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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: LINC-PINT (ImmuneEditome ID:378805)

1. Gene summary of enriched editing regions for LINC-PINT

check button Gene summary
Gene informationGene symbol

LINC-PINT

Gene ID

378805

GeneSynonymsLincRNA-Pint|MKLN1-AS1|PINT|PINT87aa|TISPL
GeneCytomap

7q32.3

GeneTypencRNA
GeneDescriptionMKLN1 antisense RNA 1 (head to head)|p53 induced noncoding transcript
GeneModificationdate20230508
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:130944816-130946492:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_exonicL1M5,AluJrchr7:130944816-130946492:-.alignment
chr7:130944816-130946492:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_exonicL1M5,AluJrchr7:130944816-130946492:-.alignment
chr7:130944816-130946492:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_exonicL1M5,AluJrchr7:130944816-130946492:-.alignment
chr7:130944816-130946492:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_exonicL1M5,AluJrchr7:130944816-130946492:-.alignment
chr7:130944816-130946492:-ENST00000443623.4ENSG00000231721.5LINC-PINTncRNA_exonicL1M5,AluJrchr7:130944816-130946492:-.alignment
chr7:130944816-130946492:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_exonicL1M5,AluJrchr7:130944816-130946492:-.alignment
chr7:130954506-130954740:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSzchr7:130954506-130954740:-.alignment
chr7:130954506-130954740:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSzchr7:130954506-130954740:-.alignment
chr7:130954506-130954740:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSzchr7:130954506-130954740:-.alignment
chr7:130954506-130954740:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSzchr7:130954506-130954740:-.alignment
chr7:130954506-130954740:-ENST00000443623.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSzchr7:130954506-130954740:-.alignment
chr7:130954506-130954740:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSzchr7:130954506-130954740:-.alignment
chr7:130957798-130958779:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluSx,AluSz6chr7:130957798-130958779:-.alignment
chr7:130957798-130958779:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluSx,AluSz6chr7:130957798-130958779:-.alignment
chr7:130957798-130958779:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluSx,AluSz6chr7:130957798-130958779:-.alignment
chr7:130957798-130958779:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluSx,AluSz6chr7:130957798-130958779:-.alignment
chr7:130957798-130958779:-ENST00000443623.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluSx,AluSz6chr7:130957798-130958779:-.alignment
chr7:130957798-130958779:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluSx,AluSz6chr7:130957798-130958779:-.alignment
chr7:130964595-130964781:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1chr7:130964595-130964781:-.alignment
chr7:130964595-130964781:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1chr7:130964595-130964781:-.alignment
chr7:130964595-130964781:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1chr7:130964595-130964781:-.alignment
chr7:130964595-130964781:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1chr7:130964595-130964781:-.alignment
chr7:130964595-130964781:-ENST00000443623.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1chr7:130964595-130964781:-.alignment
chr7:130964595-130964781:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1chr7:130964595-130964781:-.alignment
chr7:130992658-130993202:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,AluSxchr7:130992658-130993202:-.alignment
chr7:130992658-130993202:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,AluSxchr7:130992658-130993202:-.alignment
chr7:130992658-130993202:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,AluSxchr7:130992658-130993202:-.alignment
chr7:130992658-130993202:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,AluSxchr7:130992658-130993202:-.alignment
chr7:130992658-130993202:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,AluSxchr7:130992658-130993202:-.alignment
chr7:131030114-131031081:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluJb,AluSpchr7:131030114-131031081:-.alignment
chr7:131030114-131031081:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluJb,AluSpchr7:131030114-131031081:-.alignment
chr7:131030114-131031081:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluJb,AluSpchr7:131030114-131031081:-.alignment
chr7:131030114-131031081:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluJb,AluSpchr7:131030114-131031081:-.alignment
chr7:131030114-131031081:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluJb,AluSpchr7:131030114-131031081:-.alignment
chr7:131032489-131033250:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx4,AluSzchr7:131032489-131033250:-.alignment
chr7:131032489-131033250:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSx4,AluSzchr7:131032489-131033250:-.alignment
chr7:131032489-131033250:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx4,AluSzchr7:131032489-131033250:-.alignment
chr7:131032489-131033250:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx4,AluSzchr7:131032489-131033250:-.alignment
chr7:131032489-131033250:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx4,AluSzchr7:131032489-131033250:-.alignment
chr7:131035063-131036935:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,L1ME3C,AluYa5,(GGAA)n,L2c,AluSx1chr7:131035063-131036935:-.alignment
chr7:131035063-131036935:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,L1ME3C,AluYa5,(GGAA)n,L2c,AluSx1chr7:131035063-131036935:-.alignment
chr7:131035063-131036935:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,L1ME3C,AluYa5,(GGAA)n,L2c,AluSx1chr7:131035063-131036935:-.alignment
chr7:131035063-131036935:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,L1ME3C,AluYa5,(GGAA)n,L2c,AluSx1chr7:131035063-131036935:-.alignment
chr7:131035063-131036935:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSz,L1ME3C,AluYa5,(GGAA)n,L2c,AluSx1chr7:131035063-131036935:-.alignment
chr7:131041213-131041820:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSxchr7:131041213-131041820:-.alignment
chr7:131041213-131041820:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSxchr7:131041213-131041820:-.alignment
chr7:131041213-131041820:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSxchr7:131041213-131041820:-.alignment
chr7:131041213-131041820:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSxchr7:131041213-131041820:-.alignment
chr7:131041213-131041820:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSxchr7:131041213-131041820:-.alignment
chr7:131044502-131044783:-ENST00000416999.1ENSG00000231721.5LINC-PINTncRNA_intronicAluYchr7:131044502-131044783:-.alignment
chr7:131044502-131044783:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluYchr7:131044502-131044783:-.alignment
chr7:131044502-131044783:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluYchr7:131044502-131044783:-.alignment
chr7:131044502-131044783:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluYchr7:131044502-131044783:-.alignment
chr7:131044502-131044783:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluYchr7:131044502-131044783:-.alignment
chr7:131044502-131044783:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluYchr7:131044502-131044783:-.alignment
chr7:131055041-131055487:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronic(T)n,AluJrchr7:131055041-131055487:-.alignment
chr7:131055041-131055487:-ENST00000429901.1ENSG00000231721.5LINC-PINTncRNA_intronic(T)n,AluJrchr7:131055041-131055487:-.alignment
chr7:131055041-131055487:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronic(T)n,AluJrchr7:131055041-131055487:-.alignment
chr7:131055041-131055487:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronic(T)n,AluJrchr7:131055041-131055487:-.alignment
chr7:131055041-131055487:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronic(T)n,AluJrchr7:131055041-131055487:-.alignment
chr7:131055041-131055487:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronic(T)n,AluJrchr7:131055041-131055487:-.alignment
chr7:131070760-131071345:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluYchr7:131070760-131071345:-.alignment
chr7:131070760-131071345:-ENST00000429901.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluYchr7:131070760-131071345:-.alignment
chr7:131070760-131071345:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluYchr7:131070760-131071345:-.alignment
chr7:131070760-131071345:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluYchr7:131070760-131071345:-.alignment
chr7:131070760-131071345:-ENST00000435523.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluYchr7:131070760-131071345:-.alignment
chr7:131070760-131071345:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSx1,AluYchr7:131070760-131071345:-.alignment
chr7:131093560-131094275:-ENST00000423414.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSqchr7:131093560-131094275:-.alignment
chr7:131093560-131094275:-ENST00000429901.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSqchr7:131093560-131094275:-.alignment
chr7:131093560-131094275:-ENST00000431189.1ENSG00000231721.5LINC-PINTncRNA_intronicAluSqchr7:131093560-131094275:-.alignment
chr7:131093560-131094275:-ENST00000433079.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSqchr7:131093560-131094275:-.alignment
chr7:131093560-131094275:-ENST00000451786.4ENSG00000231721.5LINC-PINTncRNA_intronicAluSqchr7:131093560-131094275:-.alignment


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2. Tumor-specific enriched editing regions for LINC-PINT


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr7:130944816-130946492:-BRCAEER2.8809e-18image
ENSG00000231721.5,LINC-PINTBRCAEAG4.3855e-19image
chr7:130944816-130946492:-KICHEER2.1566e-02image
ENSG00000231721.5,LINC-PINTKICHEAG1.7577e-02image
chr7:130944816-130946492:-LUADEER2.5072e-04image
ENSG00000231721.5,LINC-PINTLUADEAG7.1662e-04image
chr7:130944816-130946492:-LUSCEER1.1487e-10image
ENSG00000231721.5,LINC-PINTLUSCEAG3.0835e-11image
chr7:130944816-130946492:-THCAEER1.0535e-09image
ENSG00000231721.5,LINC-PINTTHCAEAG2.0823e-09image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000231721.5,LINC-PINTBRCAPathEAG1.2280e-024.4852e-030.1105image
chr7:130944816-130946492:-BRCAPathEER2.3763e-021.1034e-020.0990image
ENSG00000231721.5,LINC-PINTKIRPPathEAG8.7443e-046.6352e-050.2952image
chr7:130944816-130946492:-KIRPPathEER8.8326e-051.1381e-050.3269image
chr7:131035063-131036935:-STADPathEER3.0051e-037.9298e-030.4355image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr7:130944816-130946492:-PCPGEER1.6947e-023.6701e-022.4824e-08image
ENSG00000231721.5,LINC-PINTPCPGEAG1.6947e-023.6701e-022.4824e-08image
chr7:130944816-130946492:-STADEER7.6556e-042.5374e-037.7765e+00image
chr7:131035063-131036935:-STADEER1.1880e-023.9030e-023.9459e+02image

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3. Enriched editing regions and immune related genes for LINC-PINT


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr7:130944816-130946492:-GBMEERENSG00000125170,DOK4-0.39861.4715e-048.0220e-09-0.4351imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000117226,GBP30.38492.1581e-045.9826e-080.4113imageNNGBP3MonocytesGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:130944816-130946492:-GBMEERENSG00000213626,LBH-0.38483.0179e-041.1162e-07-0.4035imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000167107,ACSF20.35967.3558e-041.3315e-070.4012imageNNACSF2T_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-THCAEERENSG00000177133,LINC00982-0.46803.6490e-254.6563e-20-0.4011imageNNNADendritic_cells_restingGSVA_HALLMARK_APOPTOSIS
chr7:130944816-130946492:-THCAEERENSG00000272622,RP11-395N3.2-0.47236.8985e-258.6114e-22-0.4179imageNNNADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000170364,SETMAR-0.44938.6424e-232.0306e-22-0.4237imageNNNANK_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000101158,NELFCD-0.44475.5405e-223.2861e-24-0.4397imageNNNAEosinophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000080823,MOK-0.44631.0749e-214.5042e-23-0.4296imageNNNANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000204852,TCTN1-0.43884.5166e-213.2777e-22-0.4218imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr7:130944816-130946492:-GBMEERENSG00000125170,DOK4-0.39861.4715e-048.0220e-09-0.4351imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000117226,GBP30.38492.1581e-045.9826e-080.4113imageNNGBP3MonocytesGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:130944816-130946492:-GBMEERENSG00000213626,LBH-0.38483.0179e-041.1162e-07-0.4035imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000167107,ACSF20.35967.3558e-041.3315e-070.4012imageNNACSF2T_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-THCAEERENSG00000177133,LINC00982-0.46803.6490e-254.6563e-20-0.4011imageNNNADendritic_cells_restingGSVA_HALLMARK_APOPTOSIS
chr7:130944816-130946492:-THCAEERENSG00000272622,RP11-395N3.2-0.47236.8985e-258.6114e-22-0.4179imageNNNADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000170364,SETMAR-0.44938.6424e-232.0306e-22-0.4237imageNNNANK_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000101158,NELFCD-0.44475.5405e-223.2861e-24-0.4397imageNNNAEosinophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000080823,MOK-0.44631.0749e-214.5042e-23-0.4296imageNNNANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000204852,TCTN1-0.43884.5166e-213.2777e-22-0.4218imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr7:130944816-130946492:-GBMEERENSG00000125170,DOK4-0.39861.4715e-048.0220e-09-0.4351imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000117226,GBP30.38492.1581e-045.9826e-080.4113imageNNGBP3MonocytesGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:130944816-130946492:-GBMEERENSG00000213626,LBH-0.38483.0179e-041.1162e-07-0.4035imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000167107,ACSF20.35967.3558e-041.3315e-070.4012imageNNACSF2T_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-THCAEERENSG00000177133,LINC00982-0.46803.6490e-254.6563e-20-0.4011imageNNNADendritic_cells_restingGSVA_HALLMARK_APOPTOSIS
chr7:130944816-130946492:-THCAEERENSG00000272622,RP11-395N3.2-0.47236.8985e-258.6114e-22-0.4179imageNNNADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000170364,SETMAR-0.44938.6424e-232.0306e-22-0.4237imageNNNANK_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000101158,NELFCD-0.44475.5405e-223.2861e-24-0.4397imageNNNAEosinophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000080823,MOK-0.44631.0749e-214.5042e-23-0.4296imageNNNANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000204852,TCTN1-0.43884.5166e-213.2777e-22-0.4218imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr7:130944816-130946492:-GBMEERENSG00000125170,DOK4-0.39861.4715e-048.0220e-09-0.4351imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000117226,GBP30.38492.1581e-045.9826e-080.4113imageNNGBP3MonocytesGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:130944816-130946492:-GBMEERENSG00000213626,LBH-0.38483.0179e-041.1162e-07-0.4035imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000167107,ACSF20.35967.3558e-041.3315e-070.4012imageNNACSF2T_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-THCAEERENSG00000177133,LINC00982-0.46803.6490e-254.6563e-20-0.4011imageNNNADendritic_cells_restingGSVA_HALLMARK_APOPTOSIS
chr7:130944816-130946492:-THCAEERENSG00000272622,RP11-395N3.2-0.47236.8985e-258.6114e-22-0.4179imageNNNADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000170364,SETMAR-0.44938.6424e-232.0306e-22-0.4237imageNNNANK_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000101158,NELFCD-0.44475.5405e-223.2861e-24-0.4397imageNNNAEosinophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000080823,MOK-0.44631.0749e-214.5042e-23-0.4296imageNNNANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000204852,TCTN1-0.43884.5166e-213.2777e-22-0.4218imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr7:130944816-130946492:-GBMEERENSG00000125170,DOK4-0.39861.4715e-048.0220e-09-0.4351imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000117226,GBP30.38492.1581e-045.9826e-080.4113imageNNGBP3MonocytesGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:130944816-130946492:-GBMEERENSG00000213626,LBH-0.38483.0179e-041.1162e-07-0.4035imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000167107,ACSF20.35967.3558e-041.3315e-070.4012imageNNACSF2T_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-THCAEERENSG00000177133,LINC00982-0.46803.6490e-254.6563e-20-0.4011imageNNNADendritic_cells_restingGSVA_HALLMARK_APOPTOSIS
chr7:130944816-130946492:-THCAEERENSG00000272622,RP11-395N3.2-0.47236.8985e-258.6114e-22-0.4179imageNNNADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000170364,SETMAR-0.44938.6424e-232.0306e-22-0.4237imageNNNANK_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000101158,NELFCD-0.44475.5405e-223.2861e-24-0.4397imageNNNAEosinophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000080823,MOK-0.44631.0749e-214.5042e-23-0.4296imageNNNANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000204852,TCTN1-0.43884.5166e-213.2777e-22-0.4218imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr7:130944816-130946492:-GBMEERENSG00000125170,DOK4-0.39861.4715e-048.0220e-09-0.4351imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000117226,GBP30.38492.1581e-045.9826e-080.4113imageNNGBP3MonocytesGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:130944816-130946492:-GBMEERENSG00000213626,LBH-0.38483.0179e-041.1162e-07-0.4035imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-GBMEERENSG00000167107,ACSF20.35967.3558e-041.3315e-070.4012imageNNACSF2T_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:130944816-130946492:-THCAEERENSG00000177133,LINC00982-0.46803.6490e-254.6563e-20-0.4011imageNNNADendritic_cells_restingGSVA_HALLMARK_APOPTOSIS
chr7:130944816-130946492:-THCAEERENSG00000272622,RP11-395N3.2-0.47236.8985e-258.6114e-22-0.4179imageNNNADendritic_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000170364,SETMAR-0.44938.6424e-232.0306e-22-0.4237imageNNNANK_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000101158,NELFCD-0.44475.5405e-223.2861e-24-0.4397imageNNNAEosinophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr7:130944816-130946492:-THCAEERENSG00000080823,MOK-0.44631.0749e-214.5042e-23-0.4296imageNNNANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr7:130944816-130946492:-THCAEERENSG00000204852,TCTN1-0.43884.5166e-213.2777e-22-0.4218imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING

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4. Enriched editing regions and immune related splicing for LINC-PINT


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check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000231721.5,LINC-PINT
ESCAEAGA3ENSG00000120896.9chr822554451:22554608:22554907:22554980:22554862:225549800.31142.1778e-021.2446e-060.4488imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LARP7;LIN28A;LIN28B;MBNL1;MBNL2;METTL3;MOV10;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184SORBS3B_cells_memoryGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000127526.9chr1916551758:16551868:16551992:165523280.56202.4175e-061.6368e-100.5070imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LARP4B;LARP7;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SBDS;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000184922.9chr1745233647:45234200:45236135:45236244-0.41906.9549e-041.7238e-07-0.4555imageNADAR;AUH;CELF2;CSTF2T;DDX42;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LIN28A;LIN28B;MBNL1;NONO;NOP56;NOP58;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1NAMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000174720.11chr4112646790:112646955:112647033:112647127-0.54434.1616e-061.2521e-08-0.4582imageNADAR;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;LARP4B;LARP7;LIN28A;LIN28B;METTL3;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM47;RBM6;RNF219;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000105483.12chr1948231659:48231810:48232452:48232493-0.37196.5836e-031.1498e-06-0.4238imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28B;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184CARD8Dendritic_cells_activatedGSVA_HALLMARK_SPERMATOGENESIS
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000183597.11chr2220061529:20061706:20063337:20063383-0.34774.9577e-035.0961e-08-0.4724imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LARP7;LIN28A;LIN28B;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SBDS;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184NAT_cells_gamma_deltaGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000231721.5,LINC-PINT
ESCAEAGESENSG00000173821.15chr1780273240:80273404:80278763:80278910:80287814:802880570.45367.7128e-041.5932e-070.4256imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;LARP7;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM6;RNF219;SBDS;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NADendritic_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000174720.11chr4112646790:112647127:112647198:112647449-0.44467.8581e-043.4787e-07-0.4148imageNADAR;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;LARP4B;LARP7;LIN28A;LIN28B;METTL3;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM47;RBM6;RNF219;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000117682.12chr126432367:26432518:26432890:26433008-0.31573.3663e-021.2802e-05-0.4029imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LARP4B;LARP7;LIN28A;LIN28B;MBNL2;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000231721.5,LINC-PINT
ESCAEAGIRENSG00000186376.10chrX135292280:135292473:135293729:135294258-0.38431.2975e-031.1694e-06-0.4442imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;LARP7;LIN28A;LIN28B;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184NAEosinophilsGSVA_HALLMARK_SPERMATOGENESIS

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5. Enriched editing regions and immune infiltration for LINC-PINT


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr7:130944816-130946492:-ACCEERT_cells_CD81.0570e-020.3517image
ENSG00000231721.5,LINC-PINTACCEAGT_cells_CD81.0570e-020.3517image
chr7:130944816-130946492:-BLCAEERT_cells_regulatory_(Tregs)9.9336e-03-0.1891image
ENSG00000231721.5,LINC-PINTBLCAEAGMacrophages_M11.5537e-020.1758image
chr7:130944816-130946492:-BRCAEERT_cells_regulatory_(Tregs)4.3958e-030.1110image
ENSG00000231721.5,LINC-PINTBRCAEAGMacrophages_M24.7063e-030.1100image
chr7:130944816-130946492:-CESCEERMonocytes2.7337e-020.2124image
ENSG00000231721.5,LINC-PINTCHOLEAGDendritic_cells_resting2.4889e-030.5580image
ENSG00000231721.5,LINC-PINTCOADEAGT_cells_follicular_helper2.7504e-020.1898image
ENSG00000231721.5,LINC-PINTDLBCEAGMonocytes9.2061e-030.4018image
chr7:131044502-131044783:-ESCAEERT_cells_follicular_helper3.1559e-020.4224image
ENSG00000231721.5,LINC-PINTESCAEAGMacrophages_M21.7120e-020.2012image
chr7:130944816-130946492:-GBMEERMacrophages_M09.1534e-04-0.2588image
ENSG00000231721.5,LINC-PINTGBMEAGMacrophages_M01.8663e-03-0.2434image
ENSG00000231721.5,LINC-PINTHNSCEAGT_cells_gamma_delta4.7181e-020.2000image
chr7:130944816-130946492:-KICHEERT_cells_regulatory_(Tregs)3.7711e-02-0.2646image
ENSG00000231721.5,LINC-PINTKICHEAGT_cells_regulatory_(Tregs)3.6055e-02-0.2668image
chr7:130944816-130946492:-KIRCEERDendritic_cells_activated4.3410e-02-0.1191image
ENSG00000231721.5,LINC-PINTKIRCEAGDendritic_cells_activated3.6900e-02-0.1224image
chr7:130944816-130946492:-KIRPEERMacrophages_M12.3259e-050.2995image
ENSG00000231721.5,LINC-PINTKIRPEAGMacrophages_M19.1852e-060.3094image
ENSG00000231721.5,LINC-PINTLAMLEAGDendritic_cells_resting1.4070e-020.2192image
chr7:130944816-130946492:-LGGEERMacrophages_M12.0578e-040.1615image
ENSG00000231721.5,LINC-PINTLGGEAGMacrophages_M11.8096e-040.1629image
chr7:130944816-130946492:-LIHCEERMacrophages_M16.5271e-030.2460image
ENSG00000231721.5,LINC-PINTLIHCEAGMacrophages_M16.0610e-030.2462image
chr7:130944816-130946492:-LUADEERT_cells_CD4_memory_resting1.9499e-03-0.1527image
ENSG00000231721.5,LINC-PINTLUADEAGT_cells_CD4_memory_resting4.3214e-04-0.1722image
chr7:130944816-130946492:-MESOEERMonocytes4.6712e-02-0.2557image
ENSG00000231721.5,LINC-PINTMESOEAGMonocytes4.7105e-02-0.2552image
chr7:130944816-130946492:-OVEERMacrophages_M14.1242e-040.2127image
ENSG00000231721.5,LINC-PINTOVEAGMacrophages_M16.7774e-040.2044image
chr7:130944816-130946492:-PAADEERB_cells_naive3.4875e-03-0.2497image
ENSG00000231721.5,LINC-PINTPAADEAGB_cells_naive3.9948e-03-0.2462image
chr7:130944816-130946492:-PCPGEERT_cells_CD83.3911e-030.2242image
ENSG00000231721.5,LINC-PINTPCPGEAGT_cells_CD82.9961e-030.2270image
chr7:130944816-130946492:-PRADEERNK_cells_activated1.0491e-02-0.1252image
chr7:130992658-130993202:-PRADEERMacrophages_M11.0998e-030.5936image
ENSG00000231721.5,LINC-PINTPRADEAGNK_cells_activated1.2785e-02-0.1204image
ENSG00000231721.5,LINC-PINTREADEAGT_cells_gamma_delta1.6529e-020.3163image
chr7:130944816-130946492:-SARCEERNK_cells_resting1.7047e-02-0.2241image
ENSG00000231721.5,LINC-PINTSARCEAGMonocytes2.0665e-02-0.2165image
chr7:130944816-130946492:-SKCMEERMast_cells_activated4.1710e-03-0.1541image
ENSG00000231721.5,LINC-PINTSKCMEAGMast_cells_activated4.6028e-03-0.1518image
chr7:130944816-130946492:-STADEERMast_cells_activated6.0741e-03-0.1594image
chr7:130957798-130958779:-STADEERT_cells_regulatory_(Tregs)2.9740e-02-0.1953image
chr7:130992658-130993202:-STADEERDendritic_cells_resting2.2424e-020.3516image
chr7:131030114-131031081:-STADEERDendritic_cells_resting3.3533e-020.2410image
chr7:131032489-131033250:-STADEERT_cells_gamma_delta1.7000e-020.4009image
chr7:131035063-131036935:-STADEERT_cells_CD4_naive9.3944e-030.4160image
chr7:131041213-131041820:-STADEERT_cells_CD84.5940e-020.2466image
chr7:131055041-131055487:-STADEERT_cells_follicular_helper1.3873e-020.1773image
chr7:131070760-131071345:-STADEERT_cells_CD85.5193e-030.3217image
chr7:131093560-131094275:-STADEERT_cells_CD4_memory_activated6.2010e-040.6478image
ENSG00000231721.5,LINC-PINTSTADEAGB_cells_memory3.3621e-04-0.1989image
chr7:130944816-130946492:-THCAEERT_cells_regulatory_(Tregs)2.2792e-060.2134image
ENSG00000231721.5,LINC-PINTTHCAEAGT_cells_regulatory_(Tregs)5.1896e-060.2054image
chr7:130944816-130946492:-THYMEERMacrophages_M03.8386e-030.3437image
ENSG00000231721.5,LINC-PINTTHYMEAGT_cells_gamma_delta5.2215e-030.3303image
ENSG00000231721.5,LINC-PINTUCECEAGMacrophages_M04.9123e-020.2918image


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6. Enriched editing regions and immune gene sets for LINC-PINT


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr7:130944816-130946492:-KIRPEER4.3280e-02image3.5723e-030.2088image
ENSG00000231721.5,LINC-PINTKIRPEAG3.4779e-02image4.8689e-030.1993image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr7:130944816-130946492:-PCPGEER2.8602e-04-0.27573.6118e-02-0.16136.5432e-07-0.37161.8237e-05-0.3232image
ENSG00000231721.5,LINC-PINTPCPGEAG3.4985e-04-0.27183.7653e-02-0.16016.4690e-07-0.37181.6010e-05-0.3252image
ENSG00000231721.5,LINC-PINTSTADEAG8.8689e-060.24521.0837e-050.24281.8128e-040.20751.4208e-060.2653image
ENSG00000231721.5,LINC-PINTUCECEAG2.8366e-040.51111.1575e-030.46418.6341e-050.54613.2063e-030.4254image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr7:130944816-130946492:-ACCGSVA_HALLMARK_DNA_REPAIREER2.8095e-03-0.4062image
ENSG00000231721.5,LINC-PINTACCGSVA_HALLMARK_DNA_REPAIREAG2.8095e-03-0.4062image
chr7:130944816-130946492:-BLCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.9614e-050.3019image
ENSG00000231721.5,LINC-PINTBLCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.0161e-050.3149image
ENSG00000231721.5,LINC-PINTBRCAGSVA_HALLMARK_PEROXISOMEEAG1.7276e-070.2019image
chr7:130944816-130946492:-BRCAGSVA_HALLMARK_PEROXISOMEEER2.2356e-050.1646image
ENSG00000231721.5,LINC-PINTCESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.0011e-030.2546image
ENSG00000231721.5,LINC-PINTCHOLGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.4221e-040.6501image
ENSG00000231721.5,LINC-PINTCOADGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.9446e-040.3154image
ENSG00000231721.5,LINC-PINTDLBCGSVA_HALLMARK_E2F_TARGETSEAG2.3041e-02-0.3543image
chr7:130944816-130946492:-ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.8299e-020.1917image
chr7:131030114-131031081:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4140e-02-0.4585image
chr7:131044502-131044783:-ESCAGSVA_HALLMARK_SPERMATOGENESISEER1.6921e-020.4641image
ENSG00000231721.5,LINC-PINTESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.1260e-040.3206image
ENSG00000231721.5,LINC-PINTGBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.6533e-050.3193image
chr7:130944816-130946492:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER6.8529e-050.3085image
ENSG00000231721.5,LINC-PINTHNSCGSVA_HALLMARK_MYOGENESISEAG1.6987e-03-0.3115image
chr7:130944816-130946492:-HNSCGSVA_HALLMARK_MYOGENESISEER1.7845e-03-0.3132image
chr7:130944816-130946492:-KICHGSVA_HALLMARK_P53_PATHWAYEER2.2939e-020.2885image
ENSG00000231721.5,LINC-PINTKICHGSVA_HALLMARK_P53_PATHWAYEAG1.7323e-020.3013image
ENSG00000231721.5,LINC-PINTKIRCGSVA_HALLMARK_COAGULATIONEAG2.2625e-050.2456image
chr7:130944816-130946492:-KIRCGSVA_HALLMARK_COAGULATIONEER1.7475e-050.2501image
chr7:130944816-130946492:-KIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.2140e-030.2312image
ENSG00000231721.5,LINC-PINTKIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.1569e-040.2706image
ENSG00000231721.5,LINC-PINTLAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.1101e-02-0.1830image
ENSG00000231721.5,LINC-PINTLGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG8.3410e-05-0.1710image
chr7:130944816-130946492:-LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.8307e-05-0.1731image
chr7:130944816-130946492:-LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.3800e-040.3205image
ENSG00000231721.5,LINC-PINTLIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.1240e-040.3136image
ENSG00000231721.5,LINC-PINTLUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.3692e-060.2347image
chr7:130944816-130946492:-LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER5.7925e-050.1975image
chr7:130944816-130946492:-LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER7.6849e-040.1877image
ENSG00000231721.5,LINC-PINTLUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.5761e-040.1922image
ENSG00000231721.5,LINC-PINTMESOGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG8.5750e-030.3338image
chr7:130944816-130946492:-MESOGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER8.7219e-030.3330image
chr7:131030114-131031081:-OVGSVA_HALLMARK_MYC_TARGETS_V1EER4.6666e-020.2856image
chr7:130944816-130946492:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.7779e-040.2006image
ENSG00000231721.5,LINC-PINTOVGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2098e-050.2614image
ENSG00000231721.5,LINC-PINTPAADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.4771e-030.2584image
chr7:130944816-130946492:-PAADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.1161e-030.2623image
ENSG00000231721.5,LINC-PINTPCPGGSVA_HALLMARK_HYPOXIAEAG1.6010e-05-0.3252image
chr7:130944816-130946492:-PCPGGSVA_HALLMARK_HYPOXIAEER1.8237e-05-0.3232image
chr7:130944816-130946492:-PRADGSVA_HALLMARK_MYC_TARGETS_V1EER9.4067e-030.1270image
ENSG00000231721.5,LINC-PINTPRADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.5515e-070.2412image
chr7:130992658-130993202:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.3591e-020.3912image
ENSG00000231721.5,LINC-PINTREADGSVA_HALLMARK_KRAS_SIGNALING_UPEAG2.4457e-030.3937image
ENSG00000231721.5,LINC-PINTSARCGSVA_HALLMARK_ADIPOGENESISEAG3.9874e-03-0.2677image
chr7:130944816-130946492:-SARCGSVA_HALLMARK_ADIPOGENESISEER1.9469e-03-0.2884image
chr7:130944816-130946492:-SKCMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.7980e-040.1947image
ENSG00000231721.5,LINC-PINTSKCMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.1711e-040.1922image
chr7:131035063-131036935:-STADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.5503e-030.4755image
chr7:130957798-130958779:-STADGSVA_HALLMARK_PEROXISOMEEER4.9160e-020.1771image
chr7:131055041-131055487:-STADGSVA_HALLMARK_G2M_CHECKPOINTEER4.3591e-040.2514image
chr7:131030114-131031081:-STADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.4785e-020.2279image
chr7:130954506-130954740:-STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.2681e-030.5509image
chr7:131032489-131033250:-STADGSVA_HALLMARK_PROTEIN_SECRETIONEER2.3474e-040.5834image
chr7:130944816-130946492:-STADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.1784e-030.1663image
chr7:131093560-131094275:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.0175e-040.6377image
chr7:131070760-131071345:-STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.0381e-050.4481image
chr7:131044502-131044783:-STADGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.4349e-020.3470image
ENSG00000231721.5,LINC-PINTSTADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.1497e-160.4347image
chr7:130992658-130993202:-STADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER2.0428e-02-0.3566image
ENSG00000231721.5,LINC-PINTTHCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.1596e-170.3756image
chr7:130944816-130946492:-THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.4133e-170.3712image
ENSG00000231721.5,LINC-PINTTHYMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.5347e-030.3717image
chr7:130944816-130946492:-THYMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.3995e-030.3597image
ENSG00000231721.5,LINC-PINTUCECGSVA_HALLMARK_GLYCOLYSISEAG3.5789e-050.5698image


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7. Enriched editing regions and drugs for LINC-PINT


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr7:130944816-130946492:-ACCBI.2536EER1.3767e-040.5044image
ENSG00000231721.5,LINC-PINTACCBI.2536EAG1.3767e-040.5044image
ENSG00000231721.5,LINC-PINTBLCAAxitinibEAG1.0611e-040.2782image
chr7:130944816-130946492:-BLCAAxitinibEER2.0955e-040.2693image
chr7:130944816-130946492:-BRCALenalidomideEER6.5889e-050.1552image
ENSG00000231721.5,LINC-PINTBRCALenalidomideEAG1.6283e-050.1672image
ENSG00000231721.5,LINC-PINTCESCGW.441756EAG2.5504e-03-0.2837image
ENSG00000231721.5,LINC-PINTCHOLGW843682XEAG5.4212e-03-0.5201image
ENSG00000231721.5,LINC-PINTCOADFH535EAG1.0323e-04-0.3279image
ENSG00000231721.5,LINC-PINTDLBCAZ628EAG4.0688e-02-0.3210image
ENSG00000231721.5,LINC-PINTESCAImatinibEAG5.7208e-03-0.2324image
chr7:131044502-131044783:-ESCACI.1040EER3.3184e-030.5540image
chr7:130944816-130946492:-GBMCEP.701EER2.5199e-060.3611image
ENSG00000231721.5,LINC-PINTGBMCEP.701EAG1.0301e-060.3739image
ENSG00000231721.5,LINC-PINTHNSCGNF.2EAG5.7742e-030.2755image
chr7:130944816-130946492:-HNSCGNF.2EER7.6389e-030.2693image
ENSG00000231721.5,LINC-PINTKICHJNK.9LEAG1.3092e-02-0.3135image
chr7:130944816-130946492:-KICHJNK.9LEER1.2527e-02-0.3154image
ENSG00000231721.5,LINC-PINTKIRCKU.55933EAG1.9963e-04-0.2164image
chr7:130944816-130946492:-KIRCKU.55933EER1.9423e-05-0.2488image
ENSG00000231721.5,LINC-PINTKIRPDMOGEAG4.0068e-06-0.3210image
chr7:130944816-130946492:-KIRPCGP.082996EER6.6252e-05-0.2831image
ENSG00000231721.5,LINC-PINTLAMLJNK.9LEAG1.2269e-02-0.2234image
ENSG00000231721.5,LINC-PINTLGGKIN001.135EAG1.4610e-06-0.2086image
chr7:130944816-130946492:-LGGKIN001.135EER1.7335e-06-0.2071image
ENSG00000231721.5,LINC-PINTLIHCBIBW2992EAG1.6574e-040.3715image
chr7:130944816-130946492:-LIHCBIBW2992EER1.1554e-030.3268image
ENSG00000231721.5,LINC-PINTLUADGW843682XEAG6.8226e-04-0.1663image
chr7:130944816-130946492:-LUADCHIR.99021EER8.4395e-040.1648image
ENSG00000231721.5,LINC-PINTLUSCEmbelinEAG2.0088e-03-0.1723image
chr7:130944816-130946492:-LUSCKIN001.135EER3.5815e-03-0.1629image
ENSG00000231721.5,LINC-PINTMESOBX.795EAG1.1772e-03-0.4058image
chr7:130944816-130946492:-MESOBX.795EER1.1964e-03-0.4052image
chr7:131030114-131031081:-OVEtoposideEER1.7625e-04-0.5109image
chr7:130944816-130946492:-OVGSK.650394EER7.1215e-050.2385image
ENSG00000231721.5,LINC-PINTOVEpothilone.BEAG1.4683e-040.2278image
ENSG00000231721.5,LINC-PINTPAADJNJ.26854165EAG9.4094e-060.3710image
chr7:130944816-130946492:-PAADJNJ.26854165EER7.4887e-060.3748image
chr7:130944816-130946492:-PCPGBX.795EER6.4638e-100.4526image
ENSG00000231721.5,LINC-PINTPCPGBX.795EAG6.2522e-100.4530image
ENSG00000231721.5,LINC-PINTPRADBryostatin.1EAG3.2936e-050.1995image
chr7:130944816-130946492:-PRADCCT018159EER9.8360e-050.1896image
chr7:130992658-130993202:-PRADCGP.60474EER3.1419e-020.4149image
ENSG00000231721.5,LINC-PINTREADBX.795EAG2.5768e-04-0.4661image
ENSG00000231721.5,LINC-PINTSARCAKT.inhibitor.VIIIEAG2.1338e-02-0.2154image
chr7:130944816-130946492:-SARCBMS.708163EER1.3817e-020.2310image
chr7:130944816-130946492:-SKCMAZD.0530EER2.1618e-020.1238image
ENSG00000231721.5,LINC-PINTSKCMAZD.0530EAG3.2535e-030.1576image
chr7:130992658-130993202:-STADEmbelinEER7.9620e-030.4040image
chr7:130957798-130958779:-STADAxitinibEER2.9712e-03-0.2647image
chr7:130954506-130954740:-STADAG.014699EER5.3732e-030.5499image
chr7:131070760-131071345:-STADMethotrexateEER6.9178e-03-0.3178image
chr7:131055041-131055487:-STADCCT007093EER1.2813e-020.1793image
chr7:131032489-131033250:-STADErlotinibEER5.5277e-04-0.5541image
chr7:131030114-131031081:-STADBI.D1870EER1.3726e-020.2780image
chr7:130944816-130946492:-STADMethotrexateEER8.8559e-03-0.1527image
chr7:131093560-131094275:-STADCisplatinEER2.9854e-02-0.4437image
chr7:131044502-131044783:-STADJNJ.26854165EER3.7330e-020.3224image
ENSG00000231721.5,LINC-PINTSTADAG.014699EAG1.1649e-040.2134image
ENSG00000231721.5,LINC-PINTTGCTBIRB.0796EAG3.3448e-020.3553image
chr7:130944816-130946492:-THCACI.1040EER2.5327e-15-0.3498image
ENSG00000231721.5,LINC-PINTTHCAAICAREAG1.8911e-13-0.3260image
ENSG00000231721.5,LINC-PINTTHYMJNK.Inhibitor.VIIIEAG3.4995e-03-0.3445image
chr7:130944816-130946492:-THYMAP.24534EER6.3604e-030.3254image
ENSG00000231721.5,LINC-PINTUCECAZD6244EAG3.0791e-030.4315image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType