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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KIFC3 (ImmuneEditome ID:3801)

1. Gene summary of enriched editing regions for KIFC3

check button Gene summary
Gene informationGene symbol

KIFC3

Gene ID

3801

GeneSynonyms-
GeneCytomap

16q21

GeneTypeprotein-coding
GeneDescriptionkinesin-like protein KIFC3
GeneModificationdate20230517
UniprotIDQ9BVG8;B7Z896;H3BSN2;H3BV47;H3BMJ1;H3BPE2;H3BTU1;H3BTN1;A0A0C4DGM9;H3BTL6;H3BTE9;F5H3M2;H3BMR0;H3BRQ1;H3BNZ0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:57773507-57774693:-ENST00000564204.1ENSG00000140859.14KIFC3ncRNA_exonicAluJrchr16:57773507-57774693:-.alignment
chr16:57779589-57781350:-ENST00000563295.1ENSG00000140859.14KIFC3ncRNA_exonic(AAAT)n,AluSx,AluJo,THE1D,L1MB3,AluSzchr16:57779589-57781350:-.alignment
chr16:57782660-57783801:-ENST00000566975.4ENSG00000140859.14KIFC3ncRNA_intronicAluSq2,L1MB7,AluSqchr16:57782660-57783801:-.alignment
chr16:57782660-57783801:-ENST00000567204.4ENSG00000140859.14KIFC3ncRNA_intronicAluSq2,L1MB7,AluSqchr16:57782660-57783801:-.alignment
chr16:57789750-57791232:-ENST00000566975.4ENSG00000140859.14KIFC3ncRNA_exonicAluSz,(T)n,AluJb,AluSx,MIRchr16:57789750-57791232:-.alignment
chr16:57794309-57794556:-ENST00000566914.1ENSG00000140859.14KIFC3ncRNA_intronicAluJochr16:57794309-57794556:-.alignment
chr16:57794309-57794556:-ENST00000566975.4ENSG00000140859.14KIFC3ncRNA_intronicAluJochr16:57794309-57794556:-.alignment
chr16:57794309-57794556:-ENST00000567204.4ENSG00000140859.14KIFC3ncRNA_intronicAluJochr16:57794309-57794556:-.alignment


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2. Tumor-specific enriched editing regions for KIFC3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000140859.14,KIFC3THCAEAG3.2319e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000140859.14,KIFC3GBMEAG6.7272e-033.2041e-023.6191e-11image

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3. Enriched editing regions and immune related genes for KIFC3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for KIFC3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for KIFC3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr16:57773507-57774693:-BLCAEERPlasma_cells1.2845e-020.4418image
ENSG00000140859.14,KIFC3BLCAEAGT_cells_CD4_memory_activated1.8963e-02-0.2997image
ENSG00000140859.14,KIFC3BRCAEAGNK_cells_activated2.5509e-02-0.2957image
chr16:57773507-57774693:-CESCEERT_cells_regulatory_(Tregs)9.7412e-030.4141image
ENSG00000140859.14,KIFC3CESCEAGT_cells_CD4_memory_resting8.6329e-030.3418image
chr16:57773507-57774693:-CHOLEERT_cells_gamma_delta3.5639e-02-0.4606image
chr16:57773507-57774693:-ESCAEERNK_cells_resting2.5480e-02-0.2597image
chr16:57779589-57781350:-ESCAEERT_cells_CD4_naive1.4836e-030.3021image
chr16:57782660-57783801:-ESCAEERDendritic_cells_resting2.1206e-020.2790image
chr16:57789750-57791232:-ESCAEERMacrophages_M13.2755e-02-0.2148image
chr16:57773507-57774693:-HNSCEERT_cells_CD87.8687e-030.4758image
ENSG00000140859.14,KIFC3HNSCEAGMacrophages_M26.1482e-03-0.2792image
ENSG00000140859.14,KIFC3KIRCEAGNeutrophils2.9218e-02-0.1805image
ENSG00000140859.14,KIFC3KIRPEAGB_cells_naive1.4974e-02-0.2516image
ENSG00000140859.14,KIFC3LIHCEAGMast_cells_resting4.8179e-02-0.2405image
chr16:57779589-57781350:-LUADEERT_cells_gamma_delta9.6172e-040.4091image
chr16:57782660-57783801:-LUADEERT_cells_CD4_memory_activated5.1739e-030.5744image
chr16:57789750-57791232:-LUADEERDendritic_cells_resting8.9286e-03-0.2276image
chr16:57773507-57774693:-LUSCEERMast_cells_resting9.4190e-030.4389image
ENSG00000140859.14,KIFC3LUSCEAGMast_cells_resting5.1132e-030.3513image
chr16:57789750-57791232:-OVEERMacrophages_M02.4700e-02-0.2664image
ENSG00000140859.14,KIFC3OVEAGT_cells_CD4_memory_resting2.3509e-020.2547image
chr16:57773507-57774693:-PAADEERNK_cells_resting3.2648e-02-0.3977image
chr16:57773507-57774693:-SKCMEERPlasma_cells2.9761e-030.4525image
ENSG00000140859.14,KIFC3SKCMEAGT_cells_regulatory_(Tregs)3.0154e-02-0.2238image
chr16:57779589-57781350:-STADEERT_cells_gamma_delta1.5495e-020.1849image
chr16:57782660-57783801:-STADEERNK_cells_resting4.3438e-030.3301image
chr16:57789750-57791232:-STADEERB_cells_memory3.7755e-050.3287image
ENSG00000140859.14,KIFC3STADEAGB_cells_memory1.4980e-020.1654image
chr16:57773507-57774693:-THCAEERDendritic_cells_resting2.0501e-020.2105image


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6. Enriched editing regions and immune gene sets for KIFC3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000140859.14,KIFC3LUADEAG3.5608e-03-0.18444.8134e-02-0.12562.5710e-02-0.14169.6882e-03-0.1640image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000140859.14,KIFC3BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.7783e-07-0.5929image
chr16:57773507-57774693:-BLCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.8528e-02-0.3935image
chr16:57773507-57774693:-BRCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.1206e-020.4288image
chr16:57789750-57791232:-BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.2952e-020.3514image
chr16:57773507-57774693:-CESCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.7034e-020.3242image
ENSG00000140859.14,KIFC3CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.9039e-04-0.4377image
chr16:57773507-57774693:-ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.7178e-02-0.2763image
chr16:57789750-57791232:-ESCAGSVA_HALLMARK_ADIPOGENESISEER2.2154e-020.2298image
chr16:57782660-57783801:-ESCAGSVA_HALLMARK_MYOGENESISEER9.8822e-030.3108image
ENSG00000140859.14,KIFC3ESCAGSVA_HALLMARK_PEROXISOMEEAG1.5736e-030.2756image
chr16:57773507-57774693:-HNSCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER4.0787e-020.3756image
ENSG00000140859.14,KIFC3HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.1004e-03-0.3298image
chr16:57773507-57774693:-KIRCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.2042e-020.2305image
ENSG00000140859.14,KIFC3KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.5010e-04-0.2825image
chr16:57773507-57774693:-KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEER9.9684e-030.3224image
ENSG00000140859.14,KIFC3KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.4053e-04-0.3520image
ENSG00000140859.14,KIFC3LIHCGSVA_HALLMARK_UV_RESPONSE_UPEAG3.9287e-05-0.4769image
chr16:57782660-57783801:-LUADGSVA_HALLMARK_SPERMATOGENESISEER9.8077e-030.5380image
chr16:57779589-57781350:-LUADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.2626e-02-0.2583image
chr16:57773507-57774693:-LUADGSVA_HALLMARK_PEROXISOMEEER2.0494e-020.1797image
ENSG00000140859.14,KIFC3LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.3322e-05-0.2566image
chr16:57789750-57791232:-LUADGSVA_HALLMARK_APOPTOSISEER2.3053e-03-0.2641image
ENSG00000140859.14,KIFC3LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG9.9025e-05-0.4742image
chr16:57773507-57774693:-LUSCGSVA_HALLMARK_UV_RESPONSE_DNEER7.9116e-040.5481image
ENSG00000140859.14,KIFC3OVGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.6907e-03-0.3230image
chr16:57789750-57791232:-OVGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6178e-02-0.2845image
ENSG00000140859.14,KIFC3PAADGSVA_HALLMARK_ADIPOGENESISEAG1.8821e-06-0.6376image
chr16:57773507-57774693:-PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.3323e-02-0.4200image
chr16:57773507-57774693:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.8401e-020.3102image
ENSG00000140859.14,KIFC3SKCMGSVA_HALLMARK_UV_RESPONSE_UPEAG1.6414e-03-0.3204image
chr16:57782660-57783801:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.6147e-020.2603image
chr16:57779589-57781350:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.8959e-020.1793image
ENSG00000140859.14,KIFC3STADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.0940e-02-0.1728image
chr16:57773507-57774693:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.9737e-020.2570image
chr16:57789750-57791232:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.8171e-02-0.1920image
ENSG00000140859.14,KIFC3THCAGSVA_HALLMARK_MYC_TARGETS_V1EAG1.2129e-03-0.2393image
chr16:57773507-57774693:-THCAGSVA_HALLMARK_MYC_TARGETS_V2EER8.6638e-030.2377image


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7. Enriched editing regions and drugs for KIFC3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr16:57773507-57774693:-BLCAGefitinibEER4.5344e-03-0.4961image
ENSG00000140859.14,KIFC3BLCACGP.082996EAG1.6575e-040.4640image
chr16:57789750-57791232:-BRCAGDC.0449EER2.4726e-020.3687image
chr16:57773507-57774693:-BRCAGefitinibEER1.3648e-020.5065image
ENSG00000140859.14,KIFC3BRCAAZD.2281EAG9.6343e-040.4257image
ENSG00000140859.14,KIFC3CESCA.770041EAG1.9966e-040.4697image
chr16:57773507-57774693:-CHOLAZD7762EER1.4404e-030.6495image
ENSG00000140859.14,KIFC3CHOLBIBW2992EAG1.1517e-02-0.5067image
chr16:57794309-57794556:-ESCAEHT.1864EER4.1909e-020.2918image
ENSG00000140859.14,KIFC3ESCABX.795EAG4.4343e-030.2490image
chr16:57779589-57781350:-ESCAABT.263EER6.5592e-030.2613image
chr16:57782660-57783801:-ESCACHIR.99021EER1.1322e-03-0.3865image
chr16:57789750-57791232:-ESCAAZ628EER6.2537e-03-0.2730image
chr16:57773507-57774693:-HNSCAZD6482EER8.8910e-03-0.4693image
ENSG00000140859.14,KIFC3HNSCBortezomibEAG1.5367e-020.2480image
chr16:57773507-57774693:-KIRCJNK.Inhibitor.VIIIEER8.3734e-030.2417image
ENSG00000140859.14,KIFC3KIRCCMKEAG1.1875e-030.2657image
chr16:57773507-57774693:-KIRPAMG.706EER7.4462e-030.3341image
ENSG00000140859.14,KIFC3KIRPDasatinibEAG2.6039e-030.3120image
ENSG00000140859.14,KIFC3LIHCMG.132EAG3.7335e-030.3630image
chr16:57773507-57774693:-LUADDMOGEER2.6630e-02-0.1721image
ENSG00000140859.14,KIFC3LUADGemcitabineEAG1.3042e-030.2030image
chr16:57779589-57781350:-LUADIPA.3EER4.4719e-02-0.2623image
chr16:57782660-57783801:-LUADGSK269962AEER3.8905e-04-0.6892image
chr16:57789750-57791232:-LUADBIBW2992EER7.0414e-030.2344image
ENSG00000140859.14,KIFC3LUSCCI.1040EAG1.0008e-030.4078image
chr16:57773507-57774693:-LUSCCMKEER1.0176e-030.5385image
ENSG00000140859.14,KIFC3OVAG.014699EAG1.4288e-02-0.2747image
chr16:57789750-57791232:-OVDocetaxelEER9.5413e-030.3056image
ENSG00000140859.14,KIFC3PAADBIRB.0796EAG5.5399e-03-0.4026image
chr16:57773507-57774693:-PAADAZD.0530EER3.9637e-020.4226image
ENSG00000140859.14,KIFC3SKCMBAY.61.3606EAG4.8749e-03-0.2880image
ENSG00000140859.14,KIFC3STADLenalidomideEAG2.0006e-03-0.2091image
chr16:57773507-57774693:-STADEmbelinEER2.3446e-030.3315image
chr16:57789750-57791232:-STADGefitinibEER7.9257e-03-0.2168image
chr16:57779589-57781350:-STADJNJ.26854165EER8.0231e-040.2540image
ENSG00000140859.14,KIFC3THCAATRAEAG2.0121e-04-0.2744image
chr16:57773507-57774693:-THCAAxitinibEER7.3478e-030.2426image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType