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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: IPP (ImmuneEditome ID:3652)

1. Gene summary of enriched editing regions for IPP

check button Gene summary
Gene informationGene symbol

IPP

Gene ID

3652

GeneSynonymsKLHL27
GeneCytomap

1p34.1

GeneTypeprotein-coding
GeneDescriptionactin-binding protein IPP|kelch-like family member 27|kelch-like protein 27
GeneModificationdate20230517
UniprotIDQ9Y573
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:45694852-45700501:-ENST00000359942.7ENSG00000197429.9IPPexonicAluSp,AluJb,AluJo,AluSx3,AluSz,AluSq2chr1:45694852-45700501:-.alignment
chr1:45694852-45700501:-ENST00000396478.3ENSG00000197429.9IPPexonicAluSp,AluJb,AluJo,AluSx3,AluSz,AluSq2chr1:45694852-45700501:-.alignment
chr1:45712049-45712291:-ENST00000495072.1ENSG00000197429.9IPPncRNA_intronicAluSzchr1:45712049-45712291:-.alignment


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2. Tumor-specific enriched editing regions for IPP


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:45694852-45700501:-BRCAEER8.5172e-18image
ENSG00000197429.9,IPPBRCAEAG9.8354e-18image
chr1:45694852-45700501:-COADEER6.0120e-07image
ENSG00000197429.9,IPPCOADEAG5.6854e-07image
chr1:45694852-45700501:-HNSCEER1.3334e-20image
ENSG00000197429.9,IPPHNSCEAG1.3052e-20image
chr1:45694852-45700501:-KIRCEER6.8329e-03image
ENSG00000197429.9,IPPKIRCEAG7.0702e-03image
chr1:45694852-45700501:-LIHCEER4.3791e-04image
ENSG00000197429.9,IPPLIHCEAG4.3791e-04image
chr1:45694852-45700501:-PRADEER5.7593e-03image
ENSG00000197429.9,IPPPRADEAG5.7593e-03image
chr1:45694852-45700501:-THCAEER4.8009e-04image
ENSG00000197429.9,IPPTHCAEAG4.8009e-04image
chr1:45694852-45700501:-UCECEER3.0651e-05image
ENSG00000197429.9,IPPUCECEAG2.9785e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr1:45694852-45700501:-CHOLPathEER1.3642e-021.1261e-020.4234image
ENSG00000197429.9,IPPCHOLPathEAG1.3642e-021.1261e-020.4234image
chr1:45694852-45700501:-THCAPathEER4.8427e-055.5983e-050.1786image
ENSG00000197429.9,IPPTHCAPathEAG4.8427e-055.5983e-050.1786image
ENSG00000197429.9,IPPUVMPathEAG2.0681e-023.5950e-02-0.2737image
chr1:45694852-45700501:-UVMPathEER2.0681e-023.5950e-02-0.2737image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr1:45694852-45700501:-READEER3.4505e-021.2480e-021.0667e+05image
ENSG00000197429.9,IPPREADEAG3.4505e-021.2480e-021.0667e+05image

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3. Enriched editing regions and immune related genes for IPP


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:45694852-45700501:-BLCAEERENSG00000197646,PDCD1LG20.59131.1289e-342.0881e-190.4297imageNNPDCD1LG2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-BLCAEERENSG00000135077,HAVCR20.58801.2461e-331.6391e-290.5234imageNNHAVCR2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-BLCAEERENSG00000154451,GBP50.58432.1668e-322.8559e-240.4784imageNNGBP5T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000133106,EPSTI10.57965.6985e-327.5221e-300.5261imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000169245,CXCL100.57594.1274e-312.3927e-280.5140imageNNCXCL10T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000140105,WARS0.57415.4150e-319.4962e-290.5172imageNNWARST_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000272666,CTA-384D8.350.57096.2209e-312.4682e-200.4396imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000275302,CCL40.57011.0929e-301.6431e-300.5312imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-BLCAEERENSG00000117228,GBP10.57141.6425e-301.6406e-280.5153imageNNGBP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000168394,TAP10.56883.1553e-303.3394e-390.5921imageNNTAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000197646,PDCD1LG20.59131.1289e-342.0881e-190.4297imageNNPDCD1LG2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-BLCAEERENSG00000135077,HAVCR20.58801.2461e-331.6391e-290.5234imageNNHAVCR2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-BLCAEERENSG00000154451,GBP50.58432.1668e-322.8559e-240.4784imageNNGBP5T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000133106,EPSTI10.57965.6985e-327.5221e-300.5261imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000169245,CXCL100.57594.1274e-312.3927e-280.5140imageNNCXCL10T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000140105,WARS0.57415.4150e-319.4962e-290.5172imageNNWARST_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000272666,CTA-384D8.350.57096.2209e-312.4682e-200.4396imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000275302,CCL40.57011.0929e-301.6431e-300.5312imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-BLCAEERENSG00000117228,GBP10.57141.6425e-301.6406e-280.5153imageNNGBP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:45694852-45700501:-BLCAEERENSG00000168394,TAP10.56883.1553e-303.3394e-390.5921imageNNTAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for IPP


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000197429.9,IPP
BLCAEAGIRENSG00000139278.5chr1275495576:75498720:75498823:75503853-0.43103.8612e-158.5667e-21-0.4454imageNADAR;DKC1;EIF4A3;ELAVL1;ELAVL3;FMR1;FUS;HNRNPC;HNRNPL;IGF2BP1;IGF2BP2;KHDRBS2;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;PTBP1;RBFOX2;RBM47;SAFB2;SND1;SRSF1;SRSF3;TAF15;TIA1;U2AF1;UPF1NADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000197429.9,IPP
BLCAEAGIRENSG00000256269.2chr11119092124:119092163:119092403:119092523-0.43364.8649e-151.3792e-17-0.4097imageNAIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chr1:45694852-45700501:-
BLCAEERIRENSG00000121281.8chr1650312035:50314062:50314291:50314406-0.32895.6322e-111.7421e-14-0.4216imageNNNAMacrophages_M1GSVA_HALLMARK_INFLAMMATORY_RESPONSE
ENSG00000197429.9,IPP
BLCAEAGMEXENSG00000112715.16chr643777539:43777665:43778459:43778536:43782010:43782087:43784540:437845620.43047.4782e-156.1019e-170.4026imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;RBM47;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7B;ZNF184VEGFAT_cells_CD4_naiveGSVA_HALLMARK_APOPTOSIS
ENSG00000197429.9,IPP
BLCAEAGIRENSG00000100911.9chr1424145709:24145896:24146207:24146240-0.42261.0832e-141.6161e-19-0.4349imageNACIN1;AIFM1;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184PSME2T_cells_CD4_memory_activatedGSVA_HALLMARK_COMPLEMENT
ENSG00000197429.9,IPP
BLCAEAGIRENSG00000077454.11chr7100574010:100574356:100575704:100575782-0.42861.7003e-141.8996e-19-0.4302imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;RBM47;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.54357.9980e-265.1714e-26-0.4941imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000197429.9,IPP
BLCAEAGIRENSG00000139193.3chr126450172:6450630:6450894:6451014-0.41471.9349e-142.9191e-20-0.4439imageNADAR;DGCR8;ELAVL1;FUS;HNRNPA1;HNRNPC;HNRNPL;IGF2BP3;SRSF1;U2AF2CD27T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000197429.9,IPP
BLCAEAGIRENSG00000139193.3chr126450172:6450352:6450540:6450630-0.41592.1586e-144.6427e-18-0.4191imageNADAR;DGCR8;ELAVL1;FUS;HNRNPA1;HNRNPC;HNRNPL;IGF2BP3;SRSF1;U2AF2CD27T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr1:45694852-45700501:-
BLCAEERIRENSG00000076928.13chr1941897314:41898113:41898441:41898587-0.48521.6355e-224.4908e-26-0.5153imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION

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5. Enriched editing regions and immune infiltration for IPP


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:45694852-45700501:-ACCEERB_cells_memory9.5539e-030.2917image
ENSG00000197429.9,IPPACCEAGB_cells_memory9.5539e-030.2917image
chr1:45694852-45700501:-BLCAEERT_cells_CD4_memory_activated7.8323e-210.4448image
ENSG00000197429.9,IPPBLCAEAGT_cells_CD4_memory_activated7.8323e-210.4448image
chr1:45694852-45700501:-BRCAEERMacrophages_M13.3238e-070.1544image
ENSG00000197429.9,IPPBRCAEAGMacrophages_M15.3728e-080.1644image
chr1:45694852-45700501:-CESCEERT_cells_CD4_memory_activated1.9171e-030.1776image
ENSG00000197429.9,IPPCESCEAGT_cells_CD4_memory_activated1.9171e-030.1776image
chr1:45694852-45700501:-CHOLEERT_cells_follicular_helper2.2700e-030.4992image
ENSG00000197429.9,IPPCHOLEAGT_cells_follicular_helper2.2700e-030.4992image
chr1:45694852-45700501:-COADEERNeutrophils3.8549e-050.2473image
ENSG00000197429.9,IPPCOADEAGNeutrophils4.4843e-050.2452image
chr1:45694852-45700501:-DLBCEERNeutrophils2.0689e-020.3331image
ENSG00000197429.9,IPPDLBCEAGNeutrophils2.0689e-020.3331image
chr1:45694852-45700501:-ESCAEERMacrophages_M22.6607e-030.2360image
ENSG00000197429.9,IPPESCAEAGMacrophages_M22.6261e-030.2363image
chr1:45694852-45700501:-GBMEERMonocytes6.8500e-040.2609image
ENSG00000197429.9,IPPGBMEAGMonocytes6.8500e-040.2609image
chr1:45694852-45700501:-HNSCEERMacrophages_M12.1430e-070.2333image
ENSG00000197429.9,IPPHNSCEAGMacrophages_M12.3205e-070.2327image
chr1:45694852-45700501:-KIRCEERT_cells_regulatory_(Tregs)1.1424e-03-0.1654image
ENSG00000197429.9,IPPKIRCEAGT_cells_regulatory_(Tregs)1.3160e-03-0.1634image
chr1:45694852-45700501:-KIRPEERMacrophages_M11.5288e-060.2803image
ENSG00000197429.9,IPPKIRPEAGMacrophages_M11.5288e-060.2803image
chr1:45694852-45700501:-LGGEERT_cells_CD4_memory_resting4.0350e-03-0.1248image
ENSG00000197429.9,IPPLGGEAGT_cells_CD4_memory_resting4.0350e-03-0.1248image
chr1:45694852-45700501:-LIHCEERMacrophages_M02.1996e-03-0.1596image
ENSG00000197429.9,IPPLIHCEAGMacrophages_M02.1996e-03-0.1596image
chr1:45694852-45700501:-LUADEERT_cells_CD4_memory_activated3.3951e-040.1591image
ENSG00000197429.9,IPPLUADEAGT_cells_CD4_memory_activated3.5564e-040.1586image
chr1:45694852-45700501:-LUSCEERT_cells_CD4_memory_activated6.4651e-070.2237image
ENSG00000197429.9,IPPLUSCEAGT_cells_CD4_memory_activated6.4602e-070.2237image
chr1:45694852-45700501:-MESOEERT_cells_CD4_memory_activated2.0389e-040.4014image
ENSG00000197429.9,IPPMESOEAGT_cells_CD4_memory_activated2.0389e-040.4014image
chr1:45694852-45700501:-OVEERT_cells_CD86.3466e-080.3105image
ENSG00000197429.9,IPPOVEAGT_cells_CD86.2156e-080.3107image
chr1:45694852-45700501:-PAADEERT_cells_CD87.8017e-03-0.1994image
ENSG00000197429.9,IPPPAADEAGT_cells_CD87.8017e-03-0.1994image
chr1:45694852-45700501:-PCPGEERPlasma_cells3.2441e-030.2177image
ENSG00000197429.9,IPPPCPGEAGPlasma_cells3.2441e-030.2177image
chr1:45694852-45700501:-PRADEERPlasma_cells1.9580e-04-0.1660image
ENSG00000197429.9,IPPPRADEAGPlasma_cells1.9580e-04-0.1660image
chr1:45694852-45700501:-SARCEERNK_cells_resting6.4895e-03-0.1701image
ENSG00000197429.9,IPPSARCEAGNK_cells_resting6.4895e-03-0.1701image
chr1:45694852-45700501:-SKCMEERT_cells_CD81.8762e-090.2772image
ENSG00000197429.9,IPPSKCMEAGT_cells_CD81.8762e-090.2772image
chr1:45694852-45700501:-STADEEREosinophils4.3398e-04-0.1840image
ENSG00000197429.9,IPPSTADEAGEosinophils4.2955e-04-0.1841image
chr1:45694852-45700501:-TGCTEERT_cells_CD4_memory_activated4.9373e-050.3819image
ENSG00000197429.9,IPPTGCTEAGT_cells_CD4_memory_activated4.9373e-050.3819image
chr1:45694852-45700501:-THCAEERT_cells_CD4_memory_activated1.7904e-080.2475image
ENSG00000197429.9,IPPTHCAEAGT_cells_CD4_memory_activated1.7904e-080.2475image
chr1:45694852-45700501:-THYMEERMacrophages_M11.2535e-080.4946image
ENSG00000197429.9,IPPTHYMEAGMacrophages_M11.2535e-080.4946image
chr1:45694852-45700501:-UCECEERMacrophages_M11.3989e-020.1866image
ENSG00000197429.9,IPPUCECEAGMacrophages_M11.5721e-020.1834image
chr1:45694852-45700501:-UCSEERT_cells_CD4_memory_activated1.0493e-030.4264image
ENSG00000197429.9,IPPUCSEAGT_cells_CD4_memory_activated1.0493e-030.4264image
chr1:45694852-45700501:-UVMEERPlasma_cells2.8656e-020.2826image
ENSG00000197429.9,IPPUVMEAGPlasma_cells2.8656e-020.2826image


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6. Enriched editing regions and immune gene sets for IPP


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr1:45694852-45700501:-BLCAEER2.3343e-04image4.0696e-150.3791image
ENSG00000197429.9,IPPBLCAEAG2.3343e-04image4.0696e-150.3791image
chr1:45694852-45700501:-BRCAEER1.6698e-02image2.1137e-020.0701image
ENSG00000197429.9,IPPBRCAEAG1.8309e-02image1.7298e-020.0724image
chr1:45694852-45700501:-KIRPEER1.6956e-02image5.2797e-030.1648image
ENSG00000197429.9,IPPKIRPEAG1.6956e-02image5.2797e-030.1648image
chr1:45694852-45700501:-LUSCEER4.0423e-03image1.5131e-040.1712image
ENSG00000197429.9,IPPLUSCEAG4.0486e-03image1.5212e-040.1712image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000197429.9,IPPBLCAEAG3.0996e-090.29085.4832e-060.22506.5880e-070.24568.7689e-130.3473image
chr1:45694852-45700501:-BLCAEER3.0996e-090.29085.4832e-060.22506.5880e-070.24568.7689e-130.3473image
ENSG00000197429.9,IPPBRCAEAG7.8806e-100.18552.4514e-090.18012.3939e-030.09221.2937e-050.1322image
chr1:45694852-45700501:-BRCAEER1.2418e-090.18335.4216e-090.17622.7190e-030.09113.0074e-050.1265image
ENSG00000197429.9,IPPHNSCEAG1.7725e-020.10795.3398e-04-0.15701.2285e-030.14663.2874e-090.2651image
chr1:45694852-45700501:-HNSCEER1.7465e-020.10815.7724e-04-0.15611.1850e-030.14713.2414e-090.2652image
ENSG00000197429.9,IPPLGGEAG2.1469e-04-0.16021.4145e-03-0.13842.8877e-04-0.15707.8702e-030.1154image
chr1:45694852-45700501:-LGGEER2.1469e-04-0.16021.4145e-03-0.13842.8877e-04-0.15707.8702e-030.1154image
ENSG00000197429.9,IPPLIHCEAG1.2153e-04-0.19959.8370e-04-0.17156.2718e-05-0.20761.6085e-020.1258image
chr1:45694852-45700501:-LIHCEER1.2153e-04-0.19959.8370e-04-0.17156.2718e-05-0.20761.6085e-020.1258image
ENSG00000197429.9,IPPLUADEAG2.7822e-070.22664.3333e-060.20325.2520e-060.20153.7122e-140.3289image
chr1:45694852-45700501:-LUADEER2.4825e-070.22763.9244e-060.20414.9644e-060.20203.3344e-140.3295image
ENSG00000197429.9,IPPPAADEAG3.8239e-030.21642.9177e-030.22257.6938e-030.19977.1552e-050.2940image
chr1:45694852-45700501:-PAADEER3.8239e-030.21642.9177e-030.22257.6938e-030.19977.1552e-050.2940image
ENSG00000197429.9,IPPPRADEAG3.6754e-040.15894.1363e-050.18247.8134e-030.11902.3493e-040.1640image
chr1:45694852-45700501:-PRADEER3.6754e-040.15894.1363e-050.18247.8134e-030.11902.3493e-040.1640image
ENSG00000197429.9,IPPTHYMEAG4.4468e-02-0.18544.0212e-05-0.36852.4359e-030.27653.1103e-090.5120image
chr1:45694852-45700501:-THYMEER4.4468e-02-0.18544.0212e-05-0.36852.4359e-030.27653.1103e-090.5120image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000197429.9,IPPACCGSVA_HALLMARK_HYPOXIAEAG1.7862e-020.2676image
chr1:45694852-45700501:-ACCGSVA_HALLMARK_HYPOXIAEER1.7862e-020.2676image
chr1:45694852-45700501:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.0808e-360.5739image
ENSG00000197429.9,IPPBLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.0808e-360.5739image
chr1:45694852-45700501:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4226e-320.3490image
ENSG00000197429.9,IPPBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0709e-330.3561image
chr1:45694852-45700501:-CESCGSVA_HALLMARK_COMPLEMENTEER2.2672e-170.4613image
ENSG00000197429.9,IPPCESCGSVA_HALLMARK_COMPLEMENTEAG2.2672e-170.4613image
ENSG00000197429.9,IPPCHOLGSVA_HALLMARK_ANGIOGENESISEAG2.4937e-020.3786image
chr1:45694852-45700501:-CHOLGSVA_HALLMARK_ANGIOGENESISEER2.4937e-020.3786image
ENSG00000197429.9,IPPCOADGSVA_HALLMARK_PEROXISOMEEAG7.5687e-07-0.2951image
chr1:45694852-45700501:-COADGSVA_HALLMARK_PEROXISOMEEER1.2958e-06-0.2891image
ENSG00000197429.9,IPPDLBCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG3.7693e-020.3009image
chr1:45694852-45700501:-DLBCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER3.7693e-020.3009image
ENSG00000197429.9,IPPESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.0433e-030.2261image
chr1:45694852-45700501:-ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.3546e-030.2243image
chr1:45694852-45700501:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.1282e-080.4100image
ENSG00000197429.9,IPPGBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.1282e-080.4100image
ENSG00000197429.9,IPPHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2637e-250.4514image
chr1:45694852-45700501:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1191e-250.4519image
ENSG00000197429.9,IPPKIRCGSVA_HALLMARK_COMPLEMENTEAG1.2808e-080.2852image
chr1:45694852-45700501:-KIRCGSVA_HALLMARK_COMPLEMENTEER1.9204e-080.2818image
chr1:45694852-45700501:-KIRPGSVA_HALLMARK_COAGULATIONEER8.8972e-060.2598image
ENSG00000197429.9,IPPKIRPGSVA_HALLMARK_COAGULATIONEAG8.8972e-060.2598image
ENSG00000197429.9,IPPLGGGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.3204e-080.2439image
chr1:45694852-45700501:-LGGGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.3204e-080.2439image
ENSG00000197429.9,IPPLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.8959e-080.2824image
chr1:45694852-45700501:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.8959e-080.2824image
chr1:45694852-45700501:-LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.4400e-140.3339image
ENSG00000197429.9,IPPLUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.6375e-140.3333image
ENSG00000197429.9,IPPLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3819e-140.3338image
chr1:45694852-45700501:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.3535e-140.3338image
ENSG00000197429.9,IPPMESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG4.5959e-050.4366image
chr1:45694852-45700501:-MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.5959e-050.4366image
ENSG00000197429.9,IPPOVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5567e-070.2966image
chr1:45694852-45700501:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.3788e-070.2973image
chr1:45694852-45700501:-PAADGSVA_HALLMARK_P53_PATHWAYEER1.4896e-060.3525image
ENSG00000197429.9,IPPPAADGSVA_HALLMARK_P53_PATHWAYEAG1.4896e-060.3525image
ENSG00000197429.9,IPPPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2969e-040.2807image
chr1:45694852-45700501:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2969e-040.2807image
ENSG00000197429.9,IPPPRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.5174e-160.3518image
chr1:45694852-45700501:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5174e-160.3518image
ENSG00000197429.9,IPPREADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.6101e-060.4411image
chr1:45694852-45700501:-READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.6101e-060.4411image
chr1:45694852-45700501:-SARCGSVA_HALLMARK_COMPLEMENTEER5.7923e-080.3317image
ENSG00000197429.9,IPPSARCGSVA_HALLMARK_COMPLEMENTEAG5.7923e-080.3317image
chr1:45694852-45700501:-SKCMGSVA_HALLMARK_UV_RESPONSE_UPEER1.7304e-100.2938image
ENSG00000197429.9,IPPSKCMGSVA_HALLMARK_UV_RESPONSE_UPEAG1.7304e-100.2938image
ENSG00000197429.9,IPPSTADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8840e-120.3562image
chr1:45694852-45700501:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1748e-120.3555image
chr1:45694852-45700501:-TGCTGSVA_HALLMARK_MYC_TARGETS_V2EER3.1804e-070.4704image
ENSG00000197429.9,IPPTGCTGSVA_HALLMARK_MYC_TARGETS_V2EAG3.1804e-070.4704image
ENSG00000197429.9,IPPTHCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG5.2887e-220.4114image
chr1:45694852-45700501:-THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER5.2887e-220.4114image
ENSG00000197429.9,IPPTHYMGSVA_HALLMARK_HYPOXIAEAG3.1103e-090.5120image
chr1:45694852-45700501:-THYMGSVA_HALLMARK_HYPOXIAEER3.1103e-090.5120image
ENSG00000197429.9,IPPUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3361e-080.4153image
chr1:45694852-45700501:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1841e-080.4167image
ENSG00000197429.9,IPPUCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0294e-030.4038image
chr1:45694852-45700501:-UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0294e-030.4038image
ENSG00000197429.9,IPPUVMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.2336e-04-0.4487image
chr1:45694852-45700501:-UVMGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2336e-04-0.4487image


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7. Enriched editing regions and drugs for IPP


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000197429.9,IPPACCBMS.536924EAG1.9506e-020.2640image
chr1:45694852-45700501:-ACCBMS.536924EER1.9506e-020.2640image
ENSG00000197429.9,IPPBLCAKU.55933EAG4.4450e-23-0.4672image
chr1:45694852-45700501:-BLCAKU.55933EER4.4450e-23-0.4672image
chr1:45694852-45700501:-BRCACGP.082996EER1.0917e-10-0.1946image
ENSG00000197429.9,IPPBRCACGP.082996EAG4.1274e-11-0.1988image
ENSG00000197429.9,IPPCESCCI.1040EAG3.6951e-12-0.3852image
chr1:45694852-45700501:-CESCCI.1040EER3.6951e-12-0.3852image
chr1:45694852-45700501:-CHOLCisplatinEER3.8720e-020.3510image
ENSG00000197429.9,IPPCHOLCisplatinEAG3.8720e-020.3510image
ENSG00000197429.9,IPPCOADGefitinibEAG6.4670e-08-0.3211image
chr1:45694852-45700501:-COADGefitinibEER7.9683e-08-0.3190image
chr1:45694852-45700501:-DLBCCytarabineEER2.1519e-030.4323image
ENSG00000197429.9,IPPDLBCCytarabineEAG2.1519e-030.4323image
ENSG00000197429.9,IPPESCACGP.60474EAG2.6419e-04-0.2846image
chr1:45694852-45700501:-ESCACGP.60474EER2.6272e-04-0.2848image
ENSG00000197429.9,IPPGBMBIBW2992EAG2.7257e-07-0.3864image
chr1:45694852-45700501:-GBMBIBW2992EER2.7257e-07-0.3864image
chr1:45694852-45700501:-HNSCCI.1040EER4.8725e-16-0.3579image
ENSG00000197429.9,IPPHNSCCI.1040EAG4.4890e-16-0.3583image
ENSG00000197429.9,IPPKICHABT.263EAG2.7601e-050.4985image
chr1:45694852-45700501:-KICHABT.263EER2.7601e-050.4985image
chr1:45694852-45700501:-KIRCCI.1040EER3.3368e-11-0.3299image
ENSG00000197429.9,IPPKIRCCI.1040EAG1.5339e-11-0.3353image
chr1:45694852-45700501:-KIRPDMOGEER2.7415e-10-0.3627image
ENSG00000197429.9,IPPKIRPDMOGEAG2.7415e-10-0.3627image
ENSG00000197429.9,IPPLGGBMS.708163EAG1.0521e-11-0.2899image
chr1:45694852-45700501:-LGGBMS.708163EER1.0521e-11-0.2899image
ENSG00000197429.9,IPPLIHCErlotinibEAG1.8343e-07-0.2932image
chr1:45694852-45700501:-LIHCErlotinibEER1.8343e-07-0.2932image
chr1:45694852-45700501:-LUADAZD.0530EER1.7396e-08-0.2480image
ENSG00000197429.9,IPPLUADAZD.0530EAG1.7661e-08-0.2479image
chr1:45694852-45700501:-LUSCCI.1040EER3.2533e-08-0.2477image
ENSG00000197429.9,IPPLUSCCI.1040EAG3.3129e-08-0.2476image
chr1:45694852-45700501:-MESOJNJ.26854165EER4.7592e-05-0.4359image
ENSG00000197429.9,IPPMESOJNJ.26854165EAG4.7592e-05-0.4359image
ENSG00000197429.9,IPPOVBMS.536924EAG1.3630e-07-0.3030image
chr1:45694852-45700501:-OVBMS.536924EER1.2875e-07-0.3035image
ENSG00000197429.9,IPPPAADBIBW2992EAG3.4766e-03-0.2185image
chr1:45694852-45700501:-PAADBIBW2992EER3.4766e-03-0.2185image
chr1:45694852-45700501:-PCPGDMOGEER1.6973e-04-0.2760image
ENSG00000197429.9,IPPPCPGDMOGEAG1.6973e-04-0.2760image
chr1:45694852-45700501:-PRADBortezomibEER1.8314e-08-0.2486image
ENSG00000197429.9,IPPPRADBortezomibEAG1.8314e-08-0.2486image
ENSG00000197429.9,IPPREADCGP.60474EAG4.1534e-03-0.2946image
chr1:45694852-45700501:-READCGP.60474EER4.1534e-03-0.2946image
ENSG00000197429.9,IPPSARCAG.014699EAG3.6067e-060.2855image
chr1:45694852-45700501:-SARCAG.014699EER3.6067e-060.2855image
ENSG00000197429.9,IPPSKCMJNK.9LEAG1.8215e-08-0.2603image
chr1:45694852-45700501:-SKCMJNK.9LEER1.8215e-08-0.2603image
ENSG00000197429.9,IPPSTADAZ628EAG5.8171e-07-0.2590image
chr1:45694852-45700501:-STADAZ628EER6.4436e-07-0.2581image
chr1:45694852-45700501:-TGCTGemcitabineEER2.7276e-07-0.4727image
ENSG00000197429.9,IPPTGCTGemcitabineEAG2.7276e-07-0.4727image
ENSG00000197429.9,IPPTHCACI.1040EAG1.0382e-27-0.4596image
chr1:45694852-45700501:-THCACI.1040EER1.0382e-27-0.4596image
ENSG00000197429.9,IPPTHYMDoxorubicinEAG2.6141e-110.5651image
chr1:45694852-45700501:-THYMDoxorubicinEER2.6141e-110.5651image
ENSG00000197429.9,IPPUCECABT.888EAG3.0550e-05-0.3113image
chr1:45694852-45700501:-UCECABT.888EER3.5913e-05-0.3087image
chr1:45694852-45700501:-UCSABT.888EER1.1818e-03-0.4224image
ENSG00000197429.9,IPPUCSABT.888EAG1.1818e-03-0.4224image
chr1:45694852-45700501:-UVMGNF.2EER9.4178e-04-0.4162image
ENSG00000197429.9,IPPUVMGNF.2EAG9.4178e-04-0.4162image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType