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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GATC (ImmuneEditome ID:283459)

1. Gene summary of enriched editing regions for GATC

check button Gene summary
Gene informationGene symbol

GATC

Gene ID

283459

GeneSynonyms15E1.2|COXPD42
GeneCytomap

12q24.31

GeneTypeprotein-coding
GeneDescriptionglutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial|glu-AdT subunit C|glutamyl-tRNA(Gln) amidotransferase, subunit C homolog
GeneModificationdate20230329
UniprotIDO43716;F8VRU3;J3KMY1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:120452856-120453793:+ENST00000229384.5ENSG00000257218.4GATCintronicFLAM_A,AluJb,MER105chr12:120452856-120453793:+.alignment
chr12:120452856-120453793:+ENST00000548171.1ENSG00000257218.4GATCintronicFLAM_A,AluJb,MER105chr12:120452856-120453793:+.alignment
chr12:120452856-120453793:+ENST00000551765.4ENSG00000257218.4GATCintronicFLAM_A,AluJb,MER105chr12:120452856-120453793:+.alignment
chr12:120460707-120461414:+ENST00000551765.4ENSG00000257218.4GATCUTR3AluY,AluJrchr12:120460707-120461414:+.alignment


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2. Tumor-specific enriched editing regions for GATC


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:120460707-120461414:+BRCAEER5.5092e-04image
ENSG00000257218.4,GATCBRCAEAG3.7915e-04image
chr12:120460707-120461414:+KICHEER1.1818e-04image
ENSG00000257218.4,GATCKICHEAG1.1187e-04image
chr12:120460707-120461414:+KIRPEER1.6420e-02image
ENSG00000257218.4,GATCKIRPEAG1.3114e-02image
chr12:120460707-120461414:+LIHCEER8.2020e-03image
ENSG00000257218.4,GATCLIHCEAG7.7554e-03image
chr12:120460707-120461414:+LUADEER9.0035e-04image
ENSG00000257218.4,GATCLUADEAG6.8306e-04image
chr12:120460707-120461414:+PRADEER3.5705e-02image
ENSG00000257218.4,GATCPRADEAG3.7304e-02image
chr12:120460707-120461414:+THCAEER1.6510e-02image
ENSG00000257218.4,GATCTHCAEAG1.4037e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000257218.4,GATCACCPathEAG5.0756e-039.0131e-04-0.3731image
chr12:120460707-120461414:+ACCPathEER4.9220e-038.5488e-04-0.3747image
ENSG00000257218.4,GATCCOADPathEAG4.1425e-024.9260e-02-0.0934image
chr12:120460707-120461414:+UCECCliEER2.4482e-027.4122e-03-0.1169image
ENSG00000257218.4,GATCUCECCliEAG2.2660e-026.4438e-03-0.1189image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:120460707-120461414:+CESCEER1.4998e-021.3083e-022.0584e+02image
ENSG00000257218.4,GATCCESCEAG1.4998e-021.3956e-021.9360e+02image
chr12:120460707-120461414:+LIHCEER3.0721e-031.1125e-026.2314e-02image
ENSG00000257218.4,GATCLIHCEAG3.0721e-031.1232e-026.3676e-02image
chr12:120460707-120461414:+LUSCEER4.4523e-043.8316e-033.8580e+01image
ENSG00000257218.4,GATCLUSCEAG3.4172e-043.5657e-033.8295e+01image
chr12:120460707-120461414:+READEER1.5690e-022.8105e-023.8050e-04image
ENSG00000257218.4,GATCREADEAG1.5690e-022.8105e-023.8050e-04image

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3. Enriched editing regions and immune related genes for GATC


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:120460707-120461414:+ACCEERENSG00000126705,AHDC1-0.59003.9160e-022.7819e-05-0.4555imageNDDX54NAMonocytesGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr12:120460707-120461414:+DLBCEERENSG00000115677,HDLBP-0.51323.9876e-027.6523e-05-0.5393imageNDDX54NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr12:120460707-120461414:+PAADEERENSG00000197771,MCMBP-0.46434.5684e-068.1185e-10-0.4398imageNDDX54NANK_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
chr12:120460707-120461414:+PCPGEERENSG00000186660,ZFP91-0.42046.3076e-063.4576e-09-0.4236imageNDDX54NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:120460707-120461414:+UVMEERENSG00000165819,METTL3-0.50939.3723e-046.8117e-06-0.4822imageNDDX54NAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:120460707-120461414:+UVMEERENSG00000112343,TRIM38-0.48841.4377e-031.0790e-04-0.4218imageNNTRIM38T_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION
chr12:120460707-120461414:+UVMEERENSG00000132793,LPIN3-0.48491.6941e-038.7683e-05-0.4268imageNDDX54NAMacrophages_M2GSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:120460707-120461414:+UVMEERENSG00000207697,MIR573-0.45751.7740e-032.0750e-04-0.4057imageNNNADendritic_cells_activatedGSVA_HALLMARK_KRAS_SIGNALING_DN
chr12:120460707-120461414:+UVMEERENSG00000162065,TBC1D24-0.47501.7820e-031.9216e-05-0.4608imageNDDX54NAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr12:120460707-120461414:+UVMEERENSG00000141664,ZCCHC2-0.46912.2220e-031.3158e-04-0.4170imageNDDX54NAEosinophilsGSVA_HALLMARK_KRAS_SIGNALING_DN

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4. Enriched editing regions and immune related splicing for GATC


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:120460707-120461414:+
LGGEERIRENSG00000134531.5chr1213211468:13213575:13216443:13216773-0.19577.7082e-045.2166e-22-0.4085imageNNNANeutrophilsGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000257218.4,GATC
LGGEAGIRENSG00000134531.5chr1213211468:13213575:13216443:13216773-0.19566.5743e-044.6845e-22-0.4089imageNADAR;CBX7;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPA2B1;HNRNPC;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MOV10;MSI1;MSI2;NOP56;NOP58;PTBP1;PUM2;RBM47;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF2;UPF1;YTHDC1;ZC3H7BNANeutrophilsGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000257218.4,GATC
PCPGEAGMEXENSG00000064601.12chr2045891915:45892027:45892272:45892323:45892724:45892880:45893219:45893299-0.38782.3603e-049.4619e-12-0.4810imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL14;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184CTSAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000257218.4,GATC
PCPGEAGIRENSG00000100949.10chr1424270836:24271169:24271486:242715100.34542.7049e-031.3876e-080.4084imageNADAR;AUH;BCCIP;BUD13;CBX7;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;DKC1;EIF4A3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184NAPlasma_cellsGSVA_HALLMARK_PROTEIN_SECRETION
chr12:120460707-120461414:+
PCPGEERIRENSG00000100949.10chr1424270836:24271169:24271486:242715100.34543.0331e-031.3876e-080.4084imageNDDX54NAPlasma_cellsGSVA_HALLMARK_PROTEIN_SECRETION
chr12:120460707-120461414:+
PCPGEERMEXENSG00000064601.12chr2045891915:45892027:45892272:45892323:45892724:45892880:45893219:45893299-0.38782.7126e-049.4619e-12-0.4810imageNDDX54CTSAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000257218.4,GATC
PCPGEAGA3ENSG00000077232.12chr2182736248:182736386:182740298:182740384:182739544:182740384-0.33212.0984e-037.7233e-08-0.4035imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184NAGSVA_HALLMARK_HEME_METABOLISM
chr12:120460707-120461414:+
PCPGEERA3ENSG00000077232.12chr2182736248:182736386:182740298:182740384:182739544:182740384-0.33212.3691e-037.7233e-08-0.4035imageNDDX54NAGSVA_HALLMARK_HEME_METABOLISM
ENSG00000257218.4,GATC
TGCTEAGESENSG00000156990.10chr39838164:9838207:9839031:9839171:9840183:9840307-0.42021.3917e-042.1980e-09-0.4560imageNADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
ENSG00000257218.4,GATC
TGCTEAGESENSG00000125319.10chr1744148126:44149027:44150960:44151044:44152636:44152767-0.31851.9207e-033.1104e-07-0.4293imageNADAR;AIFM1;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RNF219;SAFB2;SF3A3;SLBP;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAGNAB_cells_naiveGSVA_HALLMARK_GLYCOLYSIS

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5. Enriched editing regions and immune infiltration for GATC


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:120460707-120461414:+ACCEERPlasma_cells7.3705e-030.3012image
ENSG00000257218.4,GATCACCEAGPlasma_cells8.5404e-030.2959image
chr12:120460707-120461414:+BLCAEERT_cells_regulatory_(Tregs)1.2909e-060.2376image
ENSG00000257218.4,GATCBLCAEAGT_cells_regulatory_(Tregs)8.1315e-070.2419image
chr12:120460707-120461414:+BRCAEERMacrophages_M12.8891e-06-0.1416image
ENSG00000257218.4,GATCBRCAEAGMacrophages_M11.5083e-06-0.1455image
chr12:120460707-120461414:+CESCEERNeutrophils2.1521e-050.2411image
ENSG00000257218.4,GATCCESCEAGNeutrophils2.0490e-050.2417image
chr12:120460707-120461414:+CHOLEERT_cells_CD4_memory_resting4.9207e-020.3349image
chr12:120460707-120461414:+ESCAEERNK_cells_activated1.6540e-020.1887image
ENSG00000257218.4,GATCESCAEAGNK_cells_activated1.7124e-020.1877image
chr12:120460707-120461414:+HNSCEERT_cells_gamma_delta2.7074e-040.1622image
ENSG00000257218.4,GATCHNSCEAGT_cells_gamma_delta2.7272e-040.1621image
chr12:120460707-120461414:+KICHEERT_cells_CD4_memory_resting1.2767e-020.3073image
ENSG00000257218.4,GATCKICHEAGT_cells_CD4_memory_resting1.2767e-020.3073image
chr12:120460707-120461414:+KIRCEERNK_cells_activated8.7210e-050.1989image
ENSG00000257218.4,GATCKIRCEAGNK_cells_activated9.3683e-050.1980image
chr12:120460707-120461414:+LAMLEERNeutrophils2.0001e-020.1898image
ENSG00000257218.4,GATCLAMLEAGNeutrophils1.3151e-020.2021image
chr12:120460707-120461414:+LGGEERMacrophages_M21.8864e-030.1348image
ENSG00000257218.4,GATCLGGEAGMacrophages_M22.1635e-030.1331image
chr12:120460707-120461414:+LIHCEEREosinophils3.8942e-02-0.1072image
ENSG00000257218.4,GATCLIHCEAGEosinophils4.1732e-02-0.1058image
chr12:120460707-120461414:+LUADEERT_cells_CD4_naive3.7350e-03-0.1278image
ENSG00000257218.4,GATCLUADEAGT_cells_CD4_naive4.1921e-03-0.1262image
chr12:120460707-120461414:+LUSCEERT_cells_CD83.6939e-04-0.1591image
ENSG00000257218.4,GATCLUSCEAGT_cells_CD84.1849e-04-0.1577image
chr12:120460707-120461414:+MESOEERNeutrophils4.9641e-020.2175image
ENSG00000257218.4,GATCMESOEAGNeutrophils2.8870e-020.2414image
chr12:120460707-120461414:+OVEERT_cells_CD4_naive4.8334e-040.2030image
ENSG00000257218.4,GATCOVEAGT_cells_CD4_naive3.6687e-040.2071image
chr12:120460707-120461414:+PAADEERMacrophages_M25.8900e-03-0.2056image
ENSG00000257218.4,GATCPAADEAGMacrophages_M25.5645e-03-0.2070image
chr12:120460707-120461414:+PCPGEERMast_cells_activated2.2685e-020.1703image
ENSG00000257218.4,GATCPCPGEAGMast_cells_activated2.2685e-020.1703image
chr12:120460707-120461414:+PRADEERT_cells_CD4_memory_resting1.6997e-02-0.1069image
ENSG00000257218.4,GATCPRADEAGT_cells_CD4_memory_resting1.5694e-02-0.1082image
chr12:120460707-120461414:+READEERNK_cells_activated3.4095e-04-0.3599image
ENSG00000257218.4,GATCREADEAGNK_cells_activated3.5023e-04-0.3592image
chr12:120460707-120461414:+SARCEERMacrophages_M26.7178e-030.1687image
ENSG00000257218.4,GATCSARCEAGMacrophages_M26.4637e-030.1695image
chr12:120460707-120461414:+SKCMEERMacrophages_M13.4969e-04-0.1642image
ENSG00000257218.4,GATCSKCMEAGMacrophages_M14.7457e-04-0.1606image
chr12:120452856-120453793:+STADEERT_cells_gamma_delta2.5392e-030.6233image
chr12:120460707-120461414:+STADEERMonocytes2.1126e-030.1585image
ENSG00000257218.4,GATCSTADEAGMonocytes2.3357e-030.1569image
chr12:120460707-120461414:+TGCTEERB_cells_naive1.7970e-03-0.2480image
ENSG00000257218.4,GATCTGCTEAGB_cells_naive2.0607e-03-0.2449image
chr12:120460707-120461414:+THCAEERT_cells_CD82.5215e-040.1624image
ENSG00000257218.4,GATCTHCAEAGT_cells_CD81.6171e-040.1673image
chr12:120460707-120461414:+THYMEERMacrophages_M12.3016e-02-0.2092image
ENSG00000257218.4,GATCTHYMEAGMacrophages_M12.2932e-02-0.2093image
chr12:120460707-120461414:+UCECEERNeutrophils2.5000e-020.1694image
ENSG00000257218.4,GATCUCECEAGNeutrophils3.2276e-020.1619image
chr12:120460707-120461414:+UCSEERNeutrophils9.9897e-030.3415image
ENSG00000257218.4,GATCUCSEAGNeutrophils1.0038e-020.3413image
chr12:120460707-120461414:+UVMEERDendritic_cells_resting1.0716e-020.2856image
ENSG00000257218.4,GATCUVMEAGDendritic_cells_resting1.0716e-020.2856image


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6. Enriched editing regions and immune gene sets for GATC


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr12:120460707-120461414:+HNSCEER2.4319e-02image2.6509e-02-0.0992image
ENSG00000257218.4,GATCHNSCEAG2.0611e-02image2.4275e-02-0.1007image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr12:120460707-120461414:+BLCAEER1.8915e-05-0.21062.2272e-06-0.23231.0308e-05-0.21694.7863e-04-0.1726image
ENSG00000257218.4,GATCBLCAEAG1.9702e-05-0.21012.6204e-06-0.23079.3355e-06-0.21803.5143e-04-0.1765image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000257218.4,GATCACCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0971e-04-0.3978image
chr12:120460707-120461414:+ACCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0983e-04-0.3978image
chr12:120460707-120461414:+BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.8354e-06-0.2300image
ENSG00000257218.4,GATCBLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.8688e-06-0.2340image
ENSG00000257218.4,GATCBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1954e-17-0.2538image
chr12:120460707-120461414:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.0202e-16-0.2430image
chr12:120460707-120461414:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.7308e-04-0.1940image
ENSG00000257218.4,GATCCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2471e-04-0.1951image
chr12:120460707-120461414:+CHOLGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.0636e-050.6297image
ENSG00000257218.4,GATCCHOLGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.4736e-050.6400image
ENSG00000257218.4,GATCCOADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.3825e-05-0.2350image
chr12:120460707-120461414:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.3825e-05-0.2350image
ENSG00000257218.4,GATCDLBCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.0913e-02-0.3643image
chr12:120460707-120461414:+DLBCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER9.1505e-03-0.3724image
chr12:120460707-120461414:+ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER3.7825e-020.1638image
ENSG00000257218.4,GATCESCAGSVA_HALLMARK_MYC_TARGETS_V2EAG3.6691e-020.1648image
ENSG00000257218.4,GATCGBMGSVA_HALLMARK_MYC_TARGETS_V1EAG4.9172e-020.1525image
chr12:120460707-120461414:+GBMGSVA_HALLMARK_MYC_TARGETS_V1EER4.7948e-020.1533image
chr12:120460707-120461414:+HNSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.2113e-05-0.1943image
ENSG00000257218.4,GATCHNSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.1676e-05-0.1946image
ENSG00000257218.4,GATCKICHGSVA_HALLMARK_APICAL_SURFACEEAG1.0277e-020.3162image
chr12:120460707-120461414:+KICHGSVA_HALLMARK_APICAL_SURFACEEER1.0277e-020.3162image
ENSG00000257218.4,GATCKIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.5474e-07-0.2639image
chr12:120460707-120461414:+KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.8129e-07-0.2624image
ENSG00000257218.4,GATCKIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.4654e-08-0.3155image
chr12:120460707-120461414:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER2.8240e-08-0.3199image
chr12:120460707-120461414:+LAMLGSVA_HALLMARK_HEME_METABOLISMEER2.1052e-020.1883image
ENSG00000257218.4,GATCLAMLGSVA_HALLMARK_HEME_METABOLISMEAG6.9776e-030.2194image
chr12:120460707-120461414:+LGGGSVA_HALLMARK_UV_RESPONSE_DNEER3.5254e-11-0.2827image
ENSG00000257218.4,GATCLGGGSVA_HALLMARK_UV_RESPONSE_DNEAG4.0108e-11-0.2819image
chr12:120460707-120461414:+LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0847e-09-0.3097image
ENSG00000257218.4,GATCLIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.6894e-10-0.3106image
chr12:120460707-120461414:+LUADGSVA_HALLMARK_E2F_TARGETSEER4.6835e-02-0.0878image
ENSG00000257218.4,GATCLUADGSVA_HALLMARK_E2F_TARGETSEAG4.8769e-02-0.0870image
chr12:120460707-120461414:+LUSCGSVA_HALLMARK_SPERMATOGENESISEER8.4028e-04-0.1493image
ENSG00000257218.4,GATCLUSCGSVA_HALLMARK_SPERMATOGENESISEAG1.0673e-03-0.1463image
chr12:120460707-120461414:+MESOGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.5275e-03-0.3105image
ENSG00000257218.4,GATCMESOGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG9.7319e-03-0.2840image
ENSG00000257218.4,GATCOVGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.0370e-02-0.1498image
chr12:120460707-120461414:+OVGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.0081e-020.1504image
chr12:120460707-120461414:+PAADGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.5727e-04-0.2707image
ENSG00000257218.4,GATCPAADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.7621e-04-0.2775image
ENSG00000257218.4,GATCPCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2737e-06-0.3359image
chr12:120460707-120461414:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER4.2737e-06-0.3359image
ENSG00000257218.4,GATCPRADGSVA_HALLMARK_ANGIOGENESISEAG1.4122e-05-0.1932image
chr12:120460707-120461414:+PRADGSVA_HALLMARK_ANGIOGENESISEER1.5592e-05-0.1923image
chr12:120460707-120461414:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.5720e-04-0.3365image
ENSG00000257218.4,GATCREADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.3263e-04-0.3372image
ENSG00000257218.4,GATCSARCGSVA_HALLMARK_APICAL_JUNCTIONEAG3.6315e-040.2207image
chr12:120460707-120461414:+SARCGSVA_HALLMARK_APICAL_JUNCTIONEER3.4004e-040.2218image
chr12:120460707-120461414:+SKCMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER6.7574e-06-0.2059image
ENSG00000257218.4,GATCSKCMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.1297e-05-0.2010image
ENSG00000257218.4,GATCSTADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.2082e-020.1297image
chr12:120452856-120453793:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.7920e-02-0.4793image
chr12:120460707-120461414:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER9.4432e-030.1341image
ENSG00000257218.4,GATCTGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7145e-04-0.2964image
chr12:120460707-120461414:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2758e-04-0.2911image
chr12:120460707-120461414:+THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER8.5557e-14-0.3242image
ENSG00000257218.4,GATCTHCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.9272e-14-0.3233image
ENSG00000257218.4,GATCTHYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8656e-08-0.4894image
chr12:120460707-120461414:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2200e-08-0.4871image
ENSG00000257218.4,GATCUCECGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.9722e-03-0.2233image
chr12:120460707-120461414:+UCECGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.0130e-03-0.2230image
ENSG00000257218.4,GATCUVMGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.8193e-03-0.3076image
chr12:120460707-120461414:+UVMGSVA_HALLMARK_PROTEIN_SECRETIONEER5.8193e-03-0.3076image


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7. Enriched editing regions and drugs for GATC


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr12:120460707-120461414:+ACCEmbelinEER4.4677e-040.3881image
ENSG00000257218.4,GATCACCEmbelinEAG4.1553e-040.3900image
chr12:120460707-120461414:+BLCAJNK.Inhibitor.VIIIEER1.0364e-060.2396image
ENSG00000257218.4,GATCBLCAJNK.Inhibitor.VIIIEAG5.0957e-070.2462image
ENSG00000257218.4,GATCBRCABryostatin.1EAG1.2204e-07-0.1600image
chr12:120460707-120461414:+BRCABryostatin.1EER4.5480e-08-0.1653image
chr12:120460707-120461414:+CESCBryostatin.1EER1.0788e-02-0.1460image
ENSG00000257218.4,GATCCESCBryostatin.1EAG1.1934e-02-0.1440image
chr12:120460707-120461414:+CHOLDasatinibEER4.2204e-03-0.4718image
ENSG00000257218.4,GATCCHOLDasatinibEAG3.4736e-03-0.4806image
ENSG00000257218.4,GATCCOADBexaroteneEAG1.4036e-040.2293image
chr12:120460707-120461414:+COADBexaroteneEER1.4036e-040.2293image
chr12:120460707-120461414:+DLBCEmbelinEER2.4342e-020.3247image
ENSG00000257218.4,GATCDLBCAZD.2281EAG2.1992e-02-0.3300image
chr12:120460707-120461414:+ESCAAZD6482EER2.7241e-020.1740image
ENSG00000257218.4,GATCESCABX.795EAG2.6701e-020.1746image
chr12:120460707-120461414:+GBMAZD8055EER9.1396e-05-0.2981image
ENSG00000257218.4,GATCGBMAZD8055EAG9.1157e-05-0.2981image
ENSG00000257218.4,GATCHNSCA.443654EAG1.0371e-05-0.1958image
chr12:120460707-120461414:+HNSCA.443654EER1.3318e-05-0.1934image
ENSG00000257218.4,GATCKICHLapatinibEAG3.0476e-02-0.2687image
chr12:120460707-120461414:+KICHLapatinibEER3.0476e-02-0.2687image
ENSG00000257218.4,GATCKIRCEmbelinEAG1.8461e-050.2167image
chr12:120460707-120461414:+KIRCEmbelinEER1.7846e-050.2170image
ENSG00000257218.4,GATCKIRPEmbelinEAG5.8062e-080.3130image
chr12:120460707-120461414:+KIRPEmbelinEER4.6011e-080.3152image
chr12:120460707-120461414:+LAMLAZD6244EER2.2776e-03-0.2473image
ENSG00000257218.4,GATCLAMLAZD6244EAG1.6017e-03-0.2555image
ENSG00000257218.4,GATCLGGGSK269962AEAG8.8240e-13-0.3044image
chr12:120460707-120461414:+LGGGSK269962AEER8.2829e-13-0.3047image
ENSG00000257218.4,GATCLIHCCI.1040EAG1.7814e-06-0.2450image
chr12:120460707-120461414:+LIHCCI.1040EER3.0422e-06-0.2396image
chr12:120460707-120461414:+LUADJNK.Inhibitor.VIIIEER6.4101e-030.1202image
ENSG00000257218.4,GATCLUADJNK.Inhibitor.VIIIEAG5.6111e-030.1221image
ENSG00000257218.4,GATCLUSCBexaroteneEAG1.1390e-03-0.1455image
chr12:120460707-120461414:+LUSCBexaroteneEER9.4141e-04-0.1479image
chr12:120460707-120461414:+MESOBryostatin.1EER1.8888e-03-0.3381image
ENSG00000257218.4,GATCMESOEmbelinEAG3.7416e-030.3167image
chr12:120460707-120461414:+OVGNF.2EER6.2228e-04-0.1991image
ENSG00000257218.4,GATCOVGNF.2EAG4.9528e-04-0.2026image
chr12:120460707-120461414:+PAADBleomycinEER5.2913e-030.2082image
ENSG00000257218.4,GATCPAADBleomycinEAG4.8473e-030.2103image
ENSG00000257218.4,GATCPCPGJNJ.26854165EAG1.2443e-03-0.2395image
chr12:120460707-120461414:+PCPGJNJ.26854165EER1.2443e-03-0.2395image
chr12:120460707-120461414:+PRADCCT007093EER5.8674e-060.2015image
ENSG00000257218.4,GATCPRADCCT007093EAG5.6661e-060.2018image
ENSG00000257218.4,GATCREADJNK.9LEAG1.8079e-030.3160image
chr12:120460707-120461414:+READJNK.9LEER1.7728e-030.3166image
chr12:120460707-120461414:+SARCBMS.536924EER3.9259e-06-0.2839image
ENSG00000257218.4,GATCSARCBMS.536924EAG4.0168e-06-0.2836image
chr12:120460707-120461414:+SKCMBI.2536EER1.0279e-070.2424image
ENSG00000257218.4,GATCSKCMBI.2536EAG9.1784e-080.2434image
chr12:120460707-120461414:+STADDasatinibEER3.9118e-080.2808image
chr12:120452856-120453793:+STADCCT018159EER2.0019e-03-0.6346image
ENSG00000257218.4,GATCSTADDasatinibEAG3.9452e-080.2808image
chr12:120460707-120461414:+TGCTIPA.3EER2.2610e-080.4292image
ENSG00000257218.4,GATCTGCTIPA.3EAG2.8329e-080.4265image
ENSG00000257218.4,GATCTHCAAMG.706EAG7.2887e-13-0.3123image
chr12:120460707-120461414:+THCAAMG.706EER3.8938e-13-0.3158image
ENSG00000257218.4,GATCTHYMCEP.701EAG1.7230e-06-0.4239image
chr12:120460707-120461414:+THYMCEP.701EER2.2489e-06-0.4196image
ENSG00000257218.4,GATCUCECBAY.61.3606EAG1.6339e-030.2364image
chr12:120460707-120461414:+UCECBAY.61.3606EER1.9160e-030.2330image
ENSG00000257218.4,GATCUCSBIBW2992EAG3.3007e-03-0.3860image
chr12:120460707-120461414:+UCSBIBW2992EER3.5321e-03-0.3834image
ENSG00000257218.4,GATCUVMEmbelinEAG6.1365e-040.3771image
chr12:120460707-120461414:+UVMEmbelinEER6.1365e-040.3771image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType