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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: EIF3K (ImmuneEditome ID:27335)

1. Gene summary of enriched editing regions for EIF3K

check button Gene summary
Gene informationGene symbol

EIF3K

Gene ID

27335

GeneSynonymsARG134|EIF3-p28|EIF3S12|HSPC029|M9|MSTP001|PLAC-24|PLAC24|PRO1474|PTD001
GeneCytomap

19q13.2

GeneTypeprotein-coding
GeneDescriptioneukaryotic translation initiation factor 3 subunit K|eIF-3 p28|eukaryotic translation initiation factor 3, subunit 12|muscle specific|muscle-specific gene M9 protein
GeneModificationdate20230329
UniprotIDQ9UBQ5;B4DQ48;K7ERF1;A0A087WVB9;K7EK53;K7ES31;K7EQM4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:38624421-38624680:+ENST00000586513.4ENSG00000178982.8EIF3KncRNA_intronicAluSx3,L2bchr19:38624421-38624680:+.alignment
chr19:38624421-38624680:+ENST00000586932.4ENSG00000178982.8EIF3KncRNA_intronicAluSx3,L2bchr19:38624421-38624680:+.alignment
chr19:38624421-38624680:+ENST00000588422.2ENSG00000178982.8EIF3KncRNA_intronicAluSx3,L2bchr19:38624421-38624680:+.alignment
chr19:38624421-38624680:+ENST00000593062.4ENSG00000178982.8EIF3KncRNA_intronicAluSx3,L2bchr19:38624421-38624680:+.alignment
chr19:38626372-38632373:+ENST00000586513.4ENSG00000178982.8EIF3KncRNA_exonicMIRb,AluSx1,AluSp,AluSc8,MER5B,AluSz,(GTTTT)n,L2a,LTR5_Hs,AluJb,L2,AluJr,AluSx,AluJo,AluSz6chr19:38626372-38632373:+.alignment
chr19:38626372-38632373:+ENST00000590134.1ENSG00000178982.8EIF3KncRNA_exonicMIRb,AluSx1,AluSp,AluSc8,MER5B,AluSz,(GTTTT)n,L2a,LTR5_Hs,AluJb,L2,AluJr,AluSx,AluJo,AluSz6chr19:38626372-38632373:+.alignment
chr19:38626372-38632373:+ENST00000593062.4ENSG00000178982.8EIF3KncRNA_exonicMIRb,AluSx1,AluSp,AluSc8,MER5B,AluSz,(GTTTT)n,L2a,LTR5_Hs,AluJb,L2,AluJr,AluSx,AluJo,AluSz6chr19:38626372-38632373:+.alignment
chr19:38633402-38634526:+ENST00000590134.1ENSG00000178982.8EIF3KncRNA_intronicAluSx,AluSx3,AluSz,AluSq2,L1MC4a,AluSpchr19:38633402-38634526:+.alignment


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2. Tumor-specific enriched editing regions for EIF3K


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:38633402-38634526:+TGCTPathEER3.8954e-023.8954e-020.4332image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr19:38626372-38632373:+BLCAEER2.5890e-023.0115e-025.6609e+01image
ENSG00000178982.8,EIF3KBLCAEAG5.7500e-031.8297e-025.3400e+01image

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3. Enriched editing regions and immune related genes for EIF3K


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for EIF3K


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000178982.8,EIF3K
THYMEAGMEXENSG00000173264.9chr1164285256:64285380:64286509:64286881:64288064:64288214:64288339:642884680.38603.6891e-027.8149e-050.4151imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000178982.8,EIF3K
THYMEAGIRENSG00000214087.4chr1781682033:81683126:81683592:816836660.40021.4309e-022.6214e-050.4623imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000178982.8,EIF3K
THYMEAGESENSG00000144895.7chr3150575648:150575762:150581621:150581746:150583199:1505832650.23733.1499e-027.3416e-050.4388imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD8
ENSG00000178982.8,EIF3K
THYMEAGIRENSG00000163001.7chr255543937:55544074:55544906:555450750.36493.6225e-028.9686e-050.4119imageNACIN1;ADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZNF184NAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000178982.8,EIF3K
THYMEAGA3ENSG00000116698.16chr1183544352:183544497:183545019:183545312:183544929:1835453120.23501.1428e-021.3835e-040.4654imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M0GSVA_HALLMARK_DNA_REPAIR

More results



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5. Enriched editing regions and immune infiltration for EIF3K


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000178982.8,EIF3KACCEAGMast_cells_activated1.4982e-050.6472image
chr19:38626372-38632373:+BLCAEERNK_cells_activated6.8254e-03-0.2230image
chr19:38633402-38634526:+BLCAEERDendritic_cells_resting2.0433e-020.4145image
ENSG00000178982.8,EIF3KBLCAEAGNK_cells_activated4.8448e-03-0.2224image
chr19:38626372-38632373:+BRCAEERMacrophages_M12.2813e-030.1464image
ENSG00000178982.8,EIF3KBRCAEAGMacrophages_M13.7783e-030.1373image
chr19:38626372-38632373:+CESCEERMonocytes1.5140e-030.2647image
chr19:38633402-38634526:+CESCEERT_cells_CD4_memory_resting3.2332e-02-0.4291image
ENSG00000178982.8,EIF3KCESCEAGMonocytes2.2919e-030.2514image
ENSG00000178982.8,EIF3KCHOLEAGMast_cells_resting3.8993e-030.6150image
chr19:38626372-38632373:+ESCAEERT_cells_follicular_helper1.7858e-02-0.1978image
ENSG00000178982.8,EIF3KESCAEAGT_cells_follicular_helper1.6966e-02-0.1994image
chr19:38626372-38632373:+KIRCEERT_cells_regulatory_(Tregs)4.6286e-05-0.2805image
chr19:38633402-38634526:+KIRCEERT_cells_CD81.7093e-020.3094image
ENSG00000178982.8,EIF3KKIRCEAGT_cells_regulatory_(Tregs)1.4099e-04-0.2609image
chr19:38626372-38632373:+KIRPEERT_cells_CD4_memory_activated4.9608e-050.3818image
chr19:38633402-38634526:+KIRPEERT_cells_CD82.6284e-020.3808image
ENSG00000178982.8,EIF3KKIRPEAGNK_cells_resting3.6127e-040.3270image
chr19:38626372-38632373:+LGGEERNK_cells_resting2.3631e-030.1591image
ENSG00000178982.8,EIF3KLGGEAGNK_cells_resting8.4148e-040.1719image
ENSG00000178982.8,EIF3KLIHCEAGT_cells_gamma_delta9.6760e-040.4803image
chr19:38626372-38632373:+LUADEERT_cells_CD81.2016e-030.2594image
chr19:38633402-38634526:+LUADEERT_cells_gamma_delta6.1447e-030.4160image
ENSG00000178982.8,EIF3KLUADEAGT_cells_CD85.8145e-040.2650image
chr19:38626372-38632373:+LUSCEERT_cells_CD4_memory_activated4.9123e-020.1264image
chr19:38633402-38634526:+LUSCEERMast_cells_resting4.8457e-02-0.2302image
ENSG00000178982.8,EIF3KMESOEAGB_cells_naive1.9716e-030.5264image
chr19:38626372-38632373:+OVEERDendritic_cells_resting2.2922e-030.1964image
chr19:38633402-38634526:+OVEEREosinophils7.3427e-040.3613image
ENSG00000178982.8,EIF3KOVEAGDendritic_cells_resting5.4630e-040.2206image
ENSG00000178982.8,EIF3KPCPGEAGDendritic_cells_resting1.1661e-030.3351image
ENSG00000178982.8,EIF3KPRADEAGNK_cells_activated2.8694e-020.2167image
ENSG00000178982.8,EIF3KSARCEAGNK_cells_activated3.2078e-02-0.2287image
chr19:38633402-38634526:+SKCMEERT_cells_CD4_memory_activated4.4627e-02-0.3756image
chr19:38626372-38632373:+STADEERT_cells_CD4_memory_activated2.2930e-040.2338image
ENSG00000178982.8,EIF3KSTADEAGT_cells_CD4_memory_activated3.1308e-040.2284image
chr19:38626372-38632373:+TGCTEERB_cells_naive5.2424e-030.3172image
chr19:38633402-38634526:+TGCTEERT_cells_CD4_memory_resting2.1246e-02-0.3504image
ENSG00000178982.8,EIF3KTGCTEAGB_cells_naive3.5343e-020.2273image
chr19:38626372-38632373:+THCAEERDendritic_cells_resting2.1302e-060.2880image
ENSG00000178982.8,EIF3KTHCAEAGDendritic_cells_resting3.1130e-060.2809image
ENSG00000178982.8,EIF3KTHYMEAGMacrophages_M17.7523e-030.2870image
ENSG00000178982.8,EIF3KUVMEAGMast_cells_activated1.3996e-030.5652image


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6. Enriched editing regions and immune gene sets for EIF3K


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:38633402-38634526:+BLCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER6.9613e-030.4748image
ENSG00000178982.8,EIF3KBLCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.1620e-050.3236image
chr19:38626372-38632373:+BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEER2.3472e-060.3793image
chr19:38626372-38632373:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3882e-030.1533image
ENSG00000178982.8,EIF3KBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.8993e-040.1589image
chr19:38633402-38634526:+CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.3394e-020.4877image
ENSG00000178982.8,EIF3KCHOLGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.1782e-02-0.5094image
ENSG00000178982.8,EIF3KCOADGSVA_HALLMARK_COAGULATIONEAG7.4024e-03-0.3197image
chr19:38626372-38632373:+ESCAGSVA_HALLMARK_UV_RESPONSE_DNEER9.6398e-030.2158image
chr19:38633402-38634526:+ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.3875e-02-0.4063image
ENSG00000178982.8,EIF3KESCAGSVA_HALLMARK_UV_RESPONSE_DNEAG8.2990e-030.2200image
chr19:38633402-38634526:+GBMGSVA_HALLMARK_GLYCOLYSISEER3.5158e-030.4507image
ENSG00000178982.8,EIF3KHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5141e-020.2443image
ENSG00000178982.8,EIF3KKICHGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.4277e-020.4501image
chr19:38626372-38632373:+KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.8083e-020.1650image
chr19:38633402-38634526:+KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER9.5554e-030.3348image
chr19:38626372-38632373:+KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.4316e-02-0.2048image
ENSG00000178982.8,EIF3KLAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.2060e-02-0.2213image
chr19:38626372-38632373:+LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.4699e-02-0.2181image
chr19:38633402-38634526:+LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3416e-020.2807image
ENSG00000178982.8,EIF3KLGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.1835e-060.2354image
chr19:38626372-38632373:+LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.2309e-060.2365image
ENSG00000178982.8,EIF3KLIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.1764e-03-0.4500image
ENSG00000178982.8,EIF3KLUADGSVA_HALLMARK_HEME_METABOLISMEAG1.3229e-020.1925image
chr19:38633402-38634526:+LUADGSVA_HALLMARK_HEME_METABOLISMEER2.1605e-02-0.3536image
chr19:38626372-38632373:+LUADGSVA_HALLMARK_HEME_METABOLISMEER1.3605e-020.1991image
chr19:38626372-38632373:+LUSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.6189e-060.2922image
chr19:38633402-38634526:+LUSCGSVA_HALLMARK_P53_PATHWAYEER6.7940e-030.3121image
ENSG00000178982.8,EIF3KLUSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.4915e-060.2927image
chr19:38626372-38632373:+OVGSVA_HALLMARK_PEROXISOMEEER1.6676e-020.1547image
ENSG00000178982.8,EIF3KOVGSVA_HALLMARK_PEROXISOMEEAG7.9486e-030.1703image
ENSG00000178982.8,EIF3KPAADGSVA_HALLMARK_DNA_REPAIREAG1.2788e-020.3005image
chr19:38626372-38632373:+PAADGSVA_HALLMARK_P53_PATHWAYEER7.0018e-030.3339image
ENSG00000178982.8,EIF3KPCPGGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.6431e-030.3255image
ENSG00000178982.8,EIF3KPRADGSVA_HALLMARK_MYC_TARGETS_V1EAG4.9839e-02-0.1947image
ENSG00000178982.8,EIF3KSARCGSVA_HALLMARK_HEME_METABOLISMEAG1.0328e-030.3440image
chr19:38633402-38634526:+SKCMGSVA_HALLMARK_HYPOXIAEER1.8901e-020.4332image
chr19:38626372-38632373:+SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.1115e-02-0.1884image
ENSG00000178982.8,EIF3KSTADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG8.3842e-050.2486image
chr19:38626372-38632373:+STADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.1099e-040.2449image
ENSG00000178982.8,EIF3KTGCTGSVA_HALLMARK_P53_PATHWAYEAG6.4335e-03-0.2917image
chr19:38633402-38634526:+TGCTGSVA_HALLMARK_COAGULATIONEER1.0546e-020.3861image
chr19:38626372-38632373:+TGCTGSVA_HALLMARK_P53_PATHWAYEER5.4489e-04-0.3874image
chr19:38626372-38632373:+THCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER2.8457e-070.3107image
ENSG00000178982.8,EIF3KTHCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG6.0030e-070.2998image
ENSG00000178982.8,EIF3KTHYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2405e-030.3158image
ENSG00000178982.8,EIF3KUCECGSVA_HALLMARK_MYC_TARGETS_V1EAG4.7908e-03-0.2998image
chr19:38626372-38632373:+UCECGSVA_HALLMARK_MYC_TARGETS_V1EER9.6984e-03-0.2775image
ENSG00000178982.8,EIF3KUVMGSVA_HALLMARK_APICAL_SURFACEEAG2.4584e-020.4166image


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7. Enriched editing regions and drugs for EIF3K


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000178982.8,EIF3KACCBIBW2992EAG3.3835e-02-0.3498image
chr19:38626372-38632373:+BLCABMS.708163EER7.2115e-04-0.2767image
chr19:38633402-38634526:+BLCAGDC0941EER3.2672e-03-0.5116image
ENSG00000178982.8,EIF3KBLCABryostatin.1EAG4.1110e-040.2769image
ENSG00000178982.8,EIF3KBRCACMKEAG1.9176e-020.1112image
chr19:38633402-38634526:+BRCABX.795EER5.1747e-030.3429image
chr19:38626372-38632373:+BRCAA.770041EER2.6698e-020.1066image
ENSG00000178982.8,EIF3KCESCEHT.1864EAG4.5611e-020.1663image
ENSG00000178982.8,EIF3KCHOLAP.24534EAG9.0141e-030.5678image
ENSG00000178982.8,EIF3KCOADLapatinibEAG1.1842e-02-0.3036image
chr19:38626372-38632373:+ESCABicalutamideEER5.9808e-03-0.2288image
chr19:38633402-38634526:+ESCAGW.441756EER2.0117e-020.4618image
ENSG00000178982.8,EIF3KESCABicalutamideEAG5.0907e-03-0.2331image
ENSG00000178982.8,EIF3KGBMCGP.082996EAG8.3397e-03-0.2692image
chr19:38626372-38632373:+GBMAG.014699EER6.4715e-030.2835image
chr19:38633402-38634526:+GBMBX.795EER7.6670e-03-0.4155image
ENSG00000178982.8,EIF3KHNSCBIBW2992EAG1.0295e-02-0.2786image
ENSG00000178982.8,EIF3KKICHDMOGEAG3.4217e-03-0.5254image
chr19:38633402-38634526:+KIRCAZD.2281EER2.2714e-03-0.3899image
ENSG00000178982.8,EIF3KKIRCAZD.2281EAG4.7443e-04-0.2402image
chr19:38626372-38632373:+KIRCBortezomibEER1.6554e-030.2184image
chr19:38633402-38634526:+KIRPCMKEER2.2592e-02-0.3900image
ENSG00000178982.8,EIF3KKIRPATRAEAG3.5211e-02-0.1966image
chr19:38626372-38632373:+KIRPATRAEER3.0896e-03-0.2835image
ENSG00000178982.8,EIF3KLAMLATRAEAG3.3924e-02-0.2190image
chr19:38626372-38632373:+LAMLATRAEER4.2491e-02-0.2097image
ENSG00000178982.8,EIF3KLGGKU.55933EAG2.1517e-080.2848image
chr19:38626372-38632373:+LGGKU.55933EER1.4223e-080.2925image
ENSG00000178982.8,EIF3KLIHCAUY922EAG2.3739e-030.4466image
chr19:38626372-38632373:+LUADABT.263EER8.4543e-030.2122image
ENSG00000178982.8,EIF3KLUADABT.263EAG6.7215e-030.2102image
chr19:38633402-38634526:+LUSCDocetaxelEER2.0219e-02-0.2695image
ENSG00000178982.8,EIF3KLUSCAS601245EAG1.7219e-03-0.1973image
chr19:38626372-38632373:+LUSCAS601245EER2.2828e-03-0.1948image
ENSG00000178982.8,EIF3KMESOCMKEAG3.9321e-020.3661image
ENSG00000178982.8,EIF3KOVBIBW2992EAG2.0272e-03-0.1975image
chr19:38626372-38632373:+OVBIBW2992EER6.4033e-03-0.1759image
chr19:38633402-38634526:+OVBMS.708163EER1.7712e-02-0.2582image
ENSG00000178982.8,EIF3KPCPGCisplatinEAG2.0889e-020.2419image
ENSG00000178982.8,EIF3KPRADDoxorubicinEAG1.4092e-030.3120image
ENSG00000178982.8,EIF3KSARCAZ628EAG3.6390e-040.3716image
ENSG00000178982.8,EIF3KSKCMDocetaxelEAG2.1001e-040.3073image
chr19:38626372-38632373:+SKCMDocetaxelEER2.1064e-040.3184image
chr19:38633402-38634526:+SKCMFTI.277EER4.9931e-03-0.5071image
ENSG00000178982.8,EIF3KSTADGemcitabineEAG2.8458e-03-0.1899image
chr19:38626372-38632373:+STADGemcitabineEER2.4220e-03-0.1933image
chr19:38626372-38632373:+TGCTA.770041EER1.2585e-030.3633image
ENSG00000178982.8,EIF3KTGCTMetforminEAG1.8201e-030.3315image
chr19:38633402-38634526:+TGCTGNF.2EER5.9666e-03-0.4126image
chr19:38626372-38632373:+THCAAICAREER2.6321e-05-0.2565image
ENSG00000178982.8,EIF3KTHCAAICAREAG2.5456e-05-0.2546image
ENSG00000178982.8,EIF3KTHYMIPA.3EAG1.7718e-040.3958image
chr19:38626372-38632373:+UCECGDC0941EER1.9959e-04-0.3907image
ENSG00000178982.8,EIF3KUCECGDC0941EAG1.9403e-04-0.3893image
ENSG00000178982.8,EIF3KUCSAKT.inhibitor.VIIIEAG2.5755e-02-0.3568image
ENSG00000178982.8,EIF3KUVMFTI.277EAG6.2008e-030.4961image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType