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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CD46 (ImmuneEditome ID:4179)

1. Gene summary of enriched editing regions for CD46

check button Gene summary
Gene informationGene symbol

CD46

Gene ID

4179

GeneSynonymsAHUS2|MCP|MIC10|TLX|TRA2.10
GeneCytomap

1q32.2

GeneTypeprotein-coding
GeneDescriptionmembrane cofactor protein|CD46 antigen, complement regulatory protein|CD46 molecule, complement regulatory protein|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofactor protein|measles virus receptor|membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)|trophoblast leucocyte common antigen|trophoblast leukocyte common antigen|trophoblast-lymphocyte cross-reactive antigen
GeneModificationdate20230518
UniprotIDP15529
PubMed ID

33619844

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:207768955-207770058:+ENST00000469535.4ENSG00000117335.17CD46ncRNA_exonicAluSx1,AluSg4chr1:207768955-207770058:+.alignment
chr1:207768955-207770058:+ENST00000488596.4ENSG00000117335.17CD46ncRNA_exonicAluSx1,AluSg4chr1:207768955-207770058:+.alignment
chr1:207768955-207770058:+ENST00000490278.1ENSG00000117335.17CD46ncRNA_exonicAluSx1,AluSg4chr1:207768955-207770058:+.alignment
chr1:207787161-207788446:+ENST00000469535.4ENSG00000117335.17CD46ncRNA_intronicAluSx,AluY,MER5A1chr1:207787161-207788446:+.alignment
chr1:207787161-207788446:+ENST00000488596.4ENSG00000117335.17CD46ncRNA_intronicAluSx,AluY,MER5A1chr1:207787161-207788446:+.alignment


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2. Tumor-specific enriched editing regions for CD46


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr1:207768955-207770058:+BLCAPathEER5.0807e-055.6266e-050.2457image
ENSG00000117335.17,CD46BLCAPathEAG4.6310e-054.9393e-050.2475image
ENSG00000117335.17,CD46HNSCCliEAG2.6437e-028.6951e-03-0.2031image
chr1:207768955-207770058:+HNSCCliEER2.3090e-027.4658e-03-0.2070image
ENSG00000117335.17,CD46KIRPCliEAG3.8688e-025.3749e-030.2977image
chr1:207768955-207770058:+KIRPCliEER3.5426e-024.7289e-030.3019image
chr1:207768955-207770058:+LUADPathEER3.8589e-028.1362e-030.1320image
ENSG00000117335.17,CD46LUADPathEAG3.0662e-025.2502e-030.1390image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CD46


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:207768955-207770058:+ESCAEERENSG00000117335,CD46-0.38061.5170e-034.8468e-07-0.4048imageNFBLCD46T_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_JUNCTION
chr1:207768955-207770058:+ESCAEERENSG00000174886,NDUFA110.37502.3764e-031.2157e-090.4793imageNFBLNANK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000176973,FAM89B0.36733.0038e-032.5975e-070.4134imageNFBLNAB_cells_naiveGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr1:207768955-207770058:+ESCAEERENSG00000173465,SSSCA10.36553.3853e-031.6167e-080.4493imageNFBLNANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000134590,FAM127A0.35065.0144e-031.1975e-080.4529imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYOGENESIS
chr1:207768955-207770058:+ESCAEERENSG00000168894,RNF1810.34326.8660e-035.0519e-080.4351imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000173163,COMMD10.33807.5757e-039.6229e-080.4268imageNFBLNAT_cells_gamma_deltaGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000108518,PFN10.33478.8431e-038.5949e-080.4282imageNFBLNAMast_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000233762,AC007969.50.32431.3034e-022.3596e-090.4719imageNNNANK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000228474,OST40.31791.5216e-024.9723e-070.4044imageNFBLNAT_cells_gamma_deltaGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr1:207768955-207770058:+ESCAEERENSG00000117335,CD46-0.38061.5170e-034.8468e-07-0.4048imageNFBLCD46T_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_JUNCTION
chr1:207768955-207770058:+ESCAEERENSG00000174886,NDUFA110.37502.3764e-031.2157e-090.4793imageNFBLNANK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000176973,FAM89B0.36733.0038e-032.5975e-070.4134imageNFBLNAB_cells_naiveGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr1:207768955-207770058:+ESCAEERENSG00000173465,SSSCA10.36553.3853e-031.6167e-080.4493imageNFBLNANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000134590,FAM127A0.35065.0144e-031.1975e-080.4529imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYOGENESIS
chr1:207768955-207770058:+ESCAEERENSG00000168894,RNF1810.34326.8660e-035.0519e-080.4351imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000173163,COMMD10.33807.5757e-039.6229e-080.4268imageNFBLNAT_cells_gamma_deltaGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000108518,PFN10.33478.8431e-038.5949e-080.4282imageNFBLNAMast_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000233762,AC007969.50.32431.3034e-022.3596e-090.4719imageNNNANK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000228474,OST40.31791.5216e-024.9723e-070.4044imageNFBLNAT_cells_gamma_deltaGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr1:207768955-207770058:+ESCAEERENSG00000117335,CD46-0.38061.5170e-034.8468e-07-0.4048imageNFBLCD46T_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_JUNCTION
chr1:207768955-207770058:+ESCAEERENSG00000174886,NDUFA110.37502.3764e-031.2157e-090.4793imageNFBLNANK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000176973,FAM89B0.36733.0038e-032.5975e-070.4134imageNFBLNAB_cells_naiveGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr1:207768955-207770058:+ESCAEERENSG00000173465,SSSCA10.36553.3853e-031.6167e-080.4493imageNFBLNANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000134590,FAM127A0.35065.0144e-031.1975e-080.4529imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYOGENESIS
chr1:207768955-207770058:+ESCAEERENSG00000168894,RNF1810.34326.8660e-035.0519e-080.4351imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000173163,COMMD10.33807.5757e-039.6229e-080.4268imageNFBLNAT_cells_gamma_deltaGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000108518,PFN10.33478.8431e-038.5949e-080.4282imageNFBLNAMast_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr1:207768955-207770058:+ESCAEERENSG00000233762,AC007969.50.32431.3034e-022.3596e-090.4719imageNNNANK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr1:207768955-207770058:+ESCAEERENSG00000228474,OST40.31791.5216e-024.9723e-070.4044imageNFBLNAT_cells_gamma_deltaGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

More results



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4. Enriched editing regions and immune related splicing for CD46


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:207768955-207770058:+
CESCEERIRENSG00000116001.11chr270224553:70228462:70229058:70229091-0.30301.1668e-047.8302e-10-0.4212imageNFBLTIA1T_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000117335.17,CD46
CESCEAGIRENSG00000116001.11chr270224553:70228462:70229058:70229091-0.28583.8836e-041.6139e-09-0.4140imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184TIA1T_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:207768955-207770058:+
CESCEERIRENSG00000213923.6chr2238291929:38292543:38293254:38293319-0.24923.4059e-033.2871e-11-0.4510imageNFBLNAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000117335.17,CD46
CESCEAGIRENSG00000213923.6chr2238291929:38292543:38293254:38293319-0.24324.4630e-033.7031e-11-0.4499imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM39;RBM5;RC3H1;RNF219;RTCB;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184NAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr1:207768955-207770058:+
ESCAEERIRENSG00000050426.11chr1251048300:51049185:51055834:51055848-0.36783.8837e-035.5094e-08-0.4595imageNFBLNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:207768955-207770058:+
ESCAEERIRENSG00000184990.8chr14104756574:104756760:104759433:104759578-0.31531.3051e-022.1808e-07-0.4555imageNFBLSIVA1T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000117335.17,CD46
ESCAEAGIRENSG00000184990.8chr14104756574:104756760:104759433:104759578-0.35201.6895e-033.9681e-08-0.4689imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM6;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZC3H7B;ZNF184SIVA1T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
chr1:207768955-207770058:+
ESCAEERIRENSG00000203667.5chr1244839746:244842258:244843040:244843252-0.39835.4338e-035.4345e-07-0.4032imageNFBLNAT_cells_CD4_memory_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000117335.17,CD46
ESCAEAGIRENSG00000156642.12chr1573563235:73563257:73563378:73563402-0.33531.1797e-026.7813e-07-0.4225imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RTCB;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NPTNT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000117335.17,CD46
ESCAEAGIRENSG00000226742.3chr1879966611:79966678:79968094:79968183-0.30451.9374e-022.0360e-06-0.4180imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;KHDRBS2;LARP4B;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDF1;ZNF184HSBP1L1T_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for CD46


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:207768955-207770058:+BLCAEERMacrophages_M11.6574e-030.1931image
ENSG00000117335.17,CD46BLCAEAGMacrophages_M11.6263e-030.1934image
chr1:207768955-207770058:+BRCAEERB_cells_naive7.8282e-04-0.1114image
chr1:207787161-207788446:+BRCAEERB_cells_naive2.5083e-020.2520image
ENSG00000117335.17,CD46BRCAEAGB_cells_naive8.5043e-04-0.1106image
chr1:207768955-207770058:+CESCEERMacrophages_M23.0480e-020.1418image
ENSG00000117335.17,CD46CESCEAGMacrophages_M22.7796e-020.1438image
chr1:207768955-207770058:+ESCAEERT_cells_regulatory_(Tregs)6.4413e-03-0.2261image
chr1:207787161-207788446:+ESCAEERT_cells_CD4_memory_activated4.0031e-020.1979image
ENSG00000117335.17,CD46ESCAEAGT_cells_regulatory_(Tregs)2.9123e-03-0.2399image
chr1:207768955-207770058:+HNSCEERNK_cells_activated2.3875e-020.1727image
ENSG00000117335.17,CD46HNSCEAGNK_cells_activated2.6060e-020.1702image
chr1:207768955-207770058:+KIRCEERDendritic_cells_activated9.9023e-030.1872image
ENSG00000117335.17,CD46KIRCEAGDendritic_cells_activated9.9319e-030.1871image
chr1:207768955-207770058:+KIRPEERT_cells_CD4_memory_activated2.9852e-030.2565image
ENSG00000117335.17,CD46KIRPEAGT_cells_CD4_memory_activated3.1378e-030.2553image
chr1:207768955-207770058:+LAMLEERT_cells_CD4_memory_activated1.3392e-020.2491image
ENSG00000117335.17,CD46LAMLEAGT_cells_CD4_memory_activated4.2112e-020.2037image
chr1:207768955-207770058:+LGGEERNeutrophils2.8706e-02-0.1145image
ENSG00000117335.17,CD46LGGEAGNeutrophils2.8584e-02-0.1146image
chr1:207768955-207770058:+LIHCEERMacrophages_M01.6972e-020.2470image
ENSG00000117335.17,CD46LIHCEAGMacrophages_M01.1564e-020.2594image
chr1:207768955-207770058:+LUADEERT_cells_gamma_delta2.0912e-040.1851image
ENSG00000117335.17,CD46LUADEAGT_cells_gamma_delta2.5783e-040.1822image
chr1:207768955-207770058:+LUSCEERT_cells_regulatory_(Tregs)6.1345e-030.1539image
ENSG00000117335.17,CD46LUSCEAGT_cells_regulatory_(Tregs)7.8288e-030.1494image
chr1:207768955-207770058:+MESOEERDendritic_cells_activated1.4478e-020.3839image
ENSG00000117335.17,CD46MESOEAGDendritic_cells_activated1.4478e-020.3839image
chr1:207768955-207770058:+OVEERT_cells_CD82.7439e-020.1722image
ENSG00000117335.17,CD46OVEAGB_cells_memory1.4030e-030.2278image
chr1:207768955-207770058:+PAADEERNK_cells_resting2.0285e-070.4497image
ENSG00000117335.17,CD46PAADEAGNK_cells_resting1.9613e-070.4502image
chr1:207768955-207770058:+PRADEERMonocytes2.6803e-02-0.1262image
ENSG00000117335.17,CD46PRADEAGMonocytes3.3268e-02-0.1210image
chr1:207768955-207770058:+READEERNK_cells_activated5.3599e-030.3144image
ENSG00000117335.17,CD46READEAGNK_cells_activated5.4393e-030.3139image
chr1:207768955-207770058:+SARCEERPlasma_cells4.0127e-020.2533image
ENSG00000117335.17,CD46SARCEAGPlasma_cells4.0197e-020.2532image
chr1:207768955-207770058:+STADEERDendritic_cells_resting1.1863e-030.2072image
chr1:207787161-207788446:+STADEERPlasma_cells3.4274e-04-0.2471image
ENSG00000117335.17,CD46STADEAGPlasma_cells1.9618e-02-0.1372image
chr1:207768955-207770058:+TGCTEERNK_cells_activated3.8193e-020.2322image
ENSG00000117335.17,CD46TGCTEAGNK_cells_activated3.7859e-020.2326image
chr1:207768955-207770058:+THCAEERMacrophages_M23.8261e-02-0.1113image
ENSG00000117335.17,CD46THCAEAGMacrophages_M22.7155e-02-0.1184image
chr1:207768955-207770058:+UCSEERMacrophages_M24.1214e-020.4601image
ENSG00000117335.17,CD46UCSEAGMacrophages_M21.0900e-020.5434image
chr1:207768955-207770058:+UVMEERT_cells_gamma_delta3.3732e-030.5849image
ENSG00000117335.17,CD46UVMEAGT_cells_gamma_delta3.3732e-030.5849image


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6. Enriched editing regions and immune gene sets for CD46


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr1:207768955-207770058:+BRCAEER7.4494e-090.19051.4937e-020.08086.0766e-050.13281.6135e-100.2103image
ENSG00000117335.17,CD46BRCAEAG1.4387e-080.18691.7193e-020.07911.4652e-040.12581.1086e-090.2006image
chr1:207768955-207770058:+LUADEER1.5452e-040.18882.8788e-020.10984.6750e-040.17481.8244e-060.2368image
ENSG00000117335.17,CD46LUADEAG2.0898e-040.18483.7096e-020.10456.8401e-040.16951.7150e-060.2371image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr1:207768955-207770058:+BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER7.0004e-080.3249image
ENSG00000117335.17,CD46BLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG7.6845e-080.3240image
ENSG00000117335.17,CD46BRCAGSVA_HALLMARK_UV_RESPONSE_UPEAG7.0744e-150.2546image
chr1:207787161-207788446:+BRCAGSVA_HALLMARK_P53_PATHWAYEER3.7112e-030.3228image
chr1:207768955-207770058:+BRCAGSVA_HALLMARK_UV_RESPONSE_UPEER6.1232e-170.2729image
chr1:207768955-207770058:+CESCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.4056e-060.3099image
ENSG00000117335.17,CD46CESCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.4029e-060.3027image
chr1:207768955-207770058:+CHOLGSVA_HALLMARK_HEME_METABOLISMEER5.5422e-030.5707image
ENSG00000117335.17,CD46CHOLGSVA_HALLMARK_HEME_METABOLISMEAG8.3365e-030.5476image
chr1:207768955-207770058:+COADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.4841e-020.1608image
ENSG00000117335.17,CD46COADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.1761e-020.1662image
ENSG00000117335.17,CD46ESCAGSVA_HALLMARK_MYC_TARGETS_V1EAG1.8937e-020.1902image
chr1:207768955-207770058:+ESCAGSVA_HALLMARK_DNA_REPAIREER4.2184e-040.2900image
chr1:207768955-207770058:+GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.2504e-02-0.3474image
ENSG00000117335.17,CD46GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.2483e-02-0.3475image
ENSG00000117335.17,CD46HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.0871e-020.1943image
chr1:207768955-207770058:+HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER8.5790e-030.2004image
chr1:207768955-207770058:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER6.0158e-030.1991image
ENSG00000117335.17,CD46KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG6.1305e-030.1987image
ENSG00000117335.17,CD46KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.3086e-020.1977image
chr1:207768955-207770058:+KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.6909e-020.2076image
ENSG00000117335.17,CD46LAMLGSVA_HALLMARK_SPERMATOGENESISEAG1.7195e-03-0.3096image
chr1:207768955-207770058:+LAMLGSVA_HALLMARK_SPERMATOGENESISEER1.6906e-02-0.2408image
chr1:207768955-207770058:+LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.0478e-050.2210image
ENSG00000117335.17,CD46LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.0314e-050.2210image
chr1:207768955-207770058:+LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.5934e-020.2309image
ENSG00000117335.17,CD46LIHCGSVA_HALLMARK_GLYCOLYSISEAG1.7892e-020.2438image
chr1:207768955-207770058:+LUADGSVA_HALLMARK_HYPOXIAEER1.8244e-060.2368image
ENSG00000117335.17,CD46LUADGSVA_HALLMARK_HYPOXIAEAG1.7150e-060.2371image
ENSG00000117335.17,CD46LUSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG8.2315e-030.1484image
chr1:207768955-207770058:+LUSCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.1241e-020.1424image
chr1:207768955-207770058:+MESOGSVA_HALLMARK_DNA_REPAIREER3.1362e-020.3409image
ENSG00000117335.17,CD46MESOGSVA_HALLMARK_DNA_REPAIREAG3.1362e-020.3409image
ENSG00000117335.17,CD46OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.3133e-04-0.2711image
chr1:207768955-207770058:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.8072e-02-0.1844image
ENSG00000117335.17,CD46PAADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.0049e-020.2103image
chr1:207768955-207770058:+PAADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9988e-020.2104image
ENSG00000117335.17,CD46PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.2454e-040.2081image
chr1:207768955-207770058:+PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.4068e-040.2152image
chr1:207768955-207770058:+READGSVA_HALLMARK_HEME_METABOLISMEER4.0667e-020.2338image
ENSG00000117335.17,CD46READGSVA_HALLMARK_HEME_METABOLISMEAG4.1121e-020.2333image
chr1:207768955-207770058:+SARCGSVA_HALLMARK_DNA_REPAIREER1.9389e-020.2872image
ENSG00000117335.17,CD46SARCGSVA_HALLMARK_DNA_REPAIREAG1.9369e-020.2872image
chr1:207768955-207770058:+SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.3506e-020.1719image
ENSG00000117335.17,CD46SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.3506e-020.1719image
chr1:207768955-207770058:+STADGSVA_HALLMARK_DNA_REPAIREER1.0194e-020.1649image
chr1:207787161-207788446:+STADGSVA_HALLMARK_G2M_CHECKPOINTEER2.8056e-030.2072image
ENSG00000117335.17,CD46STADGSVA_HALLMARK_MYC_TARGETS_V2EAG4.0854e-020.1204image
ENSG00000117335.17,CD46TGCTGSVA_HALLMARK_GLYCOLYSISEAG1.4379e-020.2727image
chr1:207768955-207770058:+TGCTGSVA_HALLMARK_GLYCOLYSISEER1.4274e-020.2730image
chr1:207768955-207770058:+THCAGSVA_HALLMARK_COAGULATIONEER1.0175e-040.2071image
ENSG00000117335.17,CD46THCAGSVA_HALLMARK_COAGULATIONEAG6.6734e-050.2121image
chr1:207768955-207770058:+THYMGSVA_HALLMARK_DNA_REPAIREER6.8232e-030.3640image
ENSG00000117335.17,CD46THYMGSVA_HALLMARK_DNA_REPAIREAG7.0177e-030.3628image
chr1:207768955-207770058:+UCECGSVA_HALLMARK_SPERMATOGENESISEER2.4783e-020.2463image
ENSG00000117335.17,CD46UCECGSVA_HALLMARK_SPERMATOGENESISEAG2.5028e-020.2459image
ENSG00000117335.17,CD46UCSGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.9146e-02-0.4343image
chr1:207768955-207770058:+UCSGSVA_HALLMARK_HEME_METABOLISMEER5.2392e-03-0.5992image
ENSG00000117335.17,CD46UVMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.6336e-02-0.4194image
chr1:207768955-207770058:+UVMGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.6336e-02-0.4194image


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7. Enriched editing regions and drugs for CD46


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr1:207768955-207770058:+ACCLFM.A13EER1.7717e-02-0.4043image
ENSG00000117335.17,CD46ACCLFM.A13EAG1.7717e-02-0.4043image
chr1:207768955-207770058:+BLCACGP.60474EER1.3377e-07-0.3182image
ENSG00000117335.17,CD46BLCACGP.60474EAG1.6843e-07-0.3158image
ENSG00000117335.17,CD46BRCACCT007093EAG5.5251e-090.1922image
chr1:207768955-207770058:+BRCACCT007093EER3.2863e-100.2068image
chr1:207787161-207788446:+BRCABosutinibEER6.8765e-030.3018image
ENSG00000117335.17,CD46CESCBMS.509744EAG5.7311e-05-0.2599image
chr1:207768955-207770058:+CESCBMS.509744EER4.8537e-06-0.2944image
chr1:207768955-207770058:+CHOLAS601245EER4.6123e-03-0.5806image
ENSG00000117335.17,CD46CHOLAS601245EAG1.0115e-02-0.5361image
chr1:207768955-207770058:+COADCI.1040EER1.3720e-02-0.1627image
ENSG00000117335.17,CD46COADCI.1040EAG1.4138e-02-0.1620image
chr1:207787161-207788446:+ESCABIRB.0796EER3.0079e-04-0.3413image
ENSG00000117335.17,CD46ESCAKU.55933EAG2.5033e-04-0.2938image
chr1:207768955-207770058:+ESCAKU.55933EER1.0593e-06-0.3936image
ENSG00000117335.17,CD46HNSCCGP.60474EAG1.4919e-03-0.2411image
chr1:207768955-207770058:+HNSCCGP.60474EER1.1979e-03-0.2457image
ENSG00000117335.17,CD46KIRPGSK269962AEAG3.4150e-04-0.3071image
chr1:207768955-207770058:+KIRPBMS.536924EER1.6206e-04-0.3225image
ENSG00000117335.17,CD46LAMLATRAEAG9.1163e-040.3266image
chr1:207768955-207770058:+LAMLAP.24534EER2.3863e-020.2281image
ENSG00000117335.17,CD46LGGBAY.61.3606EAG1.4783e-030.1658image
chr1:207768955-207770058:+LGGGNF.2EER1.4713e-03-0.1659image
chr1:207768955-207770058:+LIHCGNF.2EER2.7465e-04-0.3688image
ENSG00000117335.17,CD46LIHCGNF.2EAG7.9279e-04-0.3402image
chr1:207768955-207770058:+LUADBMS.509744EER3.8097e-07-0.2516image
ENSG00000117335.17,CD46LUADBMS.509744EAG4.1411e-07-0.2505image
chr1:207768955-207770058:+LUSCBortezomibEER2.0120e-02-0.1307image
ENSG00000117335.17,CD46LUSCBortezomibEAG2.8492e-02-0.1232image
chr1:207768955-207770058:+MESOGW843682XEER2.0795e-03-0.4725image
ENSG00000117335.17,CD46MESOGW843682XEAG2.0795e-03-0.4725image
ENSG00000117335.17,CD46OVMG.132EAG1.1254e-04-0.2737image
chr1:207768955-207770058:+OVGDC.0449EER9.1037e-03-0.2031image
chr1:207768955-207770058:+PCPGCCT018159EER3.3927e-020.2390image
ENSG00000117335.17,CD46PCPGCCT018159EAG3.3927e-020.2390image
ENSG00000117335.17,CD46PRADEHT.1864EAG9.2022e-06-0.2489image
chr1:207768955-207770058:+PRADEHT.1864EER6.4828e-06-0.2538image
ENSG00000117335.17,CD46READBI.D1870EAG2.2443e-020.2599image
chr1:207768955-207770058:+READBI.D1870EER2.2649e-020.2595image
ENSG00000117335.17,CD46SARCAZD6482EAG4.4443e-020.2483image
chr1:207768955-207770058:+SARCAZD6482EER4.4455e-020.2482image
ENSG00000117335.17,CD46SKCMGefitinibEAG1.7703e-02-0.1651image
chr1:207768955-207770058:+SKCMGefitinibEER1.7703e-02-0.1651image
chr1:207787161-207788446:+STADGefitinibEER4.7985e-030.1963image
ENSG00000117335.17,CD46STADJNK.Inhibitor.VIIIEAG2.1090e-020.1356image
chr1:207768955-207770058:+STADBI.2536EER2.8017e-020.1412image
ENSG00000117335.17,CD46TGCTErlotinibEAG2.0368e-02-0.2590image
chr1:207768955-207770058:+TGCTErlotinibEER2.0428e-02-0.2588image
ENSG00000117335.17,CD46THCAKU.55933EAG1.5978e-03-0.1686image
chr1:207768955-207770058:+THCABMS.509744EER9.9527e-05-0.2074image
ENSG00000117335.17,CD46THYMDocetaxelEAG3.0321e-02-0.2951image
chr1:207768955-207770058:+THYMDocetaxelEER2.8575e-02-0.2981image
ENSG00000117335.17,CD46UCECGDC.0449EAG4.6743e-03-0.3076image
chr1:207768955-207770058:+UCECGDC.0449EER4.6445e-03-0.3078image
chr1:207768955-207770058:+UCSElesclomolEER1.3475e-02-0.5424image
ENSG00000117335.17,CD46UCSBIBW2992EAG7.1471e-030.5687image
chr1:207768955-207770058:+UVMA.770041EER2.1818e-02-0.4756image
ENSG00000117335.17,CD46UVMA.770041EAG2.1818e-02-0.4756image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType