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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UBXN7 (ImmuneEditome ID:26043)

1. Gene summary of enriched editing regions for UBXN7

check button Gene summary
Gene informationGene symbol

UBXN7

Gene ID

26043

GeneSynonymsUBXD7
GeneCytomap

3q29

GeneTypeprotein-coding
GeneDescriptionUBX domain-containing protein 7|UBX domain containing 7
GeneModificationdate20230329
UniprotIDO94888;C9JD50;C9JAT7;F8WB69
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:196352364-196353802:-ENST00000296328.7ENSG00000163960.10UBXN7UTR3AluSx1,MIR,AluSx,AluScchr3:196352364-196353802:-.alignment
chr3:196423979-196424570:-ENST00000493566.1ENSG00000163960.10UBXN7ncRNA_intronicAluJr,AluSx1,L2cchr3:196423979-196424570:-.alignment


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2. Tumor-specific enriched editing regions for UBXN7


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:196352364-196353802:-BRCAEER1.6129e-12image
ENSG00000163960.10,UBXN7BRCAEAG1.4634e-12image
ENSG00000163960.10,UBXN7KIRCEAG2.7636e-02image
chr3:196352364-196353802:-THCAEER6.9650e-06image
ENSG00000163960.10,UBXN7THCAEAG3.9845e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000163960.10,UBXN7BLCAPathEAG3.8953e-029.4781e-030.2052image
chr3:196352364-196353802:-BLCAPathEER4.2616e-021.0001e-020.2037image
ENSG00000163960.10,UBXN7ESCAPathEAG2.8184e-029.2909e-030.2176image
chr3:196352364-196353802:-ESCAPathEER3.3956e-021.1115e-020.2125image
ENSG00000163960.10,UBXN7THCAPathEAG2.0443e-021.8653e-020.1344image
chr3:196352364-196353802:-THCAPathEER6.3101e-033.3268e-030.1679image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr3:196352364-196353802:-LUADEER4.4895e-021.1297e-021.0301e+01image
ENSG00000163960.10,UBXN7LUADEAG4.0071e-021.6593e-028.3779e+00image

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3. Enriched editing regions and immune related genes for UBXN7


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:196352364-196353802:-LGGEERENSG00000141040,ZNF287-0.43143.7646e-152.0990e-20-0.4491imageNNZNF287MonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000262879,RP11-156P1.3-0.42043.1992e-142.8516e-19-0.4368imageNNNAT_cells_follicular_helperGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr3:196352364-196353802:-LGGEERENSG00000185900,POMK-0.41536.8660e-141.2229e-19-0.4408imageNNNAT_cells_follicular_helperGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000083168,KAT6A-0.41041.3263e-131.7606e-17-0.4162imageNNKAT6AT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000141027,NCOR1-0.40632.6548e-134.6472e-21-0.4559imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000163960,UBXN7-0.39312.0145e-128.1158e-19-0.4317imageNNNAT_cells_follicular_helperGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr3:196352364-196353802:-LGGEERENSG00000224470,ATXN1L-0.39152.6633e-121.7664e-18-0.4279imageNNNANeutrophilsGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000166439,RNF169-0.39142.6785e-128.8844e-19-0.4312imageNNNAT_cells_follicular_helperGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000037749,MFAP3-0.38754.7799e-124.5780e-19-0.4345imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-LGGEERENSG00000153107,ANAPC1-0.38565.5930e-126.3300e-17-0.4096imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for UBXN7


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000163960.10,UBXN7
KIRCEAGIRENSG00000186318.12chr11117285685:117291813:117293053:1172931880.30725.6066e-052.3201e-130.4174imageNACIN1;ADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RNF219;RTCB;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000163960.10,UBXN7
KIRCEAGMEXENSG00000126581.8chr1742810859:42810928:42811654:42811797:42815907:42816054:42818220:428184150.30507.4753e-051.5081e-120.4042imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184BECN1T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000163960.10,UBXN7
KIRCEAGMEXENSG00000013561.13chr5141973582:141973742:141974803:141974955:141983381:141983552:141984802:141984933-0.29141.7586e-041.9429e-12-0.4024imageNACIN1;ADAR;ALYREF;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SLBP;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000163960.10,UBXN7
KIRCEAGIRENSG00000164944.7chr894510416:94510652:94511184:945115620.27944.2219e-042.3711e-120.4009imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000163960.10,UBXN7
KIRCEAGMEXENSG00000130159.9chr1911507990:11508048:11513055:11513150:11513202:11513279:11513803:115138580.36841.8303e-076.5195e-140.4261imageNADAR;AUH;BCCIP;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184ECSITT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000163960.10,UBXN7
KIRCEAGMEXENSG00000104613.7chr819837080:19837160:19842847:19842927:19845703:19845797:19851648:19852083-0.32561.0246e-052.3445e-12-0.4003imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-
KIRCEERA3ENSG00000174705.7chr5172346135:172346261:172333498:172333769:172333498:1723399160.24597.5706e-054.6313e-110.4099imageNNSH3PXD2BT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr3:196352364-196353802:-
KIRCEERIRENSG00000186318.12chr11117285685:117291813:117293053:1172931880.30048.8967e-055.1187e-130.4119imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ANDROGEN_RESPONSE
chr3:196352364-196353802:-
KIRCEERMEXENSG00000126581.8chr1742810859:42810928:42811654:42811797:42815907:42816054:42818220:428184150.30039.9273e-052.2259e-120.4014imageNNBECN1T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000163960.10,UBXN7
KIRCEAGA3ENSG00000174705.7chr5172346135:172346261:172333498:172333769:172333498:1723399160.25413.6292e-058.9171e-120.4235imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184SH3PXD2BT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for UBXN7


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:196352364-196353802:-BLCAEERMacrophages_M13.4017e-030.2317image
ENSG00000163960.10,UBXN7BLCAEAGMacrophages_M14.5426e-030.2246image
chr3:196352364-196353802:-BRCAEERT_cells_follicular_helper4.5179e-040.1216image
ENSG00000163960.10,UBXN7BRCAEAGNK_cells_activated4.2625e-040.1220image
chr3:196352364-196353802:-CESCEERT_cells_follicular_helper2.1260e-040.2742image
ENSG00000163960.10,UBXN7CESCEAGT_cells_follicular_helper2.1038e-040.2744image
ENSG00000163960.10,UBXN7COADEAGDendritic_cells_activated5.6006e-040.3475image
chr3:196352364-196353802:-ESCAEERT_cells_regulatory_(Tregs)9.9496e-04-0.2579image
ENSG00000163960.10,UBXN7ESCAEAGT_cells_regulatory_(Tregs)1.0652e-03-0.2564image
chr3:196352364-196353802:-GBMEERMonocytes1.0767e-020.2619image
ENSG00000163960.10,UBXN7GBMEAGMonocytes1.0767e-020.2619image
chr3:196352364-196353802:-HNSCEERB_cells_naive6.0366e-04-0.1759image
ENSG00000163960.10,UBXN7HNSCEAGB_cells_naive5.8208e-04-0.1761image
chr3:196352364-196353802:-KIRCEERT_cells_follicular_helper8.2885e-070.2875image
ENSG00000163960.10,UBXN7KIRCEAGT_cells_follicular_helper9.2609e-070.2863image
chr3:196352364-196353802:-KIRPEERT_cells_follicular_helper1.8839e-030.2971image
ENSG00000163960.10,UBXN7KIRPEAGNK_cells_activated5.5007e-040.3271image
chr3:196352364-196353802:-LAMLEERT_cells_gamma_delta4.8607e-030.2565image
ENSG00000163960.10,UBXN7LAMLEAGT_cells_gamma_delta1.9892e-020.2097image
chr3:196352364-196353802:-LGGEERDendritic_cells_resting5.2491e-03-0.1424image
ENSG00000163960.10,UBXN7LGGEAGDendritic_cells_resting5.2491e-03-0.1424image
chr3:196352364-196353802:-LIHCEERMast_cells_activated8.7903e-040.4739image
ENSG00000163960.10,UBXN7LIHCEAGMast_cells_activated2.5491e-030.4216image
ENSG00000163960.10,UBXN7LUADEAGT_cells_CD4_memory_activated1.9462e-030.1970image
chr3:196352364-196353802:-LUSCEERT_cells_CD82.0472e-060.2326image
ENSG00000163960.10,UBXN7LUSCEAGT_cells_CD82.4269e-060.2304image
chr3:196352364-196353802:-MESOEERNeutrophils3.4408e-020.3874image
ENSG00000163960.10,UBXN7MESOEAGNeutrophils3.4408e-020.3874image
chr3:196352364-196353802:-OVEERMacrophages_M11.0008e-030.1974image
ENSG00000163960.10,UBXN7OVEAGMacrophages_M18.7452e-040.1996image
chr3:196352364-196353802:-PAADEERB_cells_memory2.9304e-020.2570image
ENSG00000163960.10,UBXN7PAADEAGB_cells_memory2.9304e-020.2570image
chr3:196352364-196353802:-PCPGEERDendritic_cells_resting2.9226e-040.5623image
ENSG00000163960.10,UBXN7PCPGEAGDendritic_cells_resting2.9226e-040.5623image
chr3:196352364-196353802:-PRADEERNeutrophils3.5484e-03-0.1887image
ENSG00000163960.10,UBXN7PRADEAGNeutrophils3.3312e-03-0.1899image
chr3:196352364-196353802:-READEERNK_cells_activated4.9723e-020.3048image
ENSG00000163960.10,UBXN7READEAGNK_cells_activated4.9723e-020.3048image
chr3:196352364-196353802:-SARCEERMacrophages_M28.4555e-050.3775image
ENSG00000163960.10,UBXN7SARCEAGMacrophages_M26.0782e-050.3845image
chr3:196352364-196353802:-SKCMEERT_cells_CD81.9855e-050.2560image
ENSG00000163960.10,UBXN7SKCMEAGT_cells_CD81.8854e-050.2567image
chr3:196352364-196353802:-STADEEREosinophils7.1655e-03-0.1419image
ENSG00000163960.10,UBXN7STADEAGEosinophils6.1648e-03-0.1445image
chr3:196352364-196353802:-TGCTEERMacrophages_M28.0893e-12-0.6461image
ENSG00000163960.10,UBXN7TGCTEAGMacrophages_M28.0893e-12-0.6461image
chr3:196352364-196353802:-THCAEERNeutrophils1.2912e-02-0.1420image
ENSG00000163960.10,UBXN7THCAEAGT_cells_CD4_naive2.1327e-02-0.1311image
ENSG00000163960.10,UBXN7UCECEAGT_cells_regulatory_(Tregs)2.2305e-020.2946image
chr3:196352364-196353802:-UCSEEREosinophils1.0227e-020.5600image
ENSG00000163960.10,UBXN7UCSEAGEosinophils1.0615e-020.5577image


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6. Enriched editing regions and immune gene sets for UBXN7


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000163960.10,UBXN7STADEAG3.0083e-070.26683.5908e-030.15356.4268e-040.17953.0205e-030.1563image
chr3:196352364-196353802:-STADEER3.7691e-070.26463.5424e-030.15385.2364e-040.18241.4580e-030.1676image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr3:196352364-196353802:-BLCAGSVA_HALLMARK_MYOGENESISEER6.8123e-030.2145image
ENSG00000163960.10,UBXN7BLCAGSVA_HALLMARK_MYOGENESISEAG9.1651e-030.2067image
chr3:196352364-196353802:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.9618e-180.2952image
ENSG00000163960.10,UBXN7BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6518e-170.2897image
chr3:196352364-196353802:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7826e-070.3698image
ENSG00000163960.10,UBXN7CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7276e-070.3699image
ENSG00000163960.10,UBXN7COADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG6.0894e-03-0.2795image
ENSG00000163960.10,UBXN7ESCAGSVA_HALLMARK_HYPOXIAEAG3.5555e-030.2292image
chr3:196352364-196353802:-ESCAGSVA_HALLMARK_HYPOXIAEER3.8448e-030.2273image
ENSG00000163960.10,UBXN7GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.7861e-030.2774image
chr3:196352364-196353802:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.7861e-030.2774image
chr3:196352364-196353802:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5370e-090.3008image
ENSG00000163960.10,UBXN7HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.4430e-090.3007image
ENSG00000163960.10,UBXN7KICHGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.5127e-03-0.5591image
chr3:196352364-196353802:-KICHGSVA_HALLMARK_PROTEIN_SECRETIONEER4.5127e-03-0.5591image
ENSG00000163960.10,UBXN7KIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.8896e-06-0.2784image
chr3:196352364-196353802:-KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.8286e-06-0.2787image
chr3:196352364-196353802:-KIRPGSVA_HALLMARK_UV_RESPONSE_DNEER2.3066e-04-0.3489image
ENSG00000163960.10,UBXN7KIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG3.4649e-06-0.4297image
ENSG00000163960.10,UBXN7LAMLGSVA_HALLMARK_DNA_REPAIREAG4.1262e-02-0.1843image
chr3:196352364-196353802:-LGGGSVA_HALLMARK_UV_RESPONSE_DNEER9.4520e-11-0.3230image
ENSG00000163960.10,UBXN7LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG9.4520e-11-0.3230image
chr3:196352364-196353802:-LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER4.4007e-020.2984image
ENSG00000163960.10,UBXN7LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.0109e-03-0.3804image
chr3:196352364-196353802:-LUADGSVA_HALLMARK_GLYCOLYSISEER1.0969e-020.1636image
ENSG00000163960.10,UBXN7LUADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.6584e-02-0.1529image
ENSG00000163960.10,UBXN7LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6926e-080.2677image
chr3:196352364-196353802:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7763e-080.2682image
ENSG00000163960.10,UBXN7MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.6594e-020.3832image
chr3:196352364-196353802:-MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.6594e-020.3832image
ENSG00000163960.10,UBXN7OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.0078e-110.3790image
chr3:196352364-196353802:-OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.5264e-110.3806image
ENSG00000163960.10,UBXN7PAADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.6795e-03-0.3381image
chr3:196352364-196353802:-PAADGSVA_HALLMARK_UV_RESPONSE_DNEER3.6795e-03-0.3381image
chr3:196352364-196353802:-PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.0406e-020.3798image
ENSG00000163960.10,UBXN7PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.0406e-020.3798image
ENSG00000163960.10,UBXN7PRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG5.3258e-06-0.2908image
chr3:196352364-196353802:-PRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER9.9686e-06-0.2826image
chr3:196352364-196353802:-READGSVA_HALLMARK_APICAL_SURFACEEER1.9553e-02-0.3590image
ENSG00000163960.10,UBXN7READGSVA_HALLMARK_APICAL_SURFACEEAG1.9553e-02-0.3590image
chr3:196352364-196353802:-SARCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER4.9404e-030.2750image
ENSG00000163960.10,UBXN7SARCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG7.7585e-030.2610image
chr3:196352364-196353802:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.1160e-050.2464image
ENSG00000163960.10,UBXN7SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5370e-050.2451image
ENSG00000163960.10,UBXN7STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.8844e-100.3186image
chr3:196352364-196353802:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.6428e-100.3259image
ENSG00000163960.10,UBXN7TGCTGSVA_HALLMARK_ANGIOGENESISEAG5.1457e-11-0.6265image
chr3:196352364-196353802:-TGCTGSVA_HALLMARK_ANGIOGENESISEER5.1457e-11-0.6265image
chr3:196352364-196353802:-THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER9.2045e-060.2505image
ENSG00000163960.10,UBXN7THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.7149e-070.2803image
chr3:196352364-196353802:-THYMGSVA_HALLMARK_P53_PATHWAYEER2.7072e-030.4916image
ENSG00000163960.10,UBXN7THYMGSVA_HALLMARK_P53_PATHWAYEAG2.7072e-030.4916image
chr3:196352364-196353802:-UCECGSVA_HALLMARK_ADIPOGENESISEER2.7475e-020.2921image


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7. Enriched editing regions and drugs for UBXN7


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr3:196352364-196353802:-BLCACGP.082996EER3.9853e-03-0.2279image
ENSG00000163960.10,UBXN7BLCACGP.082996EAG4.1818e-03-0.2267image
ENSG00000163960.10,UBXN7BRCACyclopamineEAG2.7311e-07-0.1777image
chr3:196352364-196353802:-BRCACyclopamineEER1.7013e-07-0.1808image
chr3:196352364-196353802:-CESCCI.1040EER1.9329e-03-0.2309image
ENSG00000163960.10,UBXN7CESCCI.1040EAG1.9269e-03-0.2309image
chr3:196352364-196353802:-COADAICAREER6.2308e-04-0.3465image
ENSG00000163960.10,UBXN7COADLFM.A13EAG5.0321e-04-0.3502image
chr3:196352364-196353802:-ESCACGP.60474EER5.2269e-04-0.2712image
ENSG00000163960.10,UBXN7ESCACGP.60474EAG5.0156e-04-0.2720image
chr3:196352364-196353802:-GBMGW.441756EER1.4401e-030.3241image
ENSG00000163960.10,UBXN7GBMGW.441756EAG1.4401e-030.3241image
chr3:196352364-196353802:-HNSCGefitinibEER6.6060e-10-0.3127image
ENSG00000163960.10,UBXN7HNSCGefitinibEAG5.5564e-10-0.3136image
ENSG00000163960.10,UBXN7KICHGefitinibEAG5.3730e-03-0.5499image
chr3:196352364-196353802:-KICHGefitinibEER5.3730e-03-0.5499image
ENSG00000163960.10,UBXN7KIRCEmbelinEAG5.5146e-050.2369image
chr3:196352364-196353802:-KIRCEmbelinEER5.7956e-050.2363image
ENSG00000163960.10,UBXN7KIRPAZD6482EAG1.8669e-070.4764image
chr3:196352364-196353802:-KIRPAZD6482EER7.7739e-070.4564image
chr3:196352364-196353802:-LGGKU.55933EER3.2412e-06-0.2353image
ENSG00000163960.10,UBXN7LGGKU.55933EAG3.2412e-06-0.2353image
ENSG00000163960.10,UBXN7LIHCBryostatin.1EAG2.8911e-02-0.3123image
chr3:196352364-196353802:-LUADBMS.509744EER4.4109e-03-0.1828image
ENSG00000163960.10,UBXN7LUADCyclopamineEAG3.9170e-03-0.1837image
chr3:196352364-196353802:-LUSCCCT007093EER1.1362e-060.2382image
ENSG00000163960.10,UBXN7LUSCCCT007093EAG1.3755e-060.2358image
chr3:196352364-196353802:-MESOGNF.2EER5.4231e-03-0.4950image
ENSG00000163960.10,UBXN7MESOGNF.2EAG5.4231e-03-0.4950image
ENSG00000163960.10,UBXN7OVGNF.2EAG4.7407e-05-0.2427image
chr3:196352364-196353802:-OVGNF.2EER7.7058e-05-0.2361image
chr3:196352364-196353802:-PAADATRAEER6.9612e-040.3985image
ENSG00000163960.10,UBXN7PAADATRAEAG6.9612e-040.3985image
ENSG00000163960.10,UBXN7PCPGGDC0941EAG2.3429e-020.3719image
chr3:196352364-196353802:-PCPGGDC0941EER2.3429e-020.3719image
ENSG00000163960.10,UBXN7PRADEmbelinEAG1.1608e-040.2478image
chr3:196352364-196353802:-PRADEmbelinEER2.6269e-040.2350image
chr3:196352364-196353802:-SARCEpothilone.BEER1.0877e-030.3174image
ENSG00000163960.10,UBXN7SARCAG.014699EAG1.3573e-030.3116image
chr3:196352364-196353802:-SKCMBortezomibEER8.0834e-04-0.2023image
ENSG00000163960.10,UBXN7SKCMBortezomibEAG8.1731e-04-0.2021image
ENSG00000163960.10,UBXN7STADGW843682XEAG1.6034e-06-0.2504image
chr3:196352364-196353802:-STADGW843682XEER7.3128e-07-0.2582image
ENSG00000163960.10,UBXN7TGCTAZD8055EAG8.5567e-15-0.7080image
chr3:196352364-196353802:-TGCTAZD8055EER8.5567e-15-0.7080image
chr3:196352364-196353802:-THCABMS.536924EER2.9851e-10-0.3512image
ENSG00000163960.10,UBXN7THCABMS.536924EAG4.8835e-11-0.3643image
ENSG00000163960.10,UBXN7THYMAUY922EAG4.7062e-02-0.3380image
chr3:196352364-196353802:-THYMAUY922EER4.7062e-02-0.3380image
ENSG00000163960.10,UBXN7UCECAZD6244EAG2.7865e-02-0.2864image
ENSG00000163960.10,UBXN7UCSDoxorubicinEAG6.1310e-030.5904image
chr3:196352364-196353802:-UCSDoxorubicinEER6.2764e-030.5891image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType