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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GOLGA3 (ImmuneEditome ID:2802)

1. Gene summary of enriched editing regions for GOLGA3

check button Gene summary
Gene informationGene symbol

GOLGA3

Gene ID

2802

GeneSynonymsGCP170|MEA-2
GeneCytomap

12q24.33

GeneTypeprotein-coding
GeneDescriptiongolgin subfamily A member 3|Golgi membrane associated protein|Golgi peripheral membrane protein|SY2/SY10 protein|golgi autoantigen, golgin subfamily a, 3|golgi complex-associated protein of 170 kDa|golgin-160|golgin-165|male enhanced antigen-2
GeneModificationdate20230517
UniprotIDA0A494C129;A0A8I5KUK6;A0A8I5KPC9;Q08378;A0A8I5KWY9;A0A8I5KTE5;A0A8I5KU69;A0A8I5KXF8;A0A8I5KU99;A0A8I5KSV3;A0A8I5KW20;A0A8I5KQ98;A0A8I5QKK4;A0A8I5KVX9;A0A8I5KSF0;A0A8I5KYV8;A0A8I5QJ69;A0A8I5KQL7;A0A8I5KQH9;A0A8I5KQN2;A0A8I5QKX6;A0A8I5KSX1;A0A8I5KU25
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:132769929-132770951:-ENST00000204726.6ENSG00000090615.11GOLGA3UTR3AluSx1,AluSxchr12:132769929-132770951:-.alignment
chr12:132769929-132770951:-ENST00000450791.5ENSG00000090615.11GOLGA3UTR3AluSx1,AluSxchr12:132769929-132770951:-.alignment
chr12:132782781-132783897:-ENST00000537452.2ENSG00000090615.11GOLGA3ncRNA_exonicAluSx1,AluSx,AluSgchr12:132782781-132783897:-.alignment
chr12:132799539-132800063:-ENST00000537452.2ENSG00000090615.11GOLGA3ncRNA_intronicAluSz6,AluJochr12:132799539-132800063:-.alignment


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2. Tumor-specific enriched editing regions for GOLGA3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:132769929-132770951:-COADEER2.0715e-07image
ENSG00000090615.11,GOLGA3COADEAG8.6032e-09image
chr12:132769929-132770951:-LIHCEER7.7573e-06image
ENSG00000090615.11,GOLGA3LIHCEAG1.7194e-05image
chr12:132769929-132770951:-LUSCEER6.4498e-03image
ENSG00000090615.11,GOLGA3LUSCEAG4.5476e-04image
chr12:132769929-132770951:-UCECEER5.8837e-09image
ENSG00000090615.11,GOLGA3UCECEAG5.7607e-09image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:132769929-132770951:-COADEER3.6110e-026.0360e-037.6331e+01image

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3. Enriched editing regions and immune related genes for GOLGA3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:132769929-132770951:-DLBCEERENSG00000176871,WSB2-0.64564.6472e-038.8896e-04-0.4735imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000160284,SPATC1L0.56989.0496e-033.3218e-050.5717imageNNNAMast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000183258,DDX410.58431.7678e-028.5521e-070.6534imageNNDDX41Mast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000108176,DNAJC120.58082.5699e-022.2232e-050.5818imageNNNAMast_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr12:132769929-132770951:-DLBCEERENSG00000261236,BOP10.55353.4034e-025.3206e-050.5594imageNNNAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000125967,NECAB30.55663.5324e-021.7096e-040.5265imageNNNAMacrophages_M2GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:132769929-132770951:-DLBCEERENSG00000163659,TIPARP-0.50663.5590e-026.8399e-04-0.4825imageNNTIPARPMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_DN
chr12:132769929-132770951:-DLBCEERENSG00000131507,NDFIP1-0.55783.6340e-027.3203e-04-0.4802imageNNNDFIP1B_cells_memoryGSVA_HALLMARK_DNA_REPAIR
chr12:132769929-132770951:-DLBCEERENSG00000132591,ERAL10.52323.9395e-028.7653e-040.4740imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V2
chr12:132769929-132770951:-DLBCEERENSG00000169016,E2F6-0.53754.0587e-024.0118e-04-0.5001imageNNNANK_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr12:132769929-132770951:-DLBCEERENSG00000176871,WSB2-0.64564.6472e-038.8896e-04-0.4735imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000160284,SPATC1L0.56989.0496e-033.3218e-050.5717imageNNNAMast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000183258,DDX410.58431.7678e-028.5521e-070.6534imageNNDDX41Mast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000108176,DNAJC120.58082.5699e-022.2232e-050.5818imageNNNAMast_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr12:132769929-132770951:-DLBCEERENSG00000261236,BOP10.55353.4034e-025.3206e-050.5594imageNNNAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr12:132769929-132770951:-DLBCEERENSG00000125967,NECAB30.55663.5324e-021.7096e-040.5265imageNNNAMacrophages_M2GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:132769929-132770951:-DLBCEERENSG00000163659,TIPARP-0.50663.5590e-026.8399e-04-0.4825imageNNTIPARPMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_DN
chr12:132769929-132770951:-DLBCEERENSG00000131507,NDFIP1-0.55783.6340e-027.3203e-04-0.4802imageNNNDFIP1B_cells_memoryGSVA_HALLMARK_DNA_REPAIR
chr12:132769929-132770951:-DLBCEERENSG00000132591,ERAL10.52323.9395e-028.7653e-040.4740imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V2
chr12:132769929-132770951:-DLBCEERENSG00000169016,E2F6-0.53754.0587e-024.0118e-04-0.5001imageNNNANK_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION

More results



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4. Enriched editing regions and immune related splicing for GOLGA3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000138668.14chr482353833:82355401:82356536:823566830.24441.5800e-023.6037e-280.6052imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000106258.9chr799654327:99660659:99662815:996628820.23682.1313e-026.1266e-230.5573imageNADAR;BCCIP;BUD13;CPSF6;CSTF2T;DDX42;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;MBNL2;MOV10;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2NAEosinophilsGSVA_HALLMARK_P53_PATHWAY
ENSG00000090615.11,GOLGA3
COADEAGMEXENSG00000030582.12chr1744351549:44351795:44352014:44352162:44352211:44352248:44352340:443525710.23332.7006e-029.0250e-210.5287imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL14;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184GRNEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000104419.10chr8133258365:133258426:133259167:1332592300.21324.8066e-024.2706e-390.6883imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NDRG1NeutrophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000060237.12chr12879572:880999:881691:8817890.19942.1343e-022.6999e-310.7119imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184WNK1EosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000205571.8chr570076520:70076574:70077018:700771600.22873.4198e-026.0245e-190.5066imageNADAR;AIFM1;BCCIP;BUD13;CPSF6;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;MBNL2;MOV10;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000038382.13chr514398879:14399070:14400962:144010640.20784.8112e-022.1148e-260.6154imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MBNL2;METTL14;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZC3H7B;ZNF184TRIOEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000157212.14chr7154946362:154946813:154947902:1549480030.33139.5079e-053.6090e-210.5333imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000005483.15chr7105105858:105107925:105108941:1051092280.25271.1030e-022.1715e-250.5781imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMast_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000090615.11,GOLGA3
COADEAGIRENSG00000106258.9chr799662815:99665314:99666600:996666890.22762.7182e-023.3621e-300.6313imageNADAR;BCCIP;BUD13;CPSF6;CSTF2T;DDX42;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;MBNL2;MOV10;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for GOLGA3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:132769929-132770951:-ACCEERMast_cells_resting2.4117e-02-0.2586image
ENSG00000090615.11,GOLGA3ACCEAGMast_cells_resting2.2105e-02-0.2622image
chr12:132769929-132770951:-BLCAEERB_cells_naive2.8660e-02-0.1118image
ENSG00000090615.11,GOLGA3BLCAEAGNeutrophils7.3756e-030.1362image
chr12:132769929-132770951:-BRCAEERT_cells_CD4_memory_activated3.4385e-040.1091image
ENSG00000090615.11,GOLGA3BRCAEAGDendritic_cells_activated4.3839e-040.1072image
ENSG00000090615.11,GOLGA3CHOLEAGT_cells_CD82.0874e-020.4006image
chr12:132769929-132770951:-COADEEREosinophils2.5457e-040.2221image
ENSG00000090615.11,GOLGA3COADEAGEosinophils1.7227e-080.3353image
chr12:132769929-132770951:-DLBCEERMast_cells_resting1.1730e-020.3685image
ENSG00000090615.11,GOLGA3DLBCEAGMast_cells_resting1.1587e-020.3691image
chr12:132769929-132770951:-ESCAEERMacrophages_M22.2071e-030.2418image
chr12:132782781-132783897:-ESCAEERT_cells_CD4_memory_activated1.7761e-020.2551image
ENSG00000090615.11,GOLGA3ESCAEAGB_cells_memory6.1985e-050.3112image
chr12:132769929-132770951:-GBMEERMacrophages_M12.6420e-030.2340image
ENSG00000090615.11,GOLGA3GBMEAGT_cells_regulatory_(Tregs)1.4861e-02-0.1905image
chr12:132769929-132770951:-HNSCEEREosinophils2.5299e-030.1361image
ENSG00000090615.11,GOLGA3HNSCEAGEosinophils2.8156e-030.1347image
chr12:132769929-132770951:-KIRCEERT_cells_CD4_memory_resting2.2827e-020.1180image
ENSG00000090615.11,GOLGA3KIRCEAGT_cells_CD4_memory_resting7.6989e-040.1736image
chr12:132769929-132770951:-KIRPEEREosinophils5.4089e-070.2988image
ENSG00000090615.11,GOLGA3KIRPEAGEosinophils1.0784e-040.2314image
chr12:132769929-132770951:-LAMLEERPlasma_cells3.0384e-02-0.2336image
ENSG00000090615.11,GOLGA3LAMLEAGT_cells_gamma_delta2.9418e-020.1882image
chr12:132769929-132770951:-LGGEERMacrophages_M23.9188e-02-0.0899image
chr12:132769929-132770951:-LIHCEERT_cells_gamma_delta7.6644e-030.1431image
ENSG00000090615.11,GOLGA3LIHCEAGB_cells_naive4.9015e-030.1507image
chr12:132769929-132770951:-LUADEEREosinophils1.5347e-050.1911image
ENSG00000090615.11,GOLGA3LUADEAGEosinophils8.9910e-120.2971image
chr12:132769929-132770951:-LUSCEERT_cells_follicular_helper3.8528e-02-0.0942image
ENSG00000090615.11,GOLGA3LUSCEAGMacrophages_M06.9409e-030.1227image
chr12:132769929-132770951:-OVEERT_cells_CD85.3926e-030.1638image
ENSG00000090615.11,GOLGA3OVEAGT_cells_CD4_naive5.4975e-030.1635image
chr12:132769929-132770951:-PAADEERNK_cells_resting6.7497e-030.2041image
ENSG00000090615.11,GOLGA3PAADEAGNK_cells_resting2.2230e-020.1728image
chr12:132769929-132770951:-PCPGEERMacrophages_M04.4062e-020.1494image
ENSG00000090615.11,GOLGA3PCPGEAGMacrophages_M04.7589e-020.1471image
chr12:132769929-132770951:-PRADEERT_cells_gamma_delta1.3488e-020.1111image
ENSG00000090615.11,GOLGA3PRADEAGT_cells_gamma_delta1.0421e-020.1152image
chr12:132769929-132770951:-SKCMEERMacrophages_M03.2848e-02-0.0989image
ENSG00000090615.11,GOLGA3SKCMEAGMacrophages_M02.9068e-02-0.1011image
chr12:132769929-132770951:-STADEERT_cells_CD4_memory_resting1.6588e-03-0.1668image
ENSG00000090615.11,GOLGA3STADEAGNK_cells_activated1.4016e-020.1305image
chr12:132769929-132770951:-TGCTEERB_cells_naive5.2028e-030.2263image
ENSG00000090615.11,GOLGA3TGCTEAGB_cells_naive2.9518e-040.2906image
chr12:132769929-132770951:-THCAEERMacrophages_M22.2037e-020.1027image
ENSG00000090615.11,GOLGA3THCAEAGMacrophages_M21.4068e-020.1101image
chr12:132769929-132770951:-THYMEERT_cells_gamma_delta4.6984e-020.1962image
chr12:132769929-132770951:-UCECEERMacrophages_M22.9871e-030.2284image
ENSG00000090615.11,GOLGA3UCECEAGMacrophages_M22.3655e-030.2337image
ENSG00000090615.11,GOLGA3UVMEAGDendritic_cells_activated1.5421e-120.6894image


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6. Enriched editing regions and immune gene sets for GOLGA3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr12:132769929-132770951:-BRCAEER8.1710e-060.13574.8991e-020.06013.8252e-030.08822.4424e-020.0687image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000090615.11,GOLGA3BLCAGSVA_HALLMARK_MYOGENESISEAG1.7222e-03-0.1590image
chr12:132769929-132770951:-BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEER1.4800e-030.1619image
ENSG00000090615.11,GOLGA3BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG4.4498e-04-0.1070image
chr12:132769929-132770951:-BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEER8.1566e-060.1357image
ENSG00000090615.11,GOLGA3CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG7.8350e-040.1926image
chr12:132769929-132770951:-CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER6.2585e-040.1960image
ENSG00000090615.11,GOLGA3COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.1708e-10-0.3691image
chr12:132769929-132770951:-COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.2954e-03-0.1668image
ENSG00000090615.11,GOLGA3DLBCGSVA_HALLMARK_MYC_TARGETS_V2EAG1.2381e-030.4617image
chr12:132769929-132770951:-DLBCGSVA_HALLMARK_MYC_TARGETS_V2EER1.3006e-030.4599image
ENSG00000090615.11,GOLGA3ESCAGSVA_HALLMARK_APICAL_SURFACEEAG2.0824e-05-0.3296image
chr12:132769929-132770951:-ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.5935e-02-0.1915image
chr12:132769929-132770951:-GBMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.6683e-030.2338image
chr12:132769929-132770951:-HNSCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.8536e-020.0989image
ENSG00000090615.11,GOLGA3KICHGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG5.4624e-03-0.3544image
chr12:132769929-132770951:-KIRCGSVA_HALLMARK_SPERMATOGENESISEER1.9742e-020.1208image
ENSG00000090615.11,GOLGA3KIRCGSVA_HALLMARK_PEROXISOMEEAG8.2386e-03-0.1368image
chr12:132769929-132770951:-LAMLGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.9291e-02-0.2352image
ENSG00000090615.11,GOLGA3LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.9429e-020.1782image
ENSG00000090615.11,GOLGA3LGGGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.1330e-020.1102image
chr12:132769929-132770951:-LGGGSVA_HALLMARK_COMPLEMENTEER2.0403e-030.1341image
chr12:132769929-132770951:-LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.8196e-07-0.2760image
ENSG00000090615.11,GOLGA3LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.1452e-04-0.2056image
ENSG00000090615.11,GOLGA3LUADGSVA_HALLMARK_APICAL_SURFACEEAG1.1067e-04-0.1710image
chr12:132769929-132770951:-LUADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.8787e-040.1546image
chr12:132769929-132770951:-LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.0119e-040.1604image
chr12:132769929-132770951:-MESOGSVA_HALLMARK_GLYCOLYSISEER1.7387e-02-0.2653image
ENSG00000090615.11,GOLGA3MESOGSVA_HALLMARK_GLYCOLYSISEAG2.2317e-02-0.2552image
ENSG00000090615.11,GOLGA3OVGSVA_HALLMARK_UV_RESPONSE_DNEAG2.9902e-04-0.2119image
chr12:132769929-132770951:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.9199e-070.2917image
chr12:132769929-132770951:-PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.0655e-020.1714image
chr12:132769929-132770951:-PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.7226e-020.0994image
chr12:132769929-132770951:-READGSVA_HALLMARK_GLYCOLYSISEER1.5350e-020.2563image
ENSG00000090615.11,GOLGA3READGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.4569e-020.2243image
chr12:132769929-132770951:-SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER8.1491e-030.1650image
ENSG00000090615.11,GOLGA3SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.8035e-020.1477image
chr12:132769929-132770951:-SKCMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.0007e-020.1077image
ENSG00000090615.11,GOLGA3STADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.9408e-06-0.2498image
chr12:132769929-132770951:-STADGSVA_HALLMARK_DNA_REPAIREER4.0615e-030.1526image
ENSG00000090615.11,GOLGA3TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.3722e-06-0.3812image
chr12:132769929-132770951:-TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.2656e-05-0.3374image
ENSG00000090615.11,GOLGA3THCAGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.5906e-02-0.0941image
chr12:132769929-132770951:-THCAGSVA_HALLMARK_NOTCH_SIGNALINGEER3.5494e-02-0.0944image
chr12:132769929-132770951:-THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.3559e-02-0.2230image
ENSG00000090615.11,GOLGA3THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.4206e-02-0.2410image
chr12:132769929-132770951:-UCSGSVA_HALLMARK_NOTCH_SIGNALINGEER1.2375e-020.3322image
ENSG00000090615.11,GOLGA3UCSGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.7536e-020.3164image


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7. Enriched editing regions and drugs for GOLGA3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000090615.11,GOLGA3ACCAS601245EAG4.2562e-020.2333image
chr12:132769929-132770951:-ACCAS601245EER3.3407e-020.2443image
ENSG00000090615.11,GOLGA3BLCABMS.536924EAG2.7492e-040.1842image
chr12:132769929-132770951:-BLCAElesclomolEER2.5221e-030.1539image
chr12:132769929-132770951:-BRCAATRAEER6.1177e-040.1046image
ENSG00000090615.11,GOLGA3BRCAABT.263EAG5.5058e-04-0.1055image
ENSG00000090615.11,GOLGA3CESCATRAEAG4.6409e-030.1628image
chr12:132769929-132770951:-CESCCCT007093EER3.9014e-030.1659image
ENSG00000090615.11,GOLGA3COADGW843682XEAG1.1388e-150.4626image
chr12:132769929-132770951:-COADGW843682XEER7.7635e-050.2394image
ENSG00000090615.11,GOLGA3DLBCGW843682XEAG2.0818e-04-0.5206image
chr12:132769929-132770951:-DLBCGW843682XEER1.7636e-04-0.5256image
ENSG00000090615.11,GOLGA3ESCACGP.60474EAG1.4697e-040.2957image
chr12:132769929-132770951:-ESCABMS.536924EER1.7016e-02-0.1896image
chr12:132782781-132783897:-ESCADoxorubicinEER2.0326e-02-0.2499image
chr12:132769929-132770951:-GBMKU.55933EER1.2302e-03-0.2510image
ENSG00000090615.11,GOLGA3GBMABT.888EAG1.5507e-03-0.2460image
ENSG00000090615.11,GOLGA3HNSCCCT007093EAG1.0136e-030.1480image
chr12:132769929-132770951:-HNSCCCT007093EER6.1951e-040.1541image
ENSG00000090615.11,GOLGA3KICHBIBW2992EAG1.1069e-020.3258image
chr12:132769929-132770951:-KIRCJNK.9LEER1.0103e-020.1332image
ENSG00000090615.11,GOLGA3KIRCAS601245EAG1.1146e-030.1684image
chr12:132769929-132770951:-KIRPBicalutamideEER1.2201e-02-0.1521image
ENSG00000090615.11,GOLGA3KIRPDocetaxelEAG4.9513e-020.1186image
chr12:132769929-132770951:-LAMLEHT.1864EER7.0406e-030.2886image
ENSG00000090615.11,GOLGA3LAMLCHIR.99021EAG4.1553e-03-0.2461image
ENSG00000090615.11,GOLGA3LGGABT.263EAG2.4976e-03-0.1314image
chr12:132769929-132770951:-LGGABT.263EER4.0132e-03-0.1251image
chr12:132769929-132770951:-LIHCDoxorubicinEER1.9653e-070.2753image
ENSG00000090615.11,GOLGA3LIHCBleomycinEAG2.0180e-050.2290image
ENSG00000090615.11,GOLGA3LUADBexaroteneEAG8.5968e-050.1737image
chr12:132769929-132770951:-LUADCisplatinEER2.1016e-04-0.1642image
chr12:132769929-132770951:-LUSCAUY922EER1.8404e-03-0.1414image
ENSG00000090615.11,GOLGA3LUSCEmbelinEAG9.3716e-04-0.1501image
ENSG00000090615.11,GOLGA3OVGSK269962AEAG1.9784e-050.2490image
chr12:132769929-132770951:-OVGSK269962AEER3.0701e-060.2714image
chr12:132769929-132770951:-PAADABT.263EER1.5287e-02-0.1874image
ENSG00000090615.11,GOLGA3PAADABT.263EAG1.7193e-02-0.1842image
chr12:132769929-132770951:-PCPGAxitinibEER2.8693e-020.1622image
ENSG00000090615.11,GOLGA3PRADGW843682XEAG2.3511e-020.1019image
chr12:132769929-132770951:-PRADBI.2536EER2.3162e-020.1022image
ENSG00000090615.11,GOLGA3READEHT.1864EAG1.4027e-020.2596image
chr12:132769929-132770951:-READEHT.1864EER1.5192e-020.2566image
ENSG00000090615.11,GOLGA3SARCAG.014699EAG3.2886e-040.2227image
chr12:132769929-132770951:-SARCCisplatinEER1.4190e-04-0.2356image
ENSG00000090615.11,GOLGA3SKCMJNK.9LEAG1.7139e-02-0.1104image
chr12:132769929-132770951:-SKCMJNK.9LEER1.5673e-02-0.1119image
chr12:132782781-132783897:-STADCCT007093EER4.8369e-020.1887image
ENSG00000090615.11,GOLGA3STADBIRB.0796EAG3.1626e-02-0.1144image
chr12:132769929-132770951:-STADGW843682XEER9.9627e-03-0.1370image
chr12:132769929-132770951:-TGCTMidostaurinEER5.3596e-030.2256image
ENSG00000090615.11,GOLGA3TGCTMidostaurinEAG1.2969e-030.2594image
ENSG00000090615.11,GOLGA3THCAJNK.9LEAG3.7130e-020.0935image
chr12:132769929-132770951:-THCAJNK.9LEER4.2780e-020.0909image
chr12:132769929-132770951:-THYMAZ628EER3.2463e-020.2109image
ENSG00000090615.11,GOLGA3THYMAZ628EAG3.3665e-020.2095image
ENSG00000090615.11,GOLGA3UCSFH535EAG1.6200e-02-0.3200image
chr12:132769929-132770951:-UCSFH535EER1.8340e-02-0.3143image
ENSG00000090615.11,GOLGA3UVMDMOGEAG4.9577e-02-0.2203image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType