CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CHTOP (ImmuneEditome ID:26097)

1. Gene summary of enriched editing regions for CHTOP

check button Gene summary
Gene informationGene symbol

CHTOP

Gene ID

26097

GeneSynonymsC10orf77|C1orf77|FL-SRAG|FOP|SRAG|SRAG-3|SRAG-5|pp7704
GeneCytomap

1q21.3

GeneTypeprotein-coding
GeneDescriptionchromatin target of PRMT1 protein|friend of PRMT1 protein|small protein rich in arginine and glycine
GeneModificationdate20230404
UniprotIDQ9Y3Y2;Q5T7Y7;A0A087X1B7;X6R700
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:153638972-153640769:+ENST00000495554.1ENSG00000160679.11CHTOPncRNA_intronicAluSz6,AluSx,AluSx1,AluYm1,MER3chr1:153638972-153640769:+.alignment


Top

2. Tumor-specific enriched editing regions for CHTOP


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:153638972-153640769:+THCAEER2.5447e-02image
ENSG00000160679.11,CHTOPTHCAEAG2.9987e-02image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr1:153638972-153640769:+ESCAEER3.4889e-021.8375e-032.7676e+02image
ENSG00000160679.11,CHTOPESCAEAG3.7895e-022.3840e-032.2560e+02image
chr1:153638972-153640769:+HNSCEER3.4413e-022.5766e-025.8963e-15image
ENSG00000160679.11,CHTOPHNSCEAG2.9930e-021.8236e-021.8200e-16image

Top

3. Enriched editing regions and immune related genes for CHTOP


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:153638972-153640769:+ESCAEERENSG00000196656,AC004057.10.29813.8154e-023.6257e-070.4286imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr1:153638972-153640769:+ESCAEERENSG00000128340,RAC20.29353.9877e-021.4049e-070.4420imageNCSTF2T;DDX3X;DGCR8;EIF4A3;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;MSI2;NOP58;PRPF8;PTBP1;SBDS;SMNDC1;SND1;SRSF10;TAF15;TARDBP;TNRC6A;U2AF2;YWHAGRAC2T_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE

More results



Top

4. Enriched editing regions and immune related splicing for CHTOP


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:153638972-153640769:+
ESCAEERIRENSG00000116396.9chr1110219715:110226178:110232910:110234044-0.32991.2948e-027.4781e-06-0.4333imageNACIN1;CNBP;CSTF2T;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;IGF2BP1;IGF2BP2;ILF3;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PTBP1;RBM10;TAF15;TARDBP;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr1:153638972-153640769:+
ESCAEERIRENSG00000198901.9chr1590966039:90969120:90969446:90969623-0.39118.6978e-031.9484e-06-0.4155imageNACIN1;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM5;SBDS;SF3B4;SMNDC1;SND1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184PRC1T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr1:153638972-153640769:+
ESCAEERIRENSG00000104613.7chr819845703:19849239:19851648:19851674-0.33461.3606e-022.0928e-06-0.4421imageNACIN1;BCCIP;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM5;SF3B4;SMNDC1;SND1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_gamma_deltaGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr1:153638972-153640769:+
ESCAEERIRENSG00000163636.6chr364022317:64022523:64022642:64022801-0.34292.1259e-025.2138e-06-0.4138imageNACIN1;BCCIP;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBM10;SBDS;SF3B4;SMNDC1;SND1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184PSMD6T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000160679.11,CHTOP
ESCAEAGIRENSG00000116396.9chr1110219715:110226178:110232910:110234044-0.31092.9604e-021.4824e-05-0.4184imageNACIN1;ADAR;AIFM1;ALYREF;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;FUS;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;ILF3;KHDRBS2;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RC3H1;RNF219;SRSF1;SRSF3;TAF15;TARDBP;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000160679.11,CHTOP
ESCAEAGIRENSG00000104613.7chr819845703:19849239:19851648:19851674-0.32162.4748e-023.4059e-06-0.4319imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_gamma_deltaGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr1:153638972-153640769:+
ESCAEERIRENSG00000175866.11chr1781110913:81110955:81115769:81115817-0.31923.9132e-022.9462e-05-0.4011imageNACIN1;BCCIP;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM5;SF3B4;SMNDC1;SND1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr1:153638972-153640769:+
ESCAEERIRENSG00000145919.6chr5173609567:173609670:173613130:173613255-0.32522.6640e-022.6653e-06-0.4270imageNBCCIP;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM5;SF3B4;SMNDC1;SND1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAB_cells_naiveGSVA_HALLMARK_MYC_TARGETS_V1
chr1:153638972-153640769:+
ESCAEERIRENSG00000183010.12chr1781936735:81936861:81937179:81937239-0.30514.8719e-027.1179e-06-0.4263imageNACIN1;BCCIP;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBM10;SBDS;SF3B4;SMNDC1;SND1;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
ENSG00000160679.11,CHTOP
ESCAEAGIRENSG00000163636.6chr364022317:64022523:64022642:64022801-0.33503.1001e-025.1707e-06-0.4140imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NCBP3;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184PSMD6T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING

More results



Top

5. Enriched editing regions and immune infiltration for CHTOP


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:153638972-153640769:+BLCAEERT_cells_CD4_memory_activated4.0750e-020.2545image
ENSG00000160679.11,CHTOPBLCAEAGT_cells_CD4_memory_activated4.0750e-020.2545image
chr1:153638972-153640769:+BRCAEERT_cells_gamma_delta2.0330e-020.1128image
chr1:153638972-153640769:+ESCAEERB_cells_naive1.8476e-02-0.2064image
ENSG00000160679.11,CHTOPESCAEAGB_cells_naive2.1217e-02-0.2012image
chr1:153638972-153640769:+GBMEERB_cells_memory2.9809e-02-0.3172image
ENSG00000160679.11,CHTOPGBMEAGB_cells_memory8.7985e-03-0.3742image
chr1:153638972-153640769:+KIRCEERMacrophages_M23.4519e-02-0.2160image
ENSG00000160679.11,CHTOPKIRCEAGMacrophages_M23.4519e-02-0.2160image
ENSG00000160679.11,CHTOPLAMLEAGT_cells_CD88.2203e-030.3627image
chr1:153638972-153640769:+PAADEERMast_cells_activated1.4610e-020.3787image
ENSG00000160679.11,CHTOPPAADEAGMast_cells_activated1.4618e-020.3787image
ENSG00000160679.11,CHTOPPRADEAGB_cells_naive3.2665e-02-0.3519image
chr1:153638972-153640769:+STADEERT_cells_gamma_delta3.1409e-020.1507image
ENSG00000160679.11,CHTOPSTADEAGT_cells_gamma_delta2.9593e-020.1516image
ENSG00000160679.11,CHTOPTHYMEAGEosinophils2.2128e-020.5083image


Top

6. Enriched editing regions and immune gene sets for CHTOP


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000160679.11,CHTOPBLCAGSVA_HALLMARK_MYOGENESISEAG1.5848e-02-0.2982image
chr1:153638972-153640769:+BLCAGSVA_HALLMARK_MYOGENESISEER1.5848e-02-0.2982image
ENSG00000160679.11,CHTOPBRCAGSVA_HALLMARK_ADIPOGENESISEAG2.4956e-020.1089image
chr1:153638972-153640769:+BRCAGSVA_HALLMARK_UV_RESPONSE_UPEER1.2460e-020.1214image
ENSG00000160679.11,CHTOPCESCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.0139e-03-0.3534image
chr1:153638972-153640769:+ESCAGSVA_HALLMARK_DNA_REPAIREER4.5102e-020.1761image
chr1:153638972-153640769:+HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.1509e-020.5282image
ENSG00000160679.11,CHTOPHNSCGSVA_HALLMARK_MYC_TARGETS_V1EAG1.2204e-020.5135image
chr1:153638972-153640769:+KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2688e-02-0.2535image
ENSG00000160679.11,CHTOPKIRCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2688e-02-0.2535image
ENSG00000160679.11,CHTOPKIRPGSVA_HALLMARK_P53_PATHWAYEAG2.5830e-030.4296image
chr1:153638972-153640769:+KIRPGSVA_HALLMARK_P53_PATHWAYEER2.5830e-030.4296image
chr1:153638972-153640769:+LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.4513e-020.1610image
ENSG00000160679.11,CHTOPLUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.4192e-020.1614image
chr1:153638972-153640769:+LUSCGSVA_HALLMARK_GLYCOLYSISEER2.5977e-020.1693image
ENSG00000160679.11,CHTOPLUSCGSVA_HALLMARK_GLYCOLYSISEAG2.5977e-020.1693image
ENSG00000160679.11,CHTOPOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9138e-020.1892image
chr1:153638972-153640769:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.5021e-020.1830image
ENSG00000160679.11,CHTOPPAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9605e-020.3227image
chr1:153638972-153640769:+PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.9665e-020.3226image
ENSG00000160679.11,CHTOPSTADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.5616e-020.1394image
chr1:153638972-153640769:+STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.9636e-020.1523image
ENSG00000160679.11,CHTOPTGCTGSVA_HALLMARK_APICAL_SURFACEEAG3.7478e-02-0.4362image
chr1:153638972-153640769:+THCAGSVA_HALLMARK_MTORC1_SIGNALINGEER2.9277e-020.1927image
ENSG00000160679.11,CHTOPTHCAGSVA_HALLMARK_MYC_TARGETS_V1EAG4.1771e-020.1795image
ENSG00000160679.11,CHTOPTHYMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG9.7470e-030.5630image


Top

7. Enriched editing regions and drugs for CHTOP


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000160679.11,CHTOPBLCAAS601245EAG3.1861e-030.3604image
chr1:153638972-153640769:+BLCAAS601245EER3.1861e-030.3604image
ENSG00000160679.11,CHTOPCESCGDC.0449EAG2.6320e-030.3447image
ENSG00000160679.11,CHTOPCOADCisplatinEAG1.6926e-02-0.3238image
chr1:153638972-153640769:+COADCisplatinEER1.6926e-02-0.3238image
chr1:153638972-153640769:+ESCAAZD.2281EER1.4818e-04-0.3280image
ENSG00000160679.11,CHTOPESCAAZD.2281EAG2.2015e-04-0.3186image
chr1:153638972-153640769:+GBMKU.55933EER1.3834e-02-0.3568image
chr1:153638972-153640769:+HNSCAZD6482EER3.4689e-030.5953image
ENSG00000160679.11,CHTOPHNSCBicalutamideEAG4.1311e-030.5746image
chr1:153638972-153640769:+KIRCAMG.706EER1.2824e-04-0.3810image
ENSG00000160679.11,CHTOPKIRCAMG.706EAG1.2824e-04-0.3810image
ENSG00000160679.11,CHTOPKIRPMethotrexateEAG2.7978e-02-0.3207image
chr1:153638972-153640769:+KIRPMethotrexateEER2.7978e-02-0.3207image
ENSG00000160679.11,CHTOPLAMLDocetaxelEAG3.3145e-04-0.4786image
ENSG00000160679.11,CHTOPLGGCI.1040EAG7.6028e-04-0.3932image
chr1:153638972-153640769:+LUADATRAEER5.1737e-030.1995image
ENSG00000160679.11,CHTOPLUADATRAEAG5.1026e-030.1998image
chr1:153638972-153640769:+LUSCA.443654EER1.0822e-02-0.1933image
ENSG00000160679.11,CHTOPLUSCA.443654EAG1.0822e-02-0.1933image
ENSG00000160679.11,CHTOPOVEmbelinEAG1.3866e-020.1986image
chr1:153638972-153640769:+OVEmbelinEER7.9369e-030.2160image
ENSG00000160679.11,CHTOPPAADCEP.701EAG3.1212e-020.3412image
chr1:153638972-153640769:+PAADCEP.701EER3.0623e-020.3423image
ENSG00000160679.11,CHTOPSKCMMetforminEAG5.6736e-030.2993image
chr1:153638972-153640769:+SKCMMetforminEER5.6736e-030.2993image
ENSG00000160679.11,CHTOPSTADCyclopamineEAG4.6349e-05-0.2811image
chr1:153638972-153640769:+STADCyclopamineEER6.8360e-05-0.2764image
ENSG00000160679.11,CHTOPTGCTMidostaurinEAG5.1238e-030.5634image
chr1:153638972-153640769:+THCAGefitinibEER1.8868e-02-0.2073image
ENSG00000160679.11,CHTOPTHCAGefitinibEAG2.2172e-02-0.2013image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType