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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HCK (ImmuneEditome ID:3055)

1. Gene summary of enriched editing regions for HCK

check button Gene summary
Gene informationGene symbol

HCK

Gene ID

3055

GeneSynonymsAIPCV|JTK9|p59Hck|p61Hck
GeneCytomap

20q11.21

GeneTypeprotein-coding
GeneDescriptiontyrosine-protein kinase HCK|hematopoietic cell kinase|hemopoietic cell kinase|p59-HCK/p60-HCK
GeneModificationdate20230518
UniprotIDP08631;H7BXG4;H7C5P9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:32080525-32081101:+ENST00000262651.3ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000375852.2ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000375862.5ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000486475.4ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000518730.4ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000520553.4ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000534862.4ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000538448.4ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32080525-32081101:+ENST00000629881.1ENSG00000101336.11HCKintronicAluJo,AluSz6chr20:32080525-32081101:+.alignment
chr20:32091681-32091968:+ENST00000262651.3ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000375852.2ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000375862.5ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000486475.4ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000518730.4ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000520553.4ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000534862.4ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000538448.4ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32091681-32091968:+ENST00000629881.1ENSG00000101336.11HCKintronicAluJrchr20:32091681-32091968:+.alignment
chr20:32094392-32095444:+ENST00000262651.3ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000375852.2ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000375862.5ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000486475.4ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000518730.4ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000520553.4ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000534862.4ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000538448.4ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32094392-32095444:+ENST00000629881.1ENSG00000101336.11HCKintronicL1ME3,AluSz,(GAAA)n,L1MB8,AluJochr20:32094392-32095444:+.alignment
chr20:32096588-32097984:+ENST00000262651.3ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000375852.2ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000375862.5ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000486475.4ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000518730.4ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000520553.4ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000534862.4ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000538448.4ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment
chr20:32096588-32097984:+ENST00000629881.1ENSG00000101336.11HCKintronicAluY,(ATAA)n,L1MEd,AluJo,AluJr,(AC)n,L1ME3chr20:32096588-32097984:+.alignment


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2. Tumor-specific enriched editing regions for HCK


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr20:32091681-32091968:+ESCAPathEER2.2803e-024.0030e-020.2944image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for HCK


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for HCK


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for HCK


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:32080525-32081101:+LAMLEERMacrophages_M24.0265e-040.4356image
chr20:32094392-32095444:+LAMLEERT_cells_CD4_memory_resting7.9802e-060.4585image
chr20:32096588-32097984:+LAMLEERNK_cells_activated4.7541e-050.4693image
ENSG00000101336.11,HCKLAMLEAGMast_cells_activated1.3137e-060.4460image
chr20:32091681-32091968:+STADEERB_cells_naive3.2023e-02-0.2055image
chr20:32094392-32095444:+STADEERT_cells_CD4_memory_resting1.7017e-02-0.2997image
chr20:32096588-32097984:+STADEERT_cells_CD4_memory_resting4.0608e-02-0.3893image
ENSG00000101336.11,HCKSTADEAGT_cells_CD4_memory_activated1.5243e-020.2149image


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6. Enriched editing regions and immune gene sets for HCK


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000101336.11,HCKESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.0048e-02-0.2758image
chr20:32091681-32091968:+ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEER3.3921e-030.3754image
chr20:32094392-32095444:+LAMLGSVA_HALLMARK_COMPLEMENTEER2.0620e-05-0.4394image
ENSG00000101336.11,HCKLAMLGSVA_HALLMARK_COMPLEMENTEAG4.7052e-07-0.4624image
chr20:32096588-32097984:+LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER2.0761e-040.4323image
chr20:32080525-32081101:+LAMLGSVA_HALLMARK_COMPLEMENTEER2.7787e-04-0.4462image
chr20:32091681-32091968:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.2720e-040.3225image
ENSG00000101336.11,HCKSTADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.8363e-03-0.2739image
chr20:32094392-32095444:+STADGSVA_HALLMARK_UV_RESPONSE_DNEER2.6304e-02-0.2799image


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7. Enriched editing regions and drugs for HCK


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000101336.11,HCKESCAAZ628EAG8.4977e-030.3315image
chr20:32091681-32091968:+ESCAAZ628EER6.4465e-030.3508image
chr20:32094392-32095444:+LAMLAG.014699EER1.1813e-05-0.4507image
ENSG00000101336.11,HCKLAMLGefitinibEAG8.3021e-04-0.3170image
chr20:32096588-32097984:+LAMLCytarabineEER2.8111e-06-0.5301image
chr20:32080525-32081101:+LAMLMetforminEER1.5455e-04-0.4624image
chr20:32091681-32091968:+STADAP.24534EER1.1843e-030.3066image
ENSG00000101336.11,HCKSTADAG.014699EAG7.0016e-040.2969image
chr20:32094392-32095444:+STADBIRB.0796EER3.6877e-03-0.3607image
chr20:32096588-32097984:+STADDMOGEER4.7759e-020.3773image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr20:32080525-32081101:+ENST00000518730.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32080525-32081101:+ENST00000518730.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32080525-32081101:+ENST00000520553.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32080525-32081101:+ENST00000520553.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32080525-32081101:+ENST00000538448.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32080525-32081101:+ENST00000538448.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32091681-32091968:+ENST00000518730.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32091681-32091968:+ENST00000518730.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32091681-32091968:+ENST00000520553.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32091681-32091968:+ENST00000520553.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32091681-32091968:+ENST00000538448.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32091681-32091968:+ENST00000538448.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32094392-32095444:+ENST00000518730.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32094392-32095444:+ENST00000518730.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32094392-32095444:+ENST00000520553.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32094392-32095444:+ENST00000520553.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32094392-32095444:+ENST00000538448.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32094392-32095444:+ENST00000538448.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32096588-32097984:+ENST00000518730.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32096588-32097984:+ENST00000518730.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32096588-32097984:+ENST00000520553.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32096588-32097984:+ENST00000520553.4P08631DB12010FostamatinibSmallMoleculeDrug
chr20:32096588-32097984:+ENST00000538448.4P08631DB06616BosutinibSmallMoleculeDrug
chr20:32096588-32097984:+ENST00000538448.4P08631DB12010FostamatinibSmallMoleculeDrug