CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HCLS1 (ImmuneEditome ID:3059)

1. Gene summary of enriched editing regions for HCLS1

check button Gene summary
Gene informationGene symbol

HCLS1

Gene ID

3059

GeneSynonymsCTTNL|HS1|lckBP1|p75
GeneCytomap

3q13.33

GeneTypeprotein-coding
GeneDescriptionhematopoietic lineage cell-specific protein
GeneModificationdate20230404
UniprotIDP14317;E7EVW7;F8WDD5;F8WEZ6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:121637703-121639012:-ENST00000473883.4ENSG00000180353.9HCLS1ncRNA_intronicL1MEi,L1M5,(AC)n,AluSx,AluJo,AluJr4chr3:121637703-121639012:-.alignment
chr3:121651004-121652603:-ENST00000481314.4ENSG00000180353.9HCLS1ncRNA_intronicAluJb,AluSx4,AluSz,L1ME2,(CAAT)nchr3:121651004-121652603:-.alignment
chr3:121651004-121652603:-ENST00000487290.4ENSG00000180353.9HCLS1ncRNA_intronicAluJb,AluSx4,AluSz,L1ME2,(CAAT)nchr3:121651004-121652603:-.alignment


Top

2. Tumor-specific enriched editing regions for HCLS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000180353.9,HCLS1LUSCPathEAG4.9801e-023.8453e-020.1758image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for HCLS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:121637703-121639012:-LAMLEERENSG00000140632,GLYR1-0.41701.8433e-022.7616e-06-0.4300imageNELAVL1;FUS;HNRNPA1;HNRNPU;NOP58;SAFB2;TAF15NAT_cells_CD4_memory_activatedGSVA_HALLMARK_PEROXISOME
chr3:121637703-121639012:-LAMLEERENSG00000134516,DOCK2-0.41562.5971e-026.9707e-06-0.4139imageNELAVL1;FUS;NOP58;TAF15DOCK2MonocytesGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr3:121637703-121639012:-LAMLEERENSG00000264281,CTD-2031P19.40.39753.5657e-021.2116e-060.4436imageNNNANK_cells_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM

More results



Top

4. Enriched editing regions and immune related splicing for HCLS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for HCLS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000180353.9,HCLS1BLCAEAGMacrophages_M04.2373e-040.5433image
chr3:121637703-121639012:-BRCAEERT_cells_CD4_memory_resting6.2825e-030.3930image
ENSG00000180353.9,HCLS1BRCAEAGT_cells_CD4_memory_resting6.0812e-030.3904image
ENSG00000180353.9,HCLS1ESCAEAGDendritic_cells_resting1.2456e-020.5350image
ENSG00000180353.9,HCLS1GBMEAGDendritic_cells_activated8.0017e-030.4994image
chr3:121637703-121639012:-KIRCEERDendritic_cells_activated1.1859e-020.2370image
ENSG00000180353.9,HCLS1KIRCEAGT_cells_CD4_memory_resting2.0494e-02-0.2168image
chr3:121637703-121639012:-LAMLEERT_cells_follicular_helper1.8511e-020.2243image
chr3:121651004-121652603:-LAMLEERT_cells_follicular_helper2.0832e-020.3082image
ENSG00000180353.9,HCLS1LAMLEAGT_cells_follicular_helper2.9085e-020.1961image
ENSG00000180353.9,HCLS1LGGEAGMonocytes3.6144e-02-0.3366image
chr3:121637703-121639012:-LUSCEERB_cells_naive3.3192e-03-0.2597image
ENSG00000180353.9,HCLS1LUSCEAGB_cells_naive5.1868e-03-0.2376image
ENSG00000180353.9,HCLS1OVEAGNK_cells_activated1.2560e-02-0.5227image
ENSG00000180353.9,HCLS1SKCMEAGT_cells_regulatory_(Tregs)2.4080e-03-0.5900image
ENSG00000180353.9,HCLS1STADEAGB_cells_memory1.4398e-02-0.3094image
ENSG00000180353.9,HCLS1THYMEAGT_cells_CD4_memory_resting3.6591e-03-0.5398image


Top

6. Enriched editing regions and immune gene sets for HCLS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000180353.9,HCLS1BLCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.4108e-040.5620image
chr3:121637703-121639012:-BRCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.9137e-030.3956image
ENSG00000180353.9,HCLS1BRCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.0133e-020.3345image
ENSG00000180353.9,HCLS1ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.3999e-03-0.6088image
ENSG00000180353.9,HCLS1GBMGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG3.7893e-02-0.4015image
ENSG00000180353.9,HCLS1KIRCGSVA_HALLMARK_GLYCOLYSISEAG3.3564e-080.4891image
chr3:121637703-121639012:-KIRCGSVA_HALLMARK_GLYCOLYSISEER8.7832e-070.4451image
chr3:121637703-121639012:-LAMLGSVA_HALLMARK_PEROXISOMEEER8.9992e-03-0.2480image
chr3:121651004-121652603:-LAMLGSVA_HALLMARK_P53_PATHWAYEER1.8594e-030.4069image
ENSG00000180353.9,HCLS1LAMLGSVA_HALLMARK_DNA_REPAIREAG5.5400e-04-0.3057image
ENSG00000180353.9,HCLS1LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.3094e-030.4964image
ENSG00000180353.9,HCLS1LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.7108e-020.2368image
chr3:121637703-121639012:-LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER5.1678e-030.2847image
ENSG00000180353.9,HCLS1LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG4.1320e-050.3428image
chr3:121637703-121639012:-LUSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.7199e-050.3542image
ENSG00000180353.9,HCLS1OVGSVA_HALLMARK_COMPLEMENTEAG3.8243e-020.4444image
ENSG00000180353.9,HCLS1SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.9798e-070.8309image
ENSG00000180353.9,HCLS1STADGSVA_HALLMARK_UV_RESPONSE_UPEAG6.5443e-030.3418image


Top

7. Enriched editing regions and drugs for HCLS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000180353.9,HCLS1BLCABIBW2992EAG1.6406e-020.3869image
chr3:121637703-121639012:-BRCAAZD.0530EER2.0354e-03-0.4388image
ENSG00000180353.9,HCLS1BRCALenalidomideEAG5.9880e-030.3911image
ENSG00000180353.9,HCLS1DLBCBI.D1870EAG4.3194e-02-0.4451image
ENSG00000180353.9,HCLS1GBMEmbelinEAG7.8946e-03-0.5001image
ENSG00000180353.9,HCLS1KIRCAG.014699EAG3.8693e-050.3754image
chr3:121637703-121639012:-KIRCAG.014699EER8.0262e-050.3639image
chr3:121637703-121639012:-LAMLAZD6482EER4.9098e-030.2664image
chr3:121651004-121652603:-LAMLAICAREER2.3202e-020.3030image
ENSG00000180353.9,HCLS1LAMLFTI.277EAG7.3814e-030.2395image
ENSG00000180353.9,HCLS1LGGFH535EAG7.0136e-04-0.5195image
ENSG00000180353.9,HCLS1LUADAICAREAG2.4942e-030.2978image
chr3:121637703-121639012:-LUADAICAREER9.7929e-040.3329image
ENSG00000180353.9,HCLS1LUSCGemcitabineEAG2.0473e-04-0.3121image
chr3:121637703-121639012:-LUSCGemcitabineEER9.4894e-04-0.2910image
ENSG00000180353.9,HCLS1OVDMOGEAG2.1228e-02-0.4880image
chr3:121637703-121639012:-SARCMidostaurinEER3.1866e-02-0.4585image
ENSG00000180353.9,HCLS1SARCCHIR.99021EAG4.2820e-02-0.4354image
ENSG00000180353.9,HCLS1SKCMDocetaxelEAG2.6168e-03-0.5861image
ENSG00000180353.9,HCLS1STADGDC0941EAG1.1955e-020.3174image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType