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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ENDOV (ImmuneEditome ID:284131)

1. Gene summary of enriched editing regions for ENDOV

check button Gene summary
Gene informationGene symbol

ENDOV

Gene ID

284131

GeneSynonyms-
GeneCytomap

17q25.3

GeneTypeprotein-coding
GeneDescriptionendonuclease V|hEndoV|inosine-specific endoribonuclease
GeneModificationdate20230329
UniprotIDQ8N8Q3;I3L485;I3L0L4;E5RHX4;E5RGZ9;E5RII5;E5RFW0;E5RJ92;I3L4V7;H0YAY5;H0YBZ5;I3L1V3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:80415974-80417078:+ENST00000520537.1ENSG00000173818.15ENDOVncRNA_exonicL2b,AluSp,AluJo,(CCCT)nchr17:80415974-80417078:+.alignment
chr17:80415974-80417078:+ENST00000523165.1ENSG00000173818.15ENDOVncRNA_exonicL2b,AluSp,AluJo,(CCCT)nchr17:80415974-80417078:+.alignment
chr17:80434658-80435989:+ENST00000517795.4ENSG00000173818.15ENDOVintronicL1MB7,AluY,AluJbchr17:80434658-80435989:+.alignment
chr17:80434658-80435989:+ENST00000518137.4ENSG00000173818.15ENDOVintronicL1MB7,AluY,AluJbchr17:80434658-80435989:+.alignment
chr17:80434658-80435989:+ENST00000518901.4ENSG00000173818.15ENDOVintronicL1MB7,AluY,AluJbchr17:80434658-80435989:+.alignment
chr17:80434658-80435989:+ENST00000518907.4ENSG00000173818.15ENDOVintronicL1MB7,AluY,AluJbchr17:80434658-80435989:+.alignment
chr17:80434658-80435989:+ENST00000520284.4ENSG00000173818.15ENDOVintronicL1MB7,AluY,AluJbchr17:80434658-80435989:+.alignment
chr17:80434658-80435989:+ENST00000520367.4ENSG00000173818.15ENDOVintronicL1MB7,AluY,AluJbchr17:80434658-80435989:+.alignment


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2. Tumor-specific enriched editing regions for ENDOV


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr17:80415974-80417078:+BRCAEER1.4078e-02image
ENSG00000173818.15,ENDOVBRCAEAG1.8291e-02image
chr17:80415974-80417078:+KIRCEER2.1990e-03image
ENSG00000173818.15,ENDOVKIRCEAG2.2892e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:80415974-80417078:+GBMEER2.9772e-021.5370e-027.8431e+00image
ENSG00000173818.15,ENDOVGBMEAG2.9772e-021.5370e-027.8431e+00image
chr17:80415974-80417078:+OVEER2.3339e-022.3642e-023.9623e+00image
ENSG00000173818.15,ENDOVOVEAG2.3339e-022.0831e-024.0760e+00image

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3. Enriched editing regions and immune related genes for ENDOV


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for ENDOV


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ENDOV


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:80415974-80417078:+BLCAEERDendritic_cells_resting4.4634e-02-0.2342image
ENSG00000173818.15,ENDOVBLCAEAGDendritic_cells_resting4.4634e-02-0.2342image
chr17:80415974-80417078:+BRCAEERT_cells_CD82.4685e-02-0.1364image
ENSG00000173818.15,ENDOVBRCAEAGT_cells_CD82.6833e-02-0.1333image
ENSG00000173818.15,ENDOVCESCEAGDendritic_cells_activated7.2108e-030.4882image
ENSG00000173818.15,ENDOVCOADEAGT_cells_CD4_memory_resting6.1858e-030.4736image
chr17:80415974-80417078:+ESCAEERMacrophages_M19.5185e-030.2419image
ENSG00000173818.15,ENDOVESCAEAGMacrophages_M19.5185e-030.2419image
chr17:80415974-80417078:+GBMEERT_cells_CD4_memory_activated7.4193e-050.3971image
ENSG00000173818.15,ENDOVGBMEAGT_cells_CD4_memory_activated7.4193e-050.3971image
chr17:80415974-80417078:+KIRCEERT_cells_CD82.3401e-020.2211image
ENSG00000173818.15,ENDOVKIRCEAGT_cells_CD82.7656e-020.2150image
chr17:80415974-80417078:+KIRPEERNeutrophils1.3282e-030.3263image
ENSG00000173818.15,ENDOVKIRPEAGNeutrophils1.3282e-030.3263image
chr17:80415974-80417078:+LGGEERPlasma_cells7.5373e-030.1496image
ENSG00000173818.15,ENDOVLGGEAGPlasma_cells7.5372e-030.1496image
ENSG00000173818.15,ENDOVLUADEAGT_cells_regulatory_(Tregs)3.8574e-020.2478image
chr17:80415974-80417078:+LUSCEERNeutrophils3.7851e-02-0.2298image
ENSG00000173818.15,ENDOVLUSCEAGNeutrophils3.7851e-02-0.2298image
chr17:80415974-80417078:+PRADEERNK_cells_activated1.2761e-02-0.1990image
ENSG00000173818.15,ENDOVPRADEAGNK_cells_activated7.8683e-03-0.2114image
chr17:80415974-80417078:+SARCEERMonocytes3.3130e-020.3776image
ENSG00000173818.15,ENDOVSARCEAGMonocytes3.3130e-020.3776image
chr17:80415974-80417078:+SKCMEERT_cells_CD4_memory_resting3.8191e-030.3622image
ENSG00000173818.15,ENDOVSKCMEAGT_cells_CD4_memory_resting3.8191e-030.3622image
chr17:80415974-80417078:+THCAEERDendritic_cells_activated3.8519e-020.1176image
ENSG00000173818.15,ENDOVTHCAEAGDendritic_cells_activated3.8519e-020.1176image


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6. Enriched editing regions and immune gene sets for ENDOV


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr17:80415974-80417078:+UCECEER4.7009e-040.63674.5550e-030.53837.2945e-030.51352.4325e-020.4404image
ENSG00000173818.15,ENDOVUCECEAG4.7009e-040.63674.5550e-030.53837.2945e-030.51352.4325e-020.4404image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000173818.15,ENDOVBLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6317e-02-0.2784image
chr17:80415974-80417078:+BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.6317e-02-0.2784image
ENSG00000173818.15,ENDOVBRCAGSVA_HALLMARK_GLYCOLYSISEAG8.3214e-040.2000image
chr17:80415974-80417078:+BRCAGSVA_HALLMARK_GLYCOLYSISEER5.6104e-040.2082image
ENSG00000173818.15,ENDOVCESCGSVA_HALLMARK_GLYCOLYSISEAG7.3801e-030.4870image
ENSG00000173818.15,ENDOVGBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.1565e-020.2106image
chr17:80415974-80417078:+GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.1565e-020.2106image
chr17:80415974-80417078:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.7917e-030.2733image
ENSG00000173818.15,ENDOVKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.1368e-030.2712image
ENSG00000173818.15,ENDOVLAMLGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.8401e-030.4038image
chr17:80415974-80417078:+LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9116e-030.4059image
chr17:80415974-80417078:+LUADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.7192e-03-0.3138image
chr17:80415974-80417078:+LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEER8.0174e-030.2909image
ENSG00000173818.15,ENDOVLUSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.0174e-030.2909image
chr17:80415974-80417078:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.6314e-030.2002image
ENSG00000173818.15,ENDOVOVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.6775e-030.1997image
chr17:80415974-80417078:+PCPGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.2158e-02-0.2509image
ENSG00000173818.15,ENDOVPCPGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.2158e-02-0.2509image
chr17:80415974-80417078:+PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.8826e-020.1751image
ENSG00000173818.15,ENDOVPRADGSVA_HALLMARK_PEROXISOMEEAG3.2568e-020.1707image
chr17:80415974-80417078:+SARCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.3861e-020.4307image
ENSG00000173818.15,ENDOVSARCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3861e-020.4307image
chr17:80415974-80417078:+SKCMGSVA_HALLMARK_P53_PATHWAYEER1.4868e-020.3080image
ENSG00000173818.15,ENDOVSKCMGSVA_HALLMARK_P53_PATHWAYEAG1.4868e-020.3080image
chr17:80415974-80417078:+STADGSVA_HALLMARK_ANDROGEN_RESPONSEEER5.1729e-040.2332image
ENSG00000173818.15,ENDOVSTADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.6032e-040.2318image
ENSG00000173818.15,ENDOVTHCAGSVA_HALLMARK_GLYCOLYSISEAG2.0898e-030.1741image
chr17:80415974-80417078:+THCAGSVA_HALLMARK_GLYCOLYSISEER2.0898e-030.1741image
ENSG00000173818.15,ENDOVUCECGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.0624e-040.6869image
chr17:80415974-80417078:+UCECGSVA_HALLMARK_MTORC1_SIGNALINGEER1.0624e-040.6869image


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7. Enriched editing regions and drugs for ENDOV


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000173818.15,ENDOVBLCAErlotinibEAG1.1316e-020.2929image
chr17:80415974-80417078:+BLCAErlotinibEER1.1316e-020.2929image
ENSG00000173818.15,ENDOVBRCAFH535EAG3.0944e-02-0.1299image
chr17:80415974-80417078:+BRCABosutinibEER3.2225e-020.1304image
ENSG00000173818.15,ENDOVCESCBMS.708163EAG4.7885e-040.6071image
ENSG00000173818.15,ENDOVGBMCisplatinEAG4.5208e-02-0.2071image
chr17:80415974-80417078:+GBMCisplatinEER4.5208e-02-0.2071image
chr17:80415974-80417078:+KIRCAZD.2281EER1.0473e-03-0.3154image
ENSG00000173818.15,ENDOVKIRCAZD.2281EAG1.0957e-03-0.3143image
ENSG00000173818.15,ENDOVKIRPCGP.082996EAG2.7285e-02-0.2277image
chr17:80415974-80417078:+KIRPCGP.082996EER2.7285e-02-0.2277image
ENSG00000173818.15,ENDOVLAMLAZD6482EAG1.8256e-02-0.3117image
chr17:80415974-80417078:+LAMLAZD6482EER1.8755e-02-0.3132image
ENSG00000173818.15,ENDOVLGGBX.795EAG2.1965e-020.1284image
chr17:80415974-80417078:+LGGBX.795EER2.1967e-020.1284image
chr17:80415974-80417078:+LUADGDC0941EER1.6803e-02-0.2912image
ENSG00000173818.15,ENDOVLUADGDC0941EAG1.9060e-02-0.2796image
chr17:80415974-80417078:+OVLapatinibEER5.9406e-03-0.1753image
ENSG00000173818.15,ENDOVOVLapatinibEAG6.2542e-03-0.1742image
chr17:80415974-80417078:+PCPGAZD6482EER9.4098e-04-0.3978image
ENSG00000173818.15,ENDOVPCPGAZD6482EAG9.4098e-04-0.3978image
chr17:80415974-80417078:+PRADLapatinibEER7.5986e-03-0.2130image
ENSG00000173818.15,ENDOVPRADLapatinibEAG4.6092e-03-0.2250image
chr17:80415974-80417078:+SARCCCT018159EER1.8852e-02-0.4129image
ENSG00000173818.15,ENDOVSARCCCT018159EAG1.8852e-02-0.4129image
chr17:80415974-80417078:+STADFTI.277EER1.4082e-02-0.1661image
ENSG00000173818.15,ENDOVSTADFTI.277EAG1.4965e-02-0.1646image
ENSG00000173818.15,ENDOVTHCAABT.263EAG2.7352e-050.2358image
chr17:80415974-80417078:+THCAABT.263EER2.7352e-050.2358image
ENSG00000173818.15,ENDOVUCECGefitinibEAG9.3652e-030.4996image
chr17:80415974-80417078:+UCECGefitinibEER9.3652e-030.4996image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType