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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FBXW8 (ImmuneEditome ID:26259)

1. Gene summary of enriched editing regions for FBXW8

check button Gene summary
Gene informationGene symbol

FBXW8

Gene ID

26259

GeneSynonymsFBW6|FBW8|FBX29|FBXO29|FBXW6
GeneCytomap

12q24.22

GeneTypeprotein-coding
GeneDescriptionF-box/WD repeat-containing protein 8|F-box and WD-40 domain protein 8|F-box and WD-40 domain-containing protein 8|F-box only protein 29
GeneModificationdate20230528
UniprotIDQ8N3Y1;A0A499FIY5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:116913968-116914579:+ENST00000309909.8ENSG00000174989.11FBXW8intronicAluJbchr12:116913968-116914579:+.alignment
chr12:116913968-116914579:+ENST00000455858.2ENSG00000174989.11FBXW8intronicAluJbchr12:116913968-116914579:+.alignment
chr12:117029616-117029912:+ENST00000455858.2ENSG00000174989.11FBXW8UTR3AluSx1chr12:117029616-117029912:+.alignment


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2. Tumor-specific enriched editing regions for FBXW8


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000174989.11,FBXW8KIRCEAG4.0379e-02image
chr12:117029616-117029912:+LUADEER3.2190e-02image
ENSG00000174989.11,FBXW8LUADEAG2.8820e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000174989.11,FBXW8BRCAPathEAG5.0805e-032.5599e-02-0.0747image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000174989.11,FBXW8KIRCEAG3.2515e-023.9613e-021.7959e-01image

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3. Enriched editing regions and immune related genes for FBXW8


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for FBXW8


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000174989.11,FBXW8
UVMEAGA5ENSG00000133131.10chrX106941545:106941632:106941975:106942221:106941937:106942221-0.42974.3263e-022.3703e-04-0.4686imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CBX7;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;METTL3;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_E2F_TARGETS

More results



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5. Enriched editing regions and immune infiltration for FBXW8


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000174989.11,FBXW8BLCAEAGT_cells_CD4_memory_resting9.3077e-030.1961image
ENSG00000174989.11,FBXW8BRCAEAGNeutrophils4.7469e-02-0.0661image
ENSG00000174989.11,FBXW8ESCAEAGMacrophages_M21.8521e-020.1908image
ENSG00000174989.11,FBXW8GBMEAGMonocytes2.7534e-020.1870image
chr12:117029616-117029912:+HNSCEERMacrophages_M11.0784e-040.2587image
ENSG00000174989.11,FBXW8HNSCEAGMacrophages_M11.0784e-040.2587image
ENSG00000174989.11,FBXW8KIRPEAGNeutrophils2.0357e-020.1673image
ENSG00000174989.11,FBXW8LAMLEAGMacrophages_M01.9397e-02-0.2488image
ENSG00000174989.11,FBXW8LGGEAGT_cells_CD4_memory_resting8.0520e-04-0.1557image
ENSG00000174989.11,FBXW8LIHCEAGB_cells_memory2.9477e-020.2451image
chr12:117029616-117029912:+LUADEERT_cells_gamma_delta7.7507e-03-0.1486image
ENSG00000174989.11,FBXW8LUADEAGT_cells_gamma_delta8.7701e-03-0.1458image
ENSG00000174989.11,FBXW8LUSCEAGNK_cells_activated1.1134e-020.1359image
ENSG00000174989.11,FBXW8OVEAGMast_cells_resting2.0174e-02-0.1449image
ENSG00000174989.11,FBXW8PAADEAGMacrophages_M11.3056e-02-0.2698image
ENSG00000174989.11,FBXW8PRADEAGMast_cells_resting1.8295e-030.1670image
ENSG00000174989.11,FBXW8READEAGDendritic_cells_resting1.1112e-020.3430image
ENSG00000174989.11,FBXW8SARCEAGNK_cells_resting2.0663e-020.1806image
ENSG00000174989.11,FBXW8THCAEAGT_cells_gamma_delta3.9465e-030.1412image
ENSG00000174989.11,FBXW8UCECEAGB_cells_memory7.4878e-03-0.3127image
ENSG00000174989.11,FBXW8UCSEAGMacrophages_M26.8498e-03-0.4314image
ENSG00000174989.11,FBXW8UVMEAGB_cells_memory5.1259e-040.4190image


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6. Enriched editing regions and immune gene sets for FBXW8


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000174989.11,FBXW8BLCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.8636e-020.1655image
ENSG00000174989.11,FBXW8BRCAGSVA_HALLMARK_APICAL_JUNCTIONEAG6.2744e-060.1499image
ENSG00000174989.11,FBXW8CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.9520e-020.1971image
ENSG00000174989.11,FBXW8COADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.2983e-020.1775image
ENSG00000174989.11,FBXW8ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.6303e-020.1700image
ENSG00000174989.11,FBXW8GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.9363e-030.2323image
ENSG00000174989.11,FBXW8HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.2771e-060.3085image
chr12:117029616-117029912:+HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.2771e-060.3085image
ENSG00000174989.11,FBXW8KICHGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0189e-020.3752image
ENSG00000174989.11,FBXW8KIRCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG7.2456e-030.1577image
ENSG00000174989.11,FBXW8KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.5371e-03-0.2040image
ENSG00000174989.11,FBXW8LAMLGSVA_HALLMARK_DNA_REPAIREAG5.4463e-040.3612image
ENSG00000174989.11,FBXW8LGGGSVA_HALLMARK_G2M_CHECKPOINTEAG5.7284e-04-0.1600image
chr12:117029616-117029912:+LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.9695e-040.2067image
ENSG00000174989.11,FBXW8LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG6.7612e-050.2202image
ENSG00000174989.11,FBXW8LUSCGSVA_HALLMARK_SPERMATOGENESISEAG6.7108e-04-0.1815image
chr12:117029616-117029912:+MESOGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.0324e-02-0.2655image
ENSG00000174989.11,FBXW8MESOGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.0324e-02-0.2655image
ENSG00000174989.11,FBXW8OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.0542e-030.1914image
ENSG00000174989.11,FBXW8PAADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.2860e-02-0.2481image
chr12:117029616-117029912:+PCPGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.9343e-02-0.1879image
ENSG00000174989.11,FBXW8PCPGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.9343e-02-0.1879image
ENSG00000174989.11,FBXW8PRADGSVA_HALLMARK_ADIPOGENESISEAG2.9382e-030.1594image
ENSG00000174989.11,FBXW8SARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6641e-020.1731image
ENSG00000174989.11,FBXW8SKCMGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG7.9809e-040.1676image
ENSG00000174989.11,FBXW8STADGSVA_HALLMARK_HYPOXIAEAG9.9327e-060.2500image
ENSG00000174989.11,FBXW8THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.0039e-040.1766image
ENSG00000174989.11,FBXW8UCECGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.6224e-030.3386image
ENSG00000174989.11,FBXW8UCSGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.3433e-030.4791image
ENSG00000174989.11,FBXW8UVMGSVA_HALLMARK_MYC_TARGETS_V1EAG4.2784e-02-0.2521image


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7. Enriched editing regions and drugs for FBXW8


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000174989.11,FBXW8BLCAGSK.650394EAG1.0000e-02-0.1943image
ENSG00000174989.11,FBXW8BRCACHIR.99021EAG9.3825e-06-0.1472image
ENSG00000174989.11,FBXW8CESCBMS.536924EAG1.5880e-020.2180image
ENSG00000174989.11,FBXW8COADBMS.754807EAG1.1786e-02-0.1963image
ENSG00000174989.11,FBXW8ESCAKU.55933EAG2.0049e-04-0.2982image
ENSG00000174989.11,FBXW8GBMJNK.Inhibitor.VIIIEAG8.0132e-030.2241image
ENSG00000174989.11,FBXW8HNSCDoxorubicinEAG1.3009e-04-0.2557image
chr12:117029616-117029912:+HNSCDoxorubicinEER1.3009e-04-0.2557image
ENSG00000174989.11,FBXW8KICHABT.263EAG3.2050e-02-0.3166image
ENSG00000174989.11,FBXW8KIRCFH535EAG1.9861e-020.1369image
ENSG00000174989.11,FBXW8KIRPAZD6482EAG2.2218e-030.2195image
ENSG00000174989.11,FBXW8LAMLBX.795EAG2.8893e-040.3774image
ENSG00000174989.11,FBXW8LGGATRAEAG5.8696e-030.1283image
chr12:117029616-117029912:+LUADJW.7.52.1EER9.9118e-030.1440image
ENSG00000174989.11,FBXW8LUADEpothilone.BEAG2.0855e-020.1287image
ENSG00000174989.11,FBXW8LUSCAKT.inhibitor.VIIIEAG2.2791e-03-0.1631image
chr12:117029616-117029912:+MESODoxorubicinEER6.7300e-030.3462image
ENSG00000174989.11,FBXW8MESODoxorubicinEAG6.7300e-030.3462image
ENSG00000174989.11,FBXW8OVEmbelinEAG2.5661e-040.2262image
ENSG00000174989.11,FBXW8PAADJNJ.26854165EAG1.7623e-03-0.3363image
ENSG00000174989.11,FBXW8PRADJNK.Inhibitor.VIIIEAG1.2618e-020.1340image
ENSG00000174989.11,FBXW8READCI.1040EAG2.7113e-02-0.3008image
ENSG00000174989.11,FBXW8SARCGSK.650394EAG3.7378e-040.2746image
ENSG00000174989.11,FBXW8SKCMCGP.60474EAG2.2273e-05-0.2111image
ENSG00000174989.11,FBXW8STADGW843682XEAG4.3155e-03-0.1630image
ENSG00000174989.11,FBXW8TGCTAZD7762EAG1.3400e-02-0.2754image
ENSG00000174989.11,FBXW8THCADocetaxelEAG7.7510e-04-0.1644image
ENSG00000174989.11,FBXW8UCECAMG.706EAG3.1454e-040.4128image
ENSG00000174989.11,FBXW8UCSBIBW2992EAG5.4952e-03-0.4417image
ENSG00000174989.11,FBXW8UVMGDC0941EAG4.1968e-03-0.3506image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType