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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RABGEF1 (ImmuneEditome ID:27342)

1. Gene summary of enriched editing regions for RABGEF1

check button Gene summary
Gene informationGene symbol

RABGEF1

Gene ID

27342

GeneSynonymsRABEX5|RAP1|rabex-5
GeneCytomap

7q11.21

GeneTypeprotein-coding
GeneDescriptionrab5 GDP/GTP exchange factor|RAB guanine nucleotide exchange factor (GEF) 1|rabaptin-5-associated exchange factor for Rab5
GeneModificationdate20230329
UniprotIDQ9UJ41;A0A024RDL6;E9PFK9;V9GYI8;A0A1W2PPY0;C9JDA2
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:66683723-66692055:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicA-rich,L1ME2,MER47A,AluY,AluSp,(AAACA)n,(TTAT)n,MLT1B,AluSz6,AluJo,AluSx,AluSg7,FRAM,AluJr,AluSc,AluJb,AluJr4,L1M4c,AluSz,AluSg,AluSq2chr7:66683723-66692055:+.alignment
chr7:66695184-66696659:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicAluSx1,L2c,AluYk11,AluSz,AluJrchr7:66695184-66696659:+.alignment
chr7:66701195-66701748:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicAluJo,AluSq2chr7:66701195-66701748:+.alignment
chr7:66703005-66703282:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicL1MB5,AluYchr7:66703005-66703282:+.alignment
chr7:66704512-66713438:+ENST00000607882.4ENSG00000154710.14RABGEF1splicingAluSc8,L1ME1,AluYc,(AG)n,AluY,Charlie5,L1MC,GA-rich,AluJo,AluSx,AluJb,AluJr,AluYb8,L1MD2,L1M4,AluSg,AluSq2,AluSzchr7:66704512-66713438:+.alignment
chr7:66714637-66717829:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicFAM,L1MD2,L1M5,AluSz6,AluSx,AluJr,AluJb,AluY,(TCC)nchr7:66714637-66717829:+.alignment
chr7:66721017-66721991:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicL1M4,AluSz,AluJr,MLT1Dchr7:66721017-66721991:+.alignment
chr7:66726428-66726798:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicAluJr,L1MB8,AluSzchr7:66726428-66726798:+.alignment
chr7:66738516-66739632:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicLTR54,AluJb,L2a,MIRb,AluSx1,AluSpchr7:66738516-66739632:+.alignment
chr7:66741834-66745912:+ENST00000284957.8ENSG00000154710.14RABGEF1intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment
chr7:66741834-66745912:+ENST00000437078.5ENSG00000154710.14RABGEF1intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment
chr7:66741834-66745912:+ENST00000442563.4ENSG00000154710.14RABGEF1intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment
chr7:66741834-66745912:+ENST00000450873.5ENSG00000154710.14RABGEF1intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment
chr7:66741834-66745912:+ENST00000510829.5ENSG00000154710.14RABGEF1intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment
chr7:66741834-66745912:+ENST00000607882.4ENSG00000154710.14RABGEF1intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment
chr7:66787123-66787622:+ENST00000484547.5ENSG00000154710.14RABGEF1ncRNA_intronicAluSz,AluSz6chr7:66787123-66787622:+.alignment
chr7:66803746-66804664:+ENST00000461017.1ENSG00000154710.14RABGEF1ncRNA_intronicAluSx4,AluJo,AluSqchr7:66803746-66804664:+.alignment
chr7:66803746-66804664:+ENST00000484547.5ENSG00000154710.14RABGEF1ncRNA_intronicAluSx4,AluJo,AluSqchr7:66803746-66804664:+.alignment


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2. Tumor-specific enriched editing regions for RABGEF1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000154710.14,RABGEF1BRCAEAG3.5772e-02image
chr7:66714637-66717829:+KIRPEER1.2445e-02image
ENSG00000154710.14,RABGEF1KIRPEAG8.3202e-03image
ENSG00000154710.14,RABGEF1LUSCEAG4.0938e-02image
chr7:66714637-66717829:+THCAEER3.8195e-02image
ENSG00000154710.14,RABGEF1THCAEAG3.5167e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr7:66714637-66717829:+ESCACliEER3.3526e-021.2673e-02-0.3815image
chr7:66683723-66692055:+STADPathEER2.7303e-021.4763e-020.1525image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for RABGEF1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr7:66704512-66713438:+LAMLEERENSG00000276045,ORAI10.39903.1996e-023.2009e-060.4239imageNNORAI1Mast_cells_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr7:66714637-66717829:+PRADEERENSG00000153317,ASAP10.45581.2104e-181.8875e-180.4042imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+PRADEERENSG00000010404,IDS0.44775.8837e-186.3380e-190.4094imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+UCECEERENSG00000163125,RPRD20.54111.8274e-063.6636e-070.4270imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr7:66714637-66717829:+UCECEERENSG00000160710,ADAR0.52138.0065e-068.6922e-080.4470imageNNADARDendritic_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr7:66714637-66717829:+UCECEERENSG00000116580,GON4L0.51908.3765e-061.4190e-070.4403imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr7:66714637-66717829:+UCECEERENSG00000186063,AIDA0.51521.1988e-051.2096e-090.4999imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+UCECEERENSG00000149806,FAU-0.49993.1245e-051.6663e-06-0.4044imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+UCECEERENSG00000116539,ASH1L0.49623.7061e-056.4672e-070.4187imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr7:66714637-66717829:+UCECEERENSG00000118217,ATF60.49053.9479e-056.1282e-090.4809imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr7:66714637-66717829:+UCECEERENSG00000263001,GTF2I0.49563.9644e-051.4061e-060.4070imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for RABGEF1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr7:66683723-66692055:+
OVEERIRENSG00000125089.12chr48232407:8233513:8235432:82355550.21003.6091e-023.9065e-140.5237imageNADAR;CELF2;EIF4A3;ELAVL1;FUS;IGF2BP2;PTBP1;RBFOX2;TARDBP;U2AF2NA
ENSG00000154710.14,RABGEF1
THYMEAGIRENSG00000134152.6chr1534145397:34146850:34147199:341472140.33114.7073e-026.1718e-050.4325imageNACIN1;ADAR;AIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAMonocytesGSVA_HALLMARK_DNA_REPAIR
chr7:66714637-66717829:+
THYMEERIRENSG00000100412.11chr2241526261:41527420:41527900:415280220.60814.5712e-064.6095e-080.5404imageNNNANK_cells_activatedGSVA_HALLMARK_TGF_BETA_SIGNALING
chr7:66714637-66717829:+
THYMEERIRENSG00000076662.5chr1910333775:10334408:10334527:103347230.58222.1195e-052.6141e-070.5138imageNNICAM3Mast_cells_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr7:66714637-66717829:+
THYMEERMEXENSG00000171298.8chr1780111982:80112100:80112577:80112711:80113217:80113366:80116967:801170820.53573.4714e-043.4297e-080.5473imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr7:66714637-66717829:+
THYMEERMEXENSG00000106400.7chr7101218180:101218217:101218318:101218435:101221616:101221796:101222603:1012227740.40322.1235e-029.1054e-050.4028imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr7:66714637-66717829:+
THYMEERA3ENSG00000150787.3chr11112228593:112228673:112230625:112230682:112230207:112230682-0.37962.5300e-021.1894e-05-0.4482imageNNNAMacrophages_M1GSVA_HALLMARK_ANGIOGENESIS
ENSG00000154710.14,RABGEF1
THYMEAGMEXENSG00000108010.7chr10130160795:130160997:130166506:130166586:130174866:130174906:130174996:1301750890.62341.8660e-061.4532e-090.5691imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;METTL14;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;SF3A3;SF3B4;SLBP;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YWHAG;ZC3H7B;ZFP36;ZNF184GLRX3T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000154710.14,RABGEF1
THYMEAGIRENSG00000196776.10chr3108049618:108050602:108051938:1080519700.52991.0633e-045.6709e-070.4845imageNACIN1;ADAR;AIFM1;ALYREF;AUH;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184CD47MonocytesGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000154710.14,RABGEF1
THYMEAGMEXENSG00000176261.11chr132627507:32627544:32631826:32631879:32634732:32634792:32650432:32650525-0.50744.7968e-049.4974e-07-0.4760imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HEME_METABOLISM

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5. Enriched editing regions and immune infiltration for RABGEF1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000154710.14,RABGEF1ACCEAGMast_cells_activated2.8164e-020.3766image
chr7:66683723-66692055:+BLCAEERMacrophages_M01.6353e-03-0.2344image
chr7:66714637-66717829:+BLCAEERT_cells_CD81.2150e-020.1559image
chr7:66683723-66692055:+BRCAEERMast_cells_resting1.1981e-040.1955image
chr7:66714637-66717829:+BRCAEERT_cells_CD4_memory_resting1.1458e-030.1341image
ENSG00000154710.14,RABGEF1BRCAEAGT_cells_CD4_memory_resting2.7343e-040.1354image
ENSG00000154710.14,RABGEF1CESCEAGT_cells_CD4_memory_resting2.9589e-020.1513image
ENSG00000154710.14,RABGEF1CHOLEAGMonocytes1.2080e-020.5495image
ENSG00000154710.14,RABGEF1COADEAGT_cells_CD4_memory_resting3.9681e-020.1780image
ENSG00000154710.14,RABGEF1DLBCEAGDendritic_cells_activated2.8035e-020.3662image
chr7:66683723-66692055:+ESCAEERNK_cells_activated4.1421e-020.1714image
chr7:66695184-66696659:+ESCAEERNK_cells_resting1.9840e-02-0.2779image
chr7:66701195-66701748:+ESCAEERMast_cells_activated3.3501e-020.3656image
chr7:66703005-66703282:+ESCAEERMacrophages_M23.5591e-020.4607image
ENSG00000154710.14,RABGEF1ESCAEAGEosinophils4.4551e-02-0.1606image
chr7:66714637-66717829:+GBMEERMacrophages_M11.2923e-020.1999image
ENSG00000154710.14,RABGEF1GBMEAGMacrophages_M16.0417e-030.2182image
chr7:66714637-66717829:+HNSCEERMacrophages_M11.2871e-030.1986image
ENSG00000154710.14,RABGEF1HNSCEAGMacrophages_M11.4625e-030.1820image
chr7:66714637-66717829:+KICHEERNK_cells_activated2.2645e-02-0.3790image
chr7:66714637-66717829:+KIRCEERNK_cells_activated2.4599e-02-0.2035image
chr7:66683723-66692055:+KIRPEERMast_cells_resting2.6503e-020.2219image
chr7:66704512-66713438:+KIRPEERT_cells_CD4_memory_activated6.0092e-030.4269image
chr7:66714637-66717829:+KIRPEERT_cells_CD83.3115e-03-0.2033image
ENSG00000154710.14,RABGEF1KIRPEAGT_cells_CD82.8268e-04-0.2420image
chr7:66683723-66692055:+LAMLEERB_cells_naive2.3183e-020.2089image
chr7:66695184-66696659:+LAMLEERT_cells_follicular_helper4.3811e-030.5309image
chr7:66741834-66745912:+LAMLEERNK_cells_resting1.8876e-020.2310image
ENSG00000154710.14,RABGEF1LAMLEAGMonocytes5.3469e-03-0.2302image
chr7:66704512-66713438:+LGGEEREosinophils1.4914e-020.2326image
chr7:66714637-66717829:+LGGEERNeutrophils1.6765e-020.1106image
ENSG00000154710.14,RABGEF1LGGEAGT_cells_CD4_naive1.2190e-030.1457image
chr7:66714637-66717829:+LIHCEERNeutrophils6.0913e-030.3270image
ENSG00000154710.14,RABGEF1LIHCEAGT_cells_CD4_memory_activated1.9266e-020.1909image
chr7:66683723-66692055:+LUADEERT_cells_follicular_helper3.5534e-02-0.1551image
chr7:66704512-66713438:+LUADEERT_cells_regulatory_(Tregs)3.1851e-030.3942image
chr7:66714637-66717829:+LUADEERMast_cells_resting1.2390e-050.2593image
ENSG00000154710.14,RABGEF1LUADEAGMast_cells_resting6.3863e-070.2688image
chr7:66683723-66692055:+LUSCEERMast_cells_resting2.8460e-03-0.1938image
chr7:66714637-66717829:+LUSCEERMonocytes7.0769e-03-0.1598image
ENSG00000154710.14,RABGEF1LUSCEAGMonocytes3.5908e-02-0.1078image
ENSG00000154710.14,RABGEF1MESOEAGMacrophages_M09.7655e-03-0.3621image
chr7:66683723-66692055:+OVEERMacrophages_M24.2505e-02-0.1405image
chr7:66695184-66696659:+OVEERMast_cells_activated7.3843e-040.4342image
chr7:66701195-66701748:+OVEERT_cells_regulatory_(Tregs)4.3931e-030.5604image
chr7:66714637-66717829:+OVEERNeutrophils4.0859e-020.1225image
chr7:66741834-66745912:+OVEERT_cells_regulatory_(Tregs)1.3404e-020.2453image
ENSG00000154710.14,RABGEF1PAADEAGMacrophages_M13.9483e-030.2727image
chr7:66683723-66692055:+PCPGEERMacrophages_M01.3952e-030.3233image
chr7:66683723-66692055:+PRADEERT_cells_CD83.3718e-020.1843image
chr7:66714637-66717829:+PRADEERT_cells_CD4_memory_resting2.8595e-050.1996image
ENSG00000154710.14,RABGEF1PRADEAGT_cells_CD4_memory_resting6.6643e-040.1613image
chr7:66683723-66692055:+SARCEERB_cells_naive2.6442e-030.3565image
chr7:66714637-66717829:+SARCEERT_cells_CD4_memory_resting3.3154e-030.2360image
ENSG00000154710.14,RABGEF1SARCEAGMast_cells_resting4.9999e-030.2095image
chr7:66683723-66692055:+SKCMEERB_cells_memory1.9345e-02-0.1548image
chr7:66714637-66717829:+SKCMEERT_cells_CD82.7760e-030.1745image
ENSG00000154710.14,RABGEF1SKCMEAGMacrophages_M19.8072e-030.1338image
chr7:66683723-66692055:+STADEERNK_cells_resting5.8193e-03-0.1684image
chr7:66695184-66696659:+STADEERB_cells_memory2.2083e-020.2181image
chr7:66701195-66701748:+STADEERMacrophages_M15.7944e-030.3848image
chr7:66803746-66804664:+STADEERMonocytes7.3566e-03-0.3514image
ENSG00000154710.14,RABGEF1STADEAGMonocytes4.4598e-020.1125image
chr7:66787123-66787622:+TGCTEERB_cells_naive2.6943e-030.5847image
chr7:66714637-66717829:+THCAEERNK_cells_activated5.4350e-04-0.1669image
ENSG00000154710.14,RABGEF1THCAEAGNK_cells_activated1.8538e-04-0.1744image
chr7:66714637-66717829:+THYMEERNK_cells_activated4.8273e-040.3624image
ENSG00000154710.14,RABGEF1THYMEAGNK_cells_activated1.3809e-040.3793image
chr7:66683723-66692055:+UCECEERT_cells_CD4_memory_resting1.6386e-020.2860image
chr7:66714637-66717829:+UCECEERMast_cells_activated1.0288e-020.2235image
ENSG00000154710.14,RABGEF1UCECEAGT_cells_CD82.4105e-02-0.1854image
chr7:66714637-66717829:+UCSEERMast_cells_activated3.8796e-030.4266image
ENSG00000154710.14,RABGEF1UVMEAGT_cells_gamma_delta4.2242e-02-0.4268image


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6. Enriched editing regions and immune gene sets for RABGEF1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000154710.14,RABGEF1STADEAG1.6589e-02image3.1021e-030.1651image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr7:66683723-66692055:+BRCAEER3.0861e-13-0.36151.2356e-06-0.24522.1464e-11-0.33385.9256e-04-0.1750image
ENSG00000154710.14,RABGEF1LUADEAG2.8366e-05-0.22721.5614e-03-0.17275.3619e-05-0.21951.1472e-02-0.1384image
chr7:66741834-66745912:+STADEER2.3989e-040.27431.2595e-020.18836.4031e-040.25561.4169e-060.3552image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000154710.14,RABGEF1ACCGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.1165e-02-0.3520image
chr7:66683723-66692055:+BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER8.0001e-04-0.2491image
chr7:66714637-66717829:+BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2593e-030.1893image
chr7:66704512-66713438:+BRCAGSVA_HALLMARK_NOTCH_SIGNALINGEER2.7420e-040.4844image
ENSG00000154710.14,RABGEF1BRCAGSVA_HALLMARK_MYC_TARGETS_V2EAG6.9631e-09-0.2140image
chr7:66714637-66717829:+BRCAGSVA_HALLMARK_MYC_TARGETS_V2EER8.1180e-04-0.1381image
chr7:66683723-66692055:+BRCAGSVA_HALLMARK_MYC_TARGETS_V2EER5.6770e-10-0.3103image
ENSG00000154710.14,RABGEF1CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.1789e-03-0.2240image
chr7:66714637-66717829:+CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3632e-040.2852image
ENSG00000154710.14,RABGEF1COADGSVA_HALLMARK_MYC_TARGETS_V2EAG4.1048e-03-0.2464image
ENSG00000154710.14,RABGEF1DLBCGSVA_HALLMARK_DNA_REPAIREAG8.1338e-03-0.4343image
chr7:66741834-66745912:+ESCAGSVA_HALLMARK_HEME_METABOLISMEER1.2502e-020.2465image
ENSG00000154710.14,RABGEF1ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.0693e-03-0.2142image
chr7:66704512-66713438:+ESCAGSVA_HALLMARK_UV_RESPONSE_UPEER5.5275e-030.2629image
chr7:66703005-66703282:+ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER1.0235e-02-0.5473image
chr7:66701195-66701748:+ESCAGSVA_HALLMARK_HEME_METABOLISMEER4.2474e-020.3499image
chr7:66683723-66692055:+ESCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER6.4256e-05-0.3289image
chr7:66714637-66717829:+GBMGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.3404e-040.2723image
chr7:66704512-66713438:+GBMGSVA_HALLMARK_MYOGENESISEER1.3297e-020.3479image
ENSG00000154710.14,RABGEF1GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.0326e-030.2182image
chr7:66714637-66717829:+HNSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.7124e-040.2153image
ENSG00000154710.14,RABGEF1HNSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.3358e-040.2099image
ENSG00000154710.14,RABGEF1KICHGSVA_HALLMARK_HEME_METABOLISMEAG3.5528e-020.3467image
chr7:66714637-66717829:+KICHGSVA_HALLMARK_NOTCH_SIGNALINGEER1.9939e-020.3864image
chr7:66714637-66717829:+KIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.8459e-030.2152image
ENSG00000154710.14,RABGEF1KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.1470e-040.2215image
chr7:66704512-66713438:+KIRPGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER4.5094e-02-0.3186image
chr7:66683723-66692055:+KIRPGSVA_HALLMARK_P53_PATHWAYEER9.8913e-06-0.4261image
ENSG00000154710.14,RABGEF1LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.0764e-02-0.1919image
chr7:66714637-66717829:+LGGGSVA_HALLMARK_DNA_REPAIREER5.0377e-06-0.2094image
chr7:66704512-66713438:+LGGGSVA_HALLMARK_SPERMATOGENESISEER3.5160e-02-0.2020image
ENSG00000154710.14,RABGEF1LGGGSVA_HALLMARK_DNA_REPAIREAG1.0941e-07-0.2371image
chr7:66714637-66717829:+LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1221e-030.3841image
ENSG00000154710.14,RABGEF1LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.4006e-03-0.2313image
chr7:66714637-66717829:+LUADGSVA_HALLMARK_SPERMATOGENESISEER1.0783e-02-0.1530image
chr7:66683723-66692055:+LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.2810e-03-0.2236image
ENSG00000154710.14,RABGEF1LUADGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.1130e-04-0.2102image
chr7:66683723-66692055:+LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEER6.8563e-04-0.2199image
chr7:66714637-66717829:+LUSCGSVA_HALLMARK_ADIPOGENESISEER4.1675e-04-0.2084image
ENSG00000154710.14,RABGEF1LUSCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.1664e-06-0.2339image
ENSG00000154710.14,RABGEF1MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.8083e-04-0.4598image
ENSG00000154710.14,RABGEF1OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.8056e-030.1841image
chr7:66701195-66701748:+OVGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.3196e-02-0.4360image
chr7:66695184-66696659:+OVGSVA_HALLMARK_GLYCOLYSISEER7.2504e-030.3520image
chr7:66714637-66717829:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.2349e-040.2096image
chr7:66704512-66713438:+OVGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.0536e-02-0.2095image
chr7:66683723-66692055:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.2702e-03-0.2215image
ENSG00000154710.14,RABGEF1PAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.4097e-030.2540image
chr7:66683723-66692055:+PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.8858e-02-0.2406image
ENSG00000154710.14,RABGEF1PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.1448e-030.2475image
chr7:66714637-66717829:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER2.8796e-030.3814image
chr7:66683723-66692055:+PRADGSVA_HALLMARK_GLYCOLYSISEER7.8095e-05-0.3357image
chr7:66714637-66717829:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER9.5632e-150.3606image
ENSG00000154710.14,RABGEF1PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6410e-130.3412image
chr7:66683723-66692055:+SARCGSVA_HALLMARK_GLYCOLYSISEER3.5986e-03-0.3459image
chr7:66714637-66717829:+SARCGSVA_HALLMARK_DNA_REPAIREER1.2710e-04-0.3049image
ENSG00000154710.14,RABGEF1SARCGSVA_HALLMARK_DNA_REPAIREAG7.7841e-06-0.3281image
chr7:66683723-66692055:+SKCMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1946e-04-0.2520image
ENSG00000154710.14,RABGEF1SKCMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3867e-04-0.1848image
chr7:66714637-66717829:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0112e-040.2100image
chr7:66714637-66717829:+STADGSVA_HALLMARK_APICAL_SURFACEEER1.0914e-030.2087image
chr7:66738516-66739632:+STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.1854e-030.4402image
chr7:66803746-66804664:+STADGSVA_HALLMARK_SPERMATOGENESISEER8.5597e-030.3451image
chr7:66741834-66745912:+STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.7005e-070.3730image
chr7:66701195-66701748:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER6.3290e-030.3811image
chr7:66695184-66696659:+STADGSVA_HALLMARK_APICAL_SURFACEEER6.4659e-030.2582image
chr7:66683723-66692055:+STADGSVA_HALLMARK_PEROXISOMEEER5.4472e-03-0.1696image
chr7:66704512-66713438:+STADGSVA_HALLMARK_P53_PATHWAYEER6.6108e-050.2969image
ENSG00000154710.14,RABGEF1STADGSVA_HALLMARK_APICAL_JUNCTIONEAG6.2831e-040.1904image
chr7:66714637-66717829:+TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEER2.9065e-020.2972image
chr7:66787123-66787622:+TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.0114e-04-0.6744image
ENSG00000154710.14,RABGEF1TGCTGSVA_HALLMARK_UV_RESPONSE_DNEAG4.2716e-050.3936image
chr7:66714637-66717829:+THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER8.3994e-090.2745image
ENSG00000154710.14,RABGEF1THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.1519e-070.2454image
chr7:66714637-66717829:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4022e-080.5574image
ENSG00000154710.14,RABGEF1THYMGSVA_HALLMARK_UV_RESPONSE_DNEAG3.9153e-090.5565image
ENSG00000154710.14,RABGEF1UCECGSVA_HALLMARK_UV_RESPONSE_DNEAG2.5788e-040.2961image
chr7:66714637-66717829:+UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER1.1550e-040.3305image
chr7:66683723-66692055:+UCECGSVA_HALLMARK_DNA_REPAIREER1.1635e-03-0.3803image
chr7:66714637-66717829:+UCSGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.0688e-030.4768image
ENSG00000154710.14,RABGEF1UCSGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2830e-050.5759image


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7. Enriched editing regions and drugs for RABGEF1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr7:66714637-66717829:+ACCAZD8055EER4.9472e-020.3681image
ENSG00000154710.14,RABGEF1ACCCytarabineEAG6.9120e-030.4546image
ENSG00000154710.14,RABGEF1BLCACEP.701EAG2.3265e-030.1729image
chr7:66683723-66692055:+BLCAGNF.2EER1.2466e-040.2836image
chr7:66714637-66717829:+BLCAElesclomolEER1.5152e-040.2337image
chr7:66683723-66692055:+BRCACCT007093EER7.6645e-14-0.3700image
chr7:66714637-66717829:+BRCACCT007093EER2.9099e-08-0.2268image
chr7:66704512-66713438:+BRCALenalidomideEER3.0085e-040.4816image
ENSG00000154710.14,RABGEF1BRCACCT007093EAG1.2110e-13-0.2720image
ENSG00000154710.14,RABGEF1CESCBMS.536924EAG5.2972e-070.3418image
chr7:66714637-66717829:+CESCBMS.536924EER1.3065e-070.3882image
ENSG00000154710.14,RABGEF1CHOLCCT007093EAG4.4064e-02-0.4545image
ENSG00000154710.14,RABGEF1COADBMS.708163EAG1.5067e-04-0.3217image
ENSG00000154710.14,RABGEF1DLBCGW843682XEAG1.9584e-020.3874image
chr7:66683723-66692055:+ESCAGDC.0449EER3.1361e-02-0.1814image
chr7:66701195-66701748:+ESCALapatinibEER1.0370e-02-0.4401image
chr7:66704512-66713438:+ESCAABT.263EER9.1182e-040.3118image
chr7:66741834-66745912:+ESCAAZD6482EER4.9875e-02-0.1947image
ENSG00000154710.14,RABGEF1ESCAABT.888EAG3.1214e-03-0.2345image
chr7:66703005-66703282:+ESCACCT007093EER2.6667e-03-0.6209image
chr7:66695184-66696659:+ESCACI.1040EER4.8033e-020.2372image
ENSG00000154710.14,RABGEF1GBMCytarabineEAG2.5085e-030.2396image
chr7:66704512-66713438:+GBMGefitinibEER2.5995e-02-0.3148image
chr7:66714637-66717829:+GBMCytarabineEER1.3048e-030.2568image
chr7:66714637-66717829:+HNSCDMOGEER3.4262e-04-0.2204image
ENSG00000154710.14,RABGEF1HNSCDMOGEAG4.6980e-04-0.1997image
ENSG00000154710.14,RABGEF1KICHLenalidomideEAG2.2781e-020.3735image
chr7:66714637-66717829:+KIRCAKT.inhibitor.VIIIEER5.4910e-03-0.2500image
chr7:66683723-66692055:+KIRCKIN001.135EER2.6245e-040.3540image
ENSG00000154710.14,RABGEF1KIRCAKT.inhibitor.VIIIEAG1.5973e-03-0.2299image
chr7:66704512-66713438:+KIRPAUY922EER1.3296e-020.3883image
ENSG00000154710.14,RABGEF1KIRPBAY.61.3606EAG7.0210e-05-0.2642image
chr7:66714637-66717829:+KIRPAZD6244EER9.7898e-050.2674image
chr7:66683723-66692055:+KIRPAS601245EER4.4928e-030.2819image
ENSG00000154710.14,RABGEF1LAMLGSK269962AEAG1.7094e-07-0.4178image
chr7:66683723-66692055:+LAMLCamptothecinEER4.0811e-020.1886image
chr7:66741834-66745912:+LAMLBI.2536EER1.9314e-02-0.2302image
chr7:66695184-66696659:+LAMLKIN001.135EER3.5672e-02-0.4059image
chr7:66704512-66713438:+LAMLAZD6244EER3.7159e-05-0.3793image
chr7:66714637-66717829:+LGGGW843682XEER4.9925e-090.2664image
chr7:66704512-66713438:+LGGMetforminEER9.9075e-04-0.3111image
ENSG00000154710.14,RABGEF1LGGGW843682XEAG3.3781e-100.2788image
chr7:66714637-66717829:+LIHCCI.1040EER4.0037e-030.3422image
ENSG00000154710.14,RABGEF1LIHCCMKEAG1.2935e-020.2025image
chr7:66704512-66713438:+LUADEmbelinEER6.2481e-030.3676image
chr7:66683723-66692055:+LUADEmbelinEER6.2344e-03-0.2009image
ENSG00000154710.14,RABGEF1LUADGSK269962AEAG1.9464e-040.2031image
chr7:66714637-66717829:+LUADGSK269962AEER1.4207e-040.2270image
chr7:66683723-66692055:+LUSCAZD.2281EER5.8243e-03-0.1798image
chr7:66714637-66717829:+LUSCBAY.61.3606EER2.7083e-05-0.2467image
ENSG00000154710.14,RABGEF1LUSCGNF.2EAG1.3313e-070.2669image
ENSG00000154710.14,RABGEF1MESOCCT007093EAG5.2257e-05-0.5398image
ENSG00000154710.14,RABGEF1OVBAY.61.3606EAG7.4262e-05-0.2325image
chr7:66683723-66692055:+OVGSK.650394EER3.7889e-03-0.1995image
chr7:66704512-66713438:+OVMidostaurinEER1.0114e-030.2940image
chr7:66695184-66696659:+OVAZD.0530EER3.0294e-030.3859image
chr7:66714637-66717829:+OVEmbelinEER2.0742e-03-0.1836image
chr7:66741834-66745912:+OVABT.263EER8.0172e-030.2624image
ENSG00000154710.14,RABGEF1PAADATRAEAG1.0796e-04-0.3608image
ENSG00000154710.14,RABGEF1PCPGEmbelinEAG6.9552e-03-0.2483image
chr7:66683723-66692055:+PCPGEmbelinEER3.3218e-03-0.2983image
chr7:66714637-66717829:+PCPGGDC.0449EER4.4864e-030.3649image
ENSG00000154710.14,RABGEF1PRADCCT007093EAG4.5940e-10-0.2908image
chr7:66714637-66717829:+PRADCCT007093EER7.8502e-12-0.3210image
chr7:66683723-66692055:+PRADCCT007093EER9.4223e-03-0.2244image
chr7:66714637-66717829:+SARCBMS.509744EER7.5747e-070.3873image
ENSG00000154710.14,RABGEF1SARCBMS.509744EAG3.8728e-060.3383image
chr7:66683723-66692055:+SARCCCT007093EER7.7354e-05-0.4575image
ENSG00000154710.14,RABGEF1SKCMATRAEAG1.0291e-05-0.2268image
chr7:66714637-66717829:+SKCMATRAEER2.5595e-04-0.2124image
chr7:66683723-66692055:+SKCMBMS.754807EER4.4065e-03-0.1879image
chr7:66683723-66692055:+STADGDC0941EER1.0956e-03-0.1987image
ENSG00000154710.14,RABGEF1STADCyclopamineEAG4.6805e-05-0.2266image
chr7:66803746-66804664:+STADDocetaxelEER9.6727e-03-0.3400image
chr7:66714637-66717829:+STADCyclopamineEER1.7220e-03-0.2009image
chr7:66738516-66739632:+STADCCT018159EER4.6393e-020.3440image
chr7:66695184-66696659:+STADEHT.1864EER4.1946e-03-0.2710image
chr7:66741834-66745912:+STADBMS.509744EER4.4590e-03-0.2140image
chr7:66704512-66713438:+STADAUY922EER8.8317e-03-0.1974image
ENSG00000154710.14,RABGEF1TGCTAZD6482EAG2.2423e-04-0.3576image
chr7:66714637-66717829:+TGCTDMOGEER3.0062e-03-0.3964image
chr7:66787123-66787622:+TGCTBortezomibEER1.2043e-020.5040image
chr7:66714637-66717829:+THCAAICAREER2.1640e-10-0.3013image
ENSG00000154710.14,RABGEF1THCABAY.61.3606EAG2.7176e-07-0.2382image
chr7:66714637-66717829:+THYMAKT.inhibitor.VIIIEER4.4948e-12-0.6520image
ENSG00000154710.14,RABGEF1THYMAKT.inhibitor.VIIIEAG1.1553e-12-0.6462image
ENSG00000154710.14,RABGEF1UCECAZD6482EAG2.4523e-04-0.2971image
chr7:66714637-66717829:+UCECBMS.536924EER6.5608e-060.3824image
chr7:66683723-66692055:+UCECGefitinibEER5.0377e-03-0.3316image
ENSG00000154710.14,RABGEF1UCSBicalutamideEAG3.2441e-03-0.4206image
chr7:66714637-66717829:+UCSMidostaurinEER1.3495e-02-0.3698image
ENSG00000154710.14,RABGEF1UVMBAY.61.3606EAG3.0316e-02-0.4521image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType