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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RNF149 (ImmuneEditome ID:284996)

1. Gene summary of enriched editing regions for RNF149

check button Gene summary
Gene informationGene symbol

RNF149

Gene ID

284996

GeneSynonymsDNAPTP2
GeneCytomap

2q11.2

GeneTypeprotein-coding
GeneDescriptionE3 ubiquitin-protein ligase RNF149|DNA polymerase-transactivated protein 2|RING-type E3 ubiquitin transferase RNF149
GeneModificationdate20230329
UniprotIDQ8NC42;F8WCD0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:101271349-101271619:-ENST00000485752.1ENSG00000163162.7RNF149ncRNA_exonic(A)n,AluJrchr2:101271349-101271619:-.alignment
chr2:101273521-101273789:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluJbchr2:101273521-101273789:-.alignment
chr2:101274870-101275438:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluYa5,AluSc8,AluSpchr2:101274870-101275438:-.alignment
chr2:101277478-101278321:-ENST00000295317.3ENSG00000163162.7RNF149intronicAluJb,AluSq2chr2:101277478-101278321:-.alignment
chr2:101277478-101278321:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluJb,AluSq2chr2:101277478-101278321:-.alignment
chr2:101280000-101281846:-ENST00000490553.1ENSG00000163162.7RNF149ncRNA_exonicL1MD,AluJr,AluSx,AluJo,(AAT)n,A-rich,(GAT)nchr2:101280000-101281846:-.alignment
chr2:101284309-101285207:-ENST00000463726.1ENSG00000163162.7RNF149ncRNA_intronicAluSz,AluSqchr2:101284309-101285207:-.alignment
chr2:101284309-101285207:-ENST00000490553.1ENSG00000163162.7RNF149ncRNA_intronicAluSz,AluSqchr2:101284309-101285207:-.alignment
chr2:101287141-101288514:-ENST00000295317.3ENSG00000163162.7RNF149intronicAluSz6,AluSg,AluSqchr2:101287141-101288514:-.alignment
chr2:101287141-101288514:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluSz6,AluSg,AluSqchr2:101287141-101288514:-.alignment
chr2:101291266-101291578:-ENST00000478404.1ENSG00000163162.7RNF149ncRNA_intronicAluSg,FLAM_Cchr2:101291266-101291578:-.alignment
chr2:101295448-101296133:-ENST00000295317.3ENSG00000163162.7RNF149intronicAluSx3,AluJrchr2:101295448-101296133:-.alignment
chr2:101295448-101296133:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluSx3,AluJrchr2:101295448-101296133:-.alignment
chr2:101297423-101299094:-ENST00000295317.3ENSG00000163162.7RNF149intronicL1MB7,AluSz,AluJr,AluSz6,L1ME4bchr2:101297423-101299094:-.alignment
chr2:101297423-101299094:-ENST00000424632.4ENSG00000163162.7RNF149intronicL1MB7,AluSz,AluJr,AluSz6,L1ME4bchr2:101297423-101299094:-.alignment
chr2:101300595-101301563:-ENST00000295317.3ENSG00000163162.7RNF149intronicAluJb,AluSz6chr2:101300595-101301563:-.alignment
chr2:101300595-101301563:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluJb,AluSz6chr2:101300595-101301563:-.alignment
chr2:101302775-101305112:-ENST00000295317.3ENSG00000163162.7RNF149intronicCharlie22a,AluSg,AluSz6,AluJrchr2:101302775-101305112:-.alignment
chr2:101302775-101305112:-ENST00000424632.4ENSG00000163162.7RNF149intronicCharlie22a,AluSg,AluSz6,AluJrchr2:101302775-101305112:-.alignment
chr2:101307231-101307501:-ENST00000295317.3ENSG00000163162.7RNF149intronicAluJrchr2:101307231-101307501:-.alignment
chr2:101307231-101307501:-ENST00000424632.4ENSG00000163162.7RNF149intronicAluJrchr2:101307231-101307501:-.alignment


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2. Tumor-specific enriched editing regions for RNF149


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000163162.7,RNF149BRCAEAG1.8779e-02image
chr2:101271349-101271619:-KIRCEER1.0380e-02image
chr2:101271349-101271619:-LIHCEER2.1158e-02image
ENSG00000163162.7,RNF149LIHCEAG3.0768e-02image
ENSG00000163162.7,RNF149LUADEAG2.6522e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000163162.7,RNF149STADPathEAG2.2868e-022.6688e-030.1624image
ENSG00000163162.7,RNF149UCSCliEAG3.8535e-031.7738e-03-0.4629image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr2:101271349-101271619:-STADEER9.5167e-048.0952e-031.8710e+02image

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3. Enriched editing regions and immune related genes for RNF149


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:101280000-101281846:-ESCAEERENSG00000259556,RP11-56B16.2-0.51015.1630e-071.9841e-10-0.4828imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chr2:101280000-101281846:-ESCAEERENSG00000269688,AC008982.2-0.47755.9576e-062.8331e-08-0.4278imageNNNAB_cells_naiveGSVA_HALLMARK_GLYCOLYSIS
chr2:101280000-101281846:-ESCAEERENSG00000129515,SNX60.38798.6811e-042.2762e-070.4013imageNNSNX6T_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr2:101280000-101281846:-ESCAEERENSG00000237172,B3GNT90.31421.2478e-021.3294e-070.4084imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

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4. Enriched editing regions and immune related splicing for RNF149


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:101280000-101281846:-
ESCAEERIRENSG00000196262.9chr744798747:44798904:44799246:44799277-0.39912.9552e-031.8509e-07-0.4040imageNNPPIADendritic_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr2:101280000-101281846:-
ESCAEERIRENSG00000168264.6chr1234604268:234607852:234608033:234608094-0.33652.3533e-024.1825e-08-0.4230imageNNIRF2BP2B_cells_naiveGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr2:101280000-101281846:-
ESCAEERIRENSG00000016864.12chr352694488:52695035:52695189:52695229-0.44114.0086e-046.4620e-09-0.4452imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr2:101280000-101281846:-
ESCAEERMEXENSG00000196352.9chr1207339396:207339417:207340410:207340508:207358515:207358621:207359545:2073596770.30842.0073e-024.5325e-060.4001imageNNCD55Dendritic_cells_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr2:101280000-101281846:-
ESCAEERIRENSG00000135596.13chr6109445770:109446412:109446695:109446772-0.41741.6360e-031.4873e-07-0.4069imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
chr2:101280000-101281846:-
ESCAEERIRENSG00000196510.8chr12110377392:110377617:110377704:110378014-0.37635.5510e-035.3594e-08-0.4199imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr2:101280000-101281846:-
ESCAEERIRENSG00000128309.12chr2237024191:37024810:37026998:37027053-0.37533.3595e-036.9184e-07-0.4091imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr2:101280000-101281846:-
ESCAEERIRENSG00000112787.8chr12132571306:132571524:132572287:132572338-0.42558.2603e-043.1011e-08-0.4266imageNNNAB_cells_naiveGSVA_HALLMARK_MTORC1_SIGNALING
chr2:101280000-101281846:-
ESCAEERIRENSG00000016864.12chr352694488:52695587:52695927:52696040-0.48394.5268e-055.9683e-10-0.4714imageNNNAMacrophages_M2GSVA_HALLMARK_APICAL_JUNCTION
chr2:101280000-101281846:-
ESCAEERIRENSG00000119431.5chr9113375452:113375567:113376728:113376925-0.42271.2767e-031.0677e-07-0.4137imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS

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5. Enriched editing regions and immune infiltration for RNF149


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:101274870-101275438:-ACCEERMacrophages_M24.6140e-020.4506image
ENSG00000163162.7,RNF149ACCEAGMacrophages_M13.4482e-02-0.3233image
chr2:101274870-101275438:-BLCAEERMacrophages_M12.3726e-020.1394image
chr2:101280000-101281846:-BLCAEERMast_cells_resting3.5263e-020.3794image
ENSG00000163162.7,RNF149BLCAEAGDendritic_cells_activated5.2623e-060.2477image
chr2:101271349-101271619:-BRCAEEREosinophils6.0881e-030.0999image
chr2:101274870-101275438:-BRCAEERMast_cells_resting3.0632e-090.2487image
chr2:101284309-101285207:-BRCAEEREosinophils1.0831e-030.5159image
ENSG00000163162.7,RNF149BRCAEAGMast_cells_resting1.8955e-040.1225image
ENSG00000163162.7,RNF149CESCEAGT_cells_CD4_naive1.6641e-030.2028image
chr2:101271349-101271619:-CHOLEERB_cells_naive1.6166e-02-0.5065image
ENSG00000163162.7,RNF149CHOLEAGT_cells_gamma_delta1.1461e-020.4553image
chr2:101271349-101271619:-COADEERT_cells_CD4_memory_resting3.8618e-020.1984image
ENSG00000163162.7,RNF149COADEAGEosinophils1.2790e-050.3375image
ENSG00000163162.7,RNF149DLBCEAGT_cells_CD82.0353e-02-0.4909image
chr2:101271349-101271619:-ESCAEERB_cells_naive8.2849e-03-0.2231image
chr2:101274870-101275438:-ESCAEERT_cells_regulatory_(Tregs)5.0676e-03-0.2220image
chr2:101277478-101278321:-ESCAEERMacrophages_M27.7321e-030.2731image
chr2:101280000-101281846:-ESCAEERT_cells_regulatory_(Tregs)7.2623e-05-0.3132image
chr2:101284309-101285207:-ESCAEERNK_cells_activated2.3215e-020.2365image
chr2:101297423-101299094:-ESCAEERMonocytes6.1171e-03-0.3138image
chr2:101300595-101301563:-ESCAEERB_cells_memory2.5728e-020.3252image
chr2:101302775-101305112:-ESCAEERDendritic_cells_resting4.0044e-030.2711image
chr2:101307231-101307501:-ESCAEERDendritic_cells_resting4.1146e-020.4490image
ENSG00000163162.7,RNF149ESCAEAGT_cells_regulatory_(Tregs)1.3843e-03-0.2500image
chr2:101271349-101271619:-HNSCEERB_cells_naive4.6926e-04-0.1824image
chr2:101274870-101275438:-HNSCEERNeutrophils4.2519e-02-0.1140image
ENSG00000163162.7,RNF149HNSCEAGT_cells_CD4_naive4.0816e-02-0.0981image
ENSG00000163162.7,RNF149KICHEAGNK_cells_activated4.7168e-02-0.3716image
chr2:101280000-101281846:-KIRCEERB_cells_memory2.0898e-020.2221image
ENSG00000163162.7,RNF149KIRCEAGMacrophages_M27.4635e-050.2147image
ENSG00000163162.7,RNF149KIRPEAGDendritic_cells_activated6.7328e-030.1860image
chr2:101280000-101281846:-LAMLEERMast_cells_activated8.2912e-030.2289image
chr2:101295448-101296133:-LAMLEERMonocytes9.4701e-03-0.3380image
chr2:101297423-101299094:-LAMLEERT_cells_CD4_memory_resting7.9796e-030.2911image
ENSG00000163162.7,RNF149LAMLEAGB_cells_memory9.7651e-030.2125image
ENSG00000163162.7,RNF149LGGEAGNeutrophils3.3742e-030.2333image
chr2:101274870-101275438:-LIHCEERMacrophages_M11.6251e-020.1794image
ENSG00000163162.7,RNF149LIHCEAGNK_cells_resting2.1285e-020.1306image
chr2:101271349-101271619:-LUADEERMacrophages_M21.6555e-020.1477image
chr2:101274870-101275438:-LUADEERDendritic_cells_activated9.5045e-030.1729image
chr2:101284309-101285207:-LUADEERDendritic_cells_activated4.8081e-02-0.3186image
ENSG00000163162.7,RNF149LUADEAGT_cells_CD4_memory_resting6.7627e-080.2736image
chr2:101274870-101275438:-LUSCEERMast_cells_activated2.6971e-020.1313image
ENSG00000163162.7,RNF149LUSCEAGT_cells_regulatory_(Tregs)9.2585e-03-0.1303image
ENSG00000163162.7,RNF149MESOEAGMonocytes4.3812e-020.2529image
chr2:101271349-101271619:-OVEERNK_cells_resting2.8605e-02-0.1460image
chr2:101273521-101273789:-OVEERMacrophages_M22.5232e-020.4868image
chr2:101274870-101275438:-OVEERDendritic_cells_resting3.0220e-020.1423image
ENSG00000163162.7,RNF149PRADEAGT_cells_CD4_memory_resting4.9699e-040.1960image
ENSG00000163162.7,RNF149READEAGDendritic_cells_resting4.6381e-040.4487image
chr2:101271349-101271619:-SARCEERMacrophages_M17.9962e-030.2202image
ENSG00000163162.7,RNF149SARCEAGT_cells_CD4_memory_activated1.1064e-02-0.1933image
chr2:101271349-101271619:-SKCMEERDendritic_cells_activated4.5447e-020.1341image
ENSG00000163162.7,RNF149SKCMEAGB_cells_memory3.3665e-02-0.1257image
chr2:101271349-101271619:-STADEERT_cells_CD4_memory_resting2.8472e-03-0.1711image
chr2:101273521-101273789:-STADEERDendritic_cells_resting1.5672e-020.4237image
chr2:101274870-101275438:-STADEERDendritic_cells_resting1.0353e-040.2108image
chr2:101277478-101278321:-STADEERMonocytes1.1282e-02-0.2233image
chr2:101280000-101281846:-STADEERMacrophages_M21.2829e-020.1483image
chr2:101284309-101285207:-STADEERT_cells_gamma_delta1.9116e-020.2306image
chr2:101287141-101288514:-STADEERT_cells_regulatory_(Tregs)1.5611e-03-0.2367image
chr2:101295448-101296133:-STADEERMacrophages_M21.5806e-020.3332image
chr2:101297423-101299094:-STADEERMacrophages_M19.8690e-030.2230image
chr2:101300595-101301563:-STADEERNK_cells_activated3.2830e-030.3930image
chr2:101302775-101305112:-STADEERT_cells_CD82.8198e-020.1659image
ENSG00000163162.7,RNF149STADEAGDendritic_cells_resting1.6738e-020.1264image
chr2:101271349-101271619:-TGCTEERB_cells_naive1.3695e-020.2634image
ENSG00000163162.7,RNF149TGCTEAGB_cells_naive4.6559e-020.1947image
chr2:101271349-101271619:-THCAEERB_cells_memory1.5389e-020.1931image
chr2:101271349-101271619:-THYMEERNK_cells_activated2.9434e-030.4695image
ENSG00000163162.7,RNF149THYMEAGMast_cells_resting2.9076e-040.4322image
chr2:101271349-101271619:-UCECEERMacrophages_M01.6821e-020.2410image
ENSG00000163162.7,RNF149UCECEAGT_cells_CD4_memory_resting2.3234e-020.1967image
chr2:101271349-101271619:-UCSEERDendritic_cells_activated5.1471e-040.6137image


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6. Enriched editing regions and immune gene sets for RNF149


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000163162.7,RNF149COADEAG4.5946e-07-0.38613.1416e-02-0.17021.1638e-07-0.40413.0990e-03-0.2324image
chr2:101271349-101271619:-ESCAEER1.6228e-030.26496.0564e-030.23173.2352e-040.30064.0387e-020.1741image
chr2:101280000-101281846:-ESCAEER5.3640e-050.31858.1105e-040.26632.9882e-040.28671.1712e-030.2584image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr2:101274870-101275438:-ACCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.1651e-020.4592image
chr2:101274870-101275438:-BLCAGSVA_HALLMARK_HYPOXIAEER1.9076e-020.1445image
ENSG00000163162.7,RNF149BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG7.2212e-06-0.2442image
chr2:101280000-101281846:-BLCAGSVA_HALLMARK_NOTCH_SIGNALINGEER1.9410e-020.4176image
chr2:101274870-101275438:-BRCAGSVA_HALLMARK_HEME_METABOLISMEER9.0867e-060.1875image
chr2:101271349-101271619:-BRCAGSVA_HALLMARK_HEME_METABOLISMEER1.5309e-060.1742image
ENSG00000163162.7,RNF149BRCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.1006e-06-0.1595image
chr2:101271349-101271619:-CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.2032e-02-0.1701image
ENSG00000163162.7,RNF149CESCGSVA_HALLMARK_UV_RESPONSE_DNEAG4.6963e-030.1827image
ENSG00000163162.7,RNF149CHOLGSVA_HALLMARK_UV_RESPONSE_DNEAG1.2674e-020.4496image
chr2:101271349-101271619:-CHOLGSVA_HALLMARK_ANGIOGENESISEER2.7178e-020.4703image
chr2:101274870-101275438:-COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.4879e-02-0.2634image
ENSG00000163162.7,RNF149COADGSVA_HALLMARK_UV_RESPONSE_UPEAG2.1427e-10-0.4753image
ENSG00000163162.7,RNF149DLBCGSVA_HALLMARK_ANGIOGENESISEAG4.2467e-020.4361image
chr2:101277478-101278321:-ESCAGSVA_HALLMARK_MYOGENESISEER2.0913e-020.2380image
chr2:101284309-101285207:-ESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.5991e-020.2506image
chr2:101307231-101307501:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.0727e-03-0.5878image
chr2:101280000-101281846:-ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER3.1888e-060.3642image
chr2:101274870-101275438:-ESCAGSVA_HALLMARK_HYPOXIAEER4.2092e-030.2265image
ENSG00000163162.7,RNF149ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG6.7391e-040.2652image
chr2:101271349-101271619:-ESCAGSVA_HALLMARK_G2M_CHECKPOINTEER3.5279e-030.2459image
chr2:101302775-101305112:-ESCAGSVA_HALLMARK_HYPOXIAEER1.6221e-030.2958image
chr2:101300595-101301563:-ESCAGSVA_HALLMARK_HYPOXIAEER6.9843e-03-0.3884image
ENSG00000163162.7,RNF149GBMGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG5.1825e-03-0.2892image
chr2:101271349-101271619:-GBMGSVA_HALLMARK_MYOGENESISEER2.2472e-02-0.3101image
chr2:101274870-101275438:-HNSCGSVA_HALLMARK_SPERMATOGENESISEER1.0347e-030.1834image
chr2:101271349-101271619:-HNSCGSVA_HALLMARK_MTORC1_SIGNALINGEER2.8018e-040.1894image
ENSG00000163162.7,RNF149HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.1129e-040.1842image
ENSG00000163162.7,RNF149KIRCGSVA_HALLMARK_UV_RESPONSE_UPEAG1.9613e-21-0.4879image
chr2:101280000-101281846:-KIRCGSVA_HALLMARK_SPERMATOGENESISEER3.0268e-020.2086image
chr2:101271349-101271619:-KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.7866e-040.2459image
ENSG00000163162.7,RNF149KIRPGSVA_HALLMARK_MYOGENESISEAG1.5591e-06-0.3237image
chr2:101295448-101296133:-LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2859e-02-0.3248image
chr2:101284309-101285207:-LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER9.3893e-04-0.3227image
chr2:101297423-101299094:-LAMLGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER6.1686e-05-0.4275image
chr2:101280000-101281846:-LAMLGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER2.3144e-02-0.1976image
ENSG00000163162.7,RNF149LAMLGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.7575e-04-0.2846image
chr2:101302775-101305112:-LAMLGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER8.6051e-03-0.2801image
ENSG00000163162.7,RNF149LGGGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4117e-020.1962image
chr2:101274870-101275438:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3600e-020.1842image
ENSG00000163162.7,RNF149LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.1272e-060.2651image
chr2:101271349-101271619:-LIHCGSVA_HALLMARK_ADIPOGENESISEER1.2104e-070.3067image
chr2:101271349-101271619:-LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEER7.5039e-060.2722image
chr2:101274870-101275438:-LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2196e-030.2148image
chr2:101284309-101285207:-LUADGSVA_HALLMARK_COMPLEMENTEER1.2703e-040.5754image
ENSG00000163162.7,RNF149LUADGSVA_HALLMARK_MYC_TARGETS_V2EAG2.7149e-06-0.2389image
chr2:101284309-101285207:-LUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.9911e-02-0.3674image
chr2:101274870-101275438:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1061e-02-0.1369image
chr2:101271349-101271619:-LUSCGSVA_HALLMARK_G2M_CHECKPOINTEER1.7602e-020.1400image
ENSG00000163162.7,RNF149LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0089e-05-0.2193image
ENSG00000163162.7,RNF149MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.7777e-03-0.3570image
chr2:101271349-101271619:-MESOGSVA_HALLMARK_MITOTIC_SPINDLEEER3.8505e-020.2879image
ENSG00000163162.7,RNF149OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG8.1230e-040.1990image
chr2:101274870-101275438:-OVGSVA_HALLMARK_FATTY_ACID_METABOLISMEER5.8510e-080.3468image
chr2:101271349-101271619:-OVGSVA_HALLMARK_DNA_REPAIREER1.2052e-080.3685image
chr2:101273521-101273789:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.6542e-020.4830image
chr2:101280000-101281846:-OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.8890e-02-0.2380image
ENSG00000163162.7,RNF149PAADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0411e-02-0.2052image
chr2:101271349-101271619:-PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.5386e-020.1912image
ENSG00000163162.7,RNF149PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG4.5921e-020.1131image
ENSG00000163162.7,RNF149READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.2291e-02-0.2699image
chr2:101274870-101275438:-SARCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.7614e-030.2741image
chr2:101271349-101271619:-SARCGSVA_HALLMARK_MTORC1_SIGNALINGEER1.5105e-03-0.2620image
ENSG00000163162.7,RNF149SARCGSVA_HALLMARK_DNA_REPAIREAG1.0697e-02-0.1942image
chr2:101271349-101271619:-SKCMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.7207e-040.2415image
chr2:101274870-101275438:-SKCMGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.3746e-030.2323image
ENSG00000163162.7,RNF149SKCMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.5902e-030.1859image
chr2:101307231-101307501:-STADGSVA_HALLMARK_SPERMATOGENESISEER7.8383e-030.4196image
chr2:101273521-101273789:-STADGSVA_HALLMARK_MYOGENESISEER1.7869e-020.4160image
chr2:101280000-101281846:-STADGSVA_HALLMARK_MTORC1_SIGNALINGEER6.6545e-030.1615image
chr2:101297423-101299094:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER4.3491e-020.1754image
chr2:101271349-101271619:-STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.7174e-030.1557image
chr2:101295448-101296133:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0539e-020.3518image
ENSG00000163162.7,RNF149STADGSVA_HALLMARK_GLYCOLYSISEAG3.5578e-06-0.2422image
chr2:101302775-101305112:-STADGSVA_HALLMARK_APICAL_SURFACEEER5.5612e-040.2584image
chr2:101274870-101275438:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6291e-02-0.1314image
chr2:101287141-101288514:-STADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.2217e-030.2097image
chr2:101277478-101278321:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.1048e-030.2694image
ENSG00000163162.7,RNF149TGCTGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.1969e-04-0.3666image
chr2:101271349-101271619:-TGCTGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.5692e-03-0.3340image
ENSG00000163162.7,RNF149THCAGSVA_HALLMARK_MYOGENESISEAG3.1354e-03-0.1892image
chr2:101271349-101271619:-THCAGSVA_HALLMARK_HEME_METABOLISMEER7.6223e-030.2122image
ENSG00000163162.7,RNF149THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.4340e-04-0.4202image
chr2:101271349-101271619:-THYMGSVA_HALLMARK_UV_RESPONSE_UPEER8.9465e-03-0.4184image
ENSG00000163162.7,RNF149UCECGSVA_HALLMARK_PEROXISOMEEAG2.1029e-05-0.3598image
chr2:101271349-101271619:-UCECGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.4662e-02-0.2459image
ENSG00000163162.7,RNF149UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8713e-020.3572image
chr2:101271349-101271619:-UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3902e-020.4595image


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7. Enriched editing regions and drugs for RNF149


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr2:101274870-101275438:-ACCAZD.0530EER2.5561e-020.4977image
ENSG00000163162.7,RNF149ACCCisplatinEAG1.1501e-020.3819image
chr2:101274870-101275438:-BLCACGP.082996EER9.4811e-03-0.1597image
ENSG00000163162.7,RNF149BLCABMS.536924EAG1.1354e-030.1784image
chr2:101271349-101271619:-BLCAJNK.9LEER2.3715e-020.1494image
chr2:101280000-101281846:-BLCALenalidomideEER4.7552e-030.4938image
ENSG00000163162.7,RNF149BRCACCT007093EAG3.0070e-08-0.1810image
chr2:101271349-101271619:-BRCABMS.708163EER9.8576e-03-0.0941image
chr2:101274870-101275438:-BRCAEtoposideEER6.6119e-040.1444image
chr2:101271349-101271619:-CESCAZ628EER5.8413e-03-0.2053image
ENSG00000163162.7,RNF149CESCBMS.536924EAG4.1913e-030.1858image
chr2:101271349-101271619:-CHOLBMS.754807EER4.6988e-03-0.5796image
ENSG00000163162.7,RNF149CHOLBMS.754807EAG5.1398e-04-0.5957image
chr2:101274870-101275438:-COADCCT007093EER2.0874e-02-0.2503image
chr2:101271349-101271619:-COADFTI.277EER1.3026e-02-0.2372image
ENSG00000163162.7,RNF149COADAZ628EAG5.5267e-120.5102image
ENSG00000163162.7,RNF149DLBCCGP.082996EAG6.8984e-030.5585image
chr2:101271349-101271619:-ESCADocetaxelEER1.4433e-04-0.3169image
chr2:101274870-101275438:-ESCADocetaxelEER1.8538e-03-0.2458image
chr2:101280000-101281846:-ESCACMKEER2.3725e-03-0.2424image
chr2:101302775-101305112:-ESCAImatinibEER2.9362e-03-0.2798image
chr2:101307231-101307501:-ESCAAZD6482EER1.4149e-02-0.5268image
chr2:101277478-101278321:-ESCADocetaxelEER1.0913e-06-0.4782image
ENSG00000163162.7,RNF149ESCAImatinibEAG4.4120e-04-0.2738image
chr2:101271349-101271619:-GBMCHIR.99021EER3.9497e-030.3859image
ENSG00000163162.7,RNF149GBMBicalutamideEAG5.0027e-050.4097image
chr2:101274870-101275438:-HNSCKU.55933EER5.7429e-030.1548image
chr2:101271349-101271619:-HNSCErlotinibEER1.1584e-02-0.1326image
ENSG00000163162.7,RNF149HNSCDMOGEAG6.8419e-03-0.1295image
chr2:101280000-101281846:-KIRCJNK.9LEER1.9891e-020.2238image
ENSG00000163162.7,RNF149KIRCBMS.536924EAG1.7950e-120.3736image
chr2:101284309-101285207:-KIRCEHT.1864EER2.3140e-02-0.2772image
chr2:101271349-101271619:-KIRCBIRB.0796EER1.3529e-030.2268image
ENSG00000163162.7,RNF149KIRPBMS.509744EAG7.7717e-040.2296image
chr2:101271349-101271619:-KIRPAZD6244EER1.3597e-020.2151image
chr2:101284309-101285207:-LAMLEHT.1864EER2.7566e-03-0.2935image
ENSG00000163162.7,RNF149LAMLDasatinibEAG8.7488e-040.2716image
chr2:101280000-101281846:-LAMLCytarabineEER2.1282e-02-0.2003image
chr2:101302775-101305112:-LAMLABT.888EER5.1839e-03-0.2972image
chr2:101297423-101299094:-LAMLAG.014699EER1.6280e-03-0.3426image
chr2:101295448-101296133:-LAMLCI.1040EER3.2940e-040.4553image
ENSG00000163162.7,RNF149LGGAICAREAG3.4495e-02-0.1694image
chr2:101271349-101271619:-LIHCIPA.3EER2.4132e-070.2996image
ENSG00000163162.7,RNF149LIHCIPA.3EAG7.4451e-070.2767image
chr2:101274870-101275438:-LIHCCamptothecinEER2.3722e-040.2715image
chr2:101271349-101271619:-LUADABT.888EER2.6619e-020.1367image
ENSG00000163162.7,RNF149LUADCCT007093EAG1.3776e-05-0.2218image
chr2:101284309-101285207:-LUADCCT007093EER9.0650e-040.5102image
chr2:101274870-101275438:-LUADBMS.754807EER1.0290e-03-0.2179image
chr2:101274870-101275438:-LUSCLFM.A13EER3.5054e-030.1727image
chr2:101271349-101271619:-LUSCBI.2536EER4.0024e-02-0.1213image
ENSG00000163162.7,RNF149LUSCGW843682XEAG2.4359e-040.1829image
ENSG00000163162.7,RNF149MESOAZD6482EAG6.2283e-03-0.3385image
chr2:101273521-101273789:-OVBI.D1870EER2.6722e-020.4826image
chr2:101271349-101271619:-OVA.770041EER3.8795e-06-0.3023image
chr2:101280000-101281846:-OVMethotrexateEER3.3147e-030.2954image
chr2:101274870-101275438:-OVMG.132EER6.3865e-06-0.2920image
ENSG00000163162.7,RNF149OVBMS.509744EAG2.2695e-05-0.2503image
chr2:101271349-101271619:-PAADGefitinibEER1.1987e-020.2399image
ENSG00000163162.7,RNF149PAADCGP.60474EAG5.3968e-030.2225image
chr2:101271349-101271619:-PCPGDMOGEER8.8648e-03-0.2618image
ENSG00000163162.7,RNF149PCPGAZD.0530EAG4.6030e-030.2636image
ENSG00000163162.7,RNF149PRADEHT.1864EAG3.6394e-030.1642image
ENSG00000163162.7,RNF149SARCCCT007093EAG1.9860e-04-0.2800image
chr2:101271349-101271619:-SARCCCT007093EER2.5581e-03-0.2496image
chr2:101274870-101275438:-SARCKIN001.135EER2.0679e-03-0.3241image
chr2:101271349-101271619:-SKCMGNF.2EER1.2528e-05-0.2879image
chr2:101274870-101275438:-SKCMLapatinibEER2.0179e-030.2373image
ENSG00000163162.7,RNF149SKCMBexaroteneEAG1.2192e-02-0.1481image
chr2:101307231-101307501:-STADBicalutamideEER3.8571e-020.3326image
chr2:101280000-101281846:-STADBleomycinEER1.1171e-02-0.1512image
chr2:101284309-101285207:-STADBI.2536EER1.0470e-020.2512image
ENSG00000163162.7,RNF149STADGDC0941EAG1.4852e-03-0.1673image
chr2:101271349-101271619:-STADAZD6244EER1.6485e-04-0.2151image
chr2:101302775-101305112:-STADJW.7.52.1EER1.9811e-03-0.2323image
chr2:101274870-101275438:-STADKU.55933EER2.9353e-03-0.1625image
chr2:101295448-101296133:-STADAZD8055EER6.5992e-030.3721image
chr2:101273521-101273789:-STADGSK269962AEER2.1068e-03-0.5235image
chr2:101287141-101288514:-STADBMS.536924EER2.0322e-03-0.2311image
chr2:101297423-101299094:-STADAKT.inhibitor.VIIIEER4.7567e-02-0.1721image
chr2:101277478-101278321:-STADGW.441756EER1.3545e-02-0.2178image
ENSG00000163162.7,RNF149TGCTFH535EAG4.4699e-04-0.3366image
chr2:101271349-101271619:-TGCTGW.441756EER5.9360e-03-0.2927image
ENSG00000163162.7,RNF149THCADocetaxelEAG2.7516e-030.1917image
chr2:101271349-101271619:-THCAGSK.650394EER2.8153e-020.1752image
chr2:101271349-101271619:-THYMAZD.0530EER4.7182e-02-0.3240image
ENSG00000163162.7,RNF149THYMBicalutamideEAG4.2771e-04-0.4213image
ENSG00000163162.7,RNF149UCECDocetaxelEAG1.2913e-040.3259image
chr2:101271349-101271619:-UCECDasatinibEER4.9049e-06-0.4473image
chr2:101274870-101275438:-UCECCisplatinEER5.7235e-030.2875image
chr2:101271349-101271619:-UCSAxitinibEER9.2291e-040.5912image
ENSG00000163162.7,RNF149UCSCMKEAG7.6950e-030.4010image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType