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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HINT1 (ImmuneEditome ID:3094)

1. Gene summary of enriched editing regions for HINT1

check button Gene summary
Gene informationGene symbol

HINT1

Gene ID

3094

GeneSynonymsHINT|NMAN|PKCI-1|PRKCNH1
GeneCytomap

5q23.3

GeneTypeprotein-coding
GeneDescriptionadenosine 5'-monophosphoramidase HINT1|adenosine 5'-monophosphoramidase|desumoylating isopeptidase HINT1|epididymis secretory sperm binding protein|protein kinase C inhibitor 1|protein kinase C-interacting protein 1
GeneModificationdate20230601
UniprotIDP49773;D6RD60;D6RC06;A0A384NPU2;D6RE99;H0YC49;A0A6Q8PGQ8;D6REP8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:131159838-131160175:-ENST00000506207.1ENSG00000169567.10HINT1ncRNA_intronicAluJbchr5:131159838-131160175:-.alignment
chr5:131161358-131162249:-ENST00000506207.1ENSG00000169567.10HINT1ncRNA_intronicAluY,AluSp,Tigger2achr5:131161358-131162249:-.alignment


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2. Tumor-specific enriched editing regions for HINT1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr5:131161358-131162249:-CHOLPathEER9.5655e-034.0478e-020.4504image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for HINT1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:131159838-131160175:-DLBCEERENSG00000198034,RPS4X0.54021.8055e-021.3834e-050.6046imageNNNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_DN
chr5:131159838-131160175:-DLBCEERENSG00000198755,RPL10A0.53823.5844e-021.3497e-030.4682imageNNNAMacrophages_M1GSVA_HALLMARK_HEME_METABOLISM
chr5:131159838-131160175:-DLBCEERENSG00000197818,SLC9A8-0.52403.7473e-021.2864e-04-0.5455imageNNNAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr5:131159838-131160175:-ESCAEERENSG00000176014,TUBB60.32666.2585e-031.2086e-070.4096imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr5:131159838-131160175:-LAMLEERENSG00000259834,RP11-284N8.30.33584.9263e-021.3028e-080.4622imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr5:131159838-131160175:-MESOEERENSG00000018189,RUFY3-0.52864.9571e-026.3138e-04-0.4190imageNNNANeutrophilsGSVA_HALLMARK_DNA_REPAIR

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4. Enriched editing regions and immune related splicing for HINT1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:131159838-131160175:-
COADEERMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614335:143614453:143614623:143614697-0.31881.3230e-039.2460e-12-0.4423imageNNTSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
chr5:131159838-131160175:-
COADEERMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614319:143614453:143614623:143614697-0.31841.3572e-039.4087e-12-0.4422imageNNTSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000169567.10,HINT1
COADEAGMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614335:143614453:143614623:143614697-0.25932.4552e-026.4709e-11-0.4212imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184TSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000169567.10,HINT1
COADEAGMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614319:143614453:143614623:143614697-0.25862.5210e-026.6453e-11-0.4210imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184TSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000169567.10,HINT1
KIRCEAGIRENSG00000123349.9chr1253295838:53296467:53297849:53297924-0.34952.5408e-082.3764e-14-0.4322imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000169567.10,HINT1
KIRCEAGIRENSG00000117616.13chr125243549:25243633:25245149:25245208-0.35769.7880e-084.1452e-13-0.4019imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000169567.10,HINT1
KIRCEAGIRENSG00000139636.11chr1249100387:49100646:49101249:49101263-0.33152.0360e-064.8520e-13-0.4002imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184LMBR1LMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000169567.10,HINT1
KIRCEAGIRENSG00000140416.15chr1563061197:63062645:63064063:63064142-0.34091.0774e-067.5110e-14-0.4134imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DIS3L2;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184TPM1Macrophages_M2GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000169567.10,HINT1
KIRCEAGIRENSG00000089280.14chr1631185475:31185556:31186801:31186836-0.29763.9768e-058.3415e-16-0.4437imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000169567.10,HINT1
KIRPEAGIRENSG00000103145.6chr163023232:3023548:3023846:3023961-0.17744.9860e-042.6150e-10-0.4380imageNBCCIP;BUD13;CAPRIN1;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DIS3L2;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA2B1;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;LARP4B;LARP7;LIN28;LSM11;MOV10;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184HCFC1R1GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

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5. Enriched editing regions and immune infiltration for HINT1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr5:131159838-131160175:-ACCEERDendritic_cells_resting4.0180e-020.3071image
ENSG00000169567.10,HINT1ACCEAGDendritic_cells_resting2.8309e-020.3271image
chr5:131159838-131160175:-BLCAEERT_cells_follicular_helper2.8497e-02-0.1223image
ENSG00000169567.10,HINT1BLCAEAGT_cells_follicular_helper5.4249e-03-0.1539image
chr5:131161358-131162249:-BRCAEERMacrophages_M05.3576e-030.1663image
ENSG00000169567.10,HINT1BRCAEAGB_cells_naive3.0100e-02-0.0797image
chr5:131159838-131160175:-CESCEERNeutrophils4.7289e-040.2113image
ENSG00000169567.10,HINT1CESCEAGNeutrophils3.8992e-040.2139image
chr5:131159838-131160175:-CHOLEERT_cells_CD4_memory_activated4.0911e-020.3578image
chr5:131161358-131162249:-CHOLEERT_cells_CD4_memory_activated2.1531e-020.4982image
ENSG00000169567.10,HINT1CHOLEAGT_cells_CD4_memory_activated1.5498e-020.4180image
chr5:131159838-131160175:-DLBCEERT_cells_follicular_helper4.0110e-02-0.3107image
chr5:131159838-131160175:-ESCAEERMacrophages_M24.9125e-030.2248image
chr5:131161358-131162249:-ESCAEERDendritic_cells_activated1.8071e-02-0.2282image
ENSG00000169567.10,HINT1ESCAEAGMacrophages_M21.0591e-030.2589image
chr5:131159838-131160175:-GBMEERMacrophages_M13.0835e-02-0.2139image
ENSG00000169567.10,HINT1GBMEAGMacrophages_M14.7992e-03-0.2745image
chr5:131159838-131160175:-HNSCEERT_cells_regulatory_(Tregs)4.8796e-03-0.1870image
ENSG00000169567.10,HINT1HNSCEAGT_cells_regulatory_(Tregs)1.5189e-02-0.1566image
chr5:131161358-131162249:-KIRCEERT_cells_regulatory_(Tregs)8.7379e-040.2446image
ENSG00000169567.10,HINT1KIRCEAGT_cells_CD4_memory_resting6.1247e-03-0.1574image
chr5:131159838-131160175:-KIRPEERDendritic_cells_activated1.3716e-020.1703image
ENSG00000169567.10,HINT1KIRPEAGDendritic_cells_activated9.0578e-030.1764image
chr5:131159838-131160175:-LAMLEEREosinophils7.0511e-03-0.2292image
ENSG00000169567.10,HINT1LAMLEAGMonocytes1.0656e-020.2168image
chr5:131159838-131160175:-LGGEERB_cells_naive4.9420e-020.1262image
ENSG00000169567.10,HINT1LGGEAGNK_cells_activated1.0345e-020.1588image
ENSG00000169567.10,HINT1LUADEAGMast_cells_activated5.1148e-030.1451image
chr5:131159838-131160175:-LUSCEERDendritic_cells_resting1.2728e-030.1651image
chr5:131161358-131162249:-LUSCEERMacrophages_M21.1612e-02-0.2029image
ENSG00000169567.10,HINT1LUSCEAGDendritic_cells_resting3.1000e-040.1829image
chr5:131159838-131160175:-MESOEERMacrophages_M02.9177e-020.2750image
ENSG00000169567.10,HINT1MESOEAGMacrophages_M02.9213e-020.2749image
chr5:131159838-131160175:-OVEERT_cells_CD82.0552e-020.1564image
ENSG00000169567.10,HINT1OVEAGMacrophages_M12.3155e-020.1507image
chr5:131159838-131160175:-PRADEERMast_cells_resting2.3349e-020.1153image
chr5:131161358-131162249:-PRADEERB_cells_naive1.3114e-02-0.2852image
ENSG00000169567.10,HINT1PRADEAGB_cells_naive4.7126e-03-0.1419image
chr5:131159838-131160175:-READEERT_cells_CD4_naive3.2068e-030.3499image
ENSG00000169567.10,HINT1READEAGT_cells_CD4_naive6.2820e-040.3988image
chr5:131159838-131160175:-SARCEERNK_cells_activated2.9948e-02-0.1876image
ENSG00000169567.10,HINT1SARCEAGMacrophages_M22.0594e-020.1969image
chr5:131161358-131162249:-SKCMEERNK_cells_activated5.5966e-050.4322image
ENSG00000169567.10,HINT1SKCMEAGNeutrophils3.2410e-020.1325image
chr5:131161358-131162249:-STADEERMonocytes2.9866e-020.1823image
ENSG00000169567.10,HINT1STADEAGB_cells_memory2.0540e-02-0.1360image
chr5:131159838-131160175:-THCAEERDendritic_cells_activated5.9312e-030.1405image
ENSG00000169567.10,HINT1THCAEAGMacrophages_M11.0242e-02-0.1279image
chr5:131159838-131160175:-THYMEERMast_cells_resting1.4817e-030.3107image
ENSG00000169567.10,HINT1THYMEAGMast_cells_resting4.8686e-030.2767image
ENSG00000169567.10,HINT1UCECEAGT_cells_CD83.2531e-020.1841image


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6. Enriched editing regions and immune gene sets for HINT1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr5:131159838-131160175:-ACCGSVA_HALLMARK_HYPOXIAEER1.3556e-020.3655image
ENSG00000169567.10,HINT1ACCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.9219e-030.3970image
chr5:131159838-131160175:-BLCAGSVA_HALLMARK_APICAL_SURFACEEER8.1824e-040.1859image
ENSG00000169567.10,HINT1BLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.6852e-040.1902image
chr5:131161358-131162249:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.4667e-070.2898image
ENSG00000169567.10,HINT1BRCAGSVA_HALLMARK_GLYCOLYSISEAG6.9067e-060.1645image
chr5:131159838-131160175:-CESCGSVA_HALLMARK_GLYCOLYSISEER9.8980e-040.1993image
ENSG00000169567.10,HINT1CESCGSVA_HALLMARK_GLYCOLYSISEAG2.9470e-030.1800image
chr5:131161358-131162249:-CESCGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.5619e-020.2256image
chr5:131159838-131160175:-COADGSVA_HALLMARK_UV_RESPONSE_DNEER8.7584e-030.1780image
ENSG00000169567.10,HINT1COADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.0732e-030.1925image
ENSG00000169567.10,HINT1DLBCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.5089e-020.3185image
chr5:131159838-131160175:-DLBCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.1491e-020.3087image
chr5:131161358-131162249:-ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.2516e-020.2204image
ENSG00000169567.10,HINT1ESCAGSVA_HALLMARK_MYOGENESISEAG8.1730e-030.2104image
chr5:131159838-131160175:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6268e-020.1928image
ENSG00000169567.10,HINT1GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.4195e-03-0.2571image
chr5:131159838-131160175:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4868e-02-0.2406image
chr5:131161358-131162249:-KIRCGSVA_HALLMARK_COAGULATIONEER7.5172e-070.3570image
ENSG00000169567.10,HINT1KIRCGSVA_HALLMARK_GLYCOLYSISEAG3.1562e-090.3325image
ENSG00000169567.10,HINT1KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.0823e-040.2592image
chr5:131159838-131160175:-KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1710e-030.2230image
chr5:131159838-131160175:-LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER5.2978e-04-0.2922image
ENSG00000169567.10,HINT1LAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG8.1955e-04-0.2816image
chr5:131159838-131160175:-LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.1639e-020.1616image
ENSG00000169567.10,HINT1LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.9612e-02-0.1183image
chr5:131161358-131162249:-LIHCGSVA_HALLMARK_HEME_METABOLISMEER2.0839e-02-0.2407image
ENSG00000169567.10,HINT1LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.8610e-060.2446image
chr5:131161358-131162249:-LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.6832e-030.2268image
chr5:131159838-131160175:-LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER4.9567e-040.1783image
ENSG00000169567.10,HINT1LUSCGSVA_HALLMARK_APICAL_SURFACEEAG7.6673e-040.1708image
chr5:131159838-131160175:-MESOGSVA_HALLMARK_MYC_TARGETS_V2EER2.4785e-030.3747image
ENSG00000169567.10,HINT1MESOGSVA_HALLMARK_MYC_TARGETS_V2EAG3.2405e-030.3653image
ENSG00000169567.10,HINT1OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.7177e-060.2938image
chr5:131159838-131160175:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.6217e-060.3114image
ENSG00000169567.10,HINT1PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.3784e-030.2379image
chr5:131159838-131160175:-PAADGSVA_HALLMARK_UV_RESPONSE_UPEER4.0113e-030.2352image
chr5:131159838-131160175:-PRADGSVA_HALLMARK_ADIPOGENESISEER2.2574e-030.1548image
chr5:131161358-131162249:-PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.8733e-04-0.4184image
ENSG00000169567.10,HINT1PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.8104e-040.1818image
chr5:131159838-131160175:-SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.9527e-030.2652image
ENSG00000169567.10,HINT1SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.6244e-030.2658image
chr5:131159838-131160175:-SKCMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER7.6889e-050.2499image
ENSG00000169567.10,HINT1SKCMGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0599e-020.1580image
chr5:131161358-131162249:-SKCMGSVA_HALLMARK_HEME_METABOLISMEER8.8721e-03-0.2890image
ENSG00000169567.10,HINT1STADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.0000e-020.1510image
chr5:131161358-131162249:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER8.1008e-03-0.2214image
chr5:131159838-131160175:-TGCTGSVA_HALLMARK_PEROXISOMEEER3.7827e-030.2495image
ENSG00000169567.10,HINT1TGCTGSVA_HALLMARK_PEROXISOMEEAG1.4319e-030.2717image
chr5:131159838-131160175:-THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER1.8022e-050.2175image
ENSG00000169567.10,HINT1THCAGSVA_HALLMARK_GLYCOLYSISEAG5.0023e-050.2008image
chr5:131161358-131162249:-THCAGSVA_HALLMARK_DNA_REPAIREER3.1671e-020.1779image
ENSG00000169567.10,HINT1THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.3850e-02-0.2103image
chr5:131159838-131160175:-THYMGSVA_HALLMARK_MTORC1_SIGNALINGEER4.1890e-02-0.2019image
ENSG00000169567.10,HINT1UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.8301e-020.1785image
ENSG00000169567.10,HINT1UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG7.3411e-03-0.4126image
chr5:131159838-131160175:-UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER7.5375e-03-0.4163image


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7. Enriched editing regions and drugs for HINT1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000169567.10,HINT1ACCCyclopamineEAG3.0405e-02-0.3231image
ENSG00000169567.10,HINT1BLCADocetaxelEAG2.9840e-04-0.1994image
chr5:131159838-131160175:-BLCADocetaxelEER4.3974e-04-0.1951image
ENSG00000169567.10,HINT1BRCAIPA.3EAG4.3165e-050.1498image
chr5:131161358-131162249:-BRCAAZD.0530EER1.7371e-03-0.1867image
chr5:131161358-131162249:-CESCAMG.706EER4.3931e-03-0.3026image
chr5:131159838-131160175:-CESCCGP.60474EER2.7103e-02-0.1345image
ENSG00000169567.10,HINT1CESCCGP.60474EAG6.5189e-03-0.1649image
chr5:131161358-131162249:-CHOLBortezomibEER8.7276e-040.6708image
ENSG00000169567.10,HINT1CHOLAZD6482EAG1.4659e-020.4211image
ENSG00000169567.10,HINT1COADBX.795EAG5.7504e-04-0.2298image
chr5:131159838-131160175:-COADBX.795EER4.0658e-04-0.2385image
chr5:131159838-131160175:-DLBCImatinibEER2.9359e-030.4381image
ENSG00000169567.10,HINT1DLBCAZD6482EAG2.5124e-030.4492image
chr5:131159838-131160175:-ESCABI.D1870EER1.6472e-04-0.2981image
ENSG00000169567.10,HINT1ESCAGSK269962AEAG1.1043e-04-0.3037image
ENSG00000169567.10,HINT1GBMABT.888EAG1.0749e-030.3162image
chr5:131159838-131160175:-GBMABT.888EER1.4016e-020.2426image
ENSG00000169567.10,HINT1KIRCA.770041EAG1.6906e-07-0.2955image
chr5:131161358-131162249:-KIRCGSK269962AEER3.0874e-06-0.3379image
ENSG00000169567.10,HINT1KIRPIPA.3EAG5.9738e-050.2684image
chr5:131159838-131160175:-KIRPEtoposideEER2.7692e-050.2856image
chr5:131159838-131160175:-LAMLCytarabineEER6.4834e-040.2878image
ENSG00000169567.10,HINT1LAMLCytarabineEAG1.3300e-050.3614image
chr5:131159838-131160175:-LGGJNK.9LEER1.1535e-020.1618image
ENSG00000169567.10,HINT1LGGJNK.9LEAG8.8091e-030.1621image
chr5:131161358-131162249:-LIHCAZD6482EER1.4109e-030.3280image
ENSG00000169567.10,HINT1LIHCMG.132EAG4.3870e-03-0.1677image
ENSG00000169567.10,HINT1LUADBIRB.0796EAG1.1361e-020.1313image
ENSG00000169567.10,HINT1LUSCAS601245EAG2.2162e-020.1166image
chr5:131159838-131160175:-LUSCJNJ.26854165EER1.4742e-02-0.1253image
chr5:131161358-131162249:-LUSCFH535EER2.5541e-020.1799image
chr5:131159838-131160175:-MESOA.770041EER9.3821e-06-0.5264image
ENSG00000169567.10,HINT1MESOA.770041EAG3.8844e-06-0.5449image
chr5:131159838-131160175:-OVMG.132EER2.4023e-04-0.2458image
ENSG00000169567.10,HINT1OVMG.132EAG8.6597e-06-0.2904image
ENSG00000169567.10,HINT1PAADDocetaxelEAG5.8877e-03-0.2261image
chr5:131159838-131160175:-PAADMG.132EER1.5522e-02-0.1993image
ENSG00000169567.10,HINT1PCPGLapatinibEAG3.9644e-020.2835image
chr5:131159838-131160175:-PRADFTI.277EER3.8196e-040.1797image
chr5:131161358-131162249:-PRADEmbelinEER2.7570e-020.2545image
ENSG00000169567.10,HINT1PRADFTI.277EAG1.9475e-040.1864image
ENSG00000169567.10,HINT1READBAY.61.3606EAG7.7617e-030.3157image
chr5:131159838-131160175:-READGSK.650394EER1.1638e-020.3021image
ENSG00000169567.10,HINT1SARCCyclopamineEAG4.1915e-030.2423image
chr5:131159838-131160175:-SARCCyclopamineEER1.2276e-020.2158image
chr5:131161358-131162249:-SKCMCyclopamineEER2.8224e-020.2470image
chr5:131159838-131160175:-SKCMMG.132EER5.9690e-04-0.2187image
ENSG00000169567.10,HINT1SKCMCGP.082996EAG2.6736e-03-0.1852image
ENSG00000169567.10,HINT1STADCytarabineEAG3.4535e-040.2087image
chr5:131161358-131162249:-STADBAY.61.3606EER1.1846e-020.2107image
ENSG00000169567.10,HINT1TGCTErlotinibEAG1.6355e-02-0.2063image
chr5:131159838-131160175:-TGCTLenalidomideEER2.5965e-020.1931image
ENSG00000169567.10,HINT1THCAATRAEAG8.4437e-050.1948image
chr5:131161358-131162249:-THCADMOGEER4.3314e-020.1675image
chr5:131159838-131160175:-THCAAZD.2281EER2.4786e-050.2142image
ENSG00000169567.10,HINT1THYMJNK.Inhibitor.VIIIEAG9.6816e-030.2550image
chr5:131159838-131160175:-THYMJNK.Inhibitor.VIIIEER1.9335e-020.2313image
ENSG00000169567.10,HINT1UCECBAY.61.3606EAG5.1372e-040.2950image
chr5:131159838-131160175:-UCECBAY.61.3606EER4.3301e-030.2459image
chr5:131159838-131160175:-UCSBryostatin.1EER3.2870e-05-0.6070image
ENSG00000169567.10,HINT1UCSBryostatin.1EAG1.5526e-05-0.6198image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType