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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ARL10 (ImmuneEditome ID:285598)

1. Gene summary of enriched editing regions for ARL10

check button Gene summary
Gene informationGene symbol

ARL10

Gene ID

285598

GeneSynonymsARL10A
GeneCytomap

5q35.2

GeneTypeprotein-coding
GeneDescriptionADP-ribosylation factor-like protein 10|ADP-ribosylation factor-like 10A|ADP-ribosylation factor-like membrane-associated protein
GeneModificationdate20230329
UniprotIDQ8N8L6;H0Y9R6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:176369660-176369923:+ENST00000310389.5ENSG00000175414.6ARL10intronicMIRb,AluJbchr5:176369660-176369923:+.alignment
chr5:176369660-176369923:+ENST00000503175.1ENSG00000175414.6ARL10intronicMIRb,AluJbchr5:176369660-176369923:+.alignment
chr5:176369660-176369923:+ENST00000514533.1ENSG00000175414.6ARL10intronicMIRb,AluJbchr5:176369660-176369923:+.alignment
chr5:176376058-176376361:+ENST00000310389.5ENSG00000175414.6ARL10UTR3AluSc8chr5:176376058-176376361:+.alignment
chr5:176377765-176379357:+ENST00000310389.5ENSG00000175414.6ARL10UTR3MER57A-int,AluSq,AluJb,AluYh3,ERV24B_Prim-intchr5:176377765-176379357:+.alignment
chr5:176380492-176381079:+ENST00000310389.5ENSG00000175414.6ARL10UTR3AluJb,AluSxchr5:176380492-176381079:+.alignment
chr5:176389872-176390510:+ENST00000514533.1ENSG00000175414.6ARL10intronicAluSx,MER5A,AluSpchr5:176389872-176390510:+.alignment


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2. Tumor-specific enriched editing regions for ARL10


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000175414.6,ARL10BRCAEAG1.2935e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr5:176376058-176376361:+KIRCPathEER1.1093e-028.9480e-040.2190image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ARL10


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ARL10


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ARL10


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000175414.6,ARL10BRCAEAGNK_cells_activated5.3197e-050.2567image
ENSG00000175414.6,ARL10ESCAEAGMacrophages_M14.5615e-02-0.2101image
chr5:176380492-176381079:+GBMEERDendritic_cells_activated2.4457e-020.2345image
ENSG00000175414.6,ARL10GBMEAGT_cells_CD4_memory_resting2.3448e-02-0.1901image
chr5:176376058-176376361:+HNSCEERNK_cells_activated3.9603e-040.4428image
chr5:176376058-176376361:+KIRCEERT_cells_gamma_delta3.6373e-040.2727image
ENSG00000175414.6,ARL10KIRCEAGMacrophages_M12.8924e-03-0.1923image
ENSG00000175414.6,ARL10KIRPEAGT_cells_CD4_memory_activated4.8055e-020.2654image
chr5:176380492-176381079:+LGGEERMacrophages_M01.5680e-02-0.1266image
ENSG00000175414.6,ARL10LGGEAGT_cells_follicular_helper7.1004e-03-0.1200image
ENSG00000175414.6,ARL10LUADEAGMast_cells_resting1.7109e-020.4724image
ENSG00000175414.6,ARL10LUSCEAGT_cells_CD4_memory_resting6.5768e-03-0.2390image
chr5:176377765-176379357:+OVEERMonocytes2.6699e-02-0.2227image
chr5:176380492-176381079:+OVEERMast_cells_resting4.0253e-020.3388image
chr5:176376058-176376361:+PCPGEERB_cells_naive3.5042e-020.3223image
ENSG00000175414.6,ARL10PCPGEAGT_cells_CD4_memory_activated3.4299e-020.1950image
chr5:176380492-176381079:+SARCEERT_cells_follicular_helper2.7240e-030.4510image
chr5:176376058-176376361:+SKCMEERPlasma_cells3.7616e-020.1705image
ENSG00000175414.6,ARL10SKCMEAGMonocytes4.8127e-020.1259image
ENSG00000175414.6,ARL10STADEAGT_cells_CD4_memory_resting3.4300e-03-0.2885image
ENSG00000175414.6,ARL10TGCTEAGT_cells_CD4_naive1.8445e-030.5813image
ENSG00000175414.6,ARL10THCAEAGB_cells_memory1.4950e-020.4081image
ENSG00000175414.6,ARL10UCSEAGMacrophages_M13.4389e-02-0.3197image


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6. Enriched editing regions and immune gene sets for ARL10


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000175414.6,ARL10BLCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.9952e-030.4584image
ENSG00000175414.6,ARL10BRCAGSVA_HALLMARK_P53_PATHWAYEAG4.4916e-070.3176image
ENSG00000175414.6,ARL10CESCGSVA_HALLMARK_P53_PATHWAYEAG3.2657e-03-0.3650image
chr5:176380492-176381079:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.6289e-030.3101image
ENSG00000175414.6,ARL10GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2236e-030.2687image
chr5:176376058-176376361:+HNSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.8274e-02-0.2561image
ENSG00000175414.6,ARL10HNSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG5.9451e-03-0.2529image
ENSG00000175414.6,ARL10KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.6962e-07-0.3174image
chr5:176376058-176376361:+KIRCGSVA_HALLMARK_DNA_REPAIREER5.5744e-060.3433image
ENSG00000175414.6,ARL10KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.7830e-020.2657image
chr5:176380492-176381079:+LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.7639e-030.1564image
ENSG00000175414.6,ARL10LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.8063e-090.2643image
ENSG00000175414.6,ARL10LUADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7659e-04-0.6663image
ENSG00000175414.6,ARL10LUSCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.8980e-03-0.2720image
ENSG00000175414.6,ARL10MESOGSVA_HALLMARK_G2M_CHECKPOINTEAG2.0769e-02-0.4895image
chr5:176377765-176379357:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.8163e-02-0.2207image
chr5:176380492-176381079:+OVGSVA_HALLMARK_PEROXISOMEEER4.0631e-020.3382image
ENSG00000175414.6,ARL10OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.0069e-02-0.2015image
ENSG00000175414.6,ARL10PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.8918e-02-0.3403image
chr5:176376058-176376361:+PCPGGSVA_HALLMARK_HEME_METABOLISMEER8.6007e-030.3958image
ENSG00000175414.6,ARL10PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.2337e-04-0.3145image
chr5:176380492-176381079:+SARCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER5.8054e-030.4186image
ENSG00000175414.6,ARL10SARCGSVA_HALLMARK_COAGULATIONEAG1.5641e-020.1939image
ENSG00000175414.6,ARL10SKCMGSVA_HALLMARK_COAGULATIONEAG1.2882e-020.1580image
chr5:176376058-176376361:+SKCMGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.4924e-030.2580image
ENSG00000175414.6,ARL10STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.1195e-020.2515image
ENSG00000175414.6,ARL10THCAGSVA_HALLMARK_E2F_TARGETSEAG1.5827e-02-0.4049image
ENSG00000175414.6,ARL10UCSGSVA_HALLMARK_G2M_CHECKPOINTEAG1.3313e-020.3704image


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7. Enriched editing regions and drugs for ARL10


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000175414.6,ARL10BLCABAY.61.3606EAG1.4263e-020.3712image
ENSG00000175414.6,ARL10BRCACEP.701EAG1.5903e-06-0.3028image
ENSG00000175414.6,ARL10CESCBI.2536EAG1.4815e-030.3921image
ENSG00000175414.6,ARL10ESCAFTI.277EAG2.2653e-020.2388image
chr5:176377765-176379357:+GBMAS601245EER8.7021e-03-0.2226image
chr5:176380492-176381079:+GBMCGP.082996EER2.0032e-03-0.3181image
ENSG00000175414.6,ARL10GBMGNF.2EAG2.7464e-05-0.3441image
chr5:176376058-176376361:+HNSCGW843682XEER2.2926e-02-0.2933image
ENSG00000175414.6,ARL10KIRCGSK269962AEAG6.6157e-06-0.2874image
chr5:176376058-176376361:+KIRCBMS.536924EER2.5559e-06-0.3558image
ENSG00000175414.6,ARL10KIRPAZD8055EAG4.5504e-02-0.2684image
chr5:176380492-176381079:+LGGABT.888EER2.1699e-030.1602image
ENSG00000175414.6,ARL10LGGMG.132EAG1.2182e-10-0.2822image
ENSG00000175414.6,ARL10LUSCKIN001.135EAG5.6530e-030.2433image
chr5:176377765-176379357:+OVGW843682XEER2.9548e-02-0.2188image
chr5:176380492-176381079:+OVBMS.754807EER2.4817e-020.3685image
ENSG00000175414.6,ARL10OVCCT018159EAG5.9444e-03-0.2540image
ENSG00000175414.6,ARL10PAADAICAREAG1.2623e-020.4233image
chr5:176376058-176376361:+PCPGBIBW2992EER1.2225e-020.3789image
ENSG00000175414.6,ARL10PCPGAZD.2281EAG6.6877e-03-0.2484image
chr5:176380492-176381079:+SARCAG.014699EER1.8656e-030.4661image
ENSG00000175414.6,ARL10SARCCGP.60474EAG8.2782e-03-0.2114image
ENSG00000175414.6,ARL10SKCMBortezomibEAG2.6574e-04-0.2301image
chr5:176376058-176376361:+SKCMCGP.082996EER1.0059e-03-0.2668image
ENSG00000175414.6,ARL10STADEmbelinEAG1.3508e-050.4182image
ENSG00000175414.6,ARL10TGCTCCT018159EAG2.3964e-020.4415image
ENSG00000175414.6,ARL10THCAJW.7.52.1EAG2.1366e-020.3877image
ENSG00000175414.6,ARL10UCSDocetaxelEAG1.0573e-02-0.3817image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType