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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: XIAP (ImmuneEditome ID:331)

1. Gene summary of enriched editing regions for XIAP

check button Gene summary
Gene informationGene symbol

XIAP

Gene ID

331

GeneSynonymsAPI3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3
GeneCytomap

Xq25

GeneTypeprotein-coding
GeneDescriptionE3 ubiquitin-protein ligase XIAP|IAP-like protein 1|RING-type E3 ubiquitin transferase XIAP|X-linked IAP|X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3
GeneModificationdate20230405
UniprotIDP98170;B1AKU2
PubMed ID

36401800

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:123862161-123863658:+ENST00000468503.1ENSG00000101966.11XIAPncRNA_intronicAluSq2,AluJb,AluSx,AluSpchrX:123862161-123863658:+.alignment
chrX:123862161-123863658:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicAluSq2,AluJb,AluSx,AluSpchrX:123862161-123863658:+.alignment
chrX:123862161-123863658:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicAluSq2,AluJb,AluSx,AluSpchrX:123862161-123863658:+.alignment
chrX:123862161-123863658:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicAluSq2,AluJb,AluSx,AluSpchrX:123862161-123863658:+.alignment
chrX:123862161-123863658:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicAluSq2,AluJb,AluSx,AluSpchrX:123862161-123863658:+.alignment
chrX:123864820-123866803:+ENST00000468503.1ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSx,(ATATATA)n,AluY,(GT)n,AluYj4chrX:123864820-123866803:+.alignment
chrX:123864820-123866803:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSx,(ATATATA)n,AluY,(GT)n,AluYj4chrX:123864820-123866803:+.alignment
chrX:123864820-123866803:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSx,(ATATATA)n,AluY,(GT)n,AluYj4chrX:123864820-123866803:+.alignment
chrX:123864820-123866803:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSx,(ATATATA)n,AluY,(GT)n,AluYj4chrX:123864820-123866803:+.alignment
chrX:123864820-123866803:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSx,(ATATATA)n,AluY,(GT)n,AluYj4chrX:123864820-123866803:+.alignment
chrX:123868118-123871251:+ENST00000468503.1ENSG00000101966.11XIAPncRNA_intronic(AAAC)n,(TG)n,AluJb,AluJr,AluSz6,AluSzchrX:123868118-123871251:+.alignment
chrX:123868118-123871251:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronic(AAAC)n,(TG)n,AluJb,AluJr,AluSz6,AluSzchrX:123868118-123871251:+.alignment
chrX:123868118-123871251:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronic(AAAC)n,(TG)n,AluJb,AluJr,AluSz6,AluSzchrX:123868118-123871251:+.alignment
chrX:123868118-123871251:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronic(AAAC)n,(TG)n,AluJb,AluJr,AluSz6,AluSzchrX:123868118-123871251:+.alignment
chrX:123868118-123871251:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronic(AAAC)n,(TG)n,AluJb,AluJr,AluSz6,AluSzchrX:123868118-123871251:+.alignment
chrX:123875837-123877232:+ENST00000468503.1ENSG00000101966.11XIAPncRNA_intronicSVA_B,L1MC,AluJo,AluSz6,AluJr4,AluSzchrX:123875837-123877232:+.alignment
chrX:123875837-123877232:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicSVA_B,L1MC,AluJo,AluSz6,AluJr4,AluSzchrX:123875837-123877232:+.alignment
chrX:123875837-123877232:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicSVA_B,L1MC,AluJo,AluSz6,AluJr4,AluSzchrX:123875837-123877232:+.alignment
chrX:123875837-123877232:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicSVA_B,L1MC,AluJo,AluSz6,AluJr4,AluSzchrX:123875837-123877232:+.alignment
chrX:123875837-123877232:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicSVA_B,L1MC,AluJo,AluSz6,AluJr4,AluSzchrX:123875837-123877232:+.alignment
chrX:123880255-123880631:+ENST00000468503.1ENSG00000101966.11XIAPncRNA_intronicAluSp,AluSq2chrX:123880255-123880631:+.alignment
chrX:123880255-123880631:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicAluSp,AluSq2chrX:123880255-123880631:+.alignment
chrX:123880255-123880631:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicAluSp,AluSq2chrX:123880255-123880631:+.alignment
chrX:123880255-123880631:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicAluSp,AluSq2chrX:123880255-123880631:+.alignment
chrX:123880255-123880631:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicAluSp,AluSq2chrX:123880255-123880631:+.alignment
chrX:123890438-123890588:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicAluJochrX:123890438-123890588:+.alignment
chrX:123890438-123890588:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicAluJochrX:123890438-123890588:+.alignment
chrX:123890438-123890588:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicAluJochrX:123890438-123890588:+.alignment
chrX:123890438-123890588:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicAluJochrX:123890438-123890588:+.alignment
chrX:123892901-123893699:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSc,AluSx3chrX:123892901-123893699:+.alignment
chrX:123892901-123893699:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSc,AluSx3chrX:123892901-123893699:+.alignment
chrX:123892901-123893699:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSc,AluSx3chrX:123892901-123893699:+.alignment
chrX:123892901-123893699:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicAluSg,AluSc,AluSx3chrX:123892901-123893699:+.alignment
chrX:123898455-123899111:+ENST00000468691.4ENSG00000101966.11XIAPncRNA_intronicAluSz,(TATA)n,AluSx3,AluYcchrX:123898455-123899111:+.alignment
chrX:123898455-123899111:+ENST00000481776.4ENSG00000101966.11XIAPncRNA_intronicAluSz,(TATA)n,AluSx3,AluYcchrX:123898455-123899111:+.alignment
chrX:123898455-123899111:+ENST00000497640.1ENSG00000101966.11XIAPncRNA_intronicAluSz,(TATA)n,AluSx3,AluYcchrX:123898455-123899111:+.alignment
chrX:123898455-123899111:+ENST00000497906.4ENSG00000101966.11XIAPncRNA_intronicAluSz,(TATA)n,AluSx3,AluYcchrX:123898455-123899111:+.alignment
chrX:123909019-123909341:+ENST00000355640.3ENSG00000101966.11XIAPUTR3AluSzchrX:123909019-123909341:+.alignment
chrX:123909019-123909341:+ENST00000371199.6ENSG00000101966.11XIAPUTR3AluSzchrX:123909019-123909341:+.alignment
chrX:123909019-123909341:+ENST00000434753.6ENSG00000101966.11XIAPUTR3AluSzchrX:123909019-123909341:+.alignment
chrX:123910566-123913460:+ENST00000496602.1ENSG00000101966.11XIAPncRNA_exonicAluSp,AluY,MER2B,MIRb,(ATAA)n,A-rich,MIR3,AluSz,AluJo,AluSx,AluJb,MER2chrX:123910566-123913460:+.alignment


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2. Tumor-specific enriched editing regions for XIAP


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chrX:123910566-123913460:+BRCAEER1.0531e-06image
ENSG00000101966.11,XIAPBRCAEAG2.0458e-04image
chrX:123910566-123913460:+COADEER7.1220e-04image
ENSG00000101966.11,XIAPCOADEAG1.8483e-04image
chrX:123910566-123913460:+HNSCEER3.6550e-03image
chrX:123910566-123913460:+KIRCEER1.4722e-02image
ENSG00000101966.11,XIAPKIRPEAG4.2756e-02image
chrX:123910566-123913460:+LUADEER3.7330e-06image
ENSG00000101966.11,XIAPLUADEAG8.5281e-07image
chrX:123910566-123913460:+LUSCEER6.7306e-05image
ENSG00000101966.11,XIAPLUSCEAG8.1824e-06image
chrX:123910566-123913460:+PRADEER1.2753e-03image
chrX:123910566-123913460:+UCECEER1.8051e-03image
ENSG00000101966.11,XIAPUCECEAG1.4905e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chrX:123910566-123913460:+BLCAPathEER2.7330e-023.9102e-020.1044image
chrX:123910566-123913460:+SKCMPathEER1.1036e-033.2604e-030.1490image
ENSG00000101966.11,XIAPSKCMPathEAG1.8359e-031.2975e-030.1617image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chrX:123910566-123913460:+LUSCEER2.9875e-024.2004e-031.8609e-05image
chrX:123910566-123913460:+MESOEER2.1171e-024.1716e-023.5849e+04image
ENSG00000101966.11,XIAPMESOEAG5.3915e-031.7313e-021.2227e+05image
chrX:123880255-123880631:+STADEER1.3473e-022.1701e-025.7262e-04image

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3. Enriched editing regions and immune related genes for XIAP


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for XIAP


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for XIAP


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chrX:123910566-123913460:+ACCEERT_cells_CD4_memory_resting2.0499e-02-0.2672image
chrX:123909019-123909341:+BLCAEERT_cells_regulatory_(Tregs)1.0327e-02-0.1738image
chrX:123910566-123913460:+BLCAEERMacrophages_M23.2807e-030.1483image
chrX:123910566-123913460:+BRCAEERB_cells_naive2.5700e-05-0.1276image
ENSG00000101966.11,XIAPBRCAEAGB_cells_naive1.1604e-04-0.1168image
chrX:123910566-123913460:+CESCEERT_cells_CD4_memory_activated2.6145e-020.1288image
ENSG00000101966.11,XIAPCESCEAGB_cells_memory8.4405e-030.1516image
chrX:123909019-123909341:+CHOLEERB_cells_naive2.0320e-020.4705image
ENSG00000101966.11,XIAPCHOLEAGT_cells_CD4_memory_resting8.9123e-030.4356image
chrX:123910566-123913460:+COADEERNK_cells_activated3.1368e-020.1313image
ENSG00000101966.11,XIAPCOADEAGDendritic_cells_activated3.7621e-060.2742image
ENSG00000101966.11,XIAPDLBCEAGMacrophages_M26.8071e-030.3895image
chrX:123868118-123871251:+ESCAEERT_cells_regulatory_(Tregs)9.2990e-03-0.2655image
chrX:123910566-123913460:+ESCAEERT_cells_regulatory_(Tregs)5.3204e-05-0.3129image
ENSG00000101966.11,XIAPESCAEAGPlasma_cells9.4687e-04-0.2581image
chrX:123910566-123913460:+GBMEERB_cells_naive1.0602e-02-0.1973image
ENSG00000101966.11,XIAPGBMEAGEosinophils6.8050e-030.2087image
chrX:123910566-123913460:+HNSCEERT_cells_CD4_memory_resting2.5642e-02-0.1006image
chrX:123910566-123913460:+KICHEERNK_cells_resting3.5124e-02-0.2749image
ENSG00000101966.11,XIAPKICHEAGMacrophages_M03.6946e-020.2656image
chrX:123910566-123913460:+KIRCEERMacrophages_M01.1508e-030.1659image
ENSG00000101966.11,XIAPKIRCEAGMacrophages_M11.5943e-02-0.1229image
chrX:123910566-123913460:+KIRPEERMacrophages_M11.8051e-020.1438image
ENSG00000101966.11,XIAPKIRPEAGMacrophages_M15.6321e-030.1671image
ENSG00000101966.11,XIAPLAMLEAGT_cells_CD4_memory_activated3.4194e-02-0.2371image
ENSG00000101966.11,XIAPLGGEAGMacrophages_M09.4692e-030.1130image
chrX:123910566-123913460:+LIHCEERB_cells_naive2.1327e-02-0.1198image
ENSG00000101966.11,XIAPLIHCEAGB_cells_naive3.0329e-02-0.1128image
chrX:123910566-123913460:+LUADEERT_cells_CD4_memory_activated3.8850e-040.1559image
ENSG00000101966.11,XIAPLUADEAGEosinophils2.0122e-070.2264image
chrX:123910566-123913460:+LUSCEERT_cells_CD4_memory_activated5.7825e-050.1795image
ENSG00000101966.11,XIAPLUSCEAGT_cells_CD4_memory_activated1.5603e-030.1415image
chrX:123909019-123909341:+MESOEERT_cells_follicular_helper1.8217e-020.4027image
chrX:123910566-123913460:+MESOEERT_cells_CD84.5976e-020.2238image
ENSG00000101966.11,XIAPMESOEAGNK_cells_activated3.4133e-020.2357image
chrX:123880255-123880631:+OVEERB_cells_naive2.6734e-02-0.3378image
chrX:123910566-123913460:+OVEERT_cells_CD84.0632e-040.2059image
ENSG00000101966.11,XIAPOVEAGT_cells_CD84.6361e-030.1655image
chrX:123909019-123909341:+PAADEERT_cells_follicular_helper4.8105e-040.3164image
chrX:123910566-123913460:+PAADEERNK_cells_resting2.9046e-080.4031image
ENSG00000101966.11,XIAPPAADEAGNK_cells_resting3.0138e-060.3437image
chrX:123910566-123913460:+PRADEERNeutrophils3.4962e-02-0.0948image
ENSG00000101966.11,XIAPPRADEAGDendritic_cells_activated5.4988e-030.1242image
ENSG00000101966.11,XIAPREADEAGNK_cells_resting2.9853e-020.2242image
chrX:123910566-123913460:+SKCMEERT_cells_regulatory_(Tregs)1.6474e-040.1773image
ENSG00000101966.11,XIAPSKCMEAGMacrophages_M13.2601e-04-0.1683image
chrX:123864820-123866803:+STADEERMacrophages_M02.3608e-020.3818image
chrX:123875837-123877232:+STADEERT_cells_gamma_delta5.9237e-030.4622image
chrX:123898455-123899111:+STADEERMacrophages_M03.4191e-020.3400image
chrX:123910566-123913460:+STADEERB_cells_memory1.4353e-02-0.1275image
ENSG00000101966.11,XIAPSTADEAGNK_cells_activated1.6735e-030.1631image
chrX:123910566-123913460:+TGCTEERMacrophages_M24.6460e-06-0.3607image
ENSG00000101966.11,XIAPTGCTEAGMacrophages_M28.4611e-05-0.3124image
chrX:123910566-123913460:+THCAEERT_cells_CD4_memory_activated5.3665e-030.1241image
ENSG00000101966.11,XIAPTHCAEAGPlasma_cells1.1084e-060.2150image
chrX:123909019-123909341:+THYMEERT_cells_follicular_helper1.1327e-020.4354image
ENSG00000101966.11,XIAPTHYMEAGB_cells_memory1.6642e-030.2938image
chrX:123910566-123913460:+UCECEERB_cells_naive1.0118e-02-0.1991image
ENSG00000101966.11,XIAPUCECEAGT_cells_regulatory_(Tregs)3.8753e-020.1596image
chrX:123910566-123913460:+UCSEEREosinophils1.6525e-02-0.3249image
ENSG00000101966.11,XIAPUCSEAGEosinophils9.1759e-03-0.3482image
ENSG00000101966.11,XIAPUVMEAGT_cells_follicular_helper3.9282e-02-0.2814image


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6. Enriched editing regions and immune gene sets for XIAP


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chrX:123909019-123909341:+BLCAEER3.6767e-02image2.7464e-020.1497image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chrX:123910566-123913460:+LUADEER4.2196e-050.17961.4039e-040.16721.0776e-030.14386.1284e-030.1207image
chrX:123909019-123909341:+PAADEER1.3603e-040.34413.1748e-030.26944.6030e-040.31753.4236e-020.1951image
ENSG00000101966.11,XIAPPAADEAG2.6957e-040.27142.5955e-030.22571.1605e-030.24291.2281e-020.1884image
chrX:123910566-123913460:+PAADEER9.4896e-040.24702.1708e-020.17303.0958e-030.22181.2279e-020.1884image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chrX:123910566-123913460:+ACCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.2592e-020.2868image
chrX:123909019-123909341:+ACCGSVA_HALLMARK_MYC_TARGETS_V2EER2.8156e-02-0.3660image
chrX:123909019-123909341:+BLCAGSVA_HALLMARK_E2F_TARGETSEER6.4636e-030.1844image
chrX:123910566-123913460:+BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.8386e-020.1109image
ENSG00000101966.11,XIAPBLCAGSVA_HALLMARK_PEROXISOMEEAG2.5639e-02-0.1119image
ENSG00000101966.11,XIAPBRCAGSVA_HALLMARK_P53_PATHWAYEAG7.5840e-11-0.1961image
chrX:123910566-123913460:+BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.7619e-100.1879image
chrX:123910566-123913460:+CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0042e-04-0.2234image
ENSG00000101966.11,XIAPCESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.5935e-03-0.1730image
ENSG00000101966.11,XIAPCHOLGSVA_HALLMARK_APICAL_SURFACEEAG1.1664e-020.4216image
chrX:123910566-123913460:+CHOLGSVA_HALLMARK_SPERMATOGENESISEER1.8094e-02-0.4031image
chrX:123910566-123913460:+COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.6532e-03-0.1721image
ENSG00000101966.11,XIAPCOADGSVA_HALLMARK_P53_PATHWAYEAG1.1611e-08-0.3350image
ENSG00000101966.11,XIAPDLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.4180e-030.3921image
ENSG00000101966.11,XIAPESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.5680e-04-0.2780image
chrX:123910566-123913460:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3585e-04-0.2962image
chrX:123868118-123871251:+ESCAGSVA_HALLMARK_GLYCOLYSISEER5.7497e-040.3468image
chrX:123910566-123913460:+GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.4462e-030.2064image
ENSG00000101966.11,XIAPGBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.5174e-030.2246image
ENSG00000101966.11,XIAPHNSCGSVA_HALLMARK_HYPOXIAEAG1.0006e-020.1159image
chrX:123910566-123913460:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.9782e-04-0.1624image
ENSG00000101966.11,XIAPKICHGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.3080e-030.3992image
chrX:123910566-123913460:+KICHGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.2054e-030.3909image
chrX:123910566-123913460:+KIRCGSVA_HALLMARK_NOTCH_SIGNALINGEER1.1225e-03-0.1663image
ENSG00000101966.11,XIAPKIRCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.0497e-02-0.1305image
ENSG00000101966.11,XIAPKIRPGSVA_HALLMARK_APICAL_SURFACEEAG1.7139e-02-0.1442image
chrX:123910566-123913460:+KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.0449e-05-0.2647image
ENSG00000101966.11,XIAPLAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.1992e-02-0.2558image
chrX:123910566-123913460:+LGGGSVA_HALLMARK_MYOGENESISEER1.7448e-060.2083image
ENSG00000101966.11,XIAPLGGGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG8.4573e-060.1928image
chrX:123910566-123913460:+LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER9.3147e-070.2521image
ENSG00000101966.11,XIAPLIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.3056e-050.2184image
chrX:123910566-123913460:+LUADGSVA_HALLMARK_MYC_TARGETS_V1EER1.1764e-050.1920image
ENSG00000101966.11,XIAPLUADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.6157e-07-0.2243image
chrX:123910566-123913460:+LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.9631e-030.1332image
ENSG00000101966.11,XIAPLUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.0333e-040.1515image
chrX:123910566-123913460:+MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.3377e-040.4142image
ENSG00000101966.11,XIAPMESOGSVA_HALLMARK_HYPOXIAEAG2.8273e-030.3276image
ENSG00000101966.11,XIAPOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.7004e-070.2960image
chrX:123868118-123871251:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.8266e-020.2162image
chrX:123880255-123880631:+OVGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER3.0681e-020.3300image
chrX:123910566-123913460:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.0049e-070.3060image
chrX:123910566-123913460:+PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.6048e-040.2490image
ENSG00000101966.11,XIAPPAADGSVA_HALLMARK_GLYCOLYSISEAG1.8875e-040.2778image
chrX:123909019-123909341:+PAADGSVA_HALLMARK_P53_PATHWAYEER3.3521e-060.4130image
ENSG00000101966.11,XIAPPCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG1.8276e-02-0.1762image
chrX:123910566-123913460:+PCPGGSVA_HALLMARK_UV_RESPONSE_DNEER8.5166e-03-0.1966image
ENSG00000101966.11,XIAPPRADGSVA_HALLMARK_P53_PATHWAYEAG2.0487e-03-0.1378image
chrX:123910566-123913460:+PRADGSVA_HALLMARK_APICAL_SURFACEEER1.2292e-02-0.1125image
ENSG00000101966.11,XIAPREADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.2446e-02-0.2353image
chrX:123910566-123913460:+SARCGSVA_HALLMARK_HYPOXIAEER5.0076e-040.2186image
ENSG00000101966.11,XIAPSARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.3581e-030.2011image
chrX:123909019-123909341:+SKCMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.1700e-030.1858image
ENSG00000101966.11,XIAPSKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.0877e-04-0.1629image
chrX:123910566-123913460:+SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEER8.7091e-08-0.2498image
chrX:123892901-123893699:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER4.1587e-02-0.3567image
ENSG00000101966.11,XIAPSTADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3689e-14-0.3864image
chrX:123898455-123899111:+STADGSVA_HALLMARK_SPERMATOGENESISEER1.5741e-020.3842image
chrX:123868118-123871251:+STADGSVA_HALLMARK_GLYCOLYSISEER4.6079e-030.2109image
chrX:123910566-123913460:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6968e-03-0.1631image
chrX:123875837-123877232:+STADGSVA_HALLMARK_MTORC1_SIGNALINGEER1.0134e-020.4350image
chrX:123910566-123913460:+TGCTGSVA_HALLMARK_ANGIOGENESISEER7.3835e-06-0.3535image
ENSG00000101966.11,XIAPTGCTGSVA_HALLMARK_PEROXISOMEEAG3.9120e-05-0.3260image
chrX:123910566-123913460:+THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.0769e-03-0.1371image
ENSG00000101966.11,XIAPTHCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.9895e-040.1604image
chrX:123909019-123909341:+THYMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.4092e-030.4949image
ENSG00000101966.11,XIAPTHYMGSVA_HALLMARK_HEME_METABOLISMEAG2.2960e-03-0.2853image
chrX:123910566-123913460:+UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER7.7820e-06-0.3392image
ENSG00000101966.11,XIAPUCECGSVA_HALLMARK_HEME_METABOLISMEAG3.6978e-05-0.3126image
chrX:123910566-123913460:+UCSGSVA_HALLMARK_DNA_REPAIREER1.4076e-020.3324image
ENSG00000101966.11,XIAPUCSGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.5699e-02-0.2839image
ENSG00000101966.11,XIAPUVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.3002e-030.4265image


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7. Enriched editing regions and drugs for XIAP


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chrX:123910566-123913460:+ACCAZD.2281EER1.0294e-02-0.2946image
ENSG00000101966.11,XIAPACCMG.132EAG1.7916e-020.2709image
chrX:123909019-123909341:+ACCAZ628EER3.6318e-020.3501image
ENSG00000101966.11,XIAPBLCAErlotinibEAG1.6297e-03-0.1574image
chrX:123910566-123913460:+BLCAGDC.0449EER5.9589e-04-0.1729image
chrX:123909019-123909341:+BLCACCT007093EER1.4823e-050.2894image
chrX:123910566-123913460:+BRCACHIR.99021EER7.4071e-060.1359image
ENSG00000101966.11,XIAPBRCABMS.536924EAG3.0651e-050.1266image
chrX:123910566-123913460:+CESCA.770041EER1.8372e-06-0.2723image
ENSG00000101966.11,XIAPCESCDMOGEAG4.3097e-090.3303image
ENSG00000101966.11,XIAPCHOLCCT007093EAG3.8262e-02-0.3517image
chrX:123909019-123909341:+CHOLJNJ.26854165EER4.3066e-020.4162image
chrX:123910566-123913460:+COADAZ628EER1.6216e-050.2596image
ENSG00000101966.11,XIAPCOADAZ628EAG1.3932e-140.4413image
ENSG00000101966.11,XIAPDLBCAZD6482EAG5.8545e-040.4878image
ENSG00000101966.11,XIAPESCAAZD.2281EAG2.6039e-03-0.2365image
chrX:123910566-123913460:+ESCAJNJ.26854165EER1.9333e-04-0.2906image
chrX:123868118-123871251:+ESCAABT.263EER5.0889e-040.3517image
ENSG00000101966.11,XIAPGBMIPA.3EAG1.4380e-030.2447image
chrX:123910566-123913460:+GBMGSK.650394EER9.3208e-040.2538image
ENSG00000101966.11,XIAPHNSCATRAEAG1.6954e-040.1686image
chrX:123910566-123913460:+HNSCAZD6482EER1.0940e-060.2176image
chrX:123910566-123913460:+KICHJNJ.26854165EER2.2955e-02-0.2957image
ENSG00000101966.11,XIAPKICHEmbelinEAG2.9445e-02-0.2768image
chrX:123910566-123913460:+KIRCAS601245EER3.3740e-050.2107image
ENSG00000101966.11,XIAPKIRCAZ628EAG2.8092e-08-0.2790image
ENSG00000101966.11,XIAPKIRPGSK.650394EAG2.6455e-040.2191image
chrX:123910566-123913460:+KIRPGSK.650394EER5.9745e-040.2076image
ENSG00000101966.11,XIAPLAMLJNK.9LEAG8.7999e-040.3647image
chrX:123910566-123913460:+LGGIPA.3EER2.6901e-070.2237image
ENSG00000101966.11,XIAPLGGEpothilone.BEAG7.1281e-040.1471image
ENSG00000101966.11,XIAPLIHCGW843682XEAG3.8547e-070.2606image
chrX:123910566-123913460:+LIHCBryostatin.1EER8.8659e-04-0.1723image
chrX:123910566-123913460:+LUADGemcitabineEER1.5908e-04-0.1658image
ENSG00000101966.11,XIAPLUADAKT.inhibitor.VIIIEAG1.8186e-05-0.1875image
ENSG00000101966.11,XIAPLUSCEtoposideEAG8.3852e-03-0.1181image
chrX:123910566-123913460:+LUSCEtoposideEER7.4540e-04-0.1509image
chrX:123910566-123913460:+MESOBIRB.0796EER1.3093e-030.3532image
chrX:123909019-123909341:+MESOABT.263EER9.9200e-030.4362image
ENSG00000101966.11,XIAPMESOBIRB.0796EAG1.9833e-030.3387image
ENSG00000101966.11,XIAPOVEmbelinEAG1.2547e-120.4004image
chrX:123880255-123880631:+OVA.443654EER1.4347e-020.3709image
chrX:123910566-123913460:+OVEmbelinEER1.1287e-130.4171image
ENSG00000101966.11,XIAPPAADCytarabineEAG2.5097e-050.3119image
chrX:123909019-123909341:+PAADEHT.1864EER2.0058e-030.2852image
chrX:123910566-123913460:+PAADCytarabineEER1.2595e-040.2850image
chrX:123910566-123913460:+PCPGJNJ.26854165EER9.3304e-04-0.2460image
ENSG00000101966.11,XIAPPCPGATRAEAG2.3869e-040.2714image
ENSG00000101966.11,XIAPPRADLenalidomideEAG1.1041e-06-0.2163image
chrX:123910566-123913460:+PRADAxitinibEER1.1439e-03-0.1458image
ENSG00000101966.11,XIAPREADDMOGEAG9.9214e-060.4384image
chrX:123910566-123913460:+READLapatinibEER8.8105e-030.2716image
ENSG00000101966.11,XIAPSARCBryostatin.1EAG2.7800e-04-0.2276image
chrX:123910566-123913460:+SARCCisplatinEER1.8134e-05-0.2675image
ENSG00000101966.11,XIAPSKCMGNF.2EAG4.6153e-12-0.3178image
chrX:123910566-123913460:+SKCMGNF.2EER1.4902e-13-0.3399image
chrX:123909019-123909341:+SKCMAG.014699EER7.6013e-040.2041image
chrX:123910566-123913460:+STADCisplatinEER1.0249e-03-0.1705image
chrX:123875837-123877232:+STADGefitinibEER3.7846e-02-0.3630image
ENSG00000101966.11,XIAPSTADCisplatinEAG1.7044e-05-0.2218image
chrX:123880255-123880631:+STADFH535EER4.1580e-03-0.2915image
chrX:123864820-123866803:+STADJNJ.26854165EER1.5064e-020.4077image
chrX:123898455-123899111:+STADCytarabineEER2.2204e-03-0.4755image
chrX:123868118-123871251:+STADABT.888EER4.4445e-030.2117image
chrX:123910566-123913460:+TGCTFTI.277EER4.9367e-050.3220image
ENSG00000101966.11,XIAPTGCTAUY922EAG2.3375e-040.2933image
ENSG00000101966.11,XIAPTHCAEmbelinEAG9.7923e-230.4180image
chrX:123910566-123913460:+THCAEmbelinEER7.0189e-110.2856image
chrX:123909019-123909341:+THYMMetforminEER3.0809e-02-0.3765image
ENSG00000101966.11,XIAPTHYMAZD6244EAG2.1690e-05-0.3897image
chrX:123910566-123913460:+THYMErlotinibEER7.6333e-03-0.2542image
chrX:123910566-123913460:+UCECA.770041EER3.3597e-08-0.4124image
ENSG00000101966.11,XIAPUCECGW.441756EAG4.0373e-070.3791image
chrX:123910566-123913460:+UCSAZD.2281EER2.9595e-02-0.2963image
ENSG00000101966.11,XIAPUCSAZD.2281EAG3.1973e-02-0.2896image
ENSG00000101966.11,XIAPUVMBexaroteneEAG2.6170e-06-0.5904image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chrX:123909019-123909341:+ENST00000355640.3P98170DB04209DequaliniumSmallMoleculeDrug
chrX:123909019-123909341:+ENST00000371199.6P98170DB04209DequaliniumSmallMoleculeDrug
chrX:123909019-123909341:+ENST00000434753.6P98170DB04209DequaliniumSmallMoleculeDrug