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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF429 (ImmuneEditome ID:353088)

1. Gene summary of enriched editing regions for ZNF429

check button Gene summary
Gene informationGene symbol

ZNF429

Gene ID

353088

GeneSynonyms-
GeneCytomap

19p12

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 429
GeneModificationdate20230518
UniprotIDQ86V71;M0QZ47
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:21506232-21506918:+ENST00000594022.1ENSG00000197013.8ZNF429ncRNA_intronicAluSp,AluSx1,MER57E3chr19:21506232-21506918:+.alignment
chr19:21506232-21506918:+ENST00000596126.1ENSG00000197013.8ZNF429ncRNA_intronicAluSp,AluSx1,MER57E3chr19:21506232-21506918:+.alignment
chr19:21506232-21506918:+ENST00000596237.4ENSG00000197013.8ZNF429ncRNA_intronicAluSp,AluSx1,MER57E3chr19:21506232-21506918:+.alignment
chr19:21506232-21506918:+ENST00000597556.1ENSG00000197013.8ZNF429ncRNA_intronicAluSp,AluSx1,MER57E3chr19:21506232-21506918:+.alignment
chr19:21506232-21506918:+ENST00000598747.1ENSG00000197013.8ZNF429ncRNA_intronicAluSp,AluSx1,MER57E3chr19:21506232-21506918:+.alignment
chr19:21530795-21531597:+ENST00000594022.1ENSG00000197013.8ZNF429ncRNA_intronicL1M3a,AluSx1,AluSq2chr19:21530795-21531597:+.alignment
chr19:21537967-21539700:+ENST00000358491.7ENSG00000197013.8ZNF429exonicAluSg,AluSz,AluYchr19:21537967-21539700:+.alignment
chr19:21537967-21539700:+ENST00000618549.1ENSG00000197013.8ZNF429exonicAluSg,AluSz,AluYchr19:21537967-21539700:+.alignment


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2. Tumor-specific enriched editing regions for ZNF429


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:21537967-21539700:+BRCAEER1.5974e-07image
ENSG00000197013.8,ZNF429BRCAEAG1.1286e-07image
chr19:21537967-21539700:+KIRCEER3.4643e-03image
ENSG00000197013.8,ZNF429KIRCEAG1.7335e-03image
ENSG00000197013.8,ZNF429KIRPEAG3.2518e-02image
chr19:21537967-21539700:+LUSCEER4.8805e-05image
ENSG00000197013.8,ZNF429LUSCEAG5.1276e-06image
chr19:21537967-21539700:+THCAEER1.6817e-03image
ENSG00000197013.8,ZNF429THCAEAG1.6395e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:21537967-21539700:+KIRCPathEER1.8661e-021.1028e-020.1196image
ENSG00000197013.8,ZNF429KIRCPathEAG1.6200e-025.4866e-030.1304image
ENSG00000197013.8,ZNF429KIRPCliEAG4.6972e-043.6055e-040.3204image
ENSG00000197013.8,ZNF429PAADPathEAG4.2459e-021.1209e-020.2662image
chr19:21537967-21539700:+THCAPathEER7.2310e-039.7334e-040.1565image
ENSG00000197013.8,ZNF429THCAPathEAG5.9639e-037.9054e-040.1587image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr19:21537967-21539700:+OVEER2.1102e-035.3714e-043.5060e+01image
ENSG00000197013.8,ZNF429OVEAG6.8895e-037.5360e-043.0002e+01image

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3. Enriched editing regions and immune related genes for ZNF429


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:21537967-21539700:+GBMEERENSG00000167232,ZNF91-0.42641.1804e-043.7659e-08-0.4430imageNNNAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:21537967-21539700:+GBMEERENSG00000186017,ZNF566-0.37481.1524e-038.0643e-07-0.4015imageNNNAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:21537967-21539700:+THYMEERENSG00000156587,UBE2L60.41947.9648e-044.0643e-080.5200imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000215012,C22orf29-0.40401.0881e-032.1842e-05-0.4147imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:21537967-21539700:+THYMEERENSG00000068079,IFI350.38771.8514e-032.0114e-090.5601imageNNIFI35Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000121858,TNFSF100.37473.4061e-031.6950e-050.4197imageNNTNFSF10T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000168394,TAP10.36674.2845e-031.5730e-090.5632imageNNTAP1Macrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000108771,DHX580.36324.3374e-031.9885e-050.4165imageNNDHX58Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000133106,EPSTI10.35824.5164e-034.2949e-080.5193imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000240065,PSMB90.35804.7286e-031.2742e-080.5361imageNNPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:21537967-21539700:+GBMEERENSG00000167232,ZNF91-0.42641.1804e-043.7659e-08-0.4430imageNNNAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:21537967-21539700:+GBMEERENSG00000186017,ZNF566-0.37481.1524e-038.0643e-07-0.4015imageNNNAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:21537967-21539700:+THYMEERENSG00000156587,UBE2L60.41947.9648e-044.0643e-080.5200imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000215012,C22orf29-0.40401.0881e-032.1842e-05-0.4147imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:21537967-21539700:+THYMEERENSG00000068079,IFI350.38771.8514e-032.0114e-090.5601imageNNIFI35Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000121858,TNFSF100.37473.4061e-031.6950e-050.4197imageNNTNFSF10T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000168394,TAP10.36674.2845e-031.5730e-090.5632imageNNTAP1Macrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000108771,DHX580.36324.3374e-031.9885e-050.4165imageNNDHX58Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000133106,EPSTI10.35824.5164e-034.2949e-080.5193imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:21537967-21539700:+THYMEERENSG00000240065,PSMB90.35804.7286e-031.2742e-080.5361imageNNPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION

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4. Enriched editing regions and immune related splicing for ZNF429


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:21537967-21539700:+
GBMEERMEXENSG00000129657.10chr1777216075:77216088:77216322:77216335:77216361:77216387:77216413:772168020.23503.9382e-021.7358e-050.4006imageNNNAGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:21537967-21539700:+
GBMEERESENSG00000130749.5chr1947064191:47067869:47069091:47069343:47071777:47072121-0.31511.1047e-025.2504e-07-0.4408imageNNNAT_cells_CD8GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:21537967-21539700:+
GBMEERA5ENSG00000077809.8chr774728785:74728896:74716893:74716950:74716893:747189410.39931.8871e-037.1925e-070.4044imageNNNAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:21537967-21539700:+
GBMEERMEXENSG00000129657.10chr1777216179:77216192:77216270:77216335:77216335:77216387:77216413:772168020.25842.5554e-021.1751e-050.4133imageNNNAGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000197013.8,ZNF429
GBMEAGMEXENSG00000129657.10chr1777215870:77215896:77215984:77216322:77216335:77216387:77216413:772168020.26982.7405e-022.2861e-060.4331imageNADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;PRPF8;PTBP1;PUM2;QKI;RBFOX2;RBM10;RBM22;RBM27;RBM6;RC3H1;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7BNADendritic_cells_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:21537967-21539700:+
GBMEERMEXENSG00000129657.10chr1777216179:77216192:77216270:77216335:77216361:77216387:77216413:772168020.25642.8678e-021.2986e-050.4096imageNNNAGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:21537967-21539700:+
GBMEERESENSG00000077809.8chr774716897:74716950:74718878:74718941:74728785:74728896-0.42965.5837e-042.7902e-08-0.4483imageNNNAMonocytesGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000197013.8,ZNF429
GBMEAGESENSG00000130749.5chr1947064191:47067869:47069091:47069343:47071777:47072121-0.29252.9800e-022.4453e-06-0.4166imageNADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;PRPF8;PTBP1;PUM2;QKI;RBFOX2;RBM10;RBM22;RBM27;RBM6;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2NAT_cells_CD8GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:21537967-21539700:+
GBMEERMEXENSG00000129657.10chr1777213917:77215870:77216049:77216335:77216348:77216387:77216413:772168020.23043.5888e-021.8978e-060.4456imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:21537967-21539700:+
THYMEERIRENSG00000130203.5chr1944908480:44908602:44909055:44909255-0.21882.6574e-029.7086e-06-0.4304imageNNAPOET_cells_gamma_deltaGSVA_HALLMARK_BILE_ACID_METABOLISM

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5. Enriched editing regions and immune infiltration for ZNF429


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:21537967-21539700:+ACCEERT_cells_regulatory_(Tregs)4.1576e-020.2836image
ENSG00000197013.8,ZNF429ACCEAGT_cells_regulatory_(Tregs)4.2086e-020.2830image
chr19:21537967-21539700:+BLCAEERT_cells_CD4_memory_activated4.6651e-040.2452image
ENSG00000197013.8,ZNF429BLCAEAGT_cells_CD4_memory_activated6.9125e-040.2374image
chr19:21537967-21539700:+BRCAEERT_cells_CD4_memory_activated5.3486e-040.1127image
ENSG00000197013.8,ZNF429BRCAEAGT_cells_CD4_memory_activated1.3926e-030.1037image
chr19:21537967-21539700:+CHOLEERMast_cells_activated1.7355e-020.5254image
ENSG00000197013.8,ZNF429CHOLEAGMast_cells_activated1.7355e-020.5254image
ENSG00000197013.8,ZNF429COADEAGDendritic_cells_activated1.0117e-030.3408image
ENSG00000197013.8,ZNF429DLBCEAGT_cells_CD85.0471e-030.5532image
ENSG00000197013.8,ZNF429ESCAEAGT_cells_CD4_memory_resting2.6456e-02-0.2753image
chr19:21537967-21539700:+GBMEERMacrophages_M02.5022e-03-0.2527image
ENSG00000197013.8,ZNF429GBMEAGMacrophages_M05.2408e-03-0.2331image
ENSG00000197013.8,ZNF429HNSCEAGDendritic_cells_activated1.1135e-020.3925image
chr19:21537967-21539700:+KIRCEERMast_cells_resting1.1058e-04-0.2125image
ENSG00000197013.8,ZNF429KIRCEAGMast_cells_resting2.0581e-04-0.2042image
ENSG00000197013.8,ZNF429KIRPEAGT_cells_gamma_delta1.8358e-030.2380image
ENSG00000197013.8,ZNF429LAMLEAGT_cells_follicular_helper1.6626e-02-0.4567image
chr19:21537967-21539700:+LIHCEERNK_cells_resting3.6509e-040.2657image
ENSG00000197013.8,ZNF429LIHCEAGNK_cells_resting3.9069e-040.2637image
chr19:21537967-21539700:+LUADEERT_cells_CD4_memory_activated8.3501e-060.2429image
ENSG00000197013.8,ZNF429LUADEAGT_cells_CD4_memory_activated1.7466e-050.2333image
chr19:21537967-21539700:+LUSCEERT_cells_CD4_memory_activated2.4982e-030.2671image
ENSG00000197013.8,ZNF429LUSCEAGT_cells_CD4_memory_activated6.3586e-030.2391image
chr19:21506232-21506918:+OVEERB_cells_naive3.0535e-020.3382image
chr19:21537967-21539700:+OVEERMast_cells_resting2.2250e-02-0.1401image
ENSG00000197013.8,ZNF429PAADEAGT_cells_regulatory_(Tregs)5.5597e-030.2869image
ENSG00000197013.8,ZNF429PCPGEAGB_cells_memory5.7275e-03-0.2324image
chr19:21537967-21539700:+PRADEERB_cells_naive1.4027e-020.1191image
ENSG00000197013.8,ZNF429PRADEAGB_cells_naive1.1370e-020.1224image
ENSG00000197013.8,ZNF429READEAGDendritic_cells_resting1.4897e-020.4907image
ENSG00000197013.8,ZNF429SKCMEAGMacrophages_M21.4353e-03-0.3146image
chr19:21537967-21539700:+STADEERT_cells_CD4_memory_activated1.8272e-020.1587image
ENSG00000197013.8,ZNF429STADEAGDendritic_cells_resting3.4213e-02-0.1416image
chr19:21537967-21539700:+TGCTEERT_cells_CD4_memory_activated1.6055e-030.2885image
ENSG00000197013.8,ZNF429TGCTEAGT_cells_CD4_memory_activated1.9214e-030.2839image
chr19:21537967-21539700:+THCAEERNK_cells_activated7.4129e-03-0.1275image
ENSG00000197013.8,ZNF429THCAEAGNK_cells_activated8.8786e-03-0.1242image
chr19:21537967-21539700:+THYMEERMacrophages_M19.6615e-040.3283image
ENSG00000197013.8,ZNF429THYMEAGMacrophages_M02.3234e-040.3619image
chr19:21537967-21539700:+UCECEERT_cells_CD4_memory_resting6.8380e-03-0.2488image
ENSG00000197013.8,ZNF429UCECEAGT_cells_CD4_memory_resting4.1260e-03-0.2633image


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6. Enriched editing regions and immune gene sets for ZNF429


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr19:21537967-21539700:+BLCAEER2.7311e-050.29201.3202e-040.26702.7139e-030.21108.2890e-050.2747image
ENSG00000197013.8,ZNF429BLCAEAG2.7907e-050.29091.5107e-040.26422.0821e-030.21591.5247e-040.2640image
chr19:21537967-21539700:+BRCAEER1.2859e-090.19626.0998e-050.13032.7113e-040.11846.5438e-040.1109image
ENSG00000197013.8,ZNF429BRCAEAG1.9404e-070.16822.1301e-030.09975.2224e-030.09076.9322e-040.1100image
chr19:21537967-21539700:+LUADEER1.9168e-040.20422.8519e-040.19881.7806e-030.17161.7132e-020.1314image
ENSG00000197013.8,ZNF429LUADEAG1.5920e-040.20581.1684e-040.20991.1006e-030.17834.1881e-020.1117image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:21537967-21539700:+ACCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.1615e-02-0.2836image
ENSG00000197013.8,ZNF429ACCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.0536e-02-0.2851image
ENSG00000197013.8,ZNF429BLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG7.9129e-090.3930image
chr19:21537967-21539700:+BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER4.3585e-100.4230image
ENSG00000197013.8,ZNF429BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.2474e-090.1853image
chr19:21537967-21539700:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.1008e-090.1970image
ENSG00000197013.8,ZNF429CESCGSVA_HALLMARK_SPERMATOGENESISEAG2.2621e-02-0.2684image
ENSG00000197013.8,ZNF429CHOLGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.5509e-030.6597image
chr19:21537967-21539700:+CHOLGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.5509e-030.6597image
ENSG00000197013.8,ZNF429DLBCGSVA_HALLMARK_COMPLEMENTEAG7.2889e-030.5333image
ENSG00000197013.8,ZNF429ESCAGSVA_HALLMARK_UV_RESPONSE_UPEAG2.0040e-020.2879image
ENSG00000197013.8,ZNF429GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.0344e-030.2471image
chr19:21537967-21539700:+GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.4716e-030.2530image
ENSG00000197013.8,ZNF429KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.3755e-030.1619image
chr19:21537967-21539700:+KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.7781e-030.1652image
ENSG00000197013.8,ZNF429KIRPGSVA_HALLMARK_MYC_TARGETS_V2EAG2.4297e-020.1732image
ENSG00000197013.8,ZNF429LAMLGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG9.1368e-030.4920image
ENSG00000197013.8,ZNF429LGGGSVA_HALLMARK_MYOGENESISEAG5.8237e-050.2001image
chr19:21537967-21539700:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER3.1270e-020.1624image
ENSG00000197013.8,ZNF429LIHCGSVA_HALLMARK_HEME_METABOLISMEAG4.0156e-020.1544image
chr19:21537967-21539700:+LUADGSVA_HALLMARK_MTORC1_SIGNALINGEER2.1385e-050.2320image
ENSG00000197013.8,ZNF429LUADGSVA_HALLMARK_G2M_CHECKPOINTEAG1.8088e-050.2329image
chr19:21537967-21539700:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2652e-030.2601image
ENSG00000197013.8,ZNF429LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.7187e-020.1945image
ENSG00000197013.8,ZNF429MESOGSVA_HALLMARK_UV_RESPONSE_UPEAG5.2199e-030.4010image
chr19:21537967-21539700:+OVGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER5.6658e-050.2443image
ENSG00000197013.8,ZNF429OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.1736e-030.1861image
ENSG00000197013.8,ZNF429PAADGSVA_HALLMARK_P53_PATHWAYEAG1.4398e-030.3275image
ENSG00000197013.8,ZNF429PCPGGSVA_HALLMARK_UV_RESPONSE_UPEAG7.5494e-050.3282image
chr19:21537967-21539700:+PRADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.8095e-040.1686image
ENSG00000197013.8,ZNF429PRADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.5276e-040.1762image
ENSG00000197013.8,ZNF429READGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.5883e-020.4539image
chr19:21537967-21539700:+SARCGSVA_HALLMARK_APOPTOSISEER2.0098e-040.3242image
ENSG00000197013.8,ZNF429SARCGSVA_HALLMARK_APOPTOSISEAG2.2290e-040.3196image
ENSG00000197013.8,ZNF429SKCMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.4871e-030.2619image
ENSG00000197013.8,ZNF429STADGSVA_HALLMARK_GLYCOLYSISEAG4.6308e-040.2320image
chr19:21537967-21539700:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER4.5947e-060.3027image
chr19:21537967-21539700:+TGCTGSVA_HALLMARK_COMPLEMENTEER2.5860e-040.3317image
ENSG00000197013.8,ZNF429TGCTGSVA_HALLMARK_COMPLEMENTEAG4.6327e-040.3186image
chr19:21537967-21539700:+THCAGSVA_HALLMARK_COAGULATIONEER3.6853e-110.3086image
ENSG00000197013.8,ZNF429THCAGSVA_HALLMARK_COAGULATIONEAG2.9062e-100.2937image
chr19:21537967-21539700:+THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.8503e-050.4180image
ENSG00000197013.8,ZNF429THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9134e-050.4009image
chr19:21537967-21539700:+UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.0546e-030.2822image
ENSG00000197013.8,ZNF429UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.4345e-030.2914image


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7. Enriched editing regions and drugs for ZNF429


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr19:21537967-21539700:+ACCCytarabineEER3.6223e-02-0.2912image
ENSG00000197013.8,ZNF429ACCCI.1040EAG3.8079e-02-0.2885image
ENSG00000197013.8,ZNF429BLCAJNK.Inhibitor.VIIIEAG1.3169e-05-0.3020image
chr19:21537967-21539700:+BLCAKIN001.135EER1.4010e-05-0.3018image
ENSG00000197013.8,ZNF429BRCAAZD7762EAG1.0277e-05-0.1429image
chr19:21537967-21539700:+BRCACCT007093EER5.5523e-070.1623image
ENSG00000197013.8,ZNF429CESCAICAREAG8.8761e-03-0.3063image
ENSG00000197013.8,ZNF429DLBCAG.014699EAG1.0413e-020.5127image
chr19:21537967-21539700:+ESCACHIR.99021EER3.0484e-020.2751image
ENSG00000197013.8,ZNF429ESCACHIR.99021EAG1.7394e-020.2941image
ENSG00000197013.8,ZNF429GBMGNF.2EAG5.6671e-05-0.3312image
chr19:21537967-21539700:+GBMCGP.082996EER3.2974e-06-0.3803image
ENSG00000197013.8,ZNF429HNSCABT.263EAG5.6779e-04-0.5152image
ENSG00000197013.8,ZNF429KICHBMS.754807EAG4.3064e-03-0.4473image
ENSG00000197013.8,ZNF429KIRCKU.55933EAG4.0986e-05-0.2251image
chr19:21537967-21539700:+KIRCKU.55933EER2.2608e-05-0.2324image
ENSG00000197013.8,ZNF429KIRPAZD8055EAG2.0402e-07-0.3869image
ENSG00000197013.8,ZNF429LAMLCI.1040EAG3.0482e-02-0.4170image
ENSG00000197013.8,ZNF429LGGBexaroteneEAG1.0741e-06-0.2416image
chr19:21537967-21539700:+LIHCBAY.61.3606EER2.7137e-02-0.1666image
ENSG00000197013.8,ZNF429LIHCBAY.61.3606EAG2.2501e-02-0.1714image
ENSG00000197013.8,ZNF429LUADGemcitabineEAG8.8061e-04-0.1817image
chr19:21537967-21539700:+LUADGemcitabineEER5.3566e-04-0.1899image
chr19:21537967-21539700:+LUSCCMKEER2.9906e-03-0.2624image
ENSG00000197013.8,ZNF429LUSCCMKEAG7.2232e-04-0.2939image
ENSG00000197013.8,ZNF429MESOGSK269962AEAG1.4883e-03-0.4504image
chr19:21506232-21506918:+OVMG.132EER3.3570e-020.3327image
chr19:21537967-21539700:+OVDasatinibEER1.1235e-05-0.2662image
ENSG00000197013.8,ZNF429OVDasatinibEAG1.3765e-04-0.2308image
ENSG00000197013.8,ZNF429PAADBIBW2992EAG5.9654e-04-0.3513image
ENSG00000197013.8,ZNF429PCPGBIBW2992EAG2.0007e-050.3520image
chr19:21537967-21539700:+PRADBortezomibEER3.4486e-06-0.2230image
ENSG00000197013.8,ZNF429PRADBortezomibEAG1.8708e-06-0.2283image
ENSG00000197013.8,ZNF429READDocetaxelEAG2.2232e-02-0.4644image
chr19:21537967-21539700:+SARCJNJ.26854165EER9.9322e-04-0.2888image
ENSG00000197013.8,ZNF429SARCJNJ.26854165EAG1.6199e-03-0.2749image
ENSG00000197013.8,ZNF429SKCMAS601245EAG2.2062e-03-0.3027image
ENSG00000197013.8,ZNF429STADDocetaxelEAG2.0095e-03-0.2053image
chr19:21537967-21539700:+STADDocetaxelEER3.9812e-03-0.1930image
chr19:21537967-21539700:+TGCTFH535EER1.1843e-030.2962image
ENSG00000197013.8,ZNF429TGCTFH535EAG2.7817e-030.2741image
chr19:21537967-21539700:+THCACI.1040EER1.3295e-12-0.3295image
ENSG00000197013.8,ZNF429THCACI.1040EAG2.0851e-12-0.3257image
ENSG00000197013.8,ZNF429THYMCGP.60474EAG1.1977e-04-0.3770image
chr19:21537967-21539700:+THYMEpothilone.BEER2.0669e-030.3075image
chr19:21537967-21539700:+UCECCisplatinEER1.3243e-02-0.2284image
ENSG00000197013.8,ZNF429UCECCisplatinEAG8.2266e-03-0.2432image
ENSG00000197013.8,ZNF429UCSBryostatin.1EAG3.7906e-02-0.4015image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType