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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FOXK2 (ImmuneEditome ID:3607)

1. Gene summary of enriched editing regions for FOXK2

check button Gene summary
Gene informationGene symbol

FOXK2

Gene ID

3607

GeneSynonymsILF|ILF-1|ILF1|nGTBP
GeneCytomap

17q25.3

GeneTypeprotein-coding
GeneDescriptionforkhead box protein K2|FOXK1|G/T-mismatch specific binding protein|cellular transcription factor ILF-1|interleukin enhancer-binding factor 1
GeneModificationdate20230409
UniprotIDQ01167;E9PM37;E9PPI7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:82530326-82530485:+ENST00000527313.5ENSG00000141568.18FOXK2ncRNA_intronicAluSpchr17:82530326-82530485:+.alignment
chr17:82530326-82530485:+ENST00000570585.1ENSG00000141568.18FOXK2ncRNA_intronicAluSpchr17:82530326-82530485:+.alignment
chr17:82533876-82535029:+ENST00000527313.5ENSG00000141568.18FOXK2ncRNA_intronicAluYg6,AluSx1,AluJbchr17:82533876-82535029:+.alignment
chr17:82533876-82535029:+ENST00000570585.1ENSG00000141568.18FOXK2ncRNA_intronicAluYg6,AluSx1,AluJbchr17:82533876-82535029:+.alignment
chr17:82537463-82537868:+ENST00000527313.5ENSG00000141568.18FOXK2ncRNA_intronicAluSx3,AluScchr17:82537463-82537868:+.alignment
chr17:82537463-82537868:+ENST00000570585.1ENSG00000141568.18FOXK2ncRNA_intronicAluSx3,AluScchr17:82537463-82537868:+.alignment
chr17:82594283-82595614:+ENST00000529652.1ENSG00000141568.18FOXK2ncRNA_intronicAluJb,AluJo,AluYchr17:82594283-82595614:+.alignment
chr17:82594283-82595614:+ENST00000571989.1ENSG00000141568.18FOXK2ncRNA_intronicAluJb,AluJo,AluYchr17:82594283-82595614:+.alignment


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2. Tumor-specific enriched editing regions for FOXK2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000141568.18,FOXK2KIRPPathEAG1.7702e-023.2477e-020.4470image
chr17:82537463-82537868:+OVCliEER1.7307e-021.7307e-020.4811image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:82594283-82595614:+LUSCEER2.9471e-022.0146e-021.4450e-02image
ENSG00000141568.18,FOXK2LUSCEAG6.1179e-036.6304e-031.0013e-02image

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3. Enriched editing regions and immune related genes for FOXK2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for FOXK2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for FOXK2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:82594283-82595614:+BLCAEERNK_cells_resting2.0242e-020.4807image
ENSG00000141568.18,FOXK2BLCAEAGT_cells_CD4_naive1.8881e-030.5282image
chr17:82594283-82595614:+CESCEERNeutrophils1.6340e-020.4848image
ENSG00000141568.18,FOXK2CESCEAGMast_cells_activated1.9618e-020.3873image
chr17:82594283-82595614:+ESCAEERNeutrophils1.8733e-020.2576image
ENSG00000141568.18,FOXK2ESCAEAGPlasma_cells1.0189e-020.2387image
chr17:82594283-82595614:+KIRPEERT_cells_CD4_memory_activated4.1479e-030.5986image
ENSG00000141568.18,FOXK2KIRPEAGNK_cells_resting4.6469e-030.5575image
ENSG00000141568.18,FOXK2LAMLEAGT_cells_gamma_delta4.0481e-020.2610image
ENSG00000141568.18,FOXK2LUADEAGT_cells_CD81.3689e-02-0.2799image
chr17:82594283-82595614:+LUSCEERT_cells_CD4_memory_resting9.3978e-030.3569image
ENSG00000141568.18,FOXK2LUSCEAGB_cells_memory2.9837e-020.2636image
chr17:82594283-82595614:+OVEERT_cells_CD4_memory_resting3.6988e-020.2873image
ENSG00000141568.18,FOXK2OVEAGT_cells_CD4_memory_resting7.8470e-030.2989image
ENSG00000141568.18,FOXK2PRADEAGB_cells_memory7.7064e-040.6393image
ENSG00000141568.18,FOXK2SKCMEAGT_cells_gamma_delta3.9417e-040.7016image
chr17:82533876-82535029:+STADEERMonocytes4.0552e-02-0.4209image
chr17:82537463-82537868:+STADEERMacrophages_M02.4810e-02-0.4477image
ENSG00000141568.18,FOXK2STADEAGT_cells_CD84.1449e-030.2208image


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6. Enriched editing regions and immune gene sets for FOXK2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000141568.18,FOXK2BLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.3469e-02-0.3996image
chr17:82594283-82595614:+BRCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.2399e-020.1855image
ENSG00000141568.18,FOXK2BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.5716e-020.1377image
chr17:82594283-82595614:+CESCGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.9713e-02-0.4441image
ENSG00000141568.18,FOXK2CESCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.9814e-02-0.3294image
ENSG00000141568.18,FOXK2ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.5580e-020.2251image
ENSG00000141568.18,FOXK2KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7009e-02-0.4822image
chr17:82594283-82595614:+LUSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER9.2972e-040.4457image
ENSG00000141568.18,FOXK2LUSCGSVA_HALLMARK_MYC_TARGETS_V2EAG3.7445e-03-0.3470image
chr17:82594283-82595614:+OVGSVA_HALLMARK_ANGIOGENESISEER1.6259e-020.3287image
ENSG00000141568.18,FOXK2SKCMGSVA_HALLMARK_MYC_TARGETS_V2EAG2.1267e-020.4991image
chr17:82594283-82595614:+STADGSVA_HALLMARK_P53_PATHWAYEER4.5768e-030.2827image
chr17:82537463-82537868:+STADGSVA_HALLMARK_UV_RESPONSE_DNEER3.3448e-030.5636image
chr17:82533876-82535029:+STADGSVA_HALLMARK_KRAS_SIGNALING_UPEER4.9981e-02-0.4044image
ENSG00000141568.18,FOXK2STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.1558e-040.2701image


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7. Enriched editing regions and drugs for FOXK2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr17:82594283-82595614:+BLCABMS.754807EER2.9282e-04-0.6871image
ENSG00000141568.18,FOXK2BLCABMS.754807EAG3.2798e-02-0.3782image
ENSG00000141568.18,FOXK2BRCAAKT.inhibitor.VIIIEAG4.6498e-02-0.1372image
chr17:82594283-82595614:+CESCFH535EER8.9983e-03-0.5213image
ENSG00000141568.18,FOXK2CESCFH535EAG2.9773e-02-0.3626image
chr17:82594283-82595614:+ESCAGefitinibEER1.9034e-02-0.2585image
ENSG00000141568.18,FOXK2ESCACI.1040EAG1.1912e-03-0.2986image
ENSG00000141568.18,FOXK2KIRPBIBW2992EAG1.2064e-030.6208image
chr17:82594283-82595614:+KIRPLapatinibEER1.3572e-030.6521image
ENSG00000141568.18,FOXK2LAMLCGP.60474EAG1.9323e-020.2964image
ENSG00000141568.18,FOXK2LGGBMS.509744EAG1.8892e-020.4332image
chr17:82594283-82595614:+LGGBMS.509744EER4.1050e-020.3957image
ENSG00000141568.18,FOXK2LUADBicalutamideEAG2.0943e-020.2628image
chr17:82594283-82595614:+LUADBicalutamideEER1.0743e-020.3121image
chr17:82594283-82595614:+LUSCAZ628EER8.1338e-03-0.3632image
ENSG00000141568.18,FOXK2LUSCGDC0941EAG3.6001e-03-0.3484image
chr17:82594283-82595614:+OVCamptothecinEER6.4914e-030.3694image
ENSG00000141568.18,FOXK2OVBX.795EAG3.1523e-020.2437image
ENSG00000141568.18,FOXK2PRADBAY.61.3606EAG2.2665e-020.4631image
ENSG00000141568.18,FOXK2SKCMBAY.61.3606EAG2.8220e-04-0.7134image
chr17:82594283-82595614:+STADBMS.509744EER4.0327e-02-0.2065image
chr17:82537463-82537868:+STADAKT.inhibitor.VIIIEER2.3175e-02-0.4524image
chr17:82533876-82535029:+STADAICAREER6.6359e-030.5385image
ENSG00000141568.18,FOXK2STADCI.1040EAG1.7305e-02-0.1840image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType