.5ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment
chr1:204555235-204557725:+ENST00000454264.5ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment
chr1:204555235-204557725:+ENST00000612738.3ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment
chr1:204555235-204557725:+ENST00000614459.3ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment
chr1:204555235-204557725:+ENST00000616250.3ENSG00000198625.11MDM4UTR3AluY,MIRc,AluJb,LTR8,AluSxchr1:204555235-204557725:+.alignment


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2. Tumor-specific enriched editing regions for MDM4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:204555235-204557725:+COADEER2.1648e-03image
ENSG00000198625.11,MDM4COADEAG2.8532e-03image
chr1:204555235-204557725:+HNSCEER1.1536e-02image
ENSG00000198625.11,MDM4HNSCEAG4.0950e-03image
chr1:204550350-204553184:+KIRCEER2.9350e-02image
chr1:204555235-204557725:+KIRCEER8.7130e-04image
ENSG00000198625.11,MDM4KIRCEAG1.5455e-04image
chr1:204555235-204557725:+LIHCEER1.6368e-05image
ENSG00000198625.11,MDM4LIHCEAG2.4499e-05image
chr1:204555235-204557725:+STADEER7.3686e-03image
ENSG00000198625.11,MDM4STADEAG2.7956e-02image
chr1:204555235-204557725:+THCAEER3.7620e-04image
ENSG00000198625.11,MDM4THCAEAG1.6397e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000198625.11,MDM4BLCAPathEAG3.1834e-031.3505e-030.1593image
chr1:204555235-204557725:+BLCAPathEER1.5530e-034.3013e-040.1752image
ENSG00000198625.11,MDM4LUADPathEAG3.0092e-032.6120e-030.1333image
chr1:204555235-204557725:+LUADPathEER1.0399e-021.6088e-020.1076image
ENSG00000198625.11,MDM4LUSCPathEAG2.0108e-024.2559e-030.1289image
ENSG00000198625.11,MDM4READPathEAG2.8266e-024.7885e-02-0.1618image
ENSG00000198625.11,MDM4THCAPathEAG1.1302e-034.4663e-030.1266image
chr1:204555235-204557725:+THCAPathEER7.0207e-044.4401e-030.1269image
chr1:204550350-204553184:+THCAPathEER4.0655e-022.4599e-020.1173image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr1:204555235-204557725:+BLCAEER3.5362e-022.4533e-021.2342e+01image
ENSG00000198625.11,MDM4BLCAEAG3.1552e-024.3259e-021.2388e+01image
ENSG00000198625.11,MDM4LIHCEAG4.0638e-022.3247e-022.3535e-02image
chr1:204555235-204557725:+LUSCEER2.8680e-021.2997e-034.8294e-03image
ENSG00000198625.11,MDM4LUSCEAG4.0815e-021.1237e-021.2525e-02image

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3. Enriched editing regions and immune related genes for MDM4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:204550350-204553184:+DLBCEERENSG00000134248,LAMTOR50.61224.1839e-027.0060e-040.5387imageNNNAMacrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr1:204550350-204553184:+TGCTEERENSG00000162384,C1orf1230.30381.3769e-027.8471e-060.4050imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+BLCAEERENSG00000085063,CD590.27472.2903e-062.5172e-180.4182imageNNCD59T_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr1:204555235-204557725:+UCECEERENSG00000198242,RPL23A0.26333.6517e-025.3071e-090.4325imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+UCECEERENSG00000175920,DOK70.26053.9418e-022.3356e-110.4876imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:204555235-204557725:+DLBCEERENSG00000270091,RP11-78O7.2-0.55693.1290e-021.6499e-03-0.4512imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr1:204555235-204557725:+DLBCEERENSG00000125351,UPF3B0.54444.6324e-021.0525e-030.4675imageNNNAT_cells_CD8GSVA_HALLMARK_G2M_CHECKPOINT
chr1:204555235-204557725:+UVMEERENSG00000188807,TMEM2010.61941.1626e-049.7905e-070.5643imageNNNAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000138629,UBL70.60581.7043e-043.8777e-070.5811imageNNUBL7Macrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000140553,UNC45A0.56513.4791e-049.5009e-060.5189imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr1:204555235-204557725:+UVMEERENSG00000179476,C14orf28-0.54659.5188e-049.6612e-05-0.4646imageNNNAB_cells_memoryGSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:204555235-204557725:+UVMEERENSG00000103653,CSK0.53809.7022e-044.6540e-050.4827imageNNCSKMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN

More results



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4. Enriched editing regions and immune related splicing for MDM4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:204555235-204557725:+
BLCAEERIRENSG00000101150.13chr2063882718:63887605:63889189:63889238-0.35995.2327e-118.6413e-16-0.4044imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000065029.10chr635291557:35291737:35292553:35292642-0.42507.1624e-154.3826e-18-0.4238imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MBNL1;MBNL2;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000137965.6chr178662734:78662917:78663764:78663897-0.29465.5871e-092.2264e-14-0.4226imageNADAR;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPL;IGF2BP2;IGF2BP3;MSI1;PTBP1;RBM47;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TROVE2;U2AF2;YTHDC1IFI44T_cells_CD4_memory_activatedGSVA_HALLMARK_COAGULATION
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000178028.9chr144214702:44214898:44218340:44218430-0.30541.1847e-081.9959e-15-0.4191imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000132199.14chr18690548:691276:693881:693908-0.40706.7024e-143.1620e-17-0.4208imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000172663.4chr1167464802:67465267:67467311:67467388-0.41331.0098e-132.1087e-18-0.4255imageNAIFM1;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;IGF2BP2;IGF2BP3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000198690.5chr1530925095:30925939:30928552:30928656-0.28952.4157e-081.6461e-13-0.4044imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184FAN1T_cells_CD4_memory_activatedGSVA_HALLMARK_COMPLEMENT
chr1:204555235-204557725:+
BLCAEERIRENSG00000007392.12chr16227241:227336:229278:229374-0.35521.9682e-101.1773e-16-0.4044imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198625.11,MDM4
BLCAEAGIRENSG00000205581.6chr2139345138:39345274:39347246:39347292-0.41151.4771e-139.2066e-21-0.4492imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZFP36;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chr1:204555235-204557725:+
BLCAEERIRENSG00000104529.13chr8143588990:143590081:143590607:143590729-0.31733.1702e-101.2869e-14-0.4222imageNNNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for MDM4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:204555235-204557725:+ACCEERT_cells_CD4_memory_activated3.1836e-02-0.2481image
ENSG00000198625.11,MDM4ACCEAGT_cells_CD4_memory_activated2.6409e-02-0.2564image
chr1:204550350-204553184:+BLCAEERMacrophages_M23.5651e-020.1398image
chr1:204555235-204557725:+BLCAEERMacrophages_M11.0510e-070.2624image
ENSG00000198625.11,MDM4BLCAEAGMacrophages_M12.9758e-080.2724image
chr1:204534494-204536271:+BRCAEERDendritic_cells_activated4.2219e-020.1827image
chr1:204550350-204553184:+BRCAEERT_cells_regulatory_(Tregs)1.2109e-030.1047image
chr1:204555235-204557725:+BRCAEERT_cells_follicular_helper8.5334e-04-0.1012image
ENSG00000198625.11,MDM4BRCAEAGB_cells_naive1.4998e-03-0.0964image
chr1:204555235-204557725:+CESCEERMast_cells_resting8.4942e-03-0.1525image
ENSG00000198625.11,MDM4CESCEAGB_cells_naive1.0628e-02-0.1471image
chr1:204555235-204557725:+CHOLEERT_cells_gamma_delta7.6696e-03-0.4432image
ENSG00000198625.11,MDM4CHOLEAGT_cells_gamma_delta1.2274e-02-0.4188image
chr1:204555235-204557725:+COADEERNeutrophils6.2443e-040.2073image
chr1:204550350-204553184:+DLBCEERMonocytes2.1094e-020.3831image
chr1:204555235-204557725:+DLBCEERMast_cells_resting1.1349e-030.4648image
ENSG00000198625.11,MDM4DLBCEAGMast_cells_resting1.2339e-030.4572image
chr1:204534494-204536271:+ESCAEERT_cells_gamma_delta1.5410e-040.3732image
chr1:204550350-204553184:+ESCAEERNK_cells_activated1.5899e-020.1898image
chr1:204555235-204557725:+ESCAEERMacrophages_M28.1838e-050.3063image
ENSG00000198625.11,MDM4ESCAEAGNK_cells_resting3.1384e-03-0.2314image
chr1:204550350-204553184:+GBMEERT_cells_CD4_memory_activated7.3489e-030.2477image
chr1:204555235-204557725:+GBMEERNeutrophils6.9972e-040.2605image
ENSG00000198625.11,MDM4GBMEAGNeutrophils7.8340e-040.2582image
chr1:204555235-204557725:+HNSCEERT_cells_follicular_helper1.4785e-02-0.1179image
ENSG00000198625.11,MDM4HNSCEAGT_cells_follicular_helper6.6060e-03-0.1292image
chr1:204555235-204557725:+KICHEEREosinophils1.8839e-020.2929image
ENSG00000198625.11,MDM4KICHEAGEosinophils2.1220e-020.2876image
ENSG00000198625.11,MDM4KIRCEAGPlasma_cells1.9727e-020.1200image
chr1:204550350-204553184:+KIRPEERMacrophages_M12.6972e-02-0.1765image
chr1:204555235-204557725:+KIRPEERT_cells_CD4_memory_activated1.3917e-030.1918image
ENSG00000198625.11,MDM4KIRPEAGT_cells_CD4_memory_activated3.8814e-030.1733image
chr1:204534494-204536271:+LAMLEERMonocytes3.5122e-020.1728image
chr1:204550350-204553184:+LAMLEERNeutrophils2.7924e-02-0.1999image
chr1:204555235-204557725:+LAMLEERT_cells_CD4_memory_resting9.1060e-030.2123image
ENSG00000198625.11,MDM4LAMLEAGT_cells_CD4_memory_resting1.4105e-020.2001image
chr1:204555235-204557725:+LGGEERT_cells_follicular_helper6.9483e-04-0.1472image
ENSG00000198625.11,MDM4LGGEAGT_cells_follicular_helper7.2344e-04-0.1467image
chr1:204550350-204553184:+LIHCEERT_cells_CD4_memory_activated3.8935e-02-0.1694image
chr1:204555235-204557725:+LIHCEERT_cells_CD4_memory_activated5.3249e-030.1495image
ENSG00000198625.11,MDM4LIHCEAGT_cells_CD4_memory_activated1.8431e-020.1256image
chr1:204534494-204536271:+LUADEERT_cells_regulatory_(Tregs)2.4748e-020.4026image
chr1:204550350-204553184:+LUADEERT_cells_CD84.0413e-040.1767image
chr1:204555235-204557725:+LUADEERT_cells_CD4_naive6.8974e-060.1998image
ENSG00000198625.11,MDM4LUADEAGMacrophages_M24.0467e-040.1567image
chr1:204550350-204553184:+LUSCEERPlasma_cells2.1232e-02-0.1186image
chr1:204555235-204557725:+LUSCEERT_cells_CD4_memory_activated8.7756e-030.1183image
ENSG00000198625.11,MDM4LUSCEAGT_cells_CD4_memory_activated3.0032e-030.1337image
chr1:204550350-204553184:+MESOEERB_cells_memory8.5023e-040.5186image
chr1:204555235-204557725:+MESOEERT_cells_CD83.9945e-020.2288image
ENSG00000198625.11,MDM4MESOEAGT_cells_CD82.4930e-020.2491image
chr1:204534494-204536271:+OVEERNK_cells_activated1.0643e-040.5351image
chr1:204550350-204553184:+OVEERT_cells_CD4_memory_activated1.5098e-040.2290image
chr1:204555235-204557725:+OVEERT_cells_CD81.8657e-050.2510image
ENSG00000198625.11,MDM4OVEAGT_cells_CD81.0474e-040.2262image
chr1:204550350-204553184:+PCPGEERT_cells_gamma_delta2.6607e-020.2595image
chr1:204555235-204557725:+PCPGEERMast_cells_resting4.4702e-03-0.2098image
ENSG00000198625.11,MDM4PCPGEAGMast_cells_resting6.9457e-03-0.1995image
chr1:204550350-204553184:+PRADEERMast_cells_resting5.9759e-040.1858image
chr1:204555235-204557725:+PRADEERMast_cells_activated3.0463e-02-0.0973image
ENSG00000198625.11,MDM4PRADEAGMast_cells_activated1.5363e-02-0.1088image
chr1:204550350-204553184:+READEERPlasma_cells1.5069e-020.3727image
ENSG00000198625.11,MDM4READEAGB_cells_naive4.0926e-02-0.2124image
chr1:204550350-204553184:+SARCEERT_cells_CD4_memory_resting1.1112e-02-0.2370image
chr1:204555235-204557725:+SARCEERMacrophages_M27.0721e-040.2145image
ENSG00000198625.11,MDM4SARCEAGMacrophages_M23.4521e-040.2259image
chr1:204550350-204553184:+SKCMEERT_cells_gamma_delta5.1075e-030.1513image
chr1:204555235-204557725:+SKCMEERT_cells_CD4_memory_activated1.3767e-02-0.1155image
ENSG00000198625.11,MDM4SKCMEAGT_cells_CD4_memory_activated2.2511e-02-0.1067image
chr1:204550350-204553184:+STADEEREosinophils1.3200e-02-0.1318image
chr1:204555235-204557725:+STADEEREosinophils5.4964e-050.2136image
ENSG00000198625.11,MDM4STADEAGT_cells_CD83.0242e-020.1133image
chr1:204550350-204553184:+TGCTEERMast_cells_activated2.3169e-030.2826image
chr1:204555235-204557725:+TGCTEERT_cells_CD4_memory_activated4.6706e-030.2254image
ENSG00000198625.11,MDM4TGCTEAGT_cells_CD4_memory_activated3.5946e-030.2318image
chr1:204550350-204553184:+THCAEERT_cells_CD4_memory_resting1.3195e-02-0.1291image
chr1:204555235-204557725:+THCAEERT_cells_CD4_memory_resting5.8899e-030.1228image
ENSG00000198625.11,MDM4THCAEAGDendritic_cells_activated2.3359e-020.1010image
chr1:204555235-204557725:+THYMEERMacrophages_M04.7135e-030.2596image
ENSG00000198625.11,MDM4THYMEAGMast_cells_resting3.5810e-050.3708image
chr1:204550350-204553184:+UCSEERT_cells_CD4_memory_activated5.6445e-030.4151image
chr1:204555235-204557725:+UCSEERT_cells_follicular_helper4.9768e-02-0.2635image


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6. Enriched editing regions and immune gene sets for MDM4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr1:204555235-204557725:+KIRPEER4.8598e-02image4.1215e-030.1725image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000198625.11,MDM4LUADEAG1.2789e-040.16951.8633e-020.10469.4103e-030.11533.9412e-130.3152image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000198625.11,MDM4ACCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.0630e-030.3375image
chr1:204555235-204557725:+ACCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.3015e-030.3127image
chr1:204555235-204557725:+BLCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER8.2284e-120.3334image
ENSG00000198625.11,MDM4BLCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG2.3249e-130.3551image
chr1:204550350-204553184:+BLCAGSVA_HALLMARK_GLYCOLYSISEER2.8445e-060.3056image
chr1:204555235-204557725:+BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.9374e-110.1991image
chr1:204534494-204536271:+BRCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER6.6777e-050.3502image
chr1:204550350-204553184:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3604e-180.2778image
ENSG00000198625.11,MDM4BRCAGSVA_HALLMARK_GLYCOLYSISEAG6.6836e-140.2250image
chr1:204555235-204557725:+CESCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.9514e-040.2145image
chr1:204550350-204553184:+CESCGSVA_HALLMARK_COAGULATIONEER2.2183e-040.2854image
ENSG00000198625.11,MDM4CESCGSVA_HALLMARK_COAGULATIONEAG8.7831e-050.2241image
chr1:204550350-204553184:+CHOLGSVA_HALLMARK_UV_RESPONSE_UPEER1.2439e-020.4830image
ENSG00000198625.11,MDM4CHOLGSVA_HALLMARK_APICAL_SURFACEEAG3.7490e-020.3531image
chr1:204555235-204557725:+CHOLGSVA_HALLMARK_PROTEIN_SECRETIONEER9.9429e-030.4300image
chr1:204550350-204553184:+COADGSVA_HALLMARK_PROTEIN_SECRETIONEER1.0907e-020.2087image
ENSG00000198625.11,MDM4COADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.2926e-030.1945image
chr1:204555235-204557725:+COADGSVA_HALLMARK_ANDROGEN_RESPONSEEER5.5928e-030.1685image
chr1:204555235-204557725:+DLBCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.1550e-03-0.3855image
chr1:204550350-204553184:+DLBCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.5355e-02-0.3357image
ENSG00000198625.11,MDM4DLBCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.9402e-03-0.4406image
chr1:204550350-204553184:+ESCAGSVA_HALLMARK_DNA_REPAIREER9.6502e-030.2034image
chr1:204555235-204557725:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER5.4003e-040.2705image
ENSG00000198625.11,MDM4ESCAGSVA_HALLMARK_MYOGENESISEAG2.7675e-020.1736image
chr1:204534494-204536271:+ESCAGSVA_HALLMARK_APICAL_JUNCTIONEER1.3168e-050.4246image
ENSG00000198625.11,MDM4GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3820e-030.2463image
chr1:204555235-204557725:+GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.5354e-030.2193image
chr1:204550350-204553184:+GBMGSVA_HALLMARK_MTORC1_SIGNALINGEER6.2193e-030.2526image
chr1:204555235-204557725:+HNSCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER8.3230e-080.2558image
ENSG00000198625.11,MDM4HNSCGSVA_HALLMARK_HYPOXIAEAG4.5508e-070.2374image
chr1:204550350-204553184:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER8.1693e-04-0.2314image
ENSG00000198625.11,MDM4KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.9793e-100.3119image
chr1:204555235-204557725:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.2157e-100.3245image
chr1:204550350-204553184:+KIRCGSVA_HALLMARK_COAGULATIONEER4.1700e-060.2764image
chr1:204550350-204553184:+KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.1949e-030.2220image
chr1:204555235-204557725:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER9.4414e-070.2906image
ENSG00000198625.11,MDM4KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG6.4081e-070.2943image
chr1:204555235-204557725:+LAMLGSVA_HALLMARK_G2M_CHECKPOINTEER2.2182e-05-0.3389image
chr1:204534494-204536271:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.4607e-020.1648image
ENSG00000198625.11,MDM4LAMLGSVA_HALLMARK_G2M_CHECKPOINTEAG7.4006e-04-0.2725image
chr1:204550350-204553184:+LAMLGSVA_HALLMARK_PEROXISOMEEER1.1761e-030.2916image
ENSG00000198625.11,MDM4LGGGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.3277e-170.3575image
chr1:204555235-204557725:+LGGGSVA_HALLMARK_UV_RESPONSE_DNEER1.9253e-130.3127image
chr1:204550350-204553184:+LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEER3.2902e-060.2506image
chr1:204555235-204557725:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER6.0222e-080.2862image
chr1:204550350-204553184:+LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.0411e-040.3126image
ENSG00000198625.11,MDM4LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.2557e-080.2835image
chr1:204555235-204557725:+LUADGSVA_HALLMARK_APOPTOSISEER1.1054e-120.3114image
chr1:204534494-204536271:+LUADGSVA_HALLMARK_KRAS_SIGNALING_DNEER9.8300e-040.5627image
chr1:204550350-204553184:+LUADGSVA_HALLMARK_COMPLEMENTEER2.5302e-060.2336image
ENSG00000198625.11,MDM4LUADGSVA_HALLMARK_APOPTOSISEAG7.2021e-150.3366image
ENSG00000198625.11,MDM4LUSCGSVA_HALLMARK_APOPTOSISEAG5.6741e-080.2420image
chr1:204555235-204557725:+LUSCGSVA_HALLMARK_GLYCOLYSISEER8.0339e-090.2568image
chr1:204550350-204553184:+LUSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.4126e-030.1638image
ENSG00000198625.11,MDM4MESOGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG9.2037e-040.3613image
chr1:204555235-204557725:+MESOGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER6.6348e-040.3704image
chr1:204550350-204553184:+MESOGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.7444e-020.3577image
ENSG00000198625.11,MDM4OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.9264e-090.3438image
chr1:204534494-204536271:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.5768e-030.3910image
chr1:204550350-204553184:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER7.5760e-070.2962image
chr1:204555235-204557725:+OVGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.8070e-070.2934image
chr1:204555235-204557725:+PAADGSVA_HALLMARK_MTORC1_SIGNALINGEER2.4627e-040.2738image
ENSG00000198625.11,MDM4PAADGSVA_HALLMARK_MTORC1_SIGNALINGEAG9.3750e-050.2902image
chr1:204550350-204553184:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5765e-030.3213image
ENSG00000198625.11,MDM4PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.8750e-040.2560image
chr1:204555235-204557725:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2117e-030.2255image
chr1:204550350-204553184:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER5.9646e-05-0.2166image
ENSG00000198625.11,MDM4PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.4646e-070.2334image
chr1:204555235-204557725:+PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER7.4122e-070.2203image
chr1:204550350-204553184:+READGSVA_HALLMARK_COMPLEMENTEER4.0619e-020.3173image
ENSG00000198625.11,MDM4READGSVA_HALLMARK_P53_PATHWAYEAG2.4478e-020.2332image
chr1:204555235-204557725:+READGSVA_HALLMARK_P53_PATHWAYEER2.4118e-020.2350image
ENSG00000198625.11,MDM4SARCGSVA_HALLMARK_GLYCOLYSISEAG4.2593e-060.2878image
chr1:204550350-204553184:+SARCGSVA_HALLMARK_COAGULATIONEER8.3287e-040.3087image
chr1:204555235-204557725:+SARCGSVA_HALLMARK_GLYCOLYSISEER8.0853e-060.2802image
chr1:204550350-204553184:+SKCMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.0867e-080.3034image
chr1:204555235-204557725:+SKCMGSVA_HALLMARK_APICAL_JUNCTIONEER9.8594e-110.2975image
ENSG00000198625.11,MDM4SKCMGSVA_HALLMARK_APICAL_JUNCTIONEAG3.7935e-100.2875image
chr1:204534494-204536271:+STADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.8683e-060.3410image
chr1:204555235-204557725:+STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.2599e-060.2493image
chr1:204550350-204553184:+STADGSVA_HALLMARK_MYC_TARGETS_V2EER3.1493e-030.1567image
ENSG00000198625.11,MDM4STADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.2807e-050.2259image
chr1:204555235-204557725:+TGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.9720e-030.2238image
ENSG00000198625.11,MDM4TGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5043e-030.2263image
chr1:204550350-204553184:+TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.4888e-030.2585image
chr1:204550350-204553184:+THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.3979e-040.1858image
ENSG00000198625.11,MDM4THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.8819e-050.1852image
chr1:204555235-204557725:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.8028e-070.2268image
chr1:204555235-204557725:+THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.2741e-040.3469image
chr1:204550350-204553184:+THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.2838e-030.3145image
ENSG00000198625.11,MDM4THYMGSVA_HALLMARK_G2M_CHECKPOINTEAG1.5202e-04-0.3418image
chr1:204555235-204557725:+UCECGSVA_HALLMARK_ADIPOGENESISEER1.8982e-020.1814image
chr1:204550350-204553184:+UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0192e-030.2939image
ENSG00000198625.11,MDM4UCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.4633e-04-0.2682image
ENSG00000198625.11,MDM4UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.5565e-030.3533image
chr1:204555235-204557725:+UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.8659e-030.3573image
chr1:204550350-204553184:+UCSGSVA_HALLMARK_DNA_REPAIREER7.8961e-030.3998image
ENSG00000198625.11,MDM4UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.6545e-050.5067image
chr1:204555235-204557725:+UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.4142e-050.4982image


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7. Enriched editing regions and drugs for MDM4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000198625.11,MDM4ACCEtoposideEAG1.2717e-040.4282image
chr1:204555235-204557725:+ACCEtoposideEER7.0846e-050.4423image
chr1:204555235-204557725:+BLCACMKEER2.8499e-16-0.3940image
ENSG00000198625.11,MDM4BLCACMKEAG2.6246e-17-0.4055image
chr1:204550350-204553184:+BLCACMKEER3.8827e-05-0.2701image
chr1:204534494-204536271:+BRCAABT.263EER3.0547e-040.3190image
chr1:204550350-204553184:+BRCAA.770041EER3.6813e-17-0.2684image
ENSG00000198625.11,MDM4BRCAATRAEAG4.7450e-050.1234image
chr1:204555235-204557725:+BRCAKIN001.135EER7.2444e-05-0.1203image
ENSG00000198625.11,MDM4CESCCCT007093EAG1.8079e-090.3378image
chr1:204550350-204553184:+CESCDasatinibEER1.1011e-03-0.2549image
chr1:204555235-204557725:+CESCCCT007093EER4.8691e-060.2617image
chr1:204550350-204553184:+CHOLA.770041EER1.5724e-04-0.6746image
ENSG00000198625.11,MDM4CHOLCHIR.99021EAG1.6792e-02-0.4016image
chr1:204555235-204557725:+CHOLAMG.706EER8.9576e-030.4353image
chr1:204555235-204557725:+COADBMS.708163EER2.1844e-07-0.3096image
ENSG00000198625.11,MDM4COADBMS.708163EAG7.9093e-04-0.2027image
chr1:204550350-204553184:+DLBCEHT.1864EER4.1820e-020.3410image
chr1:204555235-204557725:+DLBCBX.795EER1.6163e-020.3528image
ENSG00000198625.11,MDM4DLBCBX.795EAG8.7743e-030.3781image
chr1:204555235-204557725:+ESCAGSK269962AEER3.9315e-04-0.2769image
chr1:204534494-204536271:+ESCABexaroteneEER7.0167e-04-0.3366image
ENSG00000198625.11,MDM4GBMBI.2536EAG7.1387e-040.2601image
chr1:204555235-204557725:+GBMBI.2536EER1.2985e-030.2476image
chr1:204550350-204553184:+GBMDocetaxelEER2.4538e-03-0.2787image
chr1:204550350-204553184:+HNSCBI.D1870EER4.3582e-08-0.3701image
ENSG00000198625.11,MDM4HNSCErlotinibEAG1.6398e-11-0.3135image
chr1:204555235-204557725:+HNSCIPA.3EER1.0904e-070.2536image
ENSG00000198625.11,MDM4KICHAS601245EAG1.5878e-020.3004image
chr1:204555235-204557725:+KICHAS601245EER1.4228e-020.3051image
ENSG00000198625.11,MDM4KIRCA.770041EAG5.8456e-11-0.3289image
chr1:204555235-204557725:+KIRCA.770041EER5.8826e-06-0.2315image
chr1:204550350-204553184:+KIRCBAY.61.3606EER8.3816e-090.3422image
chr1:204555235-204557725:+KIRPIPA.3EER2.0350e-060.2819image
ENSG00000198625.11,MDM4KIRPIPA.3EAG4.4094e-070.2984image
chr1:204550350-204553184:+KIRPEmbelinEER1.9290e-040.2933image
ENSG00000198625.11,MDM4LAMLLFM.A13EAG3.5255e-03-0.2368image
chr1:204534494-204536271:+LAMLBIRB.0796EER2.4356e-020.1844image
chr1:204555235-204557725:+LAMLAS601245EER7.7708e-03-0.2166image
chr1:204550350-204553184:+LAMLFTI.277EER1.4908e-02-0.2209image
chr1:204555235-204557725:+LGGJNK.9LEER6.4069e-140.3186image
ENSG00000198625.11,MDM4LGGCytarabineEAG2.7867e-130.3107image
chr1:204550350-204553184:+LGGGNF.2EER1.1149e-07-0.2846image
chr1:204550350-204553184:+LIHCJNK.Inhibitor.VIIIEER1.3657e-030.2600image
chr1:204555235-204557725:+LIHCAZD8055EER6.2601e-05-0.2135image
ENSG00000198625.11,MDM4LIHCCCT007093EAG4.5735e-070.2649image
chr1:204555235-204557725:+LUADGemcitabineEER7.7097e-08-0.2377image
chr1:204534494-204536271:+LUADBMS.708163EER1.2983e-020.4412image
chr1:204550350-204553184:+LUADBMS.509744EER1.2635e-04-0.1912image
ENSG00000198625.11,MDM4LUADGemcitabineEAG2.8742e-08-0.2436image
chr1:204555235-204557725:+LUSCBMS.509744EER2.4480e-07-0.2306image
ENSG00000198625.11,MDM4LUSCBMS.509744EAG2.4061e-07-0.2305image
chr1:204550350-204553184:+LUSCCI.1040EER9.8542e-04-0.1690image
chr1:204555235-204557725:+MESOBIRB.0796EER9.1945e-040.3613image
ENSG00000198625.11,MDM4MESOBIRB.0796EAG1.0324e-030.3580image
chr1:204550350-204553184:+MESOA.443654EER1.0887e-02-0.4085image
ENSG00000198625.11,MDM4OVMG.132EAG8.7936e-09-0.3308image
chr1:204534494-204536271:+OVCEP.701EER1.0226e-03-0.4639image
chr1:204555235-204557725:+OVMG.132EER2.9511e-06-0.2737image
chr1:204550350-204553184:+OVA.770041EER3.2538e-09-0.3509image
chr1:204555235-204557725:+PAADAUY922EER2.3058e-02-0.1717image
ENSG00000198625.11,MDM4PAADAUY922EAG2.8485e-02-0.1652image
chr1:204550350-204553184:+PCPGAUY922EER1.8646e-02-0.2748image
chr1:204555235-204557725:+PCPGGSK.650394EER5.8261e-050.2934image
ENSG00000198625.11,MDM4PCPGCyclopamineEAG5.1170e-050.2955image
ENSG00000198625.11,MDM4PRADBMS.509744EAG1.5226e-05-0.1929image
chr1:204550350-204553184:+PRADBMS.536924EER7.6686e-05-0.2143image
chr1:204555235-204557725:+PRADBMS.754807EER4.5923e-08-0.2426image
chr1:204550350-204553184:+SARCBMS.536924EER1.8108e-06-0.4299image
chr1:204555235-204557725:+SARCDasatinibEER1.1113e-05-0.2761image
ENSG00000198625.11,MDM4SARCAG.014699EAG1.0401e-070.3306image
chr1:204550350-204553184:+SKCMGNF.2EER3.0156e-04-0.1946image
chr1:204555235-204557725:+SKCMBexaroteneEER2.4973e-16-0.3718image
ENSG00000198625.11,MDM4SKCMBexaroteneEAG9.5288e-13-0.3256image
chr1:204534494-204536271:+STADBI.2536EER3.9122e-030.2170image
chr1:204555235-204557725:+STADAZ628EER1.8239e-06-0.2515image
chr1:204550350-204553184:+STADGW843682XEER3.7673e-05-0.2175image
ENSG00000198625.11,MDM4STADAZ628EAG1.5877e-05-0.2235image
chr1:204555235-204557725:+TGCTAZD6244EER3.4291e-04-0.2831image
ENSG00000198625.11,MDM4TGCTAZD6244EAG1.3845e-04-0.3004image
chr1:204550350-204553184:+TGCTCamptothecinEER2.0054e-02-0.2176image
chr1:204550350-204553184:+THCAGSK269962AEER8.9359e-06-0.2292image
ENSG00000198625.11,MDM4THCACI.1040EAG6.8277e-06-0.1989image
chr1:204555235-204557725:+THCAAMG.706EER3.0426e-040.1606image
chr1:204555235-204557725:+THYMAZD6244EER6.8700e-10-0.5317image
chr1:204550350-204553184:+THYMCGP.082996EER1.1708e-020.2487image
ENSG00000198625.11,MDM4THYMABT.263EAG7.6577e-050.3559image
chr1:204555235-204557725:+UCECAZD6482EER1.2733e-050.3307image
chr1:204550350-204553184:+UCECErlotinibEER2.6862e-06-0.4103image
ENSG00000198625.11,MDM4UCECDasatinibEAG5.5460e-09-0.4262image
ENSG00000198625.11,MDM4UCSAZ628EAG4.8976e-03-0.3708image
chr1:204555235-204557725:+UCSAZ628EER3.3950e-03-0.3850image
chr1:204550350-204553184:+UCSABT.888EER1.3409e-02-0.3743image
ENSG00000198625.11,MDM4UVMBexaroteneEAG1.1130e-06-0.5619image
chr1:204555235-204557725:+UVMBexaroteneEER3.0139e-06-0.5427image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType