CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF283 (ImmuneEditome ID:284349)

1. Gene summary of enriched editing regions for ZNF283

check button Gene summary
Gene informationGene symbol

ZNF283

Gene ID

284349

GeneSynonymsHZF19|HZF41
GeneCytomap

19q13.31

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 283|zinc finger protein 41|zinc finger protein HZF19
GeneModificationdate20230518
UniprotIDQ4G0N1;Q8N7M2;K7ESH0;K7EL69;A0A494C0U8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:43838321-43838604:+ENST00000586976.4ENSG00000167637.15ZNF283ncRNA_intronicAluJb,L1MC4chr19:43838321-43838604:+.alignment
chr19:43840717-43841756:+ENST00000590950.4ENSG00000167637.15ZNF283exonicAluY,L1MEf,AluSxchr19:43840717-43841756:+.alignment
chr19:43843039-43843316:+ENST00000324461.9ENSG00000167637.15ZNF283intronicAluSc,Charlie1achr19:43843039-43843316:+.alignment
chr19:43843039-43843316:+ENST00000588797.4ENSG00000167637.15ZNF283intronicAluSc,Charlie1achr19:43843039-43843316:+.alignment
chr19:43843039-43843316:+ENST00000618787.3ENSG00000167637.15ZNF283intronicAluSc,Charlie1achr19:43843039-43843316:+.alignment
chr19:43850441-43851707:+ENST00000618787.3ENSG00000167637.15ZNF283UTR3Kanga1c,AluY,AluSz6chr19:43850441-43851707:+.alignment


Top

2. Tumor-specific enriched editing regions for ZNF283


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for ZNF283


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

4. Enriched editing regions and immune related splicing for ZNF283


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for ZNF283


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:43850441-43851707:+BLCAEERMacrophages_M13.7645e-020.2314image
chr19:43838321-43838604:+BRCAEERT_cells_follicular_helper5.9392e-030.3875image
chr19:43850441-43851707:+BRCAEERMacrophages_M11.8925e-020.1162image
ENSG00000167637.15,ZNF283BRCAEAGT_cells_CD4_memory_activated6.4729e-030.1236image
chr19:43850441-43851707:+CESCEERT_cells_gamma_delta1.8710e-02-0.2909image
ENSG00000167637.15,ZNF283CESCEAGT_cells_CD4_memory_activated4.6500e-030.3322image
ENSG00000167637.15,ZNF283COADEAGPlasma_cells2.7762e-040.6773image
chr19:43838321-43838604:+ESCAEERMast_cells_resting4.1362e-020.3162image
chr19:43850441-43851707:+ESCAEERMacrophages_M15.6434e-030.3298image
ENSG00000167637.15,ZNF283ESCAEAGNeutrophils1.5857e-020.2550image
chr19:43840717-43841756:+GBMEERMast_cells_activated4.7919e-020.2080image
chr19:43843039-43843316:+GBMEERT_cells_follicular_helper4.2684e-02-0.4260image
chr19:43850441-43851707:+HNSCEERMonocytes7.3659e-030.3986image
ENSG00000167637.15,ZNF283HNSCEAGMonocytes1.0855e-020.3763image
ENSG00000167637.15,ZNF283KICHEAGT_cells_CD4_memory_activated2.7421e-020.4026image
chr19:43850441-43851707:+KIRCEERDendritic_cells_resting2.6336e-020.3426image
chr19:43840717-43841756:+LGGEERT_cells_CD81.1622e-020.1857image
ENSG00000167637.15,ZNF283LGGEAGT_cells_CD84.5920e-020.1350image
chr19:43850441-43851707:+LUADEERMacrophages_M11.3859e-020.3726image
chr19:43840717-43841756:+OVEERT_cells_CD4_memory_activated2.2905e-020.2178image
chr19:43850441-43851707:+OVEERT_cells_CD4_memory_activated1.1721e-020.2859image
ENSG00000167637.15,ZNF283OVEAGT_cells_CD4_memory_activated8.7029e-030.2164image
ENSG00000167637.15,ZNF283PRADEAGMacrophages_M22.6163e-02-0.1721image
ENSG00000167637.15,ZNF283SARCEAGNeutrophils3.9810e-030.3927image
chr19:43840717-43841756:+STADEERMonocytes3.0055e-030.3625image
chr19:43850441-43851707:+STADEEREosinophils2.8906e-020.1979image
ENSG00000167637.15,ZNF283STADEAGEosinophils5.8584e-030.2075image
chr19:43850441-43851707:+TGCTEERB_cells_naive4.6808e-040.5336image
ENSG00000167637.15,ZNF283TGCTEAGB_cells_naive2.3393e-040.5504image
ENSG00000167637.15,ZNF283THCAEAGB_cells_naive6.8174e-03-0.2172image
ENSG00000167637.15,ZNF283THYMEAGNK_cells_resting2.1113e-020.3940image
chr19:43850441-43851707:+UCECEERB_cells_memory4.7662e-020.3074image
ENSG00000167637.15,ZNF283UCECEAGB_cells_memory1.9346e-020.3475image
ENSG00000167637.15,ZNF283UCSEAGMacrophages_M22.9325e-02-0.4050image


Top

6. Enriched editing regions and immune gene sets for ZNF283


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000167637.15,ZNF283STADEAG5.1846e-030.21042.8716e-020.16541.7524e-020.17942.4331e-020.1702image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:43850441-43851707:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.4699e-030.3060image
ENSG00000167637.15,ZNF283BLCAGSVA_HALLMARK_UV_RESPONSE_DNEAG4.1407e-030.3028image
chr19:43850441-43851707:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER9.8832e-070.2395image
chr19:43838321-43838604:+BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.0337e-020.3631image
ENSG00000167637.15,ZNF283BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.3664e-080.2504image
ENSG00000167637.15,ZNF283CESCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG4.4738e-040.4057image
chr19:43850441-43851707:+CESCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER2.1805e-030.3735image
ENSG00000167637.15,ZNF283COADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.0630e-040.7087image
chr19:43838321-43838604:+ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.5795e-020.3099image
chr19:43850441-43851707:+ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER4.0422e-020.2474image
chr19:43840717-43841756:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.1609e-030.2977image
chr19:43843039-43843316:+GBMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.0891e-020.5205image
ENSG00000167637.15,ZNF283GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.7074e-020.2381image
ENSG00000167637.15,ZNF283HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.0233e-030.4032image
chr19:43850441-43851707:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.8123e-030.3852image
ENSG00000167637.15,ZNF283KICHGSVA_HALLMARK_UV_RESPONSE_UPEAG3.6974e-020.3825image
ENSG00000167637.15,ZNF283KIRCGSVA_HALLMARK_GLYCOLYSISEAG1.3286e-020.2676image
chr19:43840717-43841756:+LGGGSVA_HALLMARK_HEME_METABOLISMEER2.6095e-020.1640image
ENSG00000167637.15,ZNF283LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG1.4433e-020.1651image
ENSG00000167637.15,ZNF283LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.3323e-03-0.3575image
chr19:43850441-43851707:+LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.8919e-04-0.5091image
ENSG00000167637.15,ZNF283LUSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.5269e-020.3046image
chr19:43840717-43841756:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5030e-02-0.2324image
ENSG00000167637.15,ZNF283OVGSVA_HALLMARK_G2M_CHECKPOINTEAG2.5406e-020.1850image
chr19:43850441-43851707:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0666e-040.4108image
chr19:43840717-43841756:+PCPGGSVA_HALLMARK_NOTCH_SIGNALINGEER2.0974e-020.4129image
ENSG00000167637.15,ZNF283PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.3892e-03-0.2335image
ENSG00000167637.15,ZNF283SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG9.4701e-030.3566image
chr19:43850441-43851707:+SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEER3.7837e-020.1623image
ENSG00000167637.15,ZNF283SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.0399e-020.1890image
chr19:43838321-43838604:+STADGSVA_HALLMARK_DNA_REPAIREER3.9136e-020.2648image
chr19:43840717-43841756:+STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER6.2166e-030.3360image
ENSG00000167637.15,ZNF283STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.7319e-040.2660image
ENSG00000167637.15,ZNF283TGCTGSVA_HALLMARK_COAGULATIONEAG8.4267e-04-0.5070image
chr19:43850441-43851707:+TGCTGSVA_HALLMARK_COAGULATIONEER1.1014e-03-0.5029image
ENSG00000167637.15,ZNF283THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2232e-02-0.1842image
ENSG00000167637.15,ZNF283THYMGSVA_HALLMARK_DNA_REPAIREAG4.1914e-030.4786image


Top

7. Enriched editing regions and drugs for ZNF283


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000167637.15,ZNF283BLCACGP.082996EAG1.9245e-03-0.3262image
chr19:43850441-43851707:+BLCACGP.082996EER1.7344e-03-0.3428image
chr19:43838321-43838604:+BRCAGSK269962AEER3.7781e-02-0.2977image
ENSG00000167637.15,ZNF283BRCABryostatin.1EAG1.4206e-040.1723image
chr19:43850441-43851707:+BRCAJNK.Inhibitor.VIIIEER5.4997e-07-0.2449image
ENSG00000167637.15,ZNF283CESCCGP.60474EAG7.4197e-04-0.3912image
chr19:43850441-43851707:+CESCAZD.0530EER5.9507e-03-0.3376image
ENSG00000167637.15,ZNF283COADCCT018159EAG3.5048e-02-0.4319image
chr19:43838321-43838604:+ESCAABT.888EER1.9761e-02-0.3584image
chr19:43850441-43851707:+ESCAJNK.Inhibitor.VIIIEER2.8451e-02-0.2639image
chr19:43843039-43843316:+GBMBryostatin.1EER1.8049e-020.4884image
chr19:43840717-43841756:+GBMKU.55933EER2.1470e-03-0.3177image
ENSG00000167637.15,ZNF283GBMKU.55933EAG4.3023e-03-0.2832image
chr19:43850441-43851707:+HNSCAMG.706EER1.5572e-020.3626image
ENSG00000167637.15,ZNF283HNSCAMG.706EAG1.4345e-020.3627image
ENSG00000167637.15,ZNF283KICHJW.7.52.1EAG3.9333e-04-0.6054image
chr19:43850441-43851707:+KIRCEHT.1864EER2.8431e-02-0.3383image
chr19:43838321-43838604:+KIRCBicalutamideEER2.3167e-02-0.4616image
chr19:43840717-43841756:+LGGBI.2536EER1.6937e-030.2299image
ENSG00000167637.15,ZNF283LGGGW.441756EAG2.2605e-020.1540image
ENSG00000167637.15,ZNF283LUADDasatinibEAG2.4361e-03-0.3939image
chr19:43850441-43851707:+LUADGSK.650394EER5.7217e-04-0.5038image
chr19:43840717-43841756:+OVA.770041EER4.4379e-03-0.2705image
ENSG00000167637.15,ZNF283OVABT.888EAG2.1595e-02-0.1900image
chr19:43850441-43851707:+OVBIBW2992EER2.5328e-04-0.4055image
chr19:43840717-43841756:+PCPGLFM.A13EER2.7608e-03-0.5192image
ENSG00000167637.15,ZNF283PCPGErlotinibEAG1.2037e-02-0.3841image
ENSG00000167637.15,ZNF283PRADCCT007093EAG1.6356e-03-0.2419image
ENSG00000167637.15,ZNF283SARCEHT.1864EAG5.5324e-030.3794image
chr19:43850441-43851707:+SKCMErlotinibEER1.9011e-030.2408image
ENSG00000167637.15,ZNF283SKCMABT.263EAG1.0377e-030.2406image
chr19:43843039-43843316:+STADAZD.0530EER2.0826e-02-0.5126image
chr19:43850441-43851707:+STADEmbelinEER2.7632e-02-0.1995image
chr19:43840717-43841756:+STADJNJ.26854165EER4.6185e-03-0.3471image
chr19:43838321-43838604:+STADAZD8055EER3.4154e-030.3692image
ENSG00000167637.15,ZNF283TGCTBI.D1870EAG8.8928e-04-0.5050image
chr19:43850441-43851707:+TGCTBI.D1870EER1.0698e-03-0.5040image
ENSG00000167637.15,ZNF283THCAGSK269962AEAG7.1511e-03-0.2159image
ENSG00000167637.15,ZNF283THYMAZD6482EAG2.5360e-030.5011image
ENSG00000167637.15,ZNF283UCECEpothilone.BEAG2.2611e-030.4438image
chr19:43850441-43851707:+UCECBMS.754807EER4.3457e-040.5186image
chr19:43850441-43851707:+UCSAICAREER2.1784e-020.4566image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType