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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RILPL1 (ImmuneEditome ID:353116)

1. Gene summary of enriched editing regions for RILPL1

check button Gene summary
Gene informationGene symbol

RILPL1

Gene ID

353116

GeneSynonymsGOSPEL|OPDM4|RLP1
GeneCytomap

12q24.31

GeneTypeprotein-coding
GeneDescriptionRILP-like protein 1|GAPDH competitor of SIAH protein enhances life
GeneModificationdate20230404
UniprotIDQ5EBL4;A0A1B0GVV3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:123520293-123520562:-ENST00000376874.7ENSG00000188026.10RILPL1intronic(AAAC)n,AluSxchr12:123520293-123520562:-.alignment
chr12:123521820-123522888:-ENST00000376874.7ENSG00000188026.10RILPL1intronicL2a,AluJr,L2b,AluSx1chr12:123521820-123522888:-.alignment
chr12:123525001-123528168:-ENST00000376874.7ENSG00000188026.10RILPL1intronicAluSz6,AluJo,AluJb,(CAAA)n,MLT1D,AluSx1,(AAAAT)n,MIR,L1MB7chr12:123525001-123528168:-.alignment
chr12:123529360-123530262:-ENST00000376874.7ENSG00000188026.10RILPL1intronicMER33,L2a,AluJo,AluSz6chr12:123529360-123530262:-.alignment


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2. Tumor-specific enriched editing regions for RILPL1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000188026.10,RILPL1BRCAEAG3.7755e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000188026.10,RILPL1COADPathEAG3.6510e-029.7372e-030.3234image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for RILPL1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for RILPL1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000188026.10,RILPL1
ESCAEAGA3ENSG00000138382.9chr2169819560:169819643:169812456:169812524:169812456:1698125060.28001.1956e-027.2566e-070.4850imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NA
ENSG00000188026.10,RILPL1
ESCAEAGIRENSG00000148399.7chr9137574751:137574843:137576079:1375761670.36604.2754e-023.3355e-060.4007imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NANeutrophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000188026.10,RILPL1
UVMEAGMEXENSG00000129657.10chr1777213917:77215753:77215792:77215844:77215909:77215935:77216023:77216036-0.47003.8080e-022.6216e-04-0.4290imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NA
ENSG00000188026.10,RILPL1
UVMEAGMEXENSG00000129657.10chr1777215740:77215753:77215792:77215818:77215818:77215935:77216023:77216036-0.45184.9184e-022.9188e-04-0.4290imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NA

More results



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5. Enriched editing regions and immune infiltration for RILPL1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000188026.10,RILPL1ACCEAGMonocytes1.4523e-020.5026image
chr12:123520293-123520562:-BRCAEERT_cells_regulatory_(Tregs)2.3660e-020.3229image
chr12:123521820-123522888:-BRCAEERDendritic_cells_activated2.7382e-02-0.3677image
ENSG00000188026.10,RILPL1BRCAEAGNeutrophils4.9701e-020.0879image
ENSG00000188026.10,RILPL1CHOLEAGT_cells_gamma_delta1.1868e-020.5152image
ENSG00000188026.10,RILPL1COADEAGDendritic_cells_activated1.2951e-020.3361image
chr12:123521820-123522888:-ESCAEERNeutrophils2.3212e-020.3206image
ENSG00000188026.10,RILPL1ESCAEAGT_cells_CD84.6228e-030.2498image
ENSG00000188026.10,RILPL1HNSCEAGPlasma_cells2.2508e-030.2027image
chr12:123521820-123522888:-KIRCEERB_cells_memory4.0233e-030.4346image
ENSG00000188026.10,RILPL1KIRCEAGMacrophages_M04.1748e-030.1903image
chr12:123521820-123522888:-KIRPEERMast_cells_resting1.4446e-020.4654image
ENSG00000188026.10,RILPL1KIRPEAGT_cells_CD4_memory_activated4.2598e-020.1414image
ENSG00000188026.10,RILPL1LGGEAGB_cells_naive4.0305e-020.2406image
chr12:123521820-123522888:-LUSCEERT_cells_regulatory_(Tregs)1.9315e-020.3936image
ENSG00000188026.10,RILPL1LUSCEAGT_cells_follicular_helper8.8647e-03-0.1448image
ENSG00000188026.10,RILPL1MESOEAGNeutrophils1.7765e-020.4164image
ENSG00000188026.10,RILPL1PRADEAGEosinophils1.6320e-020.1509image
ENSG00000188026.10,RILPL1READEAGT_cells_CD4_memory_activated3.6836e-020.4474image
ENSG00000188026.10,RILPL1SKCMEAGT_cells_CD81.2657e-020.1315image
ENSG00000188026.10,RILPL1STADEAGPlasma_cells1.2365e-040.2637image
ENSG00000188026.10,RILPL1TGCTEAGMacrophages_M21.4172e-020.2458image
chr12:123521820-123522888:-THCAEERT_cells_CD4_memory_activated1.2571e-040.7272image
ENSG00000188026.10,RILPL1UCSEAGDendritic_cells_activated7.7470e-040.5220image


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6. Enriched editing regions and immune gene sets for RILPL1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000188026.10,RILPL1BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG6.8561e-040.2204image
chr12:123520293-123520562:-BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4419e-040.5167image
ENSG00000188026.10,RILPL1BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.0887e-030.1458image
chr12:123521820-123522888:-BRCAGSVA_HALLMARK_MYOGENESISEER6.3070e-030.4467image
ENSG00000188026.10,RILPL1CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0513e-020.2134image
ENSG00000188026.10,RILPL1CHOLGSVA_HALLMARK_SPERMATOGENESISEAG1.4172e-020.5041image
ENSG00000188026.10,RILPL1COADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.3692e-020.3075image
ENSG00000188026.10,RILPL1ESCAGSVA_HALLMARK_E2F_TARGETSEAG9.4588e-03-0.2295image
ENSG00000188026.10,RILPL1HNSCGSVA_HALLMARK_G2M_CHECKPOINTEAG2.9242e-020.1454image
ENSG00000188026.10,RILPL1KICHGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.5899e-02-0.3509image
ENSG00000188026.10,RILPL1KIRCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG6.3479e-030.1814image
ENSG00000188026.10,RILPL1KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7892e-02-0.1649image
ENSG00000188026.10,RILPL1LGGGSVA_HALLMARK_UV_RESPONSE_UPEAG2.1332e-020.2691image
ENSG00000188026.10,RILPL1LIHCGSVA_HALLMARK_HEME_METABOLISMEAG7.4805e-03-0.2916image
chr12:123521820-123522888:-LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER9.5381e-030.5396image
ENSG00000188026.10,RILPL1LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.2245e-020.1726image
chr12:123521820-123522888:-LUSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.1987e-030.4720image
ENSG00000188026.10,RILPL1LUSCGSVA_HALLMARK_APOPTOSISEAG5.1948e-040.1912image
ENSG00000188026.10,RILPL1MESOGSVA_HALLMARK_GLYCOLYSISEAG8.1191e-030.4597image
ENSG00000188026.10,RILPL1OVGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.0081e-030.1933image
ENSG00000188026.10,RILPL1PAADGSVA_HALLMARK_P53_PATHWAYEAG4.8635e-02-0.4066image
ENSG00000188026.10,RILPL1PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.1497e-02-0.1445image
ENSG00000188026.10,RILPL1READGSVA_HALLMARK_PEROXISOMEEAG1.4710e-040.7223image
ENSG00000188026.10,RILPL1SARCGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.3610e-030.3194image
ENSG00000188026.10,RILPL1SKCMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.7492e-060.2413image
ENSG00000188026.10,RILPL1STADGSVA_HALLMARK_MYC_TARGETS_V2EAG9.0942e-04-0.2289image
ENSG00000188026.10,RILPL1TGCTGSVA_HALLMARK_COAGULATIONEAG3.9709e-070.4836image
ENSG00000188026.10,RILPL1THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.6130e-030.1758image
ENSG00000188026.10,RILPL1THYMGSVA_HALLMARK_MYC_TARGETS_V1EAG3.0394e-020.3128image
ENSG00000188026.10,RILPL1UCECGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.4575e-040.3414image
ENSG00000188026.10,RILPL1UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.3430e-030.3224image


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7. Enriched editing regions and drugs for RILPL1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000188026.10,RILPL1ACCGDC0941EAG2.2785e-03-0.6039image
ENSG00000188026.10,RILPL1BLCABicalutamideEAG9.7256e-03-0.1687image
ENSG00000188026.10,RILPL1BRCAA.770041EAG2.7969e-05-0.1866image
chr12:123521820-123522888:-BRCAGDC0941EER3.3161e-02-0.3559image
chr12:123520293-123520562:-BRCALFM.A13EER3.1685e-020.3074image
ENSG00000188026.10,RILPL1CESCCGP.082996EAG2.7695e-02-0.1841image
ENSG00000188026.10,RILPL1ESCACEP.701EAG2.1917e-030.2694image
ENSG00000188026.10,RILPL1HNSCAZD7762EAG1.2880e-020.1656image
ENSG00000188026.10,RILPL1KICHLFM.A13EAG7.0162e-03-0.4416image
ENSG00000188026.10,RILPL1KIRCGemcitabineEAG1.0949e-020.1693image
chr12:123521820-123522888:-KIRCEHT.1864EER9.2431e-030.3970image
ENSG00000188026.10,RILPL1KIRPBryostatin.1EAG3.1575e-03-0.2047image
chr12:123521820-123522888:-KIRPCamptothecinEER2.1643e-020.4400image
ENSG00000188026.10,RILPL1LGGDocetaxelEAG1.1716e-02-0.2936image
ENSG00000188026.10,RILPL1LIHCGDC.0449EAG3.7271e-02-0.2290image
chr12:123521820-123522888:-LUADGNF.2EER5.4612e-04-0.6765image
ENSG00000188026.10,RILPL1LUADAZD7762EAG6.8821e-03-0.1860image
chr12:123521820-123522888:-LUSCGDC0941EER3.8148e-04-0.5671image
ENSG00000188026.10,RILPL1LUSCA.770041EAG6.0925e-03-0.1516image
ENSG00000188026.10,RILPL1MESOJNK.9LEAG3.0846e-030.5067image
ENSG00000188026.10,RILPL1OVJNJ.26854165EAG9.8002e-040.2207image
ENSG00000188026.10,RILPL1PAADBMS.708163EAG2.5696e-030.5869image
ENSG00000188026.10,RILPL1PRADABT.888EAG7.7978e-030.1669image
ENSG00000188026.10,RILPL1READJNK.9LEAG5.4552e-030.5716image
ENSG00000188026.10,RILPL1SARCFH535EAG5.6149e-030.3108image
chr12:123521820-123522888:-SKCMCMKEER1.8079e-02-0.4599image
ENSG00000188026.10,RILPL1SKCMAZD.0530EAG2.5646e-05-0.2202image
chr12:123521820-123522888:-STADBI.D1870EER3.4343e-030.5092image
ENSG00000188026.10,RILPL1STADBI.D1870EAG6.7678e-040.2344image
ENSG00000188026.10,RILPL1TGCTAZD.0530EAG5.2905e-05-0.3947image
ENSG00000188026.10,RILPL1THCABMS.708163EAG3.5732e-05-0.2398image
chr12:123521820-123522888:-THCACI.1040EER1.4456e-02-0.5137image
ENSG00000188026.10,RILPL1THYMBI.2536EAG2.1978e-03-0.4315image
ENSG00000188026.10,RILPL1UCECAxitinibEAG1.0679e-030.3194image
ENSG00000188026.10,RILPL1UCSAP.24534EAG4.2870e-030.4530image
ENSG00000188026.10,RILPL1UVMGSK269962AEAG6.2661e-03-0.3283image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType