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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: VMAC (ImmuneEditome ID:400673)

1. Gene summary of enriched editing regions for VMAC

check button Gene summary
Gene informationGene symbol

VMAC

Gene ID

400673

GeneSynonyms-
GeneCytomap

19p13.3

GeneTypeprotein-coding
GeneDescriptionvimentin-type intermediate filament-associated coiled-coil protein|vimentin-type IF-associated coiled-coil protein
GeneModificationdate20230329
UniprotIDQ2NL98
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:5909462-5911367:+ENST00000339485.3ENSG00000187650.3VMACUTR3AluSx1,MIRb,AluJo,AluSx,(AAC)nchr19:5909462-5911367:+.alignment


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2. Tumor-specific enriched editing regions for VMAC


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:5909462-5911367:+BRCAEER3.4935e-04image
ENSG00000187650.3,VMACBRCAEAG3.6727e-04image
chr19:5909462-5911367:+KICHEER1.4547e-03image
ENSG00000187650.3,VMACKICHEAG1.9467e-03image
chr19:5909462-5911367:+KIRCEER3.3577e-02image
ENSG00000187650.3,VMACKIRCEAG3.8980e-02image
chr19:5909462-5911367:+KIRPEER1.5021e-03image
ENSG00000187650.3,VMACKIRPEAG7.8437e-04image
chr19:5909462-5911367:+LUADEER5.1246e-03image
ENSG00000187650.3,VMACLUADEAG2.9811e-03image
chr19:5909462-5911367:+LUSCEER1.5163e-02image
ENSG00000187650.3,VMACLUSCEAG8.1129e-03image
chr19:5909462-5911367:+PRADEER3.6840e-02image
ENSG00000187650.3,VMACPRADEAG2.4024e-02image
chr19:5909462-5911367:+THCAEER2.0429e-02image
ENSG00000187650.3,VMACTHCAEAG4.3374e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000187650.3,VMACUCECCliEAG1.8622e-038.4372e-030.1249image
chr19:5909462-5911367:+UCECCliEER3.1709e-031.2303e-020.1187image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for VMAC


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:5909462-5911367:+DLBCEERENSG00000122971,ACADS-0.58832.6367e-021.5857e-04-0.5505imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2NAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:5909462-5911367:+DLBCEERENSG00000112062,MAPK140.59042.9876e-024.5198e-050.5862imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2MAPK14Macrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:5909462-5911367:+DLBCEERENSG00000105879,CBLL10.57364.0899e-024.2077e-040.5196imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2CBLL1Macrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr19:5909462-5911367:+DLBCEERENSG00000161671,EMC10-0.54274.6369e-021.8335e-03-0.4668imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;TAF15;TROVE2;U2AF2;UPF1;XRN2NAT_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:5909462-5911367:+PAADEERENSG00000256229,ZNF4860.29031.6691e-025.6387e-080.4108imageNCSTF2T;ELAVL1;FMR1;FUS;HNRNPC;HNRNPM;IGF2BP2;ILF3;NOP58;RBFOX2;TAF15;TIA1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr19:5909462-5911367:+PCPGEERENSG00000100319,ZMAT5-0.44761.0544e-052.0410e-07-0.4064imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;U2AF2;UPF1NAMast_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr19:5909462-5911367:+PCPGEERENSG00000100348,TXN2-0.43581.8946e-052.4755e-08-0.4332imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2TXN2GSVA_HALLMARK_ADIPOGENESIS
chr19:5909462-5911367:+PCPGEERENSG00000008196,TFAP2B0.39501.3876e-041.5438e-080.4389imageNCSTF2T;ELAVL1;FUS;TAF15NAEosinophilsGSVA_HALLMARK_HYPOXIA
chr19:5909462-5911367:+PCPGEERENSG00000166402,TUB0.38203.6301e-042.8338e-070.4020imageNCSTF2T;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;U2AF2;UPF1TUBMacrophages_M0GSVA_HALLMARK_PROTEIN_SECRETION
chr19:5909462-5911367:+READEERENSG00000162298,SYVN1-0.50504.7855e-027.6029e-06-0.4973imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2SYVN1Macrophages_M1GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

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4. Enriched editing regions and immune related splicing for VMAC


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:5909462-5911367:+
GBMEERA5ENSG00000122390.13chr163448470:3448540:3443705:3443827:3443705:3443893-0.31596.1843e-035.0164e-07-0.4398imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2NAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000187650.3,VMAC
GBMEAGA5ENSG00000122390.13chr163448470:3448540:3443705:3443827:3443705:3443893-0.29871.6332e-022.4768e-06-0.4148imageNBUD13;CNBP;CSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RANGAP1;RBFOX2;RBM10;SF3B4;SLTM;SND1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:5909462-5911367:+
THYMEERA5ENSG00000130803.10chr199158825:9158908:9156611:9157394:9156611:9158075-0.25724.1200e-021.0036e-04-0.4139imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_SPERMATOGENESIS
ENSG00000187650.3,VMAC
THYMEAGESENSG00000168255.14chr7102541500:102541662:102566581:102566736:102566996:102567083-0.30563.4448e-026.2233e-05-0.4009imageNBUD13;CSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RANGAP1;RBFOX2;RBM10;SF3B4;SLTM;SND1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAMacrophages_M2GSVA_HALLMARK_COAGULATION
chr19:5909462-5911367:+
THYMEERMEXENSG00000115935.12chr2174585522:174585611:174597600:174597858:174677044:174677124:174682773:1746828470.31091.4681e-021.8489e-050.4417imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;TAF15;U2AF2;UPF1WIPF1Macrophages_M1GSVA_HALLMARK_DNA_REPAIR
ENSG00000187650.3,VMAC
THYMEAGMEXENSG00000028310.13chr5865413:865581:868606:868804:869244:869360:870472:8705530.35541.7850e-035.3832e-060.4761imageNBUD13;CNBP;CSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RANGAP1;RBFOX2;RBM10;SF3B4;SLTM;SND1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr19:5909462-5911367:+
THYMEERESENSG00000171163.11chr1248855750:248855946:248856372:248856422:248856513:2488565620.32332.0535e-022.6562e-050.4168imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2NAMacrophages_M1GSVA_HALLMARK_DNA_REPAIR
chr19:5909462-5911367:+
THYMEERA3ENSG00000070814.13chr5150389946:150390023:150391956:150392095:150391543:150392095-0.31284.1381e-026.4347e-06-0.4102imageNCSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RBFOX2;SLTM;SRSF9;TAF15;TIA1;TROVE2;U2AF2;UPF1;XRN2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
ENSG00000187650.3,VMAC
THYMEAGMEXENSG00000115935.12chr2174585522:174585611:174597600:174597858:174677027:174677124:174682773:1746828470.30152.1228e-025.3028e-050.4193imageNCNBP;CSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;IGF2BP3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RANGAP1;RBFOX2;RBM10;SND1;SRSF1;TAF15;U2AF1;U2AF2;UPF1;ZNF184WIPF1Macrophages_M1GSVA_HALLMARK_DNA_REPAIR
ENSG00000187650.3,VMAC
THYMEAGESENSG00000171163.11chr1248855750:248855946:248856372:248856422:248856513:2488565620.31922.4325e-022.6455e-050.4168imageNBUD13;CSTF2T;DDX3X;EIF4A3;ELAVL1;FMR1;FUS;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;NOP58;NUMA1;PRPF8;RANGAP1;RBFOX2;RBM10;SF3B4;SLTM;SND1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAMacrophages_M1GSVA_HALLMARK_DNA_REPAIR

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5. Enriched editing regions and immune infiltration for VMAC


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:5909462-5911367:+BLCAEERNeutrophils1.8809e-020.1241image
ENSG00000187650.3,VMACBLCAEAGNeutrophils1.1968e-020.1327image
chr19:5909462-5911367:+BRCAEERNK_cells_resting1.3538e-030.0988image
ENSG00000187650.3,VMACBRCAEAGNK_cells_resting9.4403e-030.0801image
chr19:5909462-5911367:+CESCEERT_cells_CD4_memory_resting1.5293e-03-0.2092image
ENSG00000187650.3,VMACCESCEAGT_cells_CD4_memory_resting8.4647e-04-0.2210image
chr19:5909462-5911367:+COADEERDendritic_cells_activated1.2009e-050.3093image
ENSG00000187650.3,VMACCOADEAGDendritic_cells_activated8.0131e-050.2822image
ENSG00000187650.3,VMACHNSCEAGB_cells_naive4.8289e-02-0.1203image
chr19:5909462-5911367:+KICHEEREosinophils9.0393e-040.4388image
ENSG00000187650.3,VMACKICHEAGEosinophils3.0044e-030.4000image
chr19:5909462-5911367:+KIRPEERT_cells_CD86.0658e-03-0.1774image
ENSG00000187650.3,VMACKIRPEAGT_cells_CD81.3318e-02-0.1602image
chr19:5909462-5911367:+LAMLEERT_cells_gamma_delta3.4485e-02-0.1734image
chr19:5909462-5911367:+LGGEEREosinophils2.6223e-060.2166image
ENSG00000187650.3,VMACLGGEAGT_cells_CD4_naive1.4392e-030.1490image
ENSG00000187650.3,VMACLIHCEAGMacrophages_M08.8705e-03-0.1672image
chr19:5909462-5911367:+LUADEERT_cells_CD4_memory_resting1.4934e-020.1193image
ENSG00000187650.3,VMACLUADEAGT_cells_regulatory_(Tregs)1.5251e-02-0.1196image
chr19:5909462-5911367:+OVEERT_cells_CD4_naive9.0182e-050.2279image
ENSG00000187650.3,VMACOVEAGT_cells_CD4_naive1.4667e-040.2211image
chr19:5909462-5911367:+PAADEERT_cells_follicular_helper6.9580e-03-0.2113image
ENSG00000187650.3,VMACPAADEAGT_cells_follicular_helper8.3869e-03-0.2065image
chr19:5909462-5911367:+PCPGEEREosinophils1.1429e-030.2614image
ENSG00000187650.3,VMACPCPGEAGEosinophils1.7959e-030.2520image
chr19:5909462-5911367:+PRADEERT_cells_CD4_memory_resting1.7234e-030.1402image
ENSG00000187650.3,VMACPRADEAGT_cells_CD4_memory_resting6.2393e-030.1226image
chr19:5909462-5911367:+READEERDendritic_cells_resting2.9079e-020.2556image
ENSG00000187650.3,VMACREADEAGDendritic_cells_resting2.5860e-020.2626image
chr19:5909462-5911367:+SARCEERT_cells_CD4_naive2.6104e-020.1483image
ENSG00000187650.3,VMACSARCEAGT_cells_CD4_naive1.1652e-020.1679image
chr19:5909462-5911367:+SKCMEERT_cells_CD4_memory_resting5.5646e-040.1664image
ENSG00000187650.3,VMACSKCMEAGT_cells_CD4_memory_resting9.3774e-040.1597image
chr19:5909462-5911367:+STADEERT_cells_CD4_memory_activated2.2550e-040.1974image
ENSG00000187650.3,VMACSTADEAGT_cells_CD4_memory_activated3.2067e-040.1926image
chr19:5909462-5911367:+THCAEERMacrophages_M03.0554e-02-0.0974image
chr19:5909462-5911367:+THYMEERT_cells_follicular_helper6.2869e-04-0.3115image
ENSG00000187650.3,VMACTHYMEAGMacrophages_M16.5316e-040.3106image
chr19:5909462-5911367:+UCECEERDendritic_cells_resting1.1144e-03-0.2554image
ENSG00000187650.3,VMACUCECEAGDendritic_cells_resting1.5651e-03-0.2480image
ENSG00000187650.3,VMACUCSEAGB_cells_memory3.7898e-020.3808image
chr19:5909462-5911367:+UVMEEREosinophils4.1794e-020.2357image
ENSG00000187650.3,VMACUVMEAGEosinophils4.7390e-020.2297image


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6. Enriched editing regions and immune gene sets for VMAC


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000187650.3,VMACBLCAEAG5.7698e-030.14564.0374e-030.15169.3716e-030.13721.7780e-030.1646image
chr19:5909462-5911367:+BLCAEER7.7503e-030.14054.2037e-030.15101.4277e-020.12943.9054e-030.1522image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000187650.3,VMACACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5683e-02-0.3035image
chr19:5909462-5911367:+ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.0266e-02-0.2800image
chr19:5909462-5911367:+BLCAGSVA_HALLMARK_HYPOXIAEER3.9054e-030.1522image
ENSG00000187650.3,VMACBLCAGSVA_HALLMARK_HYPOXIAEAG1.7780e-030.1646image
ENSG00000187650.3,VMACBRCAGSVA_HALLMARK_DNA_REPAIREAG1.4352e-06-0.1481image
chr19:5909462-5911367:+BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.0696e-08-0.1719image
chr19:5909462-5911367:+CESCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER7.1327e-03-0.1781image
ENSG00000187650.3,VMACCESCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG7.5536e-03-0.1777image
chr19:5909462-5911367:+CHOLGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER7.1569e-04-0.5670image
ENSG00000187650.3,VMACCHOLGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.1586e-02-0.4407image
ENSG00000187650.3,VMACCOADGSVA_HALLMARK_UV_RESPONSE_UPEAG4.7664e-05-0.2906image
chr19:5909462-5911367:+COADGSVA_HALLMARK_UV_RESPONSE_UPEER2.1231e-05-0.3009image
ENSG00000187650.3,VMACESCAGSVA_HALLMARK_HEME_METABOLISMEAG8.7611e-03-0.2073image
chr19:5909462-5911367:+ESCAGSVA_HALLMARK_HEME_METABOLISMEER1.0038e-02-0.2036image
ENSG00000187650.3,VMACGBMGSVA_HALLMARK_DNA_REPAIREAG2.8958e-02-0.1867image
chr19:5909462-5911367:+GBMGSVA_HALLMARK_DNA_REPAIREER4.7080e-02-0.1693image
chr19:5909462-5911367:+HNSCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER4.5366e-02-0.1217image
chr19:5909462-5911367:+KICHGSVA_HALLMARK_DNA_REPAIREER1.2086e-02-0.3393image
ENSG00000187650.3,VMACKICHGSVA_HALLMARK_DNA_REPAIREAG1.5095e-02-0.3322image
ENSG00000187650.3,VMACKIRPGSVA_HALLMARK_APICAL_SURFACEEAG9.8144e-03-0.1671image
chr19:5909462-5911367:+KIRPGSVA_HALLMARK_APICAL_SURFACEEER5.3963e-03-0.1798image
chr19:5909462-5911367:+LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.3837e-030.2225image
ENSG00000187650.3,VMACLGGGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.4271e-03-0.1369image
ENSG00000187650.3,VMACLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.9183e-070.3154image
ENSG00000187650.3,VMACLUADGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.1827e-02-0.1059image
chr19:5909462-5911367:+LUADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.8320e-02-0.1075image
ENSG00000187650.3,VMACLUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG1.6607e-05-0.2056image
chr19:5909462-5911367:+LUSCGSVA_HALLMARK_UV_RESPONSE_UPEER6.3694e-06-0.2152image
ENSG00000187650.3,VMACMESOGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.2681e-03-0.3616image
chr19:5909462-5911367:+OVGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.5047e-04-0.2135image
ENSG00000187650.3,VMACOVGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.6145e-04-0.2198image
chr19:5909462-5911367:+PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.6055e-03-0.2216image
ENSG00000187650.3,VMACPAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG5.9792e-03-0.2151image
chr19:5909462-5911367:+PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.2152e-02-0.1739image
ENSG00000187650.3,VMACPCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.6920e-02-0.1620image
ENSG00000187650.3,VMACPRADGSVA_HALLMARK_PEROXISOMEEAG2.1678e-07-0.2302image
chr19:5909462-5911367:+PRADGSVA_HALLMARK_PEROXISOMEEER1.6710e-08-0.2497image
chr19:5909462-5911367:+READGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER4.6569e-02-0.2337image
chr19:5909462-5911367:+SARCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.7576e-04-0.2476image
ENSG00000187650.3,VMACSARCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.9944e-04-0.2389image
ENSG00000187650.3,VMACSKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.5649e-03-0.1528image
chr19:5909462-5911367:+SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9735e-04-0.1792image
ENSG00000187650.3,VMACSTADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.6532e-02-0.1194image
chr19:5909462-5911367:+STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.9327e-02-0.1259image
ENSG00000187650.3,VMACTGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.1007e-020.2314image
chr19:5909462-5911367:+TGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.4095e-020.2275image
ENSG00000187650.3,VMACTHCAGSVA_HALLMARK_DNA_REPAIREAG6.7055e-04-0.1528image
chr19:5909462-5911367:+THCAGSVA_HALLMARK_DNA_REPAIREER1.0109e-04-0.1742image
ENSG00000187650.3,VMACTHYMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.1451e-030.2970image
chr19:5909462-5911367:+THYMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER5.5793e-040.3143image
ENSG00000187650.3,VMACUCECGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.0096e-08-0.4337image
chr19:5909462-5911367:+UCECGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.7774e-07-0.3987image
ENSG00000187650.3,VMACUCSGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.6250e-02-0.4351image
ENSG00000187650.3,VMACUVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.2153e-02-0.2639image
chr19:5909462-5911367:+UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2948e-02-0.2858image


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7. Enriched editing regions and drugs for VMAC


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000187650.3,VMACACCDMOGEAG1.1208e-02-0.3426image
chr19:5909462-5911367:+ACCCI.1040EER5.0383e-03-0.3763image
chr19:5909462-5911367:+BLCAAICAREER8.5403e-03-0.1388image
ENSG00000187650.3,VMACBLCAAICAREAG3.3815e-03-0.1545image
ENSG00000187650.3,VMACBRCAImatinibEAG5.6392e-05-0.1240image
chr19:5909462-5911367:+BRCAImatinibEER7.0791e-07-0.1523image
ENSG00000187650.3,VMACCESCDasatinibEAG1.8223e-02-0.1580image
chr19:5909462-5911367:+CESCCyclopamineEER2.1848e-02-0.1528image
chr19:5909462-5911367:+CHOLAP.24534EER1.6080e-030.5349image
ENSG00000187650.3,VMACCHOLAP.24534EAG1.3231e-020.4333image
ENSG00000187650.3,VMACCOADBMS.708163EAG3.6226e-05-0.2949image
chr19:5909462-5911367:+COADBMS.708163EER3.3041e-05-0.2941image
ENSG00000187650.3,VMACDLBCDasatinibEAG2.5397e-020.3488image
chr19:5909462-5911367:+DLBCDasatinibEER2.1863e-020.3572image
chr19:5909462-5911367:+ESCABMS.708163EER2.7805e-02-0.1745image
ENSG00000187650.3,VMACESCABMS.708163EAG1.9590e-02-0.1850image
ENSG00000187650.3,VMACGBMATRAEAG1.9693e-020.1991image
chr19:5909462-5911367:+GBMATRAEER1.8491e-020.2003image
chr19:5909462-5911367:+HNSCEHT.1864EER2.3737e-020.1374image
ENSG00000187650.3,VMACHNSCEHT.1864EAG1.9681e-020.1419image
ENSG00000187650.3,VMACKICHA.443654EAG1.5050e-020.3323image
chr19:5909462-5911367:+KICHA.443654EER1.0958e-020.3436image
chr19:5909462-5911367:+KIRCAxitinibEER3.0559e-02-0.1266image
ENSG00000187650.3,VMACKIRCAxitinibEAG1.2737e-02-0.1459image
chr19:5909462-5911367:+KIRPCGP.082996EER4.5858e-030.1832image
ENSG00000187650.3,VMACKIRPCGP.082996EAG6.8586e-030.1748image
chr19:5909462-5911367:+LAMLAZ628EER1.8140e-03-0.2535image
ENSG00000187650.3,VMACLAMLCHIR.99021EAG1.0568e-02-0.2132image
ENSG00000187650.3,VMACLGGEHT.1864EAG4.7700e-02-0.0929image
ENSG00000187650.3,VMACLIHCFTI.277EAG1.4627e-040.2408image
chr19:5909462-5911367:+LUADBMS.708163EER5.2478e-03-0.1366image
ENSG00000187650.3,VMACLUADBMS.708163EAG1.2661e-03-0.1585image
chr19:5909462-5911367:+LUSCGNF.2EER9.0043e-050.1873image
ENSG00000187650.3,VMACLUSCGNF.2EAG2.9436e-040.1734image
ENSG00000187650.3,VMACMESOEtoposideEAG7.1347e-03-0.3211image
ENSG00000187650.3,VMACOVCGP.082996EAG4.5045e-040.2047image
chr19:5909462-5911367:+OVCGP.082996EER2.3617e-040.2143image
ENSG00000187650.3,VMACPAADJNK.9LEAG1.4156e-03-0.2487image
chr19:5909462-5911367:+PAADJNK.9LEER1.2409e-03-0.2516image
chr19:5909462-5911367:+PCPGErlotinibEER2.4965e-050.3347image
ENSG00000187650.3,VMACPCPGErlotinibEAG2.4305e-050.3362image
ENSG00000187650.3,VMACPRADCCT007093EAG5.2289e-07-0.2230image
chr19:5909462-5911367:+PRADCCT007093EER3.3582e-08-0.2445image
chr19:5909462-5911367:+READCyclopamineEER1.9690e-05-0.4802image
ENSG00000187650.3,VMACREADA.770041EAG1.2532e-05-0.4930image
chr19:5909462-5911367:+SARCBortezomibEER3.1449e-030.1961image
ENSG00000187650.3,VMACSARCBortezomibEAG2.7201e-030.1989image
ENSG00000187650.3,VMACSKCMCGP.082996EAG1.5024e-030.1533image
chr19:5909462-5911367:+SKCMCGP.082996EER2.3381e-040.1772image
ENSG00000187650.3,VMACSTADGemcitabineEAG1.1976e-03-0.1737image
chr19:5909462-5911367:+STADGemcitabineEER9.8628e-04-0.1766image
ENSG00000187650.3,VMACTGCTGW.441756EAG3.7120e-02-0.2239image
chr19:5909462-5911367:+TGCTGW.441756EER3.0016e-02-0.2328image
ENSG00000187650.3,VMACTHCAJNJ.26854165EAG7.2416e-04-0.1519image
chr19:5909462-5911367:+THCAJNJ.26854165EER2.6081e-04-0.1638image
ENSG00000187650.3,VMACTHYMCMKEAG6.7869e-050.3597image
chr19:5909462-5911367:+THYMCMKEER1.4678e-050.3889image
ENSG00000187650.3,VMACUCECMetforminEAG3.5493e-050.3207image
chr19:5909462-5911367:+UCECMetforminEER7.1240e-050.3087image
ENSG00000187650.3,VMACUCSABT.263EAG3.1636e-02-0.3931image
ENSG00000187650.3,VMACUVMBosutinibEAG1.2331e-02-0.2877image
chr19:5909462-5911367:+UVMBosutinibEER9.7023e-03-0.2969image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType