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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TTC9C (ImmuneEditome ID:283237)

1. Gene summary of enriched editing regions for TTC9C

check button Gene summary
Gene informationGene symbol

TTC9C

Gene ID

283237

GeneSynonyms-
GeneCytomap

11q12.3

GeneTypeprotein-coding
GeneDescriptiontetratricopeptide repeat protein 9C|TPR repeat protein 9C
GeneModificationdate20230329
UniprotIDQ8N5M4;E7EST3;H0YDR3;E9PKV8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:62734708-62735118:+ENST00000294161.9ENSG00000162222.12TTC9CintronicAluSp,FLAM_Cchr11:62734708-62735118:+.alignment
chr11:62734708-62735118:+ENST00000316461.7ENSG00000162222.12TTC9CintronicAluSp,FLAM_Cchr11:62734708-62735118:+.alignment
chr11:62734708-62735118:+ENST00000530625.4ENSG00000162222.12TTC9CintronicAluSp,FLAM_Cchr11:62734708-62735118:+.alignment
chr11:62734708-62735118:+ENST00000532583.1ENSG00000162222.12TTC9CintronicAluSp,FLAM_Cchr11:62734708-62735118:+.alignment
chr11:62738787-62739952:+ENST00000601045.1ENSG00000162222.12TTC9CncRNA_exonicAluJb,AluSz6,AluSx,AluYm1chr11:62738787-62739952:+.alignment


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2. Tumor-specific enriched editing regions for TTC9C


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr11:62738787-62739952:+BRCAEER8.1734e-03image
ENSG00000162222.12,TTC9CBRCAEAG4.4070e-03image
chr11:62738787-62739952:+COADEER4.6079e-03image
ENSG00000162222.12,TTC9CCOADEAG4.6079e-03image
chr11:62738787-62739952:+KICHEER1.1908e-02image
ENSG00000162222.12,TTC9CKICHEAG1.1908e-02image
chr11:62738787-62739952:+KIRCEER2.0343e-02image
ENSG00000162222.12,TTC9CKIRCEAG2.0493e-02image
chr11:62738787-62739952:+LIHCEER1.5237e-04image
ENSG00000162222.12,TTC9CLIHCEAG1.5237e-04image
chr11:62738787-62739952:+LUADEER4.3572e-02image
ENSG00000162222.12,TTC9CLUADEAG4.3572e-02image
chr11:62738787-62739952:+LUSCEER3.8427e-03image
ENSG00000162222.12,TTC9CLUSCEAG3.8197e-03image
chr11:62738787-62739952:+STADEER4.9495e-02image
chr11:62738787-62739952:+THCAEER3.6702e-03image
ENSG00000162222.12,TTC9CTHCAEAG3.6320e-03image
chr11:62738787-62739952:+UCECEER1.1863e-04image
ENSG00000162222.12,TTC9CUCECEAG1.1863e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000162222.12,TTC9CBLCAPathEAG4.4838e-041.9375e-030.1547image
chr11:62738787-62739952:+BLCAPathEER4.4961e-041.9437e-030.1547image
ENSG00000162222.12,TTC9CKIRCPathEAG7.3256e-032.0844e-020.1004image
chr11:62738787-62739952:+KIRCPathEER7.1659e-032.0617e-020.1006image
chr11:62738787-62739952:+LUADPathEER5.0975e-032.8366e-020.0976image
ENSG00000162222.12,TTC9CLUADPathEAG5.0975e-032.8366e-020.0976image
ENSG00000162222.12,TTC9CLUSCPathEAG1.3338e-042.1382e-020.1034image
chr11:62738787-62739952:+LUSCPathEER1.3679e-042.1454e-020.1034image
chr11:62738787-62739952:+THCAPathEER3.6138e-047.7613e-050.1756image
ENSG00000162222.12,TTC9CTHCAPathEAG3.2944e-047.1874e-050.1764image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for TTC9C


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr11:62738787-62739952:+BLCAEERENSG00000130517,PGPEP1-0.42847.1975e-165.9684e-17-0.4023imageNNNAMacrophages_M1GSVA_HALLMARK_MTORC1_SIGNALING
chr11:62738787-62739952:+BLCAEERENSG00000197122,SRC-0.41509.8297e-157.1923e-17-0.4013imageNNSRCT_cells_regulatory_(Tregs)GSVA_HALLMARK_PANCREAS_BETA_CELLS
chr11:62738787-62739952:+BLCAEERENSG00000158122,AAED10.40842.0515e-143.3367e-190.4280imageNNNAMacrophages_M1GSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr11:62738787-62739952:+CESCEERENSG00000128191,DGCR8-0.41136.3970e-108.3007e-14-0.4146imageNNDGCR8T_cells_regulatory_(Tregs)GSVA_HALLMARK_COAGULATION
chr11:62738787-62739952:+CESCEERENSG00000034510,TMSB100.25907.5789e-042.2293e-130.4080imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr11:62738787-62739952:+CESCEERENSG00000231767,RP11-92K2.20.17713.7443e-026.9465e-130.4001imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr11:62738787-62739952:+COADEERENSG00000162222,TTC9C-0.44495.7571e-107.2976e-12-0.4040imageNNNAT_cells_follicular_helperGSVA_HALLMARK_DNA_REPAIR
chr11:62738787-62739952:+COADEERENSG00000178188,SH2B1-0.40473.1933e-084.1452e-13-0.4253imageNNNANeutrophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr11:62738787-62739952:+COADEERENSG00000177225,PDDC1-0.40096.5575e-084.5904e-12-0.4075imageNNNANeutrophilsGSVA_HALLMARK_MYC_TARGETS_V2
chr11:62738787-62739952:+COADEERENSG00000168397,ATG4B-0.39188.2966e-082.0063e-12-0.4137imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE

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4. Enriched editing regions and immune related splicing for TTC9C


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000162222.12,TTC9C
BLCAEAGIRENSG00000111679.12chr126951261:6951520:6951608:6951731-0.31452.3609e-092.6020e-15-0.4152imageNBUD13;CPSF6;CSTF2T;DDX3X;DDX54;DHX9;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LARP7;LIN28A;LSM11;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF1;U2AF2;UPF1;ZNF184PTPN6Dendritic_cells_activatedGSVA_HALLMARK_COMPLEMENT
chr11:62738787-62739952:+
BLCAEERIRENSG00000106400.7chr7101218180:101221796:101222603:101222774-0.35306.3564e-111.0310e-15-0.4008imageNNNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
chr11:62738787-62739952:+
BLCAEERIRENSG00000266086.1chr1757989037:57989269:57989648:57989796-0.33681.3016e-107.6903e-16-0.4230imageNNNAMacrophages_M1GSVA_HALLMARK_HYPOXIA
chr11:62738787-62739952:+
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.47627.4584e-185.5336e-19-0.4256imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr11:62738787-62739952:+
BLCAEERIRENSG00000111679.12chr126951261:6951520:6951608:6951731-0.31451.6303e-092.6173e-15-0.4152imageNNPTPN6Dendritic_cells_activatedGSVA_HALLMARK_COMPLEMENT
ENSG00000162222.12,TTC9C
BLCAEAGIRENSG00000106400.7chr7101218180:101221796:101222603:101222774-0.35309.3144e-111.0363e-15-0.4008imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000162222.12,TTC9C
BLCAEAGIRENSG00000266086.1chr1757989037:57989269:57989648:57989796-0.33681.8698e-107.6903e-16-0.4230imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZFP36;ZNF184NAMacrophages_M1GSVA_HALLMARK_HYPOXIA
ENSG00000162222.12,TTC9C
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.47628.8223e-185.6413e-19-0.4255imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr11:62738787-62739952:+
COADEERIRENSG00000058673.11chr1203795653:203796496:203801574:2038016280.32481.5373e-051.6580e-120.4454imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr11:62738787-62739952:+
COADEERMEXENSG00000129518.4chr1434524696:34524807:34529357:34529475:34533496:34533539:34536093:34536275-0.25528.2792e-031.3472e-12-0.4167imageNNNAEosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM

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5. Enriched editing regions and immune infiltration for TTC9C


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr11:62738787-62739952:+BLCAEERMacrophages_M11.9268e-120.3428image
ENSG00000162222.12,TTC9CBLCAEAGMacrophages_M11.9398e-120.3427image
chr11:62738787-62739952:+BRCAEERNK_cells_activated4.0664e-030.0875image
ENSG00000162222.12,TTC9CBRCAEAGNK_cells_activated4.1138e-030.0874image
chr11:62738787-62739952:+CESCEERB_cells_memory1.5033e-030.1831image
ENSG00000162222.12,TTC9CCESCEAGB_cells_memory1.5033e-030.1831image
chr11:62738787-62739952:+COADEERDendritic_cells_activated1.7416e-020.1457image
ENSG00000162222.12,TTC9CCOADEAGDendritic_cells_activated1.7416e-020.1457image
chr11:62738787-62739952:+ESCAEERT_cells_gamma_delta2.0785e-050.3306image
ENSG00000162222.12,TTC9CESCAEAGT_cells_gamma_delta1.9839e-050.3314image
chr11:62738787-62739952:+GBMEERT_cells_CD4_memory_resting4.0719e-040.2737image
ENSG00000162222.12,TTC9CGBMEAGT_cells_CD4_memory_resting4.0719e-040.2737image
chr11:62738787-62739952:+HNSCEERT_cells_regulatory_(Tregs)1.9023e-03-0.1436image
ENSG00000162222.12,TTC9CHNSCEAGT_cells_regulatory_(Tregs)1.9023e-03-0.1436image
chr11:62738787-62739952:+KIRCEERMonocytes5.5811e-03-0.1415image
ENSG00000162222.12,TTC9CKIRCEAGMonocytes5.5533e-03-0.1416image
chr11:62738787-62739952:+KIRPEERNK_cells_activated6.5433e-04-0.2010image
ENSG00000162222.12,TTC9CKIRPEAGNK_cells_activated6.9359e-04-0.2001image
ENSG00000162222.12,TTC9CLAMLEAGB_cells_naive4.5262e-02-0.2017image
chr11:62738787-62739952:+LGGEEREosinophils2.3845e-030.1320image
ENSG00000162222.12,TTC9CLGGEAGEosinophils2.3845e-030.1320image
chr11:62738787-62739952:+LIHCEERMacrophages_M04.6078e-04-0.1903image
ENSG00000162222.12,TTC9CLIHCEAGMacrophages_M04.6078e-04-0.1903image
chr11:62738787-62739952:+LUADEERT_cells_CD4_memory_activated1.5961e-040.1674image
ENSG00000162222.12,TTC9CLUADEAGT_cells_CD4_memory_activated1.5961e-040.1674image
chr11:62738787-62739952:+LUSCEERT_cells_CD4_memory_activated2.3555e-030.1363image
ENSG00000162222.12,TTC9CLUSCEAGT_cells_CD4_memory_activated2.3784e-030.1361image
chr11:62738787-62739952:+MESOEERMast_cells_resting4.1835e-03-0.3150image
ENSG00000162222.12,TTC9CMESOEAGMast_cells_resting4.1835e-03-0.3150image
chr11:62738787-62739952:+OVEERT_cells_CD87.9576e-080.3083image
ENSG00000162222.12,TTC9COVEAGT_cells_CD87.3248e-080.3091image
chr11:62738787-62739952:+PAADEERNK_cells_activated2.7687e-020.1660image
ENSG00000162222.12,TTC9CPAADEAGNK_cells_activated2.7687e-020.1660image
chr11:62738787-62739952:+PCPGEERT_cells_gamma_delta8.5762e-070.3600image
ENSG00000162222.12,TTC9CPCPGEAGT_cells_gamma_delta8.5762e-070.3600image
chr11:62738787-62739952:+PRADEERNK_cells_activated1.3786e-020.1104image
ENSG00000162222.12,TTC9CPRADEAGNK_cells_activated1.3786e-020.1104image
chr11:62738787-62739952:+SARCEERMacrophages_M24.5257e-030.1779image
ENSG00000162222.12,TTC9CSARCEAGMacrophages_M24.5257e-030.1779image
chr11:62738787-62739952:+SKCMEERMast_cells_activated2.1344e-02-0.1070image
ENSG00000162222.12,TTC9CSKCMEAGMast_cells_activated2.1344e-02-0.1070image
chr11:62738787-62739952:+STADEEREosinophils1.4008e-030.1673image
ENSG00000162222.12,TTC9CSTADEAGEosinophils1.4493e-030.1668image
chr11:62738787-62739952:+TGCTEERMacrophages_M22.9247e-05-0.3320image
ENSG00000162222.12,TTC9CTGCTEAGMacrophages_M22.9247e-05-0.3320image
chr11:62738787-62739952:+THCAEERMacrophages_M25.1024e-04-0.1546image
ENSG00000162222.12,TTC9CTHCAEAGMacrophages_M25.1091e-04-0.1545image
chr11:62738787-62739952:+THYMEERT_cells_CD4_naive1.1015e-07-0.4783image
ENSG00000162222.12,TTC9CTHYMEAGT_cells_CD4_naive1.1015e-07-0.4783image
chr11:62738787-62739952:+UCECEERT_cells_CD4_memory_resting6.6888e-03-0.2097image
ENSG00000162222.12,TTC9CUCECEAGT_cells_CD4_memory_resting6.6888e-03-0.2097image
chr11:62738787-62739952:+UCSEERT_cells_CD4_memory_resting1.5637e-02-0.3216image
ENSG00000162222.12,TTC9CUCSEAGT_cells_CD4_memory_resting1.5637e-02-0.3216image
chr11:62738787-62739952:+UVMEERT_cells_CD4_memory_resting2.6339e-04-0.4021image
ENSG00000162222.12,TTC9CUVMEAGT_cells_CD4_memory_resting2.6339e-04-0.4021image


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6. Enriched editing regions and immune gene sets for TTC9C


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr11:62738787-62739952:+BLCAEER6.3146e-100.30315.7475e-030.13801.1300e-100.31551.2181e-150.3862image
ENSG00000162222.12,TTC9CBLCAEAG6.3330e-100.30315.7243e-030.13811.1302e-100.31551.2397e-150.3861image
chr11:62738787-62739952:+LGGEER2.9938e-02-0.09468.0618e-08-0.23119.2947e-06-0.19184.2475e-080.2359image
ENSG00000162222.12,TTC9CLGGEAG2.9938e-02-0.09468.0618e-08-0.23119.2947e-06-0.19184.2475e-080.2359image
chr11:62738787-62739952:+LUADEER3.9927e-040.15714.3706e-030.12688.2579e-030.11758.7028e-140.3241image
ENSG00000162222.12,TTC9CLUADEAG3.9927e-040.15714.3706e-030.12688.2579e-030.11758.7028e-140.3241image
chr11:62738787-62739952:+THYMEER4.1834e-03-0.26982.1823e-08-0.50074.0390e-020.19496.3515e-050.3702image
ENSG00000162222.12,TTC9CTHYMEAG4.1834e-03-0.26982.1823e-08-0.50074.0390e-020.19496.3515e-050.3702image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000162222.12,TTC9CACCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.1786e-020.2612image
ENSG00000162222.12,TTC9CBLCAGSVA_HALLMARK_HYPOXIAEAG1.2397e-150.3861image
chr11:62738787-62739952:+BLCAGSVA_HALLMARK_HYPOXIAEER1.2181e-150.3862image
chr11:62738787-62739952:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0319e-110.2054image
ENSG00000162222.12,TTC9CBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0823e-110.2052image
ENSG00000162222.12,TTC9CCESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG4.6579e-050.2336image
chr11:62738787-62739952:+CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.6579e-050.2336image
ENSG00000162222.12,TTC9CCOADGSVA_HALLMARK_MYC_TARGETS_V2EAG1.9638e-03-0.1890image
chr11:62738787-62739952:+COADGSVA_HALLMARK_MYC_TARGETS_V2EER1.9638e-03-0.1890image
ENSG00000162222.12,TTC9CDLBCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.9310e-030.4382image
chr11:62738787-62739952:+DLBCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.9310e-030.4382image
chr11:62738787-62739952:+ESCAGSVA_HALLMARK_HYPOXIAEER2.8505e-050.3254image
ENSG00000162222.12,TTC9CESCAGSVA_HALLMARK_HYPOXIAEAG2.7992e-050.3257image
ENSG00000162222.12,TTC9CGBMGSVA_HALLMARK_MYC_TARGETS_V2EAG3.6367e-03-0.2266image
chr11:62738787-62739952:+GBMGSVA_HALLMARK_MYC_TARGETS_V2EER3.6367e-03-0.2266image
chr11:62738787-62739952:+HNSCGSVA_HALLMARK_HYPOXIAEER1.2254e-130.3348image
ENSG00000162222.12,TTC9CHNSCGSVA_HALLMARK_HYPOXIAEAG1.2254e-130.3348image
ENSG00000162222.12,TTC9CKICHGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.2404e-020.2657image
chr11:62738787-62739952:+KICHGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2404e-020.2657image
ENSG00000162222.12,TTC9CKIRCGSVA_HALLMARK_COAGULATIONEAG2.0893e-040.1886image
chr11:62738787-62739952:+KIRCGSVA_HALLMARK_COAGULATIONEER2.0553e-040.1888image
chr11:62738787-62739952:+KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.1737e-110.3883image
ENSG00000162222.12,TTC9CKIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.3137e-110.3875image
ENSG00000162222.12,TTC9CLAMLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.4201e-02-0.2458image
chr11:62738787-62739952:+LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER5.2234e-150.3318image
ENSG00000162222.12,TTC9CLGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG5.2234e-150.3318image
ENSG00000162222.12,TTC9CLIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG9.4899e-140.3920image
chr11:62738787-62739952:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER9.4899e-140.3920image
ENSG00000162222.12,TTC9CLUADGSVA_HALLMARK_HYPOXIAEAG8.7028e-140.3241image
chr11:62738787-62739952:+LUADGSVA_HALLMARK_HYPOXIAEER8.7028e-140.3241image
ENSG00000162222.12,TTC9CLUSCGSVA_HALLMARK_HYPOXIAEAG3.4657e-070.2264image
chr11:62738787-62739952:+LUSCGSVA_HALLMARK_HYPOXIAEER3.3346e-070.2267image
ENSG00000162222.12,TTC9CMESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.0964e-030.3563image
chr11:62738787-62739952:+MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.0964e-030.3563image
ENSG00000162222.12,TTC9COVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9979e-100.3618image
chr11:62738787-62739952:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.1358e-100.3612image
chr11:62738787-62739952:+PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.4018e-020.1849image
ENSG00000162222.12,TTC9CPAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.4018e-020.1849image
ENSG00000162222.12,TTC9CPCPGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.3697e-050.2987image
chr11:62738787-62739952:+PCPGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.3697e-050.2987image
ENSG00000162222.12,TTC9CPRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3914e-05-0.1936image
chr11:62738787-62739952:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.3914e-05-0.1936image
chr11:62738787-62739952:+READGSVA_HALLMARK_MYC_TARGETS_V2EER9.0333e-03-0.2679image
ENSG00000162222.12,TTC9CREADGSVA_HALLMARK_MYC_TARGETS_V2EAG9.0333e-03-0.2679image
ENSG00000162222.12,TTC9CSARCGSVA_HALLMARK_COMPLEMENTEAG5.9943e-050.2495image
chr11:62738787-62739952:+SARCGSVA_HALLMARK_COMPLEMENTEER5.9943e-050.2495image
chr11:62738787-62739952:+SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.7509e-050.1936image
ENSG00000162222.12,TTC9CSKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.7509e-050.1936image
ENSG00000162222.12,TTC9CSTADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.7327e-060.2483image
chr11:62738787-62739952:+STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.3385e-060.2509image
chr11:62738787-62739952:+TGCTGSVA_HALLMARK_MYC_TARGETS_V2EER3.6949e-070.3985image
ENSG00000162222.12,TTC9CTGCTGSVA_HALLMARK_MYC_TARGETS_V2EAG3.6949e-070.3985image
chr11:62738787-62739952:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.6803e-090.2648image
ENSG00000162222.12,TTC9CTHCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.8331e-090.2642image
ENSG00000162222.12,TTC9CTHYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.4752e-10-0.5613image
chr11:62738787-62739952:+THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4752e-10-0.5613image
ENSG00000162222.12,TTC9CUCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.0723e-040.2841image
chr11:62738787-62739952:+UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.0723e-040.2841image
chr11:62738787-62739952:+UCSGSVA_HALLMARK_HYPOXIAEER1.8256e-030.4075image
ENSG00000162222.12,TTC9CUCSGSVA_HALLMARK_HYPOXIAEAG1.8256e-030.4075image
chr11:62738787-62739952:+UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER7.2704e-070.5268image
ENSG00000162222.12,TTC9CUVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.2704e-070.5268image


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7. Enriched editing regions and drugs for TTC9C


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000162222.12,TTC9CACCGDC.0449EAG1.4634e-020.2773image
chr11:62738787-62739952:+BLCACMKEER1.1966e-17-0.4105image
ENSG00000162222.12,TTC9CBLCACMKEAG1.2121e-17-0.4104image
chr11:62738787-62739952:+BRCAGNF.2EER1.6000e-05-0.1311image
ENSG00000162222.12,TTC9CBRCAGNF.2EAG1.6312e-05-0.1310image
ENSG00000162222.12,TTC9CCESCErlotinibEAG4.8410e-10-0.3505image
chr11:62738787-62739952:+CESCErlotinibEER4.8410e-10-0.3505image
ENSG00000162222.12,TTC9CCHOLABT.263EAG8.8228e-030.4361image
chr11:62738787-62739952:+CHOLABT.263EER8.8228e-030.4361image
ENSG00000162222.12,TTC9CCOADGW843682XEAG2.5556e-070.3096image
chr11:62738787-62739952:+COADGW843682XEER2.5556e-070.3096image
chr11:62738787-62739952:+DLBCA.770041EER6.5060e-05-0.5648image
ENSG00000162222.12,TTC9CDLBCA.770041EAG6.5060e-05-0.5648image
chr11:62738787-62739952:+ESCACGP.60474EER1.3919e-05-0.3371image
ENSG00000162222.12,TTC9CESCACGP.60474EAG1.5543e-05-0.3353image
ENSG00000162222.12,TTC9CGBMDMOGEAG1.7866e-03-0.2428image
chr11:62738787-62739952:+GBMDMOGEER1.7866e-03-0.2428image
ENSG00000162222.12,TTC9CHNSCAZD.0530EAG8.0087e-09-0.2635image
chr11:62738787-62739952:+HNSCAZD.0530EER8.0087e-09-0.2635image
ENSG00000162222.12,TTC9CKICHABT.263EAG3.5867e-020.2608image
chr11:62738787-62739952:+KICHABT.263EER3.5867e-020.2608image
chr11:62738787-62739952:+KIRCCI.1040EER1.5620e-05-0.2190image
ENSG00000162222.12,TTC9CKIRCCI.1040EAG1.5810e-05-0.2189image
chr11:62738787-62739952:+KIRPCCT018159EER1.7882e-090.3473image
ENSG00000162222.12,TTC9CKIRPCCT018159EAG1.7153e-090.3477image
ENSG00000162222.12,TTC9CLAMLAZD6482EAG1.7313e-030.3110image
ENSG00000162222.12,TTC9CLGGABT.888EAG1.9797e-170.3585image
chr11:62738787-62739952:+LGGABT.888EER1.9797e-170.3585image
ENSG00000162222.12,TTC9CLIHCDoxorubicinEAG7.2742e-110.3462image
chr11:62738787-62739952:+LIHCDoxorubicinEER7.2742e-110.3462image
ENSG00000162222.12,TTC9CLUADGemcitabineEAG3.2329e-06-0.2057image
chr11:62738787-62739952:+LUADGemcitabineEER3.2329e-06-0.2057image
chr11:62738787-62739952:+LUSCABT.263EER3.7591e-050.1840image
ENSG00000162222.12,TTC9CLUSCABT.263EAG3.8083e-050.1838image
chr11:62738787-62739952:+MESOA.770041EER5.8608e-03-0.3036image
ENSG00000162222.12,TTC9CMESOA.770041EAG5.8608e-03-0.3036image
ENSG00000162222.12,TTC9COVBMS.536924EAG4.4160e-11-0.3738image
chr11:62738787-62739952:+OVBMS.536924EER4.1765e-11-0.3742image
ENSG00000162222.12,TTC9CPAADLFM.A13EAG1.5072e-040.2819image
chr11:62738787-62739952:+PAADLFM.A13EER1.5072e-040.2819image
ENSG00000162222.12,TTC9CPCPGBI.2536EAG5.7553e-040.2563image
chr11:62738787-62739952:+PCPGBI.2536EER5.7553e-040.2563image
chr11:62738787-62739952:+PRADBMS.509744EER9.0769e-09-0.2542image
ENSG00000162222.12,TTC9CPRADBMS.509744EAG9.0769e-09-0.2542image
ENSG00000162222.12,TTC9CREADBIRB.0796EAG9.0017e-050.3928image
chr11:62738787-62739952:+READBIRB.0796EER9.0017e-050.3928image
chr11:62738787-62739952:+SARCAZD.2281EER4.2746e-09-0.3587image
ENSG00000162222.12,TTC9CSARCAZD.2281EAG4.2746e-09-0.3587image
ENSG00000162222.12,TTC9CSKCMAG.014699EAG3.1764e-040.1668image
chr11:62738787-62739952:+SKCMAG.014699EER3.1764e-040.1668image
ENSG00000162222.12,TTC9CSTADKU.55933EAG3.2244e-04-0.1880image
chr11:62738787-62739952:+STADKU.55933EER4.5083e-04-0.1835image
chr11:62738787-62739952:+TGCTGemcitabineEER1.8383e-05-0.3399image
ENSG00000162222.12,TTC9CTGCTGemcitabineEAG1.8383e-05-0.3399image
chr11:62738787-62739952:+THCACI.1040EER3.5941e-11-0.2898image
ENSG00000162222.12,TTC9CTHCACI.1040EAG3.5018e-11-0.2900image
ENSG00000162222.12,TTC9CTHYMABT.263EAG7.7964e-150.6533image
chr11:62738787-62739952:+THYMABT.263EER7.7964e-150.6533image
ENSG00000162222.12,TTC9CUCECAZD6244EAG4.1220e-08-0.4100image
chr11:62738787-62739952:+UCECAZD6244EER4.1220e-08-0.4100image
ENSG00000162222.12,TTC9CUCSDasatinibEAG8.4267e-03-0.3488image
chr11:62738787-62739952:+UCSDasatinibEER8.4267e-03-0.3488image
ENSG00000162222.12,TTC9CUVMCGP.60474EAG1.4293e-06-0.5147image
chr11:62738787-62739952:+UVMCGP.60474EER1.4293e-06-0.5147image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType