CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: POLR1A (ImmuneEditome ID:25885)

1. Gene summary of enriched editing regions for POLR1A

check button Gene summary
Gene informationGene symbol

POLR1A

Gene ID

25885

GeneSynonymsA190|AFDCIN|RPA1|RPA190|RPA194|RPO1-4|RPO14
GeneCytomap

2p11.2

GeneTypeprotein-coding
GeneDescriptionDNA-directed RNA polymerase I subunit RPA1|DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|DNA-directed RNA polymerase I subunit A1|RNA polymerase I 194 kDa subunit|polymerase (RNA) I polypeptide A, 194kDa|polymerase (RNA) I subunit A
GeneModificationdate20230515
UniprotIDO95602;F2Z3I7;B9ZVN9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:86020239-86020550:-ENST00000263857.9ENSG00000068654.14POLR1AUTR3L1ME3G,AluJbchr2:86020239-86020550:-.alignment
chr2:86022605-86025141:-ENST00000263857.9ENSG00000068654.14POLR1AUTR3L1MB2,AluSx3,AluJo,AluSx,MER5B,AluSq2chr2:86022605-86025141:-.alignment
chr2:86063874-86064278:-ENST00000483538.1ENSG00000068654.14POLR1AncRNA_intronicL1M5chr2:86063874-86064278:-.alignment
chr2:86084694-86085040:-ENST00000486964.4ENSG00000068654.14POLR1AncRNA_intronicAluSx3,AluYchr2:86084694-86085040:-.alignment


Top

2. Tumor-specific enriched editing regions for POLR1A


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr2:86022605-86025141:-KIRCEER4.1399e-04image
ENSG00000068654.14,POLR1AKIRCEAG1.9025e-03image
chr2:86022605-86025141:-STADEER1.9039e-02image
chr2:86022605-86025141:-THCAEER1.1921e-05image
ENSG00000068654.14,POLR1ATHCAEAG2.1638e-03image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000068654.14,POLR1ATGCTPathEAG5.1724e-053.3038e-020.2401image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000068654.14,POLR1AUCECEAG1.0650e-022.5834e-023.5494e-02image

Top

3. Enriched editing regions and immune related genes for POLR1A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:86020239-86020550:-UCECEERENSG00000111911,HINT30.35525.4383e-031.1670e-060.4000imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr2:86020239-86020550:-UCECEERENSG00000197077,KIAA16710.31971.7504e-025.9369e-070.4100imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr2:86020239-86020550:-PCPGEERENSG00000268836,LA16c-OS12.2-0.52232.9455e-078.9198e-09-0.4550imageNNNAMast_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr2:86020239-86020550:-PCPGEERENSG00000275854,RP11-278C7.5-0.51423.8661e-076.6611e-08-0.4302imageNNNAB_cells_naiveGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:86020239-86020550:-PCPGEERENSG00000273156,RP11-127B20.2-0.48163.7451e-063.7535e-07-0.4071imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:86020239-86020550:-PCPGEERENSG00000275580,RP11-295H24.4-0.48093.7585e-066.1956e-08-0.4311imageNNNANeutrophilsGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:86020239-86020550:-PCPGEERENSG00000168096,ANKS3-0.47485.6040e-061.7577e-08-0.4469imageNNNAGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:86020239-86020550:-PCPGEERENSG00000241370,RPP21-0.47376.3200e-064.9715e-08-0.4339imageNNNAT_cells_CD8GSVA_HALLMARK_PROTEIN_SECRETION
chr2:86020239-86020550:-PCPGEERENSG00000266910,CTC-448F2.6-0.47048.1616e-064.0486e-08-0.4365imageNNNANeutrophilsGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:86020239-86020550:-PCPGEERENSG00000106246,PTCD1-0.46968.5818e-062.9327e-08-0.4406imageNNNAMast_cells_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:86022605-86025141:-PRADEERENSG00000270640,RP11-373D23.20.22454.8443e-051.0735e-210.4306imageNNNADendritic_cells_activatedGSVA_HALLMARK_PEROXISOME
chr2:86022605-86025141:-PRADEERENSG00000225972,MTND1P230.19436.3861e-041.3429e-270.4828imageNNNADendritic_cells_activatedGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALING
chr2:86022605-86025141:-PRADEERENSG00000250321,RP11-478C6.40.19157.2015e-041.5656e-230.4478imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_HEME_METABOLISM
chr2:86022605-86025141:-PRADEERENSG00000263050,RP11-667K14.30.18511.2892e-038.4402e-220.4316imageNNNADendritic_cells_activatedGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr2:86022605-86025141:-PRADEERENSG00000238741,SCARNA70.17531.6836e-037.3349e-220.4322imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PEROXISOME
chr2:86022605-86025141:-PRADEERENSG00000257647,RP11-701H24.3-0.17152.8487e-031.8146e-190.4083imageNNNADendritic_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr2:86022605-86025141:-PRADEERENSG00000265996,MIR36710.16025.4089e-032.7766e-200.4167imageNNNADendritic_cells_activatedGSVA_HALLMARK_PEROXISOME
chr2:86022605-86025141:-PRADEERENSG00000231721,LINC-PINT0.16026.5811e-031.5632e-220.4386imageNNNADendritic_cells_activatedGSVA_HALLMARK_PEROXISOME
chr2:86022605-86025141:-PRADEERENSG00000234263,RP3-325F22.30.15449.2482e-034.4052e-190.4043imageNNNADendritic_cells_activatedGSVA_HALLMARK_HEME_METABOLISM
chr2:86022605-86025141:-PRADEERENSG00000252498,RNU6-1016P-0.12832.7593e-021.5362e-190.4091imageNNNADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP

More results



Top

4. Enriched editing regions and immune related splicing for POLR1A


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000134255.9chr1111174878:111182957:111183461:1111835510.27547.3663e-032.4063e-140.4705imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000135945.5chr299400949:99403815:99404443:994046770.26891.1723e-022.3889e-120.4356imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NANeutrophilsGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000141027.16chr1716065484:16065694:16067893:160681210.25631.7166e-022.9513e-110.4186imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000120800.4chr12101383040:101383313:101383542:1013835990.27247.8982e-031.1189e-170.5200imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000048405.5chr7127370042:127371814:127373341:1273734790.25791.8094e-024.6456e-110.4123imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANeutrophilsGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000164164.11chr4145143364:145143445:145143945:1451440010.27551.7590e-038.5165e-130.4655imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000151694.8chr29488485:9492986:9493746:94938250.24952.3510e-021.7038e-100.4003imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184ADAM17EosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000052795.8chr4158832066:158832138:158833527:1588336280.19722.3891e-022.7066e-140.5302imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000158941.12chr822612702:22613136:22614091:226143140.26271.3442e-024.9058e-190.5371imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000068654.14,POLR1A
COADEAGIRENSG00000126216.8chr13112545698:112545865:112547619:1125477520.23604.5306e-023.9396e-110.4129imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMast_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY

More results



Top

5. Enriched editing regions and immune infiltration for POLR1A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:86022605-86025141:-ACCEERMast_cells_resting8.1851e-050.5187image
ENSG00000068654.14,POLR1AACCEAGMast_cells_resting1.7959e-020.3046image
ENSG00000068654.14,POLR1ABLCAEAGMacrophages_M21.5215e-020.1251image
chr2:86022605-86025141:-BRCAEERNK_cells_activated1.1509e-040.1219image
ENSG00000068654.14,POLR1ABRCAEAGPlasma_cells2.0498e-030.0962image
chr2:86022605-86025141:-CESCEERPlasma_cells2.7816e-020.1397image
chr2:86022605-86025141:-CHOLEERB_cells_naive1.2698e-02-0.4356image
ENSG00000068654.14,POLR1ACHOLEAGT_cells_CD4_memory_activated2.0304e-020.3964image
ENSG00000068654.14,POLR1ACOADEAGMast_cells_activated6.0658e-030.1782image
chr2:86022605-86025141:-DLBCEERMacrophages_M21.7114e-020.3750image
ENSG00000068654.14,POLR1AESCAEAGT_cells_CD86.1551e-030.2150image
ENSG00000068654.14,POLR1AGBMEAGNK_cells_activated1.2556e-020.1994image
chr2:86022605-86025141:-HNSCEERT_cells_CD84.4154e-050.1924image
ENSG00000068654.14,POLR1AHNSCEAGT_cells_CD87.1237e-030.1257image
chr2:86022605-86025141:-KICHEERT_cells_gamma_delta1.8558e-020.3254image
chr2:86022605-86025141:-KIRCEERDendritic_cells_resting2.1184e-02-0.1290image
chr2:86022605-86025141:-KIRPEERDendritic_cells_resting1.0132e-02-0.1767image
ENSG00000068654.14,POLR1AKIRPEAGDendritic_cells_resting2.1395e-02-0.1479image
chr2:86022605-86025141:-LGGEERB_cells_memory8.0001e-040.1482image
ENSG00000068654.14,POLR1ALGGEAGB_cells_memory3.8653e-030.1272image
chr2:86022605-86025141:-LIHCEERMacrophages_M11.3591e-020.1591image
chr2:86022605-86025141:-LUADEERT_cells_CD4_memory_activated2.7600e-040.1758image
ENSG00000068654.14,POLR1ALUADEAGT_cells_CD4_memory_activated1.1003e-040.1835image
chr2:86022605-86025141:-LUSCEERMast_cells_activated3.9259e-020.0968image
ENSG00000068654.14,POLR1ALUSCEAGT_cells_CD4_memory_resting2.6551e-02-0.1029image
chr2:86022605-86025141:-MESOEERMonocytes1.1248e-02-0.2856image
chr2:86022605-86025141:-OVEERT_cells_CD4_memory_resting4.0586e-02-0.1225image
chr2:86084694-86085040:-OVEERMast_cells_resting1.0288e-020.3748image
ENSG00000068654.14,POLR1AOVEAGT_cells_CD4_memory_resting1.2284e-02-0.1489image
ENSG00000068654.14,POLR1APAADEAGT_cells_CD4_naive2.0045e-020.1885image
chr2:86020239-86020550:-PCPGEERT_cells_CD4_memory_activated5.0003e-030.2319image
chr2:86020239-86020550:-PRADEERB_cells_naive5.0964e-040.1846image
chr2:86022605-86025141:-PRADEERDendritic_cells_activated9.2424e-070.2291image
ENSG00000068654.14,POLR1APRADEAGDendritic_cells_activated4.7778e-100.2853image
chr2:86022605-86025141:-READEERDendritic_cells_activated1.1721e-02-0.2722image
ENSG00000068654.14,POLR1AREADEAGDendritic_cells_activated3.8060e-03-0.3107image
ENSG00000068654.14,POLR1ASARCEAGT_cells_CD4_memory_resting2.8279e-02-0.1428image
chr2:86022605-86025141:-SKCMEERT_cells_CD87.7977e-030.1236image
ENSG00000068654.14,POLR1ASKCMEAGT_cells_CD83.0213e-030.1371image
chr2:86022605-86025141:-STADEERMacrophages_M01.3258e-04-0.2004image
ENSG00000068654.14,POLR1ASTADEAGMacrophages_M01.7301e-04-0.1967image
chr2:86020239-86020550:-TGCTEERPlasma_cells1.1692e-020.2407image
chr2:86022605-86025141:-TGCTEERMacrophages_M12.2936e-02-0.1869image
ENSG00000068654.14,POLR1ATGCTEAGMast_cells_resting1.2799e-020.2028image
chr2:86022605-86025141:-THCAEERT_cells_regulatory_(Tregs)9.5330e-040.1554image
ENSG00000068654.14,POLR1ATHCAEAGT_cells_regulatory_(Tregs)1.3276e-020.1130image
ENSG00000068654.14,POLR1ATHYMEAGMacrophages_M13.9882e-030.2654image
chr2:86020239-86020550:-UCECEERMacrophages_M12.8880e-020.1861image
ENSG00000068654.14,POLR1AUCECEAGMast_cells_activated2.5534e-020.1760image
chr2:86022605-86025141:-UCSEERT_cells_CD83.2148e-020.2976image
ENSG00000068654.14,POLR1AUCSEAGB_cells_naive3.3301e-03-0.3960image


Top

6. Enriched editing regions and immune gene sets for POLR1A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr2:86022605-86025141:-STADEER2.9172e-03image4.6169e-020.1053image
ENSG00000068654.14,POLR1ASTADEAG1.3757e-02image4.1677e-020.1074image


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000068654.14,POLR1AUCSEAG1.3551e-020.33722.3551e-040.48465.0537e-030.37961.2301e-020.3416image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000068654.14,POLR1AACCGSVA_HALLMARK_MYC_TARGETS_V1EAG4.3305e-02-0.2618image
chr2:86022605-86025141:-ACCGSVA_HALLMARK_MYC_TARGETS_V1EER1.1816e-03-0.4375image
chr2:86022605-86025141:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.3563e-040.1822image
ENSG00000068654.14,POLR1ABLCAGSVA_HALLMARK_COMPLEMENTEAG2.0394e-070.2641image
chr2:86022605-86025141:-BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER7.1623e-08-0.1697image
ENSG00000068654.14,POLR1ABRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.2257e-06-0.1406image
chr2:86022605-86025141:-CESCGSVA_HALLMARK_G2M_CHECKPOINTEER2.8067e-03-0.1890image
chr2:86020239-86020550:-CESCGSVA_HALLMARK_HYPOXIAEER9.1622e-040.2417image
ENSG00000068654.14,POLR1ACESCGSVA_HALLMARK_MYC_TARGETS_V1EAG3.0676e-02-0.1318image
ENSG00000068654.14,POLR1ACHOLGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.7045e-02-0.3590image
chr2:86022605-86025141:-CHOLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.0379e-030.4837image
chr2:86022605-86025141:-COADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER6.3199e-03-0.1792image
ENSG00000068654.14,POLR1ACOADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.0893e-05-0.2732image
ENSG00000068654.14,POLR1ADLBCGSVA_HALLMARK_SPERMATOGENESISEAG2.1321e-02-0.3462image
chr2:86022605-86025141:-DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.3084e-03-0.4062image
ENSG00000068654.14,POLR1AESCAGSVA_HALLMARK_MYC_TARGETS_V2EAG3.9069e-03-0.2262image
chr2:86022605-86025141:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.3567e-030.2243image
chr2:86022605-86025141:-GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.5890e-03-0.2419image
ENSG00000068654.14,POLR1AGBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.4700e-06-0.3744image
chr2:86022605-86025141:-HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6218e-06-0.2250image
ENSG00000068654.14,POLR1AHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9907e-030.1344image
chr2:86022605-86025141:-KICHGSVA_HALLMARK_NOTCH_SIGNALINGEER2.1753e-020.3176image
chr2:86022605-86025141:-KIRCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.3656e-050.2343image
ENSG00000068654.14,POLR1AKIRCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG8.8667e-050.2122image
chr2:86022605-86025141:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER3.7067e-06-0.3124image
ENSG00000068654.14,POLR1AKIRPGSVA_HALLMARK_SPERMATOGENESISEAG9.8709e-03-0.1656image
chr2:86022605-86025141:-LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.5308e-03-0.3123image
ENSG00000068654.14,POLR1ALAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG9.9455e-03-0.3084image
ENSG00000068654.14,POLR1ALGGGSVA_HALLMARK_G2M_CHECKPOINTEAG1.1704e-11-0.2933image
chr2:86022605-86025141:-LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER4.9929e-11-0.2859image
chr2:86022605-86025141:-LIHCGSVA_HALLMARK_MYC_TARGETS_V1EER1.2788e-03-0.2067image
ENSG00000068654.14,POLR1ALIHCGSVA_HALLMARK_MYC_TARGETS_V1EAG2.4449e-02-0.1347image
chr2:86022605-86025141:-LUADGSVA_HALLMARK_COMPLEMENTEER3.0291e-040.1746image
ENSG00000068654.14,POLR1ALUADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.8550e-050.1983image
ENSG00000068654.14,POLR1ALUSCGSVA_HALLMARK_UV_RESPONSE_DNEAG3.7530e-02-0.0965image
chr2:86022605-86025141:-LUSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.7295e-020.1117image
chr2:86022605-86025141:-MESOGSVA_HALLMARK_COAGULATIONEER1.0518e-020.2882image
ENSG00000068654.14,POLR1AMESOGSVA_HALLMARK_APICAL_SURFACEEAG1.9171e-030.3397image
chr2:86022605-86025141:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1704e-04-0.2282image
ENSG00000068654.14,POLR1AOVGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6830e-05-0.2532image
chr2:86084694-86085040:-OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.5120e-02-0.3300image
chr2:86022605-86025141:-PAADGSVA_HALLMARK_P53_PATHWAYEER1.7613e-030.2621image
ENSG00000068654.14,POLR1APAADGSVA_HALLMARK_P53_PATHWAYEAG2.4432e-030.2441image
chr2:86020239-86020550:-PCPGGSVA_HALLMARK_UV_RESPONSE_DNEER2.7157e-040.2980image
ENSG00000068654.14,POLR1APCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG4.2424e-020.1545image
chr2:86022605-86025141:-PCPGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.4457e-03-0.2230image
chr2:86022605-86025141:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.1562e-09-0.2749image
chr2:86020239-86020550:-PRADGSVA_HALLMARK_UV_RESPONSE_DNEER4.7809e-070.2649image
ENSG00000068654.14,POLR1APRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0816e-04-0.1797image
chr2:86022605-86025141:-READGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.7786e-03-0.3109image
ENSG00000068654.14,POLR1AREADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.1344e-03-0.3168image
chr2:86022605-86025141:-SARCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.5030e-05-0.2728image
ENSG00000068654.14,POLR1ASARCGSVA_HALLMARK_COAGULATIONEAG8.1648e-050.2536image
chr2:86022605-86025141:-SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4393e-07-0.2417image
ENSG00000068654.14,POLR1ASKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.9565e-05-0.1805image
ENSG00000068654.14,POLR1ASTADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.1803e-07-0.2691image
chr2:86022605-86025141:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER9.3119e-07-0.2555image
chr2:86022605-86025141:-TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER5.5344e-07-0.3978image
ENSG00000068654.14,POLR1ATGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0283e-03-0.2405image
chr2:86020239-86020550:-TGCTGSVA_HALLMARK_SPERMATOGENESISEER2.3146e-030.2889image
chr2:86022605-86025141:-THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER9.7138e-03-0.1219image
ENSG00000068654.14,POLR1ATHCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.5950e-030.1327image
ENSG00000068654.14,POLR1ATHYMGSVA_HALLMARK_COAGULATIONEAG1.7274e-040.3419image
chr2:86022605-86025141:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1602e-04-0.3657image
chr2:86020239-86020550:-UCECGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.1635e-040.3222image
chr2:86022605-86025141:-UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER1.6015e-04-0.3044image
ENSG00000068654.14,POLR1AUCECGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.0981e-02-0.1818image
ENSG00000068654.14,POLR1AUCSGSVA_HALLMARK_GLYCOLYSISEAG1.7904e-030.4190image
chr2:86022605-86025141:-UCSGSVA_HALLMARK_DNA_REPAIREER1.4990e-020.3356image
ENSG00000068654.14,POLR1AUVMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.7053e-040.3884image
chr2:86022605-86025141:-UVMGSVA_HALLMARK_MITOTIC_SPINDLEEER8.5496e-04-0.3678image


Top

7. Enriched editing regions and drugs for POLR1A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000068654.14,POLR1AACCJNK.Inhibitor.VIIIEAG2.5827e-02-0.2877image
chr2:86022605-86025141:-ACCLFM.A13EER7.3669e-03-0.3675image
ENSG00000068654.14,POLR1ABLCACGP.60474EAG3.5268e-06-0.2365image
chr2:86022605-86025141:-BLCAGefitinibEER7.4406e-04-0.1802image
chr2:86022605-86025141:-BRCAA.770041EER1.2201e-03-0.1024image
ENSG00000068654.14,POLR1ABRCAABT.263EAG9.8882e-040.1029image
chr2:86022605-86025141:-CESCA.770041EER1.4231e-04-0.2392image
chr2:86020239-86020550:-CESCFTI.277EER5.2146e-03-0.2046image
chr2:86022605-86025141:-CHOLAZD6482EER1.3733e-020.4312image
ENSG00000068654.14,POLR1ACOADAZ628EAG4.8020e-060.2927image
chr2:86022605-86025141:-COADGW843682XEER4.3890e-020.1327image
ENSG00000068654.14,POLR1ADLBCGNF.2EAG1.9057e-03-0.4552image
chr2:86022605-86025141:-DLBCBMS.536924EER5.1292e-04-0.5245image
chr2:86022605-86025141:-ESCABleomycinEER1.2315e-03-0.2533image
ENSG00000068654.14,POLR1AESCABleomycinEAG1.0880e-04-0.3003image
ENSG00000068654.14,POLR1AGBMGDC.0449EAG1.3458e-05-0.3407image
chr2:86022605-86025141:-GBMGDC.0449EER1.2883e-05-0.3446image
chr2:86022605-86025141:-HNSCBMS.509744EER2.5824e-09-0.2776image
ENSG00000068654.14,POLR1AHNSCDocetaxelEAG3.4283e-03-0.1366image
chr2:86022605-86025141:-KICHJW.7.52.1EER3.0794e-02-0.2999image
ENSG00000068654.14,POLR1AKIRCBMS.509744EAG1.4972e-07-0.2818image
chr2:86022605-86025141:-KIRCBMS.509744EER2.5276e-07-0.2838image
ENSG00000068654.14,POLR1AKIRPCMKEAG4.8831e-020.1268image
chr2:86022605-86025141:-KIRPBryostatin.1EER7.4568e-05-0.2692image
ENSG00000068654.14,POLR1ALAMLGDC0941EAG2.7129e-02-0.2661image
chr2:86022605-86025141:-LAMLGDC0941EER2.6583e-02-0.2689image
ENSG00000068654.14,POLR1ALGGEpothilone.BEAG1.3832e-110.2923image
chr2:86022605-86025141:-LGGGemcitabineEER2.3223e-050.1864image
chr2:86022605-86025141:-LIHCCyclopamineEER1.5968e-02-0.1587image
ENSG00000068654.14,POLR1ALIHCCHIR.99021EAG1.9270e-020.1516image
ENSG00000068654.14,POLR1ALUADFH535EAG3.2898e-040.1706image
chr2:86022605-86025141:-LUADAZD7762EER1.4464e-04-0.1835image
chr2:86022605-86025141:-LUSCCI.1040EER9.2991e-03-0.1219image
ENSG00000068654.14,POLR1ALUSCCEP.701EAG3.8118e-02-0.0962image
ENSG00000068654.14,POLR1AMESOBIRB.0796EAG6.6120e-050.4284image
chr2:86022605-86025141:-MESOA.770041EER8.9088e-04-0.3688image
chr2:86022605-86025141:-OVAZD6482EER1.3208e-040.2269image
ENSG00000068654.14,POLR1AOVEmbelinEAG1.3388e-050.2561image
chr2:86022605-86025141:-PAADBexaroteneEER3.4476e-03-0.2456image
ENSG00000068654.14,POLR1APAADBexaroteneEAG3.7697e-03-0.2336image
ENSG00000068654.14,POLR1APCPGLenalidomideEAG5.5525e-030.2100image
chr2:86022605-86025141:-PCPGBMS.536924EER1.8416e-03-0.2498image
chr2:86020239-86020550:-PCPGDMOGEER3.9506e-04-0.2904image
ENSG00000068654.14,POLR1APRADATRAEAG6.7794e-06-0.2086image
chr2:86020239-86020550:-PRADBMS.708163EER3.4476e-07-0.2680image
chr2:86022605-86025141:-PRADGefitinibEER3.6677e-07-0.2372image
ENSG00000068654.14,POLR1AREADKIN001.135EAG9.3099e-030.2805image
chr2:86022605-86025141:-READKIN001.135EER5.3955e-030.2993image
chr2:86022605-86025141:-SARCBAY.61.3606EER4.7547e-040.2316image
ENSG00000068654.14,POLR1ASARCEmbelinEAG1.6054e-040.2433image
chr2:86022605-86025141:-SKCMAZD6244EER4.0473e-07-0.2331image
ENSG00000068654.14,POLR1ASKCMAZD6244EAG1.7251e-06-0.2195image
ENSG00000068654.14,POLR1ASTADBMS.536924EAG1.4228e-05-0.2266image
chr2:86022605-86025141:-STADKU.55933EER1.6347e-05-0.2253image
chr2:86020239-86020550:-TGCTBMS.708163EER2.1443e-03-0.2910image
chr2:86022605-86025141:-TGCTEmbelinEER3.5302e-100.4868image
ENSG00000068654.14,POLR1ATGCTEtoposideEAG2.5536e-050.3365image
chr2:86022605-86025141:-THCAEmbelinEER4.4009e-040.1652image
ENSG00000068654.14,POLR1ATHCAAG.014699EAG2.4644e-050.1912image
chr2:86022605-86025141:-THYMDMOGEER1.1878e-040.3651image
ENSG00000068654.14,POLR1ATHYMBI.D1870EAG1.1696e-030.2978image
chr2:86022605-86025141:-UCECDasatinibEER1.2475e-03-0.2638image
ENSG00000068654.14,POLR1AUCECAKT.inhibitor.VIIIEAG3.8909e-04-0.2763image
chr2:86020239-86020550:-UCECAMG.706EER7.0883e-040.2848image
chr2:86022605-86025141:-UCSCCT007093EER3.1372e-040.4803image
ENSG00000068654.14,POLR1AUCSFTI.277EAG2.3463e-04-0.4848image
chr2:86022605-86025141:-UVMBAY.61.3606EER9.2248e-050.4256image
ENSG00000068654.14,POLR1AUVMIPA.3EAG1.3209e-060.5104image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType