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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ANKRD17 (ImmuneEditome ID:26057)

1. Gene summary of enriched editing regions for ANKRD17

check button Gene summary
Gene informationGene symbol

ANKRD17

Gene ID

26057

GeneSynonymsCAGS|GTAR|MASK2|NY-BR-16
GeneCytomap

4q13.3

GeneTypeprotein-coding
GeneDescriptionankyrin repeat domain-containing protein 17|gene trap ankyrin repeat protein|serologically defined breast cancer antigen NY-BR-16
GeneModificationdate20230422
UniprotIDO75179;H0YLQ3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:73160389-73160540:-ENST00000330838.9ENSG00000132466.16ANKRD17intronicAluSpchr4:73160389-73160540:-.alignment
chr4:73160389-73160540:-ENST00000358602.7ENSG00000132466.16ANKRD17intronicAluSpchr4:73160389-73160540:-.alignment
chr4:73160389-73160540:-ENST00000509867.5ENSG00000132466.16ANKRD17intronicAluSpchr4:73160389-73160540:-.alignment
chr4:73160389-73160540:-ENST00000558247.4ENSG00000132466.16ANKRD17intronicAluSpchr4:73160389-73160540:-.alignment
chr4:73160389-73160540:-ENST00000561029.1ENSG00000132466.16ANKRD17intronicAluSpchr4:73160389-73160540:-.alignment
chr4:73162672-73163878:-ENST00000559367.1ENSG00000132466.16ANKRD17ncRNA_intronicMER5B,AluJb,MER5A1chr4:73162672-73163878:-.alignment
chr4:73189419-73190153:-ENST00000559367.1ENSG00000132466.16ANKRD17ncRNA_intronicAluSx,L2a,L1M5,AluYcchr4:73189419-73190153:-.alignment
chr4:73202433-73203341:-ENST00000559367.1ENSG00000132466.16ANKRD17ncRNA_intronicL1MEcchr4:73202433-73203341:-.alignment
chr4:73225647-73227452:-ENST00000330838.9ENSG00000132466.16ANKRD17intronicL2a,AluSx3,AluSx1,AluSc8chr4:73225647-73227452:-.alignment
chr4:73225647-73227452:-ENST00000358602.7ENSG00000132466.16ANKRD17intronicL2a,AluSx3,AluSx1,AluSc8chr4:73225647-73227452:-.alignment
chr4:73225647-73227452:-ENST00000558247.4ENSG00000132466.16ANKRD17intronicL2a,AluSx3,AluSx1,AluSc8chr4:73225647-73227452:-.alignment
chr4:73225647-73227452:-ENST00000561029.1ENSG00000132466.16ANKRD17intronicL2a,AluSx3,AluSx1,AluSc8chr4:73225647-73227452:-.alignment
chr4:73240332-73241132:-ENST00000330838.9ENSG00000132466.16ANKRD17intronicAluSx,AluJochr4:73240332-73241132:-.alignment
chr4:73240332-73241132:-ENST00000358602.7ENSG00000132466.16ANKRD17intronicAluSx,AluJochr4:73240332-73241132:-.alignment
chr4:73240332-73241132:-ENST00000558247.4ENSG00000132466.16ANKRD17intronicAluSx,AluJochr4:73240332-73241132:-.alignment
chr4:73240332-73241132:-ENST00000561029.1ENSG00000132466.16ANKRD17intronicAluSx,AluJochr4:73240332-73241132:-.alignment


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2. Tumor-specific enriched editing regions for ANKRD17


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000132466.16,ANKRD17LUADPathEAG9.5994e-045.5898e-040.6756image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr4:73225647-73227452:-OVEER2.0828e-028.0674e-032.2111e-03image

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3. Enriched editing regions and immune related genes for ANKRD17


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for ANKRD17


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ANKRD17


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:73225647-73227452:-ESCAEERMonocytes3.8796e-02-0.3322image
chr4:73240332-73241132:-ESCAEERNK_cells_resting3.3720e-02-0.2241image
ENSG00000132466.16,ANKRD17ESCAEAGDendritic_cells_resting2.2130e-020.2151image
chr4:73202433-73203341:-LAMLEERMacrophages_M11.6113e-020.2847image
ENSG00000132466.16,ANKRD17OVEAGNK_cells_activated2.3048e-020.2032image
chr4:73189419-73190153:-STADEERT_cells_CD81.3052e-020.2319image
chr4:73225647-73227452:-STADEERT_cells_gamma_delta3.1339e-030.3412image
ENSG00000132466.16,ANKRD17STADEAGMast_cells_resting4.2528e-03-0.2065image


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6. Enriched editing regions and immune gene sets for ANKRD17


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000132466.16,ANKRD17STADEAG3.2158e-020.15553.2208e-020.15554.7022e-020.14431.4593e-050.3088image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000132466.16,ANKRD17ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.1334e-030.2860image
chr4:73240332-73241132:-ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.6491e-02-0.2208image
chr4:73225647-73227452:-ESCAGSVA_HALLMARK_HEME_METABOLISMEER4.5280e-020.3224image
ENSG00000132466.16,ANKRD17LAMLGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.3826e-020.1900image
chr4:73162672-73163878:-LAMLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.6414e-020.3019image
ENSG00000132466.16,ANKRD17OVGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0961e-030.2887image
chr4:73225647-73227452:-STADGSVA_HALLMARK_MYC_TARGETS_V2EER3.3786e-030.3387image
ENSG00000132466.16,ANKRD17STADGSVA_HALLMARK_UV_RESPONSE_UPEAG5.9126e-080.3809image
chr4:73240332-73241132:-STADGSVA_HALLMARK_P53_PATHWAYEER4.6011e-060.3620image
chr4:73189419-73190153:-STADGSVA_HALLMARK_APICAL_SURFACEEER3.5331e-040.3289image


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7. Enriched editing regions and drugs for ANKRD17


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000132466.16,ANKRD17BRCAGDC0941EAG3.4020e-02-0.4535image
ENSG00000132466.16,ANKRD17ESCABryostatin.1EAG1.3218e-02-0.2325image
chr4:73240332-73241132:-ESCABAY.61.3606EER2.7534e-02-0.2324image
chr4:73225647-73227452:-ESCABMS.509744EER4.9529e-030.4410image
chr4:73202433-73203341:-LAMLBX.795EER9.0528e-030.3077image
ENSG00000132466.16,ANKRD17LAMLGDC0941EAG4.7925e-020.1865image
chr4:73162672-73163878:-LAMLErlotinibEER4.3132e-02-0.3063image
ENSG00000132466.16,ANKRD17OVAZD8055EAG6.9852e-030.2402image
chr4:73225647-73227452:-OVGemcitabineEER3.4394e-02-0.3694image
chr4:73225647-73227452:-STADCisplatinEER2.0776e-02-0.2702image
ENSG00000132466.16,ANKRD17STADGW843682XEAG2.1108e-02-0.1672image
chr4:73240332-73241132:-STADGW843682XEER6.0720e-04-0.2750image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType