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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CCDC57 (ImmuneEditome ID:284001)

1. Gene summary of enriched editing regions for CCDC57

check button Gene summary
Gene informationGene symbol

CCDC57

Gene ID

284001

GeneSynonyms-
GeneCytomap

17q25.3

GeneTypeprotein-coding
GeneDescriptioncoiled-coil domain-containing protein 57
GeneModificationdate20230329
UniprotIDQ2TAC2;J3QQX7;A0A590UJT6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:82109552-82112295:-ENST00000392346.5ENSG00000176155.17CCDC57UTR3AluJb,AluSz6,L1MEh,(A)n,A-rich,AluSx1,AluSp,AluYchr17:82109552-82112295:-.alignment
chr17:82109552-82112295:-ENST00000419322.5ENSG00000176155.17CCDC57UTR3AluJb,AluSz6,L1MEh,(A)n,A-rich,AluSx1,AluSp,AluYchr17:82109552-82112295:-.alignment
chr17:82113704-82113883:-ENST00000392346.5ENSG00000176155.17CCDC57exonicAluJbchr17:82113704-82113883:-.alignment
chr17:82113704-82113883:-ENST00000419322.5ENSG00000176155.17CCDC57exonicAluJbchr17:82113704-82113883:-.alignment
chr17:82115465-82116118:-ENST00000389641.7ENSG00000176155.17CCDC57intronicAluSg4,AluJb,(T)nchr17:82115465-82116118:-.alignment
chr17:82115465-82116118:-ENST00000392345.5ENSG00000176155.17CCDC57intronicAluSg4,AluJb,(T)nchr17:82115465-82116118:-.alignment
chr17:82115465-82116118:-ENST00000392346.5ENSG00000176155.17CCDC57intronicAluSg4,AluJb,(T)nchr17:82115465-82116118:-.alignment
chr17:82115465-82116118:-ENST00000392347.4ENSG00000176155.17CCDC57intronicAluSg4,AluJb,(T)nchr17:82115465-82116118:-.alignment
chr17:82115465-82116118:-ENST00000419322.5ENSG00000176155.17CCDC57intronicAluSg4,AluJb,(T)nchr17:82115465-82116118:-.alignment
chr17:82115465-82116118:-ENST00000583593.2ENSG00000176155.17CCDC57intronicAluSg4,AluJb,(T)nchr17:82115465-82116118:-.alignment
chr17:82123196-82123429:-ENST00000389641.7ENSG00000176155.17CCDC57intronicL1ME4b,AluJochr17:82123196-82123429:-.alignment
chr17:82123196-82123429:-ENST00000392345.5ENSG00000176155.17CCDC57intronicL1ME4b,AluJochr17:82123196-82123429:-.alignment
chr17:82123196-82123429:-ENST00000392346.5ENSG00000176155.17CCDC57intronicL1ME4b,AluJochr17:82123196-82123429:-.alignment
chr17:82123196-82123429:-ENST00000392347.4ENSG00000176155.17CCDC57intronicL1ME4b,AluJochr17:82123196-82123429:-.alignment
chr17:82123196-82123429:-ENST00000419322.5ENSG00000176155.17CCDC57intronicL1ME4b,AluJochr17:82123196-82123429:-.alignment
chr17:82123196-82123429:-ENST00000583593.2ENSG00000176155.17CCDC57intronicL1ME4b,AluJochr17:82123196-82123429:-.alignment
chr17:82125254-82126245:-ENST00000389641.7ENSG00000176155.17CCDC57intronicAluSz,AluSq2,AluJo,A-richchr17:82125254-82126245:-.alignment
chr17:82125254-82126245:-ENST00000392345.5ENSG00000176155.17CCDC57intronicAluSz,AluSq2,AluJo,A-richchr17:82125254-82126245:-.alignment
chr17:82125254-82126245:-ENST00000392346.5ENSG00000176155.17CCDC57intronicAluSz,AluSq2,AluJo,A-richchr17:82125254-82126245:-.alignment
chr17:82125254-82126245:-ENST00000392347.4ENSG00000176155.17CCDC57intronicAluSz,AluSq2,AluJo,A-richchr17:82125254-82126245:-.alignment
chr17:82125254-82126245:-ENST00000419322.5ENSG00000176155.17CCDC57intronicAluSz,AluSq2,AluJo,A-richchr17:82125254-82126245:-.alignment
chr17:82125254-82126245:-ENST00000583593.2ENSG00000176155.17CCDC57intronicAluSz,AluSq2,AluJo,A-richchr17:82125254-82126245:-.alignment
chr17:82130146-82130380:-ENST00000483145.1ENSG00000176155.17CCDC57ncRNA_intronicAluSx1,AluJbchr17:82130146-82130380:-.alignment
chr17:82145041-82145534:-ENST00000582040.1ENSG00000176155.17CCDC57ncRNA_intronicAluSx,AluSx1chr17:82145041-82145534:-.alignment
chr17:82185407-82187204:-ENST00000389641.7ENSG00000176155.17CCDC57intronicFLAM_C,AluJr4,AluJb,AluSc8chr17:82185407-82187204:-.alignment
chr17:82185407-82187204:-ENST00000392343.3ENSG00000176155.17CCDC57intronicFLAM_C,AluJr4,AluJb,AluSc8chr17:82185407-82187204:-.alignment
chr17:82185407-82187204:-ENST00000392347.4ENSG00000176155.17CCDC57intronicFLAM_C,AluJr4,AluJb,AluSc8chr17:82185407-82187204:-.alignment


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2. Tumor-specific enriched editing regions for CCDC57


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr17:82109552-82112295:-KIRPCliEER5.5422e-034.8053e-030.6039image
chr17:82185407-82187204:-KIRPPathEER1.0629e-022.4544e-020.4485image
ENSG00000176155.17,CCDC57KIRPCliEAG3.0802e-031.2058e-030.5055image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CCDC57


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for CCDC57


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for CCDC57


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000176155.17,CCDC57BRCAEAGT_cells_CD4_memory_activated3.0941e-020.1566image
ENSG00000176155.17,CCDC57CESCEAGB_cells_memory2.3076e-020.4527image
ENSG00000176155.17,CCDC57COADEAGDendritic_cells_activated3.0288e-030.6146image
chr17:82109552-82112295:-ESCAEERT_cells_regulatory_(Tregs)7.5738e-03-0.2929image
chr17:82113704-82113883:-ESCAEERMast_cells_resting2.5701e-030.3953image
chr17:82115465-82116118:-ESCAEERNK_cells_resting1.6049e-03-0.3925image
chr17:82123196-82123429:-ESCAEEREosinophils2.2183e-020.4306image
ENSG00000176155.17,CCDC57ESCAEAGMast_cells_resting2.6847e-020.2083image
chr17:82109552-82112295:-KIRPEERT_cells_CD4_memory_activated5.9623e-050.6404image
chr17:82185407-82187204:-KIRPEERNK_cells_resting6.5558e-030.5193image
ENSG00000176155.17,CCDC57KIRPEAGT_cells_CD4_memory_activated2.4360e-030.3812image
ENSG00000176155.17,CCDC57LAMLEAGB_cells_memory2.1581e-02-0.2420image
chr17:82109552-82112295:-LUADEERPlasma_cells4.3370e-02-0.2015image
ENSG00000176155.17,CCDC57LUADEAGT_cells_follicular_helper2.2955e-02-0.2129image
ENSG00000176155.17,CCDC57LUSCEAGT_cells_CD4_memory_resting7.5471e-030.3735image
chr17:82109552-82112295:-OVEERMacrophages_M04.7227e-02-0.1879image
chr17:82115465-82116118:-OVEERNK_cells_activated7.0077e-030.3365image
ENSG00000176155.17,CCDC57OVEAGNK_cells_activated3.7800e-020.1810image
ENSG00000176155.17,CCDC57PRADEAGDendritic_cells_resting1.1685e-020.4867image
chr17:82123196-82123429:-STADEERNK_cells_resting4.9570e-040.5580image


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6. Enriched editing regions and immune gene sets for CCDC57


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000176155.17,CCDC57BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3445e-020.1790image
chr17:82109552-82112295:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5450e-020.1942image
ENSG00000176155.17,CCDC57CESCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.2664e-030.5648image
chr17:82113704-82113883:-ESCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.4891e-020.2825image
ENSG00000176155.17,CCDC57ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.8909e-02-0.2205image
chr17:82109552-82112295:-ESCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER8.5933e-030.2884image
chr17:82115465-82116118:-ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2000e-02-0.2727image
ENSG00000176155.17,CCDC57LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.5061e-030.2903image
chr17:82109552-82112295:-LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2344e-02-0.2857image
ENSG00000176155.17,CCDC57LUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7685e-020.2063image
ENSG00000176155.17,CCDC57LUSCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.3710e-050.5730image
ENSG00000176155.17,CCDC57OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.2347e-040.3280image
chr17:82109552-82112295:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.3255e-030.2566image
chr17:82115465-82116118:-OVGSVA_HALLMARK_MYC_TARGETS_V1EER3.8575e-040.4336image
ENSG00000176155.17,CCDC57PRADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.2189e-030.5422image
chr17:82115465-82116118:-STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER8.3330e-050.3209image
chr17:82123196-82123429:-STADGSVA_HALLMARK_ANDROGEN_RESPONSEEER5.5240e-040.5542image
ENSG00000176155.17,CCDC57STADGSVA_HALLMARK_ADIPOGENESISEAG1.1798e-020.1739image


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7. Enriched editing regions and drugs for CCDC57


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000176155.17,CCDC57BLCABMS.754807EAG1.5031e-04-0.6658image
ENSG00000176155.17,CCDC57BRCACEP.701EAG3.9380e-020.1496image
chr17:82109552-82112295:-BRCAAxitinibEER1.4871e-020.1960image
ENSG00000176155.17,CCDC57CESCGNF.2EAG2.7545e-04-0.6664image
ENSG00000176155.17,CCDC57COADEpothilone.BEAG3.6788e-030.6048image
chr17:82113704-82113883:-ESCACMKEER1.0808e-020.3381image
ENSG00000176155.17,CCDC57ESCAGefitinibEAG2.3946e-04-0.3405image
chr17:82109552-82112295:-ESCAAZD.0530EER1.6579e-04-0.4042image
chr17:82115465-82116118:-ESCAAZD.2281EER3.8392e-03-0.3620image
chr17:82145041-82145534:-ESCAMidostaurinEER6.9314e-03-0.4058image
ENSG00000176155.17,CCDC57KIRCAG.014699EAG9.9220e-030.4425image
ENSG00000176155.17,CCDC57KIRPBI.D1870EAG5.4880e-03-0.3514image
chr17:82109552-82112295:-KIRPAZD8055EER2.9213e-03-0.5019image
chr17:82185407-82187204:-KIRPBMS.754807EER2.1936e-03-0.5735image
ENSG00000176155.17,CCDC57LAMLLenalidomideEAG8.7009e-050.4017image
chr17:82109552-82112295:-LAMLGDC0941EER1.3395e-030.3614image
chr17:82109552-82112295:-LUADGefitinibEER1.0893e-02-0.2536image
ENSG00000176155.17,CCDC57LUSCCI.1040EAG4.7255e-04-0.4762image
ENSG00000176155.17,CCDC57OVBMS.509744EAG1.2581e-04-0.3276image
chr17:82109552-82112295:-OVABT.263EER4.3511e-030.2675image
chr17:82115465-82116118:-OVDMOGEER1.5790e-050.5149image
ENSG00000176155.17,CCDC57PRADAS601245EAG2.1802e-02-0.4478image
chr17:82123196-82123429:-STADABT.263EER5.3861e-030.4604image
ENSG00000176155.17,CCDC57STADBIRB.0796EAG9.4402e-040.2271image
chr17:82109552-82112295:-STADCyclopamineEER3.9238e-02-0.1877image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType