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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF793 (ImmuneEditome ID:390927)

1. Gene summary of enriched editing regions for ZNF793

check button Gene summary
Gene informationGene symbol

ZNF793

Gene ID

390927

GeneSynonyms-
GeneCytomap

19q13.12

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 793
GeneModificationdate20230518
UniprotIDQ6ZN11;K7EQP3;K7EN11;K7EMU0;K7ERJ7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:37538002-37538630:+ENST00000445217.4ENSG00000188227.11ZNF793UTR3AluY,AluSg4chr19:37538002-37538630:+.alignment
chr19:37538002-37538630:+ENST00000542455.2ENSG00000188227.11ZNF793UTR3AluY,AluSg4chr19:37538002-37538630:+.alignment
chr19:37538002-37538630:+ENST00000588578.4ENSG00000188227.11ZNF793UTR3AluY,AluSg4chr19:37538002-37538630:+.alignment
chr19:37539979-37540271:+ENST00000445217.4ENSG00000188227.11ZNF793UTR3AluSq2,L1ME3Czchr19:37539979-37540271:+.alignment
chr19:37539979-37540271:+ENST00000542455.2ENSG00000188227.11ZNF793UTR3AluSq2,L1ME3Czchr19:37539979-37540271:+.alignment
chr19:37539979-37540271:+ENST00000588578.4ENSG00000188227.11ZNF793UTR3AluSq2,L1ME3Czchr19:37539979-37540271:+.alignment
chr19:37541374-37542433:+ENST00000589319.4ENSG00000188227.11ZNF793exonicAluSx,L1ME3Cz,AluSx1chr19:37541374-37542433:+.alignment


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2. Tumor-specific enriched editing regions for ZNF793


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:37538002-37538630:+TGCTPathEER2.1683e-023.5770e-020.4397image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000188227.11,ZNF793GBMEAG4.9187e-021.4742e-021.9742e+01image
ENSG00000188227.11,ZNF793LGGEAG6.8073e-032.9506e-028.7520e+00image

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3. Enriched editing regions and immune related genes for ZNF793


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ZNF793


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for ZNF793


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:37538002-37538630:+BLCAEERNK_cells_resting3.9172e-02-0.4068image
chr19:37541374-37542433:+BLCAEERB_cells_naive1.8260e-040.4190image
ENSG00000188227.11,ZNF793BLCAEAGB_cells_naive2.4000e-050.4434image
ENSG00000188227.11,ZNF793BRCAEAGT_cells_CD4_memory_activated6.6889e-03-0.1415image
chr19:37539979-37540271:+ESCAEERMacrophages_M26.2817e-040.5883image
chr19:37541374-37542433:+ESCAEERMacrophages_M14.5783e-020.4204image
ENSG00000188227.11,ZNF793ESCAEAGT_cells_CD4_memory_resting4.3158e-02-0.3255image
chr19:37538002-37538630:+GBMEERT_cells_regulatory_(Tregs)3.0207e-020.4850image
ENSG00000188227.11,ZNF793KIRCEAGT_cells_CD4_memory_activated4.4802e-030.4455image
ENSG00000188227.11,ZNF793KIRPEAGT_cells_CD4_memory_activated2.9529e-030.5410image
chr19:37541374-37542433:+LGGEERT_cells_follicular_helper2.2601e-030.2808image
ENSG00000188227.11,ZNF793LGGEAGB_cells_memory4.7048e-020.1454image
chr19:37541374-37542433:+OVEERMast_cells_activated1.7663e-020.1621image
ENSG00000188227.11,ZNF793OVEAGMast_cells_activated1.5167e-020.1600image
chr19:37539979-37540271:+PRADEERNeutrophils2.3303e-02-0.3454image
chr19:37541374-37542433:+PRADEERT_cells_CD81.2416e-020.2717image
ENSG00000188227.11,ZNF793PRADEAGT_cells_CD81.0889e-020.2387image
chr19:37541374-37542433:+SARCEERDendritic_cells_resting7.6195e-030.4318image
ENSG00000188227.11,ZNF793SARCEAGDendritic_cells_resting6.0002e-030.4034image
chr19:37538002-37538630:+STADEERPlasma_cells1.9642e-020.3196image
chr19:37541374-37542433:+STADEERT_cells_CD4_memory_resting7.4044e-03-0.4172image
ENSG00000188227.11,ZNF793STADEAGPlasma_cells4.6590e-020.1985image
chr19:37541374-37542433:+TGCTEERMonocytes3.4151e-020.2199image
ENSG00000188227.11,ZNF793TGCTEAGNK_cells_activated9.1101e-040.3282image
chr19:37541374-37542433:+THCAEERT_cells_regulatory_(Tregs)8.2545e-030.1921image
ENSG00000188227.11,ZNF793THCAEAGT_cells_regulatory_(Tregs)8.5921e-030.1686image
chr19:37541374-37542433:+THYMEERPlasma_cells2.5362e-030.5154image
ENSG00000188227.11,ZNF793THYMEAGPlasma_cells2.5047e-020.3631image
chr19:37541374-37542433:+UCSEERT_cells_gamma_delta4.6717e-020.3790image
ENSG00000188227.11,ZNF793UCSEAGT_cells_gamma_delta4.1739e-020.3873image


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6. Enriched editing regions and immune gene sets for ZNF793


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000188227.11,ZNF793BLCAGSVA_HALLMARK_MYOGENESISEAG5.9813e-040.3669image
chr19:37541374-37542433:+BLCAGSVA_HALLMARK_APICAL_JUNCTIONEER5.9602e-040.3874image
chr19:37538002-37538630:+BLCAGSVA_HALLMARK_COMPLEMENTEER8.6038e-030.5044image
ENSG00000188227.11,ZNF793BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.4318e-030.1661image
chr19:37541374-37542433:+BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.5012e-030.1762image
ENSG00000188227.11,ZNF793CESCGSVA_HALLMARK_HEME_METABOLISMEAG3.2499e-04-0.4925image
chr19:37541374-37542433:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.7451e-020.4594image
ENSG00000188227.11,ZNF793ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.4815e-030.4364image
chr19:37539979-37540271:+ESCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.8597e-02-0.4270image
chr19:37538002-37538630:+ESCAGSVA_HALLMARK_HYPOXIAEER4.9353e-020.3682image
ENSG00000188227.11,ZNF793GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG9.1100e-03-0.2846image
chr19:37541374-37542433:+GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.6854e-02-0.2617image
ENSG00000188227.11,ZNF793KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG8.5427e-03-0.4872image
ENSG00000188227.11,ZNF793LGGGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG7.9845e-03-0.1934image
chr19:37541374-37542433:+LGGGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3125e-02-0.2297image
chr19:37541374-37542433:+LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.7355e-020.2716image
ENSG00000188227.11,ZNF793LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.5225e-040.3670image
chr19:37541374-37542433:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3797e-030.2173image
ENSG00000188227.11,ZNF793OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.5331e-040.2471image
chr19:37538002-37538630:+OVGSVA_HALLMARK_ADIPOGENESISEER1.3364e-040.3693image
ENSG00000188227.11,ZNF793PCPGGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.2748e-020.3252image
chr19:37541374-37542433:+PRADGSVA_HALLMARK_NOTCH_SIGNALINGEER4.5773e-020.2186image
chr19:37539979-37540271:+PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.8113e-02-0.3589image
chr19:37541374-37542433:+SARCGSVA_HALLMARK_PEROXISOMEEER1.3089e-020.4042image
ENSG00000188227.11,ZNF793STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.8156e-020.2066image
chr19:37538002-37538630:+STADGSVA_HALLMARK_MYOGENESISEER1.4659e-030.4261image
chr19:37541374-37542433:+TGCTGSVA_HALLMARK_APOPTOSISEER1.3040e-020.2566image
chr19:37538002-37538630:+TGCTGSVA_HALLMARK_HEME_METABOLISMEER1.1816e-020.3569image
ENSG00000188227.11,ZNF793TGCTGSVA_HALLMARK_APOPTOSISEAG6.2603e-030.2730image
chr19:37541374-37542433:+THCAGSVA_HALLMARK_DNA_REPAIREER2.3920e-020.1647image
ENSG00000188227.11,ZNF793THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.8532e-02-0.1408image
chr19:37541374-37542433:+THYMGSVA_HALLMARK_MYC_TARGETS_V2EER1.4448e-020.4284image
ENSG00000188227.11,ZNF793THYMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.4554e-030.4771image
chr19:37541374-37542433:+UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3461e-020.3139image
ENSG00000188227.11,ZNF793UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.4770e-030.3764image
chr19:37541374-37542433:+UCSGSVA_HALLMARK_P53_PATHWAYEER3.7526e-03-0.5296image
ENSG00000188227.11,ZNF793UCSGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.9176e-02-0.4398image


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7. Enriched editing regions and drugs for ZNF793


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000188227.11,ZNF793BLCAEpothilone.BEAG1.9874e-030.3327image
chr19:37541374-37542433:+BLCAAICAREER6.3234e-03-0.3126image
chr19:37538002-37538630:+BLCACGP.082996EER2.5460e-03-0.5666image
ENSG00000188227.11,ZNF793BRCAABT.263EAG1.0570e-020.1339image
chr19:37541374-37542433:+BRCAABT.263EER1.8200e-020.1434image
ENSG00000188227.11,ZNF793CESCLapatinibEAG1.7129e-020.3462image
ENSG00000188227.11,ZNF793ESCAKIN001.135EAG8.0108e-03-0.4185image
chr19:37538002-37538630:+ESCAKIN001.135EER8.4196e-03-0.4799image
chr19:37539979-37540271:+ESCAAZD8055EER2.3802e-02-0.4117image
ENSG00000188227.11,ZNF793GBMLenalidomideEAG2.5760e-020.2447image
chr19:37538002-37538630:+GBMKU.55933EER4.0023e-02-0.4625image
chr19:37541374-37542433:+GBMLenalidomideEER1.1767e-020.2753image
ENSG00000188227.11,ZNF793KIRCCGP.082996EAG3.6306e-020.3363image
ENSG00000188227.11,ZNF793KIRPLapatinibEAG1.3298e-030.5763image
chr19:37541374-37542433:+LUADAKT.inhibitor.VIIIEER1.4099e-02-0.3806image
ENSG00000188227.11,ZNF793LUSCAZD.2281EAG3.4932e-02-0.2347image
chr19:37538002-37538630:+OVGW.441756EER5.0630e-03-0.2755image
chr19:37541374-37542433:+OVCCT007093EER1.9142e-030.2110image
ENSG00000188227.11,ZNF793OVImatinibEAG1.5997e-040.2464image
chr19:37541374-37542433:+PCPGCisplatinEER4.3923e-02-0.2985image
ENSG00000188227.11,ZNF793PCPGBI.D1870EAG3.2495e-020.2812image
chr19:37541374-37542433:+PRADCGP.082996EER3.0041e-03-0.3200image
ENSG00000188227.11,ZNF793PRADCMKEAG6.0169e-03-0.2569image
chr19:37539979-37540271:+PRADMidostaurinEER5.7948e-03-0.4139image
chr19:37538002-37538630:+STADBexaroteneEER2.7838e-03-0.4028image
chr19:37541374-37542433:+STADAZD.2281EER4.0264e-03-0.4448image
ENSG00000188227.11,ZNF793STADMetforminEAG4.7745e-05-0.3931image
chr19:37541374-37542433:+TGCTJNJ.26854165EER1.3961e-02-0.2542image
ENSG00000188227.11,ZNF793TGCTJNJ.26854165EAG2.8861e-02-0.2197image
chr19:37541374-37542433:+THCADocetaxelEER4.6203e-04-0.2529image
ENSG00000188227.11,ZNF793THCAErlotinibEAG1.0811e-03-0.2089image
ENSG00000188227.11,ZNF793THYMJNK.Inhibitor.VIIIEAG1.2726e-03-0.5035image
chr19:37541374-37542433:+THYMJNK.Inhibitor.VIIIEER1.7706e-02-0.4166image
ENSG00000188227.11,ZNF793UCECCGP.082996EAG5.0974e-03-0.3793image
chr19:37541374-37542433:+UCECCGP.082996EER6.0802e-03-0.3755image
chr19:37541374-37542433:+UCSIPA.3EER6.9838e-05-0.6795image
ENSG00000188227.11,ZNF793UCSBAY.61.3606EAG1.0729e-04-0.6666image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType