CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GGCX (ImmuneEditome ID:2677)

1. Gene summary of enriched editing regions for GGCX

check button Gene summary
Gene informationGene symbol

GGCX

Gene ID

2677

GeneSynonymsVKCFD1
GeneCytomap

2p11.2

GeneTypeprotein-coding
GeneDescriptionvitamin K-dependent gamma-carboxylase|peptidyl-glutamate 4-carboxylase
GeneModificationdate20230329
UniprotIDA0A8I5KZ18;P38435;A0A8I5QJA4;A0A8I5QKY1;A0A8I5KXJ8;F8WCF0;A0A8I5KT68;A0A8I5KV68;F8WB98;A0A8I5QJS0;A0A8I5KY98;A0A8I5QJ91;A0A8I5KXY4;A0A8I5KXQ8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:85546155-85546715:-ENST00000233838.7ENSG00000115486.10GGCXUTR3AluY,AluSx1chr2:85546155-85546715:-.alignment
chr2:85547946-85548162:-ENST00000465637.4ENSG00000115486.10GGCXncRNA_exonicAluSx1chr2:85547946-85548162:-.alignment
chr2:85549449-85549682:-ENST00000465637.4ENSG00000115486.10GGCXncRNA_intronicAluSz6chr2:85549449-85549682:-.alignment


Top

2. Tumor-specific enriched editing regions for GGCX


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr2:85546155-85546715:-BRCAEER1.6268e-19image
ENSG00000115486.10,GGCXBRCAEAG5.1135e-08image
ENSG00000115486.10,GGCXHNSCEAG7.5801e-03image
chr2:85546155-85546715:-KICHEER1.3533e-03image
chr2:85546155-85546715:-KIRCEER1.9136e-02image
ENSG00000115486.10,GGCXKIRCEAG5.6206e-07image
chr2:85546155-85546715:-KIRPEER1.2068e-05image
ENSG00000115486.10,GGCXKIRPEAG6.0278e-03image
chr2:85546155-85546715:-LUSCEER7.5051e-10image
ENSG00000115486.10,GGCXLUSCEAG6.4526e-03image
chr2:85546155-85546715:-PRADEER2.7469e-02image
ENSG00000115486.10,GGCXPRADEAG1.8593e-02image
chr2:85546155-85546715:-THCAEER4.2047e-03image
ENSG00000115486.10,GGCXTHCAEAG4.0999e-14image
ENSG00000115486.10,GGCXUCECEAG1.8554e-03image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000115486.10,GGCXESCACliEAG2.2247e-021.7039e-02-0.3265image
ENSG00000115486.10,GGCXKIRCPathEAG2.2899e-031.7127e-030.1360image
chr2:85546155-85546715:-KIRCPathEER5.9748e-039.5353e-040.1462image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000115486.10,GGCXHNSCEAG8.3125e-031.2050e-021.1884e-01image
ENSG00000115486.10,GGCXLUADEAG2.9502e-023.8026e-021.1240e+01image
ENSG00000115486.10,GGCXOVEAG1.8433e-022.8026e-028.5992e-02image

Top

3. Enriched editing regions and immune related genes for GGCX


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:85546155-85546715:-GBMEERENSG00000158158,CNNM4-0.39481.0881e-031.2620e-06-0.4086imageNAUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;MOV10;MSI1;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_FATTY_ACID_METABOLISM
chr2:85546155-85546715:-GBMEERENSG00000160213,CSTB0.32731.0125e-021.3730e-060.4074imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1CSTBMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr2:85546155-85546715:-KIRCEERENSG00000198561,CTNND1-0.42531.8357e-136.3445e-21-0.4638imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1CTNND1T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:85546155-85546715:-KIRCEERENSG00000158352,SHROOM4-0.41258.0672e-137.0661e-17-0.4176imageNADAR;CSTF2T;DGCR8;EIF4A3;ELAVL1;HNRNPA1;HNRNPA2B1;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;MOV10;MSI1;NOP58;RBFOX2;SRSF1;SRSF7;TAF15;TARDBP;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr2:85546155-85546715:-KIRCEERENSG00000011523,CEP68-0.39842.7766e-121.1230e-15-0.4024imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr2:85546155-85546715:-KIRCEERENSG00000128052,KDR-0.40393.1399e-124.6019e-16-0.4074imageNADAR;DGCR8;FBL;HNRNPM;RBFOX2;RBM47;TAF15;TARDBP;UPF1KDRMast_cells_restingGSVA_HALLMARK_TGF_BETA_SIGNALING
chr2:85546155-85546715:-KIRCEERENSG00000083168,KAT6A-0.40364.9113e-126.6557e-16-0.4053imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1KAT6AT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:85546155-85546715:-KIRCEERENSG00000134954,ETS1-0.40256.0606e-128.8289e-16-0.4037imageNADAR;BUD13;CSTF2T;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;HNRNPA1;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RBFOX2;RBM47;SMNDC1;SRSF1;TAF15;TARDBP;TIA1;TROVE2;U2AF2;UPF1ETS1T_cells_regulatory_(Tregs)GSVA_HALLMARK_TGF_BETA_SIGNALING
chr2:85546155-85546715:-KIRCEERENSG00000159658,EFCAB14-0.39611.9503e-114.6146e-16-0.4074imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RC3H1;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr2:85546155-85546715:-KIRCEERENSG00000196914,ARHGEF12-0.38753.1970e-119.0282e-17-0.4163imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1ARHGEF12T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr2:85547946-85548162:-MESOEERENSG00000238123,MID1IP1-AS1-0.60451.6943e-022.8054e-04-0.4331imageNDGCR8;EIF4A3;FUS;NOP58;U2AF2;UPF1NAMonocytesGSVA_HALLMARK_COAGULATION
chr2:85547946-85548162:-MESOEERENSG00000018189,RUFY3-0.60181.7736e-023.0189e-05-0.4896imageNCELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;MBNL2;MOV10;MSI1;MSI2;NONO;NOP58;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM27;RBM47;RNF219;SAFB2;SMNDC1;SND1;SRSF1;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr2:85547946-85548162:-MESOEERENSG00000270871,AC015849.19-0.59591.7736e-022.4253e-06-0.5434imageNFUS;NOP58;TAF15;UPF1NAT_cells_CD4_naiveGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr2:85547946-85548162:-MESOEERENSG00000196914,ARHGEF12-0.57832.4627e-027.8637e-05-0.4666imageNCELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28A;MBNL2;MOV10;MSI1;MSI2;NONO;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM27;RBM47;RNF219;SAFB2;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184ARHGEF12MonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr2:85547946-85548162:-MESOEERENSG00000116580,GON4L-0.57162.8005e-022.1491e-06-0.5457imageNCELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP7;LIN28A;MBNL2;MOV10;MSI1;MSI2;NONO;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM27;RBM47;RNF219;SAFB2;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NADendritic_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr2:85547946-85548162:-MESOEERENSG00000185608,MRPL400.56393.0070e-027.1742e-060.5214imageNCAPRIN1;CELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G1;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP7;MOV10;MSI2;NONO;NOP58;NPM1;PRPF8;PTBP1;RBFOX2;RBM27;SAFB2;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr2:85547946-85548162:-MESOEERENSG00000100387,RBX10.55123.2081e-024.3575e-050.4810imageNCAPRIN1;CELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G1;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP7;LIN28A;MBNL2;MOV10;MSI1;MSI2;NONO;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM27;RBM47;SAFB2;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NAMonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr2:85547946-85548162:-MESOEERENSG00000008405,CRY1-0.54553.2176e-027.3981e-05-0.4681imageNCAPRIN1;CELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP7;LIN28A;MOV10;MSI1;MSI2;NONO;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM27;RBM47;RNF219;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;U2AF1;U2AF2;UPF1;ZNF184NAMast_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:85547946-85548162:-MESOEERENSG00000129559,NEDD80.53763.4245e-028.2248e-040.4019imageNCELF2;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G1;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP7;LIN28A;MBNL2;MOV10;MSI2;NONO;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM27;RBM47;RNF219;SAFB2;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr2:85547946-85548162:-MESOEERENSG00000087302,C14orf1660.53943.4812e-028.7553e-040.4000imageNCAPRIN1;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28A;MBNL2;MOV10;MSI2;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM27;RBM47;SAFB2;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NAMonocytesGSVA_HALLMARK_DNA_REPAIR

More results



Top

4. Enriched editing regions and immune related splicing for GGCX


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:85546155-85546715:-
GBMEERA3ENSG00000146701.7chr776048160:76048226:76048611:76049047:76048575:760490470.23744.4225e-031.8474e-070.4955imageNAIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALING
chr2:85546155-85546715:-
GBMEERIRENSG00000188542.5chr2240561329:240561519:240563673:240564013-0.36731.0177e-021.7416e-06-0.4081imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LIN28B;MOV10;NOP58;PRPF8;PTBP1;RBFOX2;SF3A3;SF3B4;SLTM;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;UPF1NAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr2:85546155-85546715:-
GBMEERIRENSG00000169740.9chr1043643858:43644801:43646059:43646202-0.36174.9988e-031.7353e-06-0.4238imageNAIFM1;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;ELAVL1;FAM120A;FBL;FMR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;LIN28;LIN28B;MOV10;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RC3H1;SAFB2;SF3A3;SLTM;SRSF1;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
ENSG00000115486.10,GGCX
KICHEAGA5ENSG00000132716.14chr1160261284:160261358:160262448:160262476:160262275:160262476-0.65584.1961e-021.7845e-03-0.4230imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAGSVA_HALLMARK_DNA_REPAIR
chr2:85546155-85546715:-
KIRCEERIRENSG00000101849.11chrX9714901:9715003:9716219:97162620.31226.0711e-079.6583e-160.4053imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;NPM1;PRPF8;PTBP1;RBFOX2;RBM22;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NADendritic_cells_restingGSVA_HALLMARK_HYPOXIA
chr2:85546155-85546715:-
KIRCEERMEXENSG00000036549.8chr177584516:77584655:77584766:77584829:77631849:77632649:77633114:776334050.17702.0908e-026.7921e-150.4061imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:85546155-85546715:-
KIRCEERIRENSG00000149716.8chr1169665562:69667587:69667894:696680120.24401.5311e-046.7810e-140.4002imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000115486.10,GGCX
LIHCEAGIRENSG00000160953.10chr191356977:1358464:1360135:13602580.22862.1285e-042.8115e-130.4115imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000115486.10,GGCX
LIHCEAGMEXENSG00000109180.10chr448832619:48832682:48833400:48833481:48857212:48857365:48860724:48860790-0.38801.7702e-101.2938e-16-0.4128imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000115486.10,GGCX
LIHCEAGMEXENSG00000022840.11chr12120557545:120557682:120560725:120560886:120571190:120571291:120575630:120575688-0.38681.8594e-103.2380e-19-0.4435imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN

More results



Top

5. Enriched editing regions and immune infiltration for GGCX


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:85546155-85546715:-ACCEERT_cells_CD84.7328e-020.3780image
ENSG00000115486.10,GGCXACCEAGDendritic_cells_resting2.5397e-020.3041image
chr2:85546155-85546715:-BLCAEERDendritic_cells_activated1.2814e-02-0.1486image
chr2:85546155-85546715:-BRCAEERT_cells_CD4_memory_resting3.6425e-04-0.1163image
ENSG00000115486.10,GGCXBRCAEAGDendritic_cells_resting4.7940e-02-0.0609image
chr2:85546155-85546715:-CESCEERMast_cells_resting8.7826e-03-0.1728image
chr2:85546155-85546715:-CHOLEERT_cells_CD82.8639e-030.4958image
ENSG00000115486.10,GGCXCHOLEAGT_cells_CD84.7709e-030.4661image
chr2:85546155-85546715:-ESCAEERT_cells_CD87.0419e-060.3521image
ENSG00000115486.10,GGCXESCAEAGDendritic_cells_resting1.9393e-02-0.1853image
chr2:85546155-85546715:-GBMEERB_cells_memory5.2406e-040.2989image
ENSG00000115486.10,GGCXGBMEAGT_cells_CD4_memory_activated1.1538e-020.2005image
chr2:85546155-85546715:-HNSCEERMast_cells_activated3.4474e-030.1648image
chr2:85549449-85549682:-HNSCEERT_cells_regulatory_(Tregs)4.1163e-060.2413image
ENSG00000115486.10,GGCXHNSCEAGT_cells_CD4_memory_activated1.1329e-020.1201image
chr2:85546155-85546715:-KICHEERT_cells_CD4_memory_activated1.5159e-020.4323image
ENSG00000115486.10,GGCXKICHEAGMast_cells_resting2.7910e-02-0.2966image
chr2:85546155-85546715:-KIRCEERT_cells_regulatory_(Tregs)8.7541e-050.2036image
ENSG00000115486.10,GGCXKIRCEAGMonocytes1.7982e-03-0.1592image
chr2:85546155-85546715:-KIRPEERMacrophages_M01.1963e-020.1765image
ENSG00000115486.10,GGCXKIRPEAGT_cells_regulatory_(Tregs)8.4073e-030.1613image
chr2:85546155-85546715:-LGGEERT_cells_CD4_memory_activated1.9324e-030.1577image
ENSG00000115486.10,GGCXLGGEAGDendritic_cells_resting2.7590e-02-0.0961image
ENSG00000115486.10,GGCXLIHCEAGT_cells_regulatory_(Tregs)2.5929e-030.1564image
ENSG00000115486.10,GGCXLUADEAGT_cells_regulatory_(Tregs)8.7224e-060.1966image
chr2:85546155-85546715:-LUSCEERT_cells_CD4_memory_activated6.9276e-030.1324image
chr2:85549449-85549682:-LUSCEERMacrophages_M23.5519e-030.1447image
ENSG00000115486.10,GGCXLUSCEAGNK_cells_activated4.5511e-030.1288image
chr2:85547946-85548162:-MESOEERDendritic_cells_resting1.1733e-03-0.3909image
ENSG00000115486.10,GGCXMESOEAGT_cells_CD84.2285e-020.2262image
ENSG00000115486.10,GGCXOVEAGMonocytes2.9162e-02-0.1290image
chr2:85546155-85546715:-PAADEERT_cells_regulatory_(Tregs)1.4754e-020.2231image
chr2:85546155-85546715:-PCPGEERMacrophages_M05.4466e-030.2831image
ENSG00000115486.10,GGCXPCPGEAGMast_cells_resting2.5338e-020.1802image
chr2:85546155-85546715:-PRADEERB_cells_naive1.3575e-05-0.2098image
ENSG00000115486.10,GGCXPRADEAGDendritic_cells_resting2.6001e-02-0.1015image
chr2:85549449-85549682:-READEERT_cells_CD82.9317e-020.2839image
chr2:85546155-85546715:-SARCEERPlasma_cells3.2311e-020.1418image
ENSG00000115486.10,GGCXSARCEAGMacrophages_M21.3340e-020.1573image
chr2:85546155-85546715:-SKCMEERT_cells_CD4_memory_resting4.3020e-03-0.1469image
ENSG00000115486.10,GGCXSKCMEAGB_cells_memory4.4031e-02-0.0944image
chr2:85546155-85546715:-STADEERMacrophages_M21.1640e-020.1452image
ENSG00000115486.10,GGCXSTADEAGT_cells_CD83.8021e-030.1539image
ENSG00000115486.10,GGCXTGCTEAGNeutrophils2.8308e-02-0.1902image
chr2:85546155-85546715:-THCAEERT_cells_CD4_memory_resting1.0138e-02-0.1188image
ENSG00000115486.10,GGCXTHCAEAGB_cells_naive2.8324e-02-0.0984image
chr2:85546155-85546715:-THYMEERNK_cells_resting1.8852e-020.2725image
ENSG00000115486.10,GGCXTHYMEAGT_cells_gamma_delta9.4943e-040.3337image
chr2:85546155-85546715:-UCECEERMast_cells_activated1.3331e-020.2492image
ENSG00000115486.10,GGCXUCECEAGT_cells_follicular_helper4.6153e-02-0.1604image
chr2:85546155-85546715:-UCSEERDendritic_cells_activated2.7745e-02-0.3083image
ENSG00000115486.10,GGCXUCSEAGMacrophages_M22.6151e-02-0.2971image
ENSG00000115486.10,GGCXUVMEAGMast_cells_resting3.0326e-020.2486image


Top

6. Enriched editing regions and immune gene sets for GGCX


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000115486.10,GGCXACCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.0640e-020.2945image
ENSG00000115486.10,GGCXBLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.0624e-04-0.1809image
chr2:85546155-85546715:-BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER8.7072e-030.1565image
chr2:85546155-85546715:-BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.7667e-090.1889image
ENSG00000115486.10,GGCXBRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG8.6722e-050.1206image
chr2:85546155-85546715:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2123e-020.1512image
ENSG00000115486.10,GGCXCHOLGSVA_HALLMARK_SPERMATOGENESISEAG9.3793e-030.4330image
ENSG00000115486.10,GGCXCOADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.2047e-06-0.3436image
chr2:85546155-85546715:-COADGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.2866e-030.3396image
chr2:85546155-85546715:-ESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.5170e-020.1948image
ENSG00000115486.10,GGCXESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9472e-020.1851image
chr2:85546155-85546715:-GBMGSVA_HALLMARK_UV_RESPONSE_UPEER5.1826e-050.3459image
ENSG00000115486.10,GGCXGBMGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.7487e-020.1657image
chr2:85546155-85546715:-HNSCGSVA_HALLMARK_MYC_TARGETS_V2EER1.5799e-030.1779image
chr2:85549449-85549682:-HNSCGSVA_HALLMARK_SPERMATOGENESISEER1.2671e-040.2018image
ENSG00000115486.10,GGCXHNSCGSVA_HALLMARK_MYC_TARGETS_V2EAG2.3062e-020.1078image
chr2:85546155-85546715:-KICHGSVA_HALLMARK_PROTEIN_SECRETIONEER1.8180e-02-0.4216image
ENSG00000115486.10,GGCXKIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.5072e-07-0.2529image
chr2:85546155-85546715:-KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.3629e-12-0.3593image
chr2:85546155-85546715:-KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.1721e-030.2066image
ENSG00000115486.10,GGCXKIRPGSVA_HALLMARK_DNA_REPAIREAG1.0879e-030.1992image
ENSG00000115486.10,GGCXLAMLGSVA_HALLMARK_ANGIOGENESISEAG2.9913e-02-0.3277image
chr2:85546155-85546715:-LGGGSVA_HALLMARK_UV_RESPONSE_DNEER6.5119e-06-0.2278image
ENSG00000115486.10,GGCXLGGGSVA_HALLMARK_COAGULATIONEAG4.9232e-09-0.2516image
ENSG00000115486.10,GGCXLIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.3130e-12-0.3544image
ENSG00000115486.10,GGCXLUADGSVA_HALLMARK_COAGULATIONEAG1.9771e-020.1038image
ENSG00000115486.10,GGCXLUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.5805e-020.0908image
chr2:85549449-85549682:-LUSCGSVA_HALLMARK_ANGIOGENESISEER6.2510e-03-0.1358image
chr2:85546155-85546715:-LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.6710e-020.1174image
chr2:85546155-85546715:-MESOGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.0368e-020.2502image
ENSG00000115486.10,GGCXMESOGSVA_HALLMARK_UV_RESPONSE_UPEAG8.7785e-030.2894image
chr2:85547946-85548162:-MESOGSVA_HALLMARK_UV_RESPONSE_UPEER8.7284e-060.5172image
ENSG00000115486.10,GGCXOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG6.3156e-050.2343image
chr2:85546155-85546715:-PAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.9718e-020.1803image
ENSG00000115486.10,GGCXPCPGGSVA_HALLMARK_APICAL_JUNCTIONEAG1.3864e-050.3424image
chr2:85546155-85546715:-PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER3.3216e-04-0.1737image
ENSG00000115486.10,GGCXPRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.0164e-04-0.1607image
chr2:85546155-85546715:-READGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.1704e-020.4336image
chr2:85549449-85549682:-READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1054e-020.2811image
chr2:85546155-85546715:-SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.8462e-090.3720image
ENSG00000115486.10,GGCXSARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.0215e-060.2858image
chr2:85546155-85546715:-SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER5.1450e-05-0.2072image
ENSG00000115486.10,GGCXSTADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG9.7479e-030.1376image
chr2:85546155-85546715:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.6850e-050.2452image
ENSG00000115486.10,GGCXTGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7763e-020.2053image
chr2:85546155-85546715:-THCAGSVA_HALLMARK_UV_RESPONSE_DNEER4.0331e-06-0.2112image
ENSG00000115486.10,GGCXTHCAGSVA_HALLMARK_HEME_METABOLISMEAG9.4475e-06-0.1972image
chr2:85546155-85546715:-THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0227e-040.4362image
ENSG00000115486.10,GGCXTHYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG9.0806e-030.2663image
chr2:85546155-85546715:-UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.5659e-030.3014image
chr2:85546155-85546715:-UCSGSVA_HALLMARK_NOTCH_SIGNALINGEER1.5029e-02-0.3388image
chr2:85546155-85546715:-UVMGSVA_HALLMARK_COAGULATIONEER2.6749e-030.3586image


Top

7. Enriched editing regions and drugs for GGCX


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000115486.10,GGCXACCCMKEAG2.8045e-03-0.3990image
chr2:85546155-85546715:-ACCEmbelinEER2.7470e-020.4165image
chr2:85546155-85546715:-BLCAGDC.0449EER1.0083e-03-0.1955image
ENSG00000115486.10,GGCXBLCAGNF.2EAG1.8988e-03-0.1618image
chr2:85546155-85546715:-BRCAABT.263EER4.3584e-060.1497image
ENSG00000115486.10,GGCXBRCAJW.7.52.1EAG1.6723e-02-0.0737image
ENSG00000115486.10,GGCXCESCCamptothecinEAG8.3210e-03-0.1563image
chr2:85546155-85546715:-CESCAKT.inhibitor.VIIIEER4.1667e-020.1347image
ENSG00000115486.10,GGCXCHOLCisplatinEAG6.3285e-03-0.4526image
chr2:85546155-85546715:-CHOLCisplatinEER3.5121e-02-0.3625image
ENSG00000115486.10,GGCXCOADLenalidomideEAG5.4717e-05-0.3034image
chr2:85546155-85546715:-COADDasatinibEER7.9129e-03-0.3085image
chr2:85546155-85546715:-ESCAA.770041EER9.3519e-03-0.2081image
ENSG00000115486.10,GGCXESCABIRB.0796EAG7.6545e-03-0.2108image
ENSG00000115486.10,GGCXGBMBIRB.0796EAG2.3921e-030.2400image
chr2:85546155-85546715:-GBMBosutinibEER7.8128e-050.3381image
ENSG00000115486.10,GGCXHNSCDocetaxelEAG1.3103e-02-0.1177image
chr2:85549449-85549682:-HNSCDocetaxelEER1.0804e-070.2770image
chr2:85546155-85546715:-HNSCDocetaxelEER3.4797e-05-0.2317image
chr2:85546155-85546715:-KICHABT.263EER6.9349e-040.5762image
ENSG00000115486.10,GGCXKICHBortezomibEAG6.5579e-03-0.3623image
chr2:85546155-85546715:-KIRCBMS.536924EER1.5819e-13-0.3740image
ENSG00000115486.10,GGCXKIRCBMS.536924EAG1.1907e-07-0.2679image
chr2:85546155-85546715:-KIRPKIN001.135EER1.2125e-040.2672image
ENSG00000115486.10,GGCXKIRPMetforminEAG9.6446e-05-0.2368image
ENSG00000115486.10,GGCXLAMLDasatinibEAG1.8090e-020.3549image
chr2:85546155-85546715:-LGGEmbelinEER5.3898e-040.1758image
ENSG00000115486.10,GGCXLGGGNF.2EAG1.0467e-080.2463image
ENSG00000115486.10,GGCXLIHCBMS.536924EAG1.5908e-12-0.3615image
ENSG00000115486.10,GGCXLUADBMS.536924EAG1.0043e-04-0.1732image
chr2:85546155-85546715:-LUSCCGP.60474EER9.7365e-03-0.1268image
ENSG00000115486.10,GGCXLUSCBMS.536924EAG4.5258e-02-0.0911image
chr2:85549449-85549682:-LUSCJNJ.26854165EER1.7697e-050.2118image
chr2:85546155-85546715:-MESOGSK269962AEER4.9528e-03-0.3212image
chr2:85547946-85548162:-MESOGNF.2EER1.2995e-06-0.5554image
ENSG00000115486.10,GGCXMESOGSK269962AEAG5.6527e-03-0.3049image
ENSG00000115486.10,GGCXOVBAY.61.3606EAG5.6045e-040.2028image
chr2:85546155-85546715:-PAADLenalidomideEER1.3420e-020.2261image
ENSG00000115486.10,GGCXPAADKU.55933EAG9.9909e-03-0.2025image
ENSG00000115486.10,GGCXPCPGMethotrexateEAG5.8641e-05-0.3179image
ENSG00000115486.10,GGCXPRADAZ628EAG1.6696e-03-0.1439image
chr2:85546155-85546715:-PRADAMG.706EER1.5686e-06-0.2310image
ENSG00000115486.10,GGCXREADMidostaurinEAG3.2441e-02-0.2542image
chr2:85549449-85549682:-READDocetaxelEER3.0517e-020.2819image
ENSG00000115486.10,GGCXSARCAG.014699EAG1.0924e-060.3043image
chr2:85546155-85546715:-SARCAG.014699EER7.5155e-110.4139image
chr2:85546155-85546715:-SKCMCCT007093EER1.4340e-070.2672image
ENSG00000115486.10,GGCXSKCMGW843682XEAG4.7495e-03-0.1320image
ENSG00000115486.10,GGCXSTADCamptothecinEAG6.6079e-04-0.1806image
chr2:85546155-85546715:-STADAP.24534EER2.6684e-040.2087image
chr2:85546155-85546715:-TGCTAZD7762EER5.1352e-03-0.2806image
ENSG00000115486.10,GGCXTGCTFH535EAG3.7783e-03-0.2495image
chr2:85546155-85546715:-THCAEmbelinEER7.9172e-100.2792image
ENSG00000115486.10,GGCXTHCABMS.536924EAG5.3302e-07-0.2233image
ENSG00000115486.10,GGCXTHYMJNK.Inhibitor.VIIIEAG3.0208e-02-0.2225image
chr2:85546155-85546715:-THYMAZD6482EER4.3102e-070.5481image
chr2:85546155-85546715:-UCECDMOGEER5.1645e-03-0.2804image
ENSG00000115486.10,GGCXUCECBAY.61.3606EAG1.9702e-02-0.1872image
ENSG00000115486.10,GGCXUCSJNJ.26854165EAG2.2955e-020.3035image
chr2:85546155-85546715:-UCSMetforminEER1.5906e-03-0.4310image
ENSG00000115486.10,GGCXUVMBMS.536924EAG4.7896e-02-0.2277image
chr2:85546155-85546715:-UVMGSK269962AEER2.5991e-03-0.3596image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr2:85546155-85546715:-ENST00000233838.7P38435DB00036Coagulation factor VIIa Recombinant HumanBiotechDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB00100Coagulation Factor IX (Recombinant)BiotechDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB00142Glutamic acidSmallMoleculeDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB00170MenadioneSmallMoleculeDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB01022PhylloquinoneSmallMoleculeDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB01125AnisindioneSmallMoleculeDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB09332KappadioneSmallMoleculeDrug
chr2:85546155-85546715:-ENST00000233838.7P38435DB13152Coagulation Factor IX HumanBiotechDrug