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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: MCM4 (ImmuneEditome ID:4173)

1. Gene summary of enriched editing regions for MCM4

check button Gene summary
Gene informationGene symbol

MCM4

Gene ID

4173

GeneSynonymsCDC21|CDC54|IMD54|NKCD|NKGCD|P1-CDC21|hCdc21
GeneCytomap

8q11.21

GeneTypeprotein-coding
GeneDescriptionDNA replication licensing factor MCM4|homolog of S. pombe cell devision cycle 21|minichromosome maintenance deficient 4
GeneModificationdate20230409
UniprotIDP33991;E5RFR3;E5RG53;A0A3B3ITP6;A0A3B3IT92;E5RG31;A0A3B3IS57;A0A3B3IS88;A0A3B3IU45;A0A3B3IRR8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr8:47977055-47977743:+ENST00000521151.1ENSG00000104738.15MCM4ncRNA_exonicAluJb,AluSx3chr8:47977055-47977743:+.alignment


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2. Tumor-specific enriched editing regions for MCM4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr8:47977055-47977743:+BRCAEER5.2322e-25image
ENSG00000104738.15,MCM4BRCAEAG7.2095e-25image
ENSG00000104738.15,MCM4COADEAG1.0400e-18image
ENSG00000104738.15,MCM4HNSCEAG5.2173e-16image
ENSG00000104738.15,MCM4KICHEAG1.3201e-09image
ENSG00000104738.15,MCM4KIRPEAG5.7903e-08image
chr8:47977055-47977743:+LIHCEER4.1732e-04image
ENSG00000104738.15,MCM4LIHCEAG4.0570e-04image
ENSG00000104738.15,MCM4PRADEAG2.4933e-02image
chr8:47977055-47977743:+THCAEER3.6550e-13image
ENSG00000104738.15,MCM4THCAEAG3.6550e-13image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000104738.15,MCM4KIRPCliEAG3.8918e-021.1325e-020.1824image
chr8:47977055-47977743:+STADPathEER7.3012e-033.3098e-030.1584image
ENSG00000104738.15,MCM4STADPathEAG1.0026e-024.2363e-030.1543image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for MCM4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr8:47977055-47977743:+STADEERENSG00000160710,ADAR0.38322.4537e-102.2079e-160.4130imageNNADART_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr8:47977055-47977743:+THCAEERENSG00000155252,PI4K2A0.41727.0329e-201.0752e-210.4100imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr8:47977055-47977743:+ESCAEERENSG00000261716,RP11-196G18.220.44272.6104e-057.4726e-090.4384imageNNNAPlasma_cellsGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr8:47977055-47977743:+ESCAEERENSG00000117533,VAMP40.44053.9847e-053.7331e-080.4194imageNNNAMacrophages_M0GSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr8:47977055-47977743:+ESCAEERENSG00000132680,KIAA09070.43176.3980e-054.5745e-080.4170imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr8:47977055-47977743:+OVEERENSG00000123609,NMI0.42083.9149e-102.1206e-130.4134imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr8:47977055-47977743:+PCPGEERENSG00000180389,ATP5EP20.35851.8220e-043.0087e-100.4442imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr8:47977055-47977743:+PCPGEERENSG00000259330,INAFM20.31301.8590e-031.9436e-080.4004imageNNNAMast_cells_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM
chr8:47977055-47977743:+PCPGEERENSG00000179271,GADD45GIP10.28874.8589e-039.4533e-090.4085imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr8:47977055-47977743:+PCPGEERENSG00000186010,NDUFA130.28725.7012e-036.4970e-090.4126imageNNNDUFA13T_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for MCM4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000104738.15,MCM4
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.54792.9304e-261.2835e-38-0.5914imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000104738.15,MCM4
CESCEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.46892.6285e-126.1270e-19-0.4844imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000104738.15,MCM4
COADEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.39921.4686e-076.8580e-13-0.4291imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000104738.15,MCM4
GBMEAGESENSG00000135439.7chr1257727936:57728085:57728317:57728377:57729638:577297670.27888.9676e-039.6444e-070.4218imageNADAR;AIFM1;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA2B1;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LIN28;LIN28A;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SRSF1;SRSF3;TAF15;U2AF2;ZNF184NAMonocytesGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000104738.15,MCM4
GBMEAGA5ENSG00000101361.10chr202656400:2656549:2655933:2656034:2655933:26562140.46601.8196e-056.6184e-100.4548imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMonocytesGSVA_HALLMARK_DNA_REPAIR
ENSG00000104738.15,MCM4
GBMEAGESENSG00000196476.7chr20283962:284081:289558:289676:290258:2903070.46051.9614e-052.6246e-090.4464imageNACIN1;ADAR;AIFM1;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAGNAMonocytesGSVA_HALLMARK_MYC_TARGETS_V1
ENSG00000104738.15,MCM4
GBMEAGESENSG00000084234.12chr11130122304:130122513:130123611:130123779:130126699:1301268300.46702.0175e-051.4819e-090.4464imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RC3H1;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMonocytesGSVA_HALLMARK_MYC_TARGETS_V2
ENSG00000104738.15,MCM4
GBMEAGESENSG00000168958.15chr2227340291:227340380:227347225:227347384:227352513:2273525730.41422.9453e-045.1531e-080.4062imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;ZC3H7B;ZNF184MFFMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000104738.15,MCM4
GBMEAGESENSG00000077809.8chr774711031:74711109:74714859:74714916:74716893:74716950-0.40672.9458e-043.7403e-09-0.4388imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000104738.15,MCM4
GBMEAGESENSG00000077809.8chr774711031:74711109:74714856:74714916:74716893:74716950-0.41981.7677e-047.9632e-09-0.4304imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM

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5. Enriched editing regions and immune infiltration for MCM4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000104738.15,MCM4ACCEAGT_cells_CD4_memory_resting1.6935e-02-0.2750image
ENSG00000104738.15,MCM4BLCAEAGMacrophages_M12.2911e-090.2949image
chr8:47977055-47977743:+BRCAEERPlasma_cells2.8835e-02-0.0665image
ENSG00000104738.15,MCM4BRCAEAGPlasma_cells2.4881e-02-0.0682image
ENSG00000104738.15,MCM4CESCEAGT_cells_regulatory_(Tregs)9.9033e-050.2236image
ENSG00000104738.15,MCM4COADEAGPlasma_cells1.0526e-03-0.1987image
ENSG00000104738.15,MCM4DLBCEAGNK_cells_activated3.8290e-020.3099image
chr8:47977055-47977743:+ESCAEERT_cells_regulatory_(Tregs)7.5864e-03-0.2110image
ENSG00000104738.15,MCM4ESCAEAGT_cells_regulatory_(Tregs)7.5463e-03-0.2111image
ENSG00000104738.15,MCM4GBMEAGMonocytes1.5965e-050.3271image
ENSG00000104738.15,MCM4HNSCEAGMacrophages_M19.9820e-040.1478image
ENSG00000104738.15,MCM4KICHEAGMonocytes7.9258e-030.3291image
ENSG00000104738.15,MCM4KIRCEAGT_cells_gamma_delta6.2778e-030.1396image
ENSG00000104738.15,MCM4KIRPEAGMacrophages_M11.2532e-050.2600image
ENSG00000104738.15,MCM4LAMLEAGMast_cells_resting1.9845e-03-0.2784image
chr8:47977055-47977743:+LGGEERT_cells_CD4_memory_activated3.6999e-030.1260image
ENSG00000104738.15,MCM4LGGEAGT_cells_CD4_memory_activated3.5730e-030.1265image
chr8:47977055-47977743:+LIHCEERT_cells_regulatory_(Tregs)8.9545e-030.1355image
ENSG00000104738.15,MCM4LIHCEAGT_cells_regulatory_(Tregs)1.0148e-020.1333image
chr8:47977055-47977743:+LUADEERNK_cells_activated2.7283e-02-0.0974image
ENSG00000104738.15,MCM4LUADEAGNK_cells_activated2.6003e-02-0.0982image
ENSG00000104738.15,MCM4LUSCEAGT_cells_CD83.4008e-050.1850image
ENSG00000104738.15,MCM4MESOEAGMonocytes1.7131e-02-0.2627image
chr8:47977055-47977743:+OVEERT_cells_CD83.5034e-050.2405image
ENSG00000104738.15,MCM4OVEAGT_cells_CD84.1815e-050.2382image
ENSG00000104738.15,MCM4PAADEAGMacrophages_M22.2579e-030.2275image
ENSG00000104738.15,MCM4PRADEAGT_cells_regulatory_(Tregs)1.0677e-020.1152image
ENSG00000104738.15,MCM4READEAGT_cells_CD4_memory_activated4.0041e-03-0.3022image
chr8:47977055-47977743:+SARCEERT_cells_CD4_naive1.5524e-03-0.1972image
ENSG00000104738.15,MCM4SARCEAGT_cells_CD4_naive1.5524e-03-0.1972image
ENSG00000104738.15,MCM4SKCMEAGT_cells_CD82.6118e-060.2159image
chr8:47977055-47977743:+STADEERB_cells_memory6.0701e-03-0.1438image
ENSG00000104738.15,MCM4STADEAGB_cells_memory5.6276e-03-0.1451image
ENSG00000104738.15,MCM4TGCTEAGMacrophages_M22.3891e-12-0.5263image
chr8:47977055-47977743:+THCAEEREosinophils1.1072e-04-0.1720image
ENSG00000104738.15,MCM4THCAEAGEosinophils1.1072e-04-0.1720image
ENSG00000104738.15,MCM4THYMEAGMacrophages_M16.6663e-130.6025image
ENSG00000104738.15,MCM4UCECEAGT_cells_CD4_naive1.3889e-02-0.1846image
ENSG00000104738.15,MCM4UCSEAGEosinophils4.8351e-02-0.2700image
ENSG00000104738.15,MCM4UVMEAGNK_cells_activated4.1399e-040.4163image


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6. Enriched editing regions and immune gene sets for MCM4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr8:47977055-47977743:+LIHCEER9.9026e-03image7.2115e-03-0.1393image
ENSG00000104738.15,MCM4LIHCEAG9.8179e-03image6.3887e-03-0.1413image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000104738.15,MCM4BLCAEAG6.7225e-040.17042.1336e-040.18532.4038e-030.15236.4256e-040.1710image
ENSG00000104738.15,MCM4THYMEAG6.3258e-04-0.31149.7038e-07-0.43474.9689e-050.36591.0714e-080.4984image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000104738.15,MCM4ACCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.8098e-030.3404image
ENSG00000104738.15,MCM4BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.5281e-130.3535image
chr8:47977055-47977743:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1921e-080.1621image
ENSG00000104738.15,MCM4BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1963e-070.1601image
ENSG00000104738.15,MCM4CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3997e-110.3697image
ENSG00000104738.15,MCM4CHOLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.6937e-020.3382image
ENSG00000104738.15,MCM4COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG6.2662e-060.2715image
chr8:47977055-47977743:+ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.4984e-03-0.2382image
ENSG00000104738.15,MCM4ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.3763e-03-0.2394image
ENSG00000104738.15,MCM4GBMGSVA_HALLMARK_MYC_TARGETS_V2EAG3.3016e-10-0.4620image
ENSG00000104738.15,MCM4HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9724e-080.2442image
ENSG00000104738.15,MCM4KICHGSVA_HALLMARK_APICAL_SURFACEEAG5.0945e-03-0.3461image
ENSG00000104738.15,MCM4KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG6.4691e-040.1738image
ENSG00000104738.15,MCM4KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.6950e-060.2678image
ENSG00000104738.15,MCM4LAMLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1466e-040.3435image
chr8:47977055-47977743:+LGGGSVA_HALLMARK_G2M_CHECKPOINTEER1.8317e-11-0.2866image
ENSG00000104738.15,MCM4LGGGSVA_HALLMARK_G2M_CHECKPOINTEAG1.6197e-11-0.2874image
chr8:47977055-47977743:+LIHCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER7.4625e-04-0.1743image
ENSG00000104738.15,MCM4LIHCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG8.5196e-04-0.1724image
chr8:47977055-47977743:+LUADGSVA_HALLMARK_APICAL_JUNCTIONEER2.1966e-02-0.1010image
ENSG00000104738.15,MCM4LUADGSVA_HALLMARK_APICAL_JUNCTIONEAG2.4326e-02-0.0993image
ENSG00000104738.15,MCM4LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3208e-070.2297image
ENSG00000104738.15,MCM4MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.7306e-020.2622image
chr8:47977055-47977743:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.4593e-110.3763image
ENSG00000104738.15,MCM4OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.0961e-110.3750image
chr8:47977055-47977743:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0035e-04-0.2643image
ENSG00000104738.15,MCM4PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.8767e-04-0.2651image
ENSG00000104738.15,MCM4PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3624e-090.2694image
ENSG00000104738.15,MCM4READGSVA_HALLMARK_PEROXISOMEEAG1.0861e-03-0.3407image
chr8:47977055-47977743:+SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.3188e-05-0.2617image
ENSG00000104738.15,MCM4SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.3188e-05-0.2617image
ENSG00000104738.15,MCM4SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.6610e-050.1902image
ENSG00000104738.15,MCM4STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1996e-060.2516image
chr8:47977055-47977743:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.1841e-070.2566image
ENSG00000104738.15,MCM4TGCTGSVA_HALLMARK_GLYCOLYSISEAG2.0804e-12-0.5275image
ENSG00000104738.15,MCM4THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.2986e-100.2731image
chr8:47977055-47977743:+THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.2986e-100.2731image
ENSG00000104738.15,MCM4THYMGSVA_HALLMARK_E2F_TARGETSEAG2.4589e-15-0.6491image
ENSG00000104738.15,MCM4UCECGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG5.3824e-030.2084image
ENSG00000104738.15,MCM4UCSGSVA_HALLMARK_HEME_METABOLISMEAG1.9430e-020.3172image
ENSG00000104738.15,MCM4UVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.7416e-050.4852image


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7. Enriched editing regions and drugs for MCM4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000104738.15,MCM4ACCCI.1040EAG6.4465e-04-0.3852image
ENSG00000104738.15,MCM4BLCAAxitinibEAG4.4764e-160.3934image
chr8:47977055-47977743:+BRCAJNK.Inhibitor.VIIIEER9.9444e-08-0.1612image
ENSG00000104738.15,MCM4BRCAJNK.Inhibitor.VIIIEAG9.8162e-08-0.1612image
ENSG00000104738.15,MCM4CESCABT.888EAG3.6800e-06-0.2644image
ENSG00000104738.15,MCM4CHOLAZD6244EAG1.8728e-030.5072image
ENSG00000104738.15,MCM4COADAZD8055EAG5.1508e-06-0.2739image
ENSG00000104738.15,MCM4DLBCAZD8055EAG4.7382e-02-0.2972image
chr8:47977055-47977743:+ESCAAG.014699EER3.6919e-03-0.2290image
ENSG00000104738.15,MCM4ESCAAG.014699EAG3.4971e-03-0.2303image
ENSG00000104738.15,MCM4GBMBI.D1870EAG1.0245e-100.4736image
ENSG00000104738.15,MCM4HNSCAS601245EAG1.5699e-04-0.1694image
ENSG00000104738.15,MCM4KICHBMS.754807EAG4.8308e-04-0.4238image
ENSG00000104738.15,MCM4KIRCLenalidomideEAG2.4486e-06-0.2390image
ENSG00000104738.15,MCM4KIRPBosutinibEAG2.0800e-070.3069image
ENSG00000104738.15,MCM4LAMLCCT018159EAG2.3208e-040.3287image
chr8:47977055-47977743:+LGGDoxorubicinEER1.1715e-120.3025image
ENSG00000104738.15,MCM4LGGDoxorubicinEAG1.0272e-120.3032image
chr8:47977055-47977743:+LIHCCCT007093EER1.9971e-050.2195image
ENSG00000104738.15,MCM4LIHCCCT007093EAG2.4363e-050.2172image
chr8:47977055-47977743:+LUADAZ628EER7.8939e-050.1746image
ENSG00000104738.15,MCM4LUADAZ628EAG7.7453e-050.1748image
ENSG00000104738.15,MCM4LUSCGW843682XEAG4.9634e-060.2034image
ENSG00000104738.15,MCM4MESOBAY.61.3606EAG8.5467e-040.3613image
chr8:47977055-47977743:+OVBexaroteneEER5.0094e-050.2358image
ENSG00000104738.15,MCM4OVBexaroteneEAG4.4232e-050.2374image
ENSG00000104738.15,MCM4PAADGW843682XEAG1.0338e-030.2439image
chr8:47977055-47977743:+PCPGAZD6482EER9.3439e-060.3211image
ENSG00000104738.15,MCM4PCPGAZD6482EAG8.9663e-060.3217image
ENSG00000104738.15,MCM4PRADGSK269962AEAG1.2238e-05-0.1961image
ENSG00000104738.15,MCM4READCyclopamineEAG4.0065e-03-0.3038image
chr8:47977055-47977743:+SARCAxitinibEER1.2291e-040.2382image
ENSG00000104738.15,MCM4SARCAxitinibEAG1.2291e-040.2382image
ENSG00000104738.15,MCM4SKCMABT.263EAG2.8504e-070.2356image
chr8:47977055-47977743:+STADGW.441756EER1.1107e-02-0.1331image
ENSG00000104738.15,MCM4STADGW.441756EAG1.0327e-02-0.1345image
ENSG00000104738.15,MCM4TGCTDocetaxelEAG6.5315e-090.4464image
ENSG00000104738.15,MCM4THCAAZD6244EAG2.8840e-10-0.2779image
chr8:47977055-47977743:+THCAAZD6244EER2.8840e-10-0.2779image
ENSG00000104738.15,MCM4THYMBleomycinEAG1.4850e-240.7738image
ENSG00000104738.15,MCM4UCECGSK.650394EAG1.0878e-040.2868image
ENSG00000104738.15,MCM4UCSCHIR.99021EAG7.6592e-030.3591image
ENSG00000104738.15,MCM4UVMFTI.277EAG2.4089e-050.4882image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType