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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: OSTM1 (ImmuneEditome ID:28962)

1. Gene summary of enriched editing regions for OSTM1

check button Gene summary
Gene informationGene symbol

OSTM1

Gene ID

28962

GeneSynonymsGIPN|GL|HSPC019|OPTB5
GeneCytomap

6q21

GeneTypeprotein-coding
GeneDescriptionosteopetrosis-associated transmembrane protein 1|CLCN7 accessory beta subunit|GAIP-interacting protein N terminus|chloride channel 7 beta subunit|grey-lethal osteopetrosis|osteopetrosis associated transmembrane protein 1
GeneModificationdate20230517
UniprotIDQ86WC4;A0A0A0MSP4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr6:108042126-108042734:-ENST00000492130.1ENSG00000081087.13OSTM1ncRNA_exonicAluJb,FLAM_Cchr6:108042126-108042734:-.alignment
chr6:108071381-108072462:-ENST00000467960.1ENSG00000081087.13OSTM1ncRNA_intronicAluSz,AluSxchr6:108071381-108072462:-.alignment


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2. Tumor-specific enriched editing regions for OSTM1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000081087.13,OSTM1KICHEAG7.1223e-03image
chr6:108042126-108042734:-KIRCEER8.1803e-03image
ENSG00000081087.13,OSTM1KIRCEAG8.1803e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr6:108042126-108042734:-LUSCEER3.3675e-024.2641e-021.7004e-01image
ENSG00000081087.13,OSTM1LUSCEAG3.3675e-024.2641e-021.7004e-01image

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3. Enriched editing regions and immune related genes for OSTM1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:108042126-108042734:-GBMEERENSG00000181284,TMEM1020.37654.1807e-042.4268e-070.4017imageNNTMEM102T_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr6:108042126-108042734:-ESCAEERENSG00000263813,MIR3679-0.43432.7722e-043.8192e-07-0.4219imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr6:108042126-108042734:-ESCAEERENSG00000263272,CTC-524C5.2-0.44263.1031e-041.0496e-07-0.4399imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr6:108042126-108042734:-ESCAEERENSG00000200651,Y_RNA-0.43374.1078e-048.3277e-07-0.4106imageNNNAB_cells_naiveGSVA_HALLMARK_SPERMATOGENESIS
chr6:108042126-108042734:-ESCAEERENSG00000005801,ZNF195-0.40921.3287e-038.5919e-07-0.4101imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr6:108042126-108042734:-ESCAEERENSG00000178935,ZNF552-0.38712.3579e-031.5347e-06-0.4014imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr6:108042126-108042734:-ESCAEERENSG00000198466,ZNF587-0.37823.3406e-032.0823e-07-0.4305imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr6:108042126-108042734:-ESCAEERENSG00000273226,RP11-513M16.8-0.36475.2587e-031.9763e-07-0.4312imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr6:108042126-108042734:-PCPGEERENSG00000126709,IFI60.51452.6871e-091.9620e-150.5508imageNNIFI6Macrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr6:108042126-108042734:-PCPGEERENSG00000187608,ISG150.49662.6300e-086.1073e-100.4438imageNNISG15T_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for OSTM1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:108042126-108042734:-
ESCAEERIRENSG00000168502.13chr188821466:8826232:8831606:8832777-0.35382.8116e-029.7652e-07-0.4200imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr6:108042126-108042734:-
ESCAEERIRENSG00000066248.10chr2232883980:232884144:232885279:232885369-0.34922.0083e-023.4417e-06-0.4159imageNNNGEFT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_JUNCTION
chr6:108042126-108042734:-
ESCAEERIRENSG00000162520.10chr132679905:32681860:32684257:32684376-0.38431.3352e-025.0043e-07-0.4210imageNNNAMast_cells_restingGSVA_HALLMARK_MYOGENESIS
chr6:108042126-108042734:-
ESCAEERESENSG00000144306.9chr2174410343:174410503:174422884:174423047:174424474:1744245700.39606.8944e-041.2031e-070.5135imageNNNAMacrophages_M0GSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000081087.13,OSTM1
ESCAEAGIRENSG00000168502.13chr188821466:8826232:8831606:8832777-0.37301.4547e-023.7351e-07-0.4267imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
ENSG00000081087.13,OSTM1
ESCAEAGIRENSG00000183963.14chr2231101875:31103975:31104315:31104623-0.27384.0489e-021.3905e-05-0.4031imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184NANeutrophilsGSVA_HALLMARK_MTORC1_SIGNALING
chr6:108042126-108042734:-
ESCAEERIRENSG00000112787.8chr12132571306:132571524:132572287:132572338-0.38891.3992e-027.3926e-07-0.4124imageNNNAB_cells_naiveGSVA_HALLMARK_MTORC1_SIGNALING
chr6:108042126-108042734:-
ESCAEERIRENSG00000162520.10chr132679905:32681860:32684009:32684089-0.39081.4190e-029.4910e-07-0.4115imageNNNAMast_cells_restingGSVA_HALLMARK_MYOGENESIS
chr6:108042126-108042734:-
ESCAEERIRENSG00000133275.11chr191978858:1979093:1979162:1979248-0.36872.5641e-021.3650e-06-0.4032imageNNNAMast_cells_activatedGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALING
chr6:108042126-108042734:-
ESCAEERIRENSG00000163734.4chr474036588:74037277:74038092:74038176-0.30673.7736e-024.2019e-05-0.4033imageNNCXCL3Mast_cells_activatedGSVA_HALLMARK_SPERMATOGENESIS

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5. Enriched editing regions and immune infiltration for OSTM1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr6:108042126-108042734:-ACCEERNK_cells_activated3.5953e-020.2810image
ENSG00000081087.13,OSTM1ACCEAGNK_cells_activated3.5953e-020.2810image
chr6:108042126-108042734:-BLCAEERDendritic_cells_resting8.5813e-05-0.2728image
ENSG00000081087.13,OSTM1BLCAEAGDendritic_cells_resting8.5813e-05-0.2728image
chr6:108042126-108042734:-BRCAEERNK_cells_resting9.6007e-030.0872image
ENSG00000081087.13,OSTM1BRCAEAGNK_cells_resting8.9112e-030.0880image
ENSG00000081087.13,OSTM1CHOLEAGT_cells_CD4_memory_activated2.9586e-02-0.4866image
chr6:108042126-108042734:-COADEERNeutrophils1.2530e-030.2936image
ENSG00000081087.13,OSTM1COADEAGT_cells_CD4_memory_resting2.4863e-02-0.2048image
ENSG00000081087.13,OSTM1DLBCEAGDendritic_cells_resting4.9186e-030.4998image
chr6:108042126-108042734:-ESCAEERT_cells_regulatory_(Tregs)1.2639e-02-0.2149image
ENSG00000081087.13,OSTM1ESCAEAGT_cells_regulatory_(Tregs)1.2202e-02-0.2121image
chr6:108042126-108042734:-GBMEERB_cells_naive1.1865e-02-0.2023image
ENSG00000081087.13,OSTM1GBMEAGB_cells_naive1.1865e-02-0.2023image
chr6:108042126-108042734:-HNSCEERMonocytes3.6967e-020.1054image
ENSG00000081087.13,OSTM1HNSCEAGMonocytes3.6967e-020.1054image
ENSG00000081087.13,OSTM1KICHEAGT_cells_CD4_memory_resting1.9210e-020.4322image
chr6:108042126-108042734:-KIRCEERB_cells_memory1.3483e-020.1287image
ENSG00000081087.13,OSTM1KIRCEAGB_cells_memory1.3483e-020.1287image
chr6:108042126-108042734:-KIRPEERNK_cells_resting4.1848e-020.1527image
ENSG00000081087.13,OSTM1KIRPEAGNK_cells_resting4.1848e-020.1527image
ENSG00000081087.13,OSTM1LAMLEAGT_cells_follicular_helper1.3271e-020.5192image
chr6:108042126-108042734:-LGGEERNeutrophils4.5399e-02-0.1002image
ENSG00000081087.13,OSTM1LGGEAGNeutrophils4.5399e-02-0.1002image
chr6:108042126-108042734:-LIHCEERT_cells_CD4_memory_resting3.5536e-020.1555image
ENSG00000081087.13,OSTM1LIHCEAGT_cells_CD4_memory_resting3.5536e-020.1555image
chr6:108042126-108042734:-LUADEERDendritic_cells_resting8.0487e-03-0.1399image
ENSG00000081087.13,OSTM1LUADEAGDendritic_cells_resting8.0487e-03-0.1399image
chr6:108042126-108042734:-LUSCEEREosinophils1.0419e-020.1278image
ENSG00000081087.13,OSTM1LUSCEAGEosinophils1.0419e-020.1278image
chr6:108042126-108042734:-MESOEERDendritic_cells_activated2.6798e-020.2686image
ENSG00000081087.13,OSTM1MESOEAGDendritic_cells_activated2.6798e-020.2686image
chr6:108042126-108042734:-OVEERT_cells_CD4_memory_resting4.0466e-020.2282image
ENSG00000081087.13,OSTM1OVEAGT_cells_follicular_helper4.1269e-02-0.2232image
chr6:108042126-108042734:-PCPGEERT_cells_regulatory_(Tregs)2.9567e-040.2689image
ENSG00000081087.13,OSTM1PCPGEAGT_cells_regulatory_(Tregs)2.9567e-040.2689image
chr6:108042126-108042734:-PRADEERDendritic_cells_activated1.0548e-050.2328image
ENSG00000081087.13,OSTM1PRADEAGNK_cells_activated9.1773e-050.2070image
ENSG00000081087.13,OSTM1READEAGT_cells_CD4_memory_resting4.8812e-020.2830image
chr6:108042126-108042734:-SARCEERPlasma_cells2.9489e-020.1576image
ENSG00000081087.13,OSTM1SARCEAGPlasma_cells2.9489e-020.1576image
chr6:108042126-108042734:-SKCMEERT_cells_CD4_memory_resting1.4101e-04-0.1799image
ENSG00000081087.13,OSTM1SKCMEAGT_cells_CD4_memory_resting1.4434e-04-0.1796image
chr6:108042126-108042734:-STADEERMacrophages_M11.6003e-020.1544image
ENSG00000081087.13,OSTM1STADEAGMacrophages_M11.4977e-020.1513image
chr6:108042126-108042734:-THCAEERB_cells_memory1.7241e-02-0.1236image
ENSG00000081087.13,OSTM1THCAEAGB_cells_memory1.7241e-02-0.1236image
ENSG00000081087.13,OSTM1THYMEAGMast_cells_resting1.1417e-020.2986image
ENSG00000081087.13,OSTM1UVMEAGNK_cells_resting1.8426e-02-0.2734image


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6. Enriched editing regions and immune gene sets for OSTM1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr6:108042126-108042734:-ESCAEER1.9498e-040.31652.0215e-020.20051.8227e-040.31782.0878e-030.2636image
ENSG00000081087.13,OSTM1ESCAEAG2.9148e-040.30281.4070e-020.20792.1418e-040.30909.7201e-030.2186image
ENSG00000081087.13,OSTM1LUADEAG5.2445e-040.18242.3569e-040.19329.2696e-050.20512.4242e-030.1598image
chr6:108042126-108042734:-LUADEER5.2445e-040.18242.3569e-040.19329.2696e-050.20512.4242e-030.1598image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000081087.13,OSTM1ACCGSVA_HALLMARK_ANGIOGENESISEAG6.6078e-03-0.3589image
chr6:108042126-108042734:-ACCGSVA_HALLMARK_ANGIOGENESISEER6.6078e-03-0.3589image
ENSG00000081087.13,OSTM1BLCAGSVA_HALLMARK_APICAL_JUNCTIONEAG8.5161e-030.1847image
chr6:108042126-108042734:-BLCAGSVA_HALLMARK_APICAL_JUNCTIONEER8.5161e-030.1847image
chr6:108042126-108042734:-BRCAGSVA_HALLMARK_PEROXISOMEEER5.7100e-050.1351image
ENSG00000081087.13,OSTM1BRCAGSVA_HALLMARK_PEROXISOMEEAG1.0879e-040.1299image
chr6:108042126-108042734:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9267e-02-0.1715image
ENSG00000081087.13,OSTM1CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.9267e-02-0.1715image
ENSG00000081087.13,OSTM1DLBCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.6964e-030.5136image
chr6:108042126-108042734:-ESCAGSVA_HALLMARK_APICAL_SURFACEEER2.5304e-040.3111image
ENSG00000081087.13,OSTM1ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG5.9529e-040.2877image
chr6:108042126-108042734:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4452e-040.2915image
ENSG00000081087.13,OSTM1GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.4452e-040.2915image
ENSG00000081087.13,OSTM1HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.4042e-020.1071image
chr6:108042126-108042734:-HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.4042e-020.1071image
chr6:108042126-108042734:-KIRCGSVA_HALLMARK_DNA_REPAIREER3.9413e-020.1074image
ENSG00000081087.13,OSTM1KIRCGSVA_HALLMARK_DNA_REPAIREAG3.9413e-020.1074image
ENSG00000081087.13,OSTM1KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.5469e-03-0.2071image
chr6:108042126-108042734:-KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER5.5469e-03-0.2071image
ENSG00000081087.13,OSTM1LAMLGSVA_HALLMARK_UV_RESPONSE_DNEAG3.5711e-03-0.5938image
chr6:108042126-108042734:-LGGGSVA_HALLMARK_ADIPOGENESISEER1.1151e-030.1626image
ENSG00000081087.13,OSTM1LGGGSVA_HALLMARK_ADIPOGENESISEAG1.1151e-030.1626image
ENSG00000081087.13,OSTM1LUADGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.7437e-050.2197image
chr6:108042126-108042734:-LUADGSVA_HALLMARK_MTORC1_SIGNALINGEER2.7437e-050.2197image
chr6:108042126-108042734:-MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.1215e-040.4050image
ENSG00000081087.13,OSTM1MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.1215e-040.4050image
ENSG00000081087.13,OSTM1PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.6301e-020.2109image
ENSG00000081087.13,OSTM1PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2291e-080.4119image
chr6:108042126-108042734:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2291e-080.4119image
chr6:108042126-108042734:-PRADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.5817e-06-0.2479image
ENSG00000081087.13,OSTM1PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2413e-05-0.2306image
ENSG00000081087.13,OSTM1READGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG5.4171e-030.3914image
ENSG00000081087.13,OSTM1SARCGSVA_HALLMARK_APICAL_SURFACEEAG1.5849e-030.2270image
chr6:108042126-108042734:-SARCGSVA_HALLMARK_APICAL_SURFACEEER1.5849e-030.2270image
chr6:108042126-108042734:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7247e-040.1776image
ENSG00000081087.13,OSTM1SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.7782e-040.1772image
ENSG00000081087.13,OSTM1STADGSVA_HALLMARK_COMPLEMENTEAG2.2223e-040.2280image
chr6:108042126-108042734:-STADGSVA_HALLMARK_COMPLEMENTEER1.1870e-050.2769image
ENSG00000081087.13,OSTM1TGCTGSVA_HALLMARK_KRAS_SIGNALING_DNEAG8.7303e-030.3008image
ENSG00000081087.13,OSTM1THCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.0438e-03-0.1453image
chr6:108042126-108042734:-THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER5.0438e-03-0.1453image
ENSG00000081087.13,OSTM1THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0613e-04-0.4162image
ENSG00000081087.13,OSTM1UCECGSVA_HALLMARK_P53_PATHWAYEAG7.2784e-040.4347image
ENSG00000081087.13,OSTM1UVMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.5210e-040.4264image


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7. Enriched editing regions and drugs for OSTM1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000081087.13,OSTM1ACCLenalidomideEAG3.4822e-03-0.3840image
chr6:108042126-108042734:-ACCLenalidomideEER3.4822e-03-0.3840image
chr6:108042126-108042734:-BLCACMKEER1.7682e-06-0.3288image
ENSG00000081087.13,OSTM1BLCACMKEAG1.7682e-06-0.3288image
chr6:108042126-108042734:-BRCAA.443654EER7.2678e-03-0.0903image
ENSG00000081087.13,OSTM1BRCAA.443654EAG8.3023e-03-0.0888image
chr6:108042126-108042734:-CESCErlotinibEER8.3782e-06-0.3202image
ENSG00000081087.13,OSTM1CESCErlotinibEAG8.3782e-06-0.3202image
ENSG00000081087.13,OSTM1CHOLCGP.082996EAG4.9799e-040.7065image
chr6:108042126-108042734:-ESCAKIN001.135EER6.9472e-05-0.3367image
ENSG00000081087.13,OSTM1ESCACGP.082996EAG1.8259e-04-0.3122image
ENSG00000081087.13,OSTM1GBMAZD8055EAG1.8767e-040.2966image
chr6:108042126-108042734:-GBMAZD8055EER1.8767e-040.2966image
ENSG00000081087.13,OSTM1HNSCAS601245EAG3.6583e-02-0.1056image
chr6:108042126-108042734:-HNSCAS601245EER3.6583e-02-0.1056image
ENSG00000081087.13,OSTM1KICHJNK.9LEAG1.3204e-020.4547image
chr6:108042126-108042734:-KIRCBMS.708163EER2.8573e-030.1551image
ENSG00000081087.13,OSTM1KIRCBMS.708163EAG2.8573e-030.1551image
chr6:108042126-108042734:-KIRPFH535EER9.4208e-030.1941image
ENSG00000081087.13,OSTM1KIRPFH535EAG9.4208e-030.1941image
ENSG00000081087.13,OSTM1LAMLAMG.706EAG2.8095e-04-0.7007image
chr6:108042126-108042734:-LGGIPA.3EER1.4362e-040.1892image
ENSG00000081087.13,OSTM1LGGIPA.3EAG1.4362e-040.1892image
ENSG00000081087.13,OSTM1LIHCMetforminEAG1.6315e-03-0.2313image
chr6:108042126-108042734:-LIHCMetforminEER1.6315e-03-0.2313image
ENSG00000081087.13,OSTM1LUADElesclomolEAG3.5809e-04-0.1876image
chr6:108042126-108042734:-LUADElesclomolEER3.5809e-04-0.1876image
chr6:108042126-108042734:-LUSCDMOGEER6.8358e-03-0.1349image
ENSG00000081087.13,OSTM1LUSCDMOGEAG6.8358e-03-0.1349image
ENSG00000081087.13,OSTM1MESOErlotinibEAG2.8644e-03-0.3563image
chr6:108042126-108042734:-MESOErlotinibEER2.8644e-03-0.3563image
ENSG00000081087.13,OSTM1OVCytarabineEAG1.3133e-02-0.2696image
chr6:108042126-108042734:-OVCytarabineEER3.8020e-02-0.2310image
ENSG00000081087.13,OSTM1PAADATRAEAG2.2570e-020.2193image
chr6:108042126-108042734:-PCPGEmbelinEER4.3719e-060.3374image
ENSG00000081087.13,OSTM1PCPGEmbelinEAG4.3719e-060.3374image
ENSG00000081087.13,OSTM1PRADBMS.509744EAG2.1279e-04-0.1962image
chr6:108042126-108042734:-PRADAZD.2281EER3.2472e-04-0.1913image
ENSG00000081087.13,OSTM1READBortezomibEAG1.2004e-02-0.3562image
chr6:108042126-108042734:-SARCA.770041EER1.4348e-03-0.2291image
ENSG00000081087.13,OSTM1SARCA.770041EAG1.4348e-03-0.2291image
chr6:108042126-108042734:-SKCMCEP.701EER3.1598e-04-0.1704image
ENSG00000081087.13,OSTM1SKCMCEP.701EAG3.1023e-04-0.1706image
ENSG00000081087.13,OSTM1STADAS601245EAG3.0207e-03-0.1839image
chr6:108042126-108042734:-STADAZD6482EER2.6738e-04-0.2318image
ENSG00000081087.13,OSTM1TGCTBIBW2992EAG3.1897e-02-0.2480image
chr6:108042126-108042734:-THCAAZ628EER2.4231e-04-0.1895image
ENSG00000081087.13,OSTM1THCAAZ628EAG2.4231e-04-0.1895image
ENSG00000081087.13,OSTM1THYMBMS.536924EAG1.4851e-07-0.5759image
ENSG00000081087.13,OSTM1UCECAZD6244EAG9.4355e-03-0.3410image
ENSG00000081087.13,OSTM1UCSAZD6244EAG2.6857e-020.4108image
ENSG00000081087.13,OSTM1UVMCGP.60474EAG1.1705e-04-0.4329image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType