CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZDHHC20 (ImmuneEditome ID:253832)

1. Gene summary of enriched editing regions for ZDHHC20

check button Gene summary
Gene informationGene symbol

ZDHHC20

Gene ID

253832

GeneSynonyms4933421L13Rik|DHHC-20|DHHC20
GeneCytomap

13q12.11

GeneTypeprotein-coding
GeneDescriptionpalmitoyltransferase ZDHHC20|DHHC domain-containing cysteine-rich protein 20|acyltransferase ZDHHC20|probable palmitoyltransferase ZDHHC20|zinc finger DHHC domain-containing protein 20|zinc finger DHHC-type containing 20
GeneModificationdate20230517
UniprotIDQ5W0Z9;B4DRN8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr13:21374272-21375145:-ENST00000626464.1ENSG00000180776.14ZDHHC20splicingAluSz,AluSxchr13:21374272-21375145:-.alignment
chr13:21379905-21380693:-ENST00000464055.4ENSG00000180776.14ZDHHC20ncRNA_intronicTigger15a,AluYe5,AluSg,AluSc8chr13:21379905-21380693:-.alignment
chr13:21379905-21380693:-ENST00000477811.4ENSG00000180776.14ZDHHC20ncRNA_intronicTigger15a,AluYe5,AluSg,AluSc8chr13:21379905-21380693:-.alignment
chr13:21379905-21380693:-ENST00000494731.4ENSG00000180776.14ZDHHC20ncRNA_intronicTigger15a,AluYe5,AluSg,AluSc8chr13:21379905-21380693:-.alignment
chr13:21391063-21391289:-ENST00000494731.4ENSG00000180776.14ZDHHC20ncRNA_intronicAluJbchr13:21391063-21391289:-.alignment
chr13:21395169-21397539:-ENST00000494731.4ENSG00000180776.14ZDHHC20ncRNA_intronicAluSq2,L1M5,AluJb,AluSc,AluSx,MIRb,AluY,MER74Achr13:21395169-21397539:-.alignment
chr13:21400799-21401271:-ENST00000494731.4ENSG00000180776.14ZDHHC20ncRNA_intronicAluJo,AluSx1,L1MB2chr13:21400799-21401271:-.alignment
chr13:21426659-21426923:-ENST00000320220.12ENSG00000180776.14ZDHHC20intronicAluSzchr13:21426659-21426923:-.alignment
chr13:21426659-21426923:-ENST00000382466.6ENSG00000180776.14ZDHHC20intronicAluSzchr13:21426659-21426923:-.alignment
chr13:21426659-21426923:-ENST00000400590.6ENSG00000180776.14ZDHHC20intronicAluSzchr13:21426659-21426923:-.alignment
chr13:21426659-21426923:-ENST00000415724.2ENSG00000180776.14ZDHHC20intronicAluSzchr13:21426659-21426923:-.alignment
chr13:21426659-21426923:-ENST00000542645.4ENSG00000180776.14ZDHHC20intronicAluSzchr13:21426659-21426923:-.alignment
chr13:21432392-21433544:-ENST00000320220.12ENSG00000180776.14ZDHHC20intronicAluSz,L1M5,FLAM_A,AluYchr13:21432392-21433544:-.alignment
chr13:21432392-21433544:-ENST00000382466.6ENSG00000180776.14ZDHHC20intronicAluSz,L1M5,FLAM_A,AluYchr13:21432392-21433544:-.alignment
chr13:21432392-21433544:-ENST00000400590.6ENSG00000180776.14ZDHHC20intronicAluSz,L1M5,FLAM_A,AluYchr13:21432392-21433544:-.alignment
chr13:21432392-21433544:-ENST00000415724.2ENSG00000180776.14ZDHHC20intronicAluSz,L1M5,FLAM_A,AluYchr13:21432392-21433544:-.alignment
chr13:21432392-21433544:-ENST00000542645.4ENSG00000180776.14ZDHHC20intronicAluSz,L1M5,FLAM_A,AluYchr13:21432392-21433544:-.alignment
chr13:21441410-21442679:-ENST00000320220.12ENSG00000180776.14ZDHHC20intronicAluY,(T)n,L1M7,AluSzchr13:21441410-21442679:-.alignment
chr13:21441410-21442679:-ENST00000382466.6ENSG00000180776.14ZDHHC20intronicAluY,(T)n,L1M7,AluSzchr13:21441410-21442679:-.alignment
chr13:21441410-21442679:-ENST00000400590.6ENSG00000180776.14ZDHHC20intronicAluY,(T)n,L1M7,AluSzchr13:21441410-21442679:-.alignment
chr13:21441410-21442679:-ENST00000415724.2ENSG00000180776.14ZDHHC20intronicAluY,(T)n,L1M7,AluSzchr13:21441410-21442679:-.alignment
chr13:21441410-21442679:-ENST00000542645.4ENSG00000180776.14ZDHHC20intronicAluY,(T)n,L1M7,AluSzchr13:21441410-21442679:-.alignment
chr13:21444061-21445029:-ENST00000320220.12ENSG00000180776.14ZDHHC20intronicCharlie18a,AluSx,AluJo,(TA)nchr13:21444061-21445029:-.alignment
chr13:21444061-21445029:-ENST00000382466.6ENSG00000180776.14ZDHHC20intronicCharlie18a,AluSx,AluJo,(TA)nchr13:21444061-21445029:-.alignment
chr13:21444061-21445029:-ENST00000400590.6ENSG00000180776.14ZDHHC20intronicCharlie18a,AluSx,AluJo,(TA)nchr13:21444061-21445029:-.alignment
chr13:21444061-21445029:-ENST00000415724.2ENSG00000180776.14ZDHHC20intronicCharlie18a,AluSx,AluJo,(TA)nchr13:21444061-21445029:-.alignment
chr13:21444061-21445029:-ENST00000542645.4ENSG00000180776.14ZDHHC20intronicCharlie18a,AluSx,AluJo,(TA)nchr13:21444061-21445029:-.alignment
chr13:21449779-21451959:-ENST00000320220.12ENSG00000180776.14ZDHHC20intronicAluSx,AluJr,L2,AluSq2,(ATTCA)n,L1MB7chr13:21449779-21451959:-.alignment
chr13:21449779-21451959:-ENST00000382466.6ENSG00000180776.14ZDHHC20intronicAluSx,AluJr,L2,AluSq2,(ATTCA)n,L1MB7chr13:21449779-21451959:-.alignment
chr13:21449779-21451959:-ENST00000400590.6ENSG00000180776.14ZDHHC20intronicAluSx,AluJr,L2,AluSq2,(ATTCA)n,L1MB7chr13:21449779-21451959:-.alignment
chr13:21449779-21451959:-ENST00000415724.2ENSG00000180776.14ZDHHC20intronicAluSx,AluJr,L2,AluSq2,(ATTCA)n,L1MB7chr13:21449779-21451959:-.alignment
chr13:21449779-21451959:-ENST00000542645.4ENSG00000180776.14ZDHHC20intronicAluSx,AluJr,L2,AluSq2,(ATTCA)n,L1MB7chr13:21449779-21451959:-.alignment


Top

2. Tumor-specific enriched editing regions for ZDHHC20


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr13:21374272-21375145:-BRCAEER4.3932e-31image
ENSG00000180776.14,ZDHHC20BRCAEAG4.0270e-31image
chr13:21374272-21375145:-COADEER3.3578e-24image
ENSG00000180776.14,ZDHHC20COADEAG2.1884e-24image
chr13:21374272-21375145:-HNSCEER1.0009e-09image
ENSG00000180776.14,ZDHHC20HNSCEAG3.9099e-10image
chr13:21374272-21375145:-KIRCEER2.0811e-08image
ENSG00000180776.14,ZDHHC20KIRCEAG2.6933e-08image
chr13:21374272-21375145:-LUADEER1.2839e-16image
ENSG00000180776.14,ZDHHC20LUADEAG9.0079e-17image
chr13:21374272-21375145:-STADEER1.4470e-07image
ENSG00000180776.14,ZDHHC20STADEAG2.2061e-07image
chr13:21374272-21375145:-THCAEER5.2167e-05image
ENSG00000180776.14,ZDHHC20THCAEAG4.3259e-05image
chr13:21374272-21375145:-UCECEER2.3715e-05image
ENSG00000180776.14,ZDHHC20UCECEAG2.2013e-05image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr13:21374272-21375145:-BLCAPathEER2.4753e-035.9679e-040.1735image
ENSG00000180776.14,ZDHHC20BLCAPathEAG4.8030e-037.8267e-040.1683image
chr13:21374272-21375145:-BRCAPathEER2.8824e-021.7387e-020.0734image
ENSG00000180776.14,ZDHHC20BRCAPathEAG4.4537e-022.3615e-020.0698image
ENSG00000180776.14,ZDHHC20DLBCCliEAG3.7216e-023.6623e-02-0.4286image
ENSG00000180776.14,ZDHHC20KIRCPathEAG1.0011e-023.7057e-030.1276image
chr13:21374272-21375145:-KIRCPathEER1.5567e-025.2958e-030.1227image
chr13:21374272-21375145:-LIHCPathEER1.4555e-023.3419e-03-0.1903image
ENSG00000180776.14,ZDHHC20LIHCPathEAG1.4555e-023.3419e-03-0.1903image
chr13:21374272-21375145:-READPathEER3.2340e-029.8121e-03-0.2075image
ENSG00000180776.14,ZDHHC20READPathEAG1.9890e-023.3073e-03-0.2346image
ENSG00000180776.14,ZDHHC20THCAPathEAG5.2445e-049.7714e-040.1488image
chr13:21374272-21375145:-THCAPathEER3.4506e-045.5036e-040.1562image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for ZDHHC20


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr13:21374272-21375145:-BLCAEERENSG00000204267,TAP20.56822.0617e-282.2104e-320.5530imageNACIN1;BUD13;CPSF6;CSTF2T;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1TAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000168394,TAP10.54132.5703e-252.2201e-280.5216imageNBUD13;CSTF2T;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;NOP56;NOP58;PRPF8;PTBP1;SF3A3;SF3B4;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1TAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000134470,IL15RA0.53469.4422e-254.3279e-310.5432imageNCPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;IGF2BP1;IGF2BP2;LIN28;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM22;SLTM;SMNDC1;SRSF1;SRSF3;TARDBP;TRA2A;U2AF1;U2AF2;UPF1IL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000059378,PARP120.52881.8124e-241.5717e-270.5144imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;METTL3;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000156587,UBE2L60.53252.3206e-241.2497e-270.5153imageNBUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM22;SF3B4;SLTM;SMNDC1;SRSF1;TARDBP;TRA2A;U2AF1;U2AF2;UPF1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000240065,PSMB90.52804.7213e-243.1889e-290.5285imageNBUD13;EIF4A3;ELAVL1;FBL;FUS;IGF2BP2;LIN28B;NOP58;PRPF8;SRSF1;SRSF3;U2AF2;UPF1PSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000125347,IRF10.52122.5085e-238.3914e-240.4810imageNALYREF;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1IRF1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000115267,IFIH10.51341.4606e-221.9121e-210.4578imageNBUD13;CNBP;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1IFIH1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000068079,IFI350.51212.3519e-221.3036e-270.5151imageNBUD13;CSTF2T;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;METTL3;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1IFI35T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-BLCAEERENSG00000234745,HLA-B0.50955.1090e-222.2452e-290.5297imageNACIN1;ALYREF;BUD13;CNBP;CPSF6;CSTF2T;DGCR8;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TRA2A;U2AF1;U2AF2;UPF1HLA-BT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

More results



Top

4. Enriched editing regions and immune related splicing for ZDHHC20


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr13:21374272-21375145:-
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.66282.0973e-412.7003e-46-0.6424imageNACIN1;ALYREF;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr13:21374272-21375145:-
BLCAEERMEXENSG00000140105.13chr14100342397:100342571:100343274:100343387:100369086:100369258:100376259:1003762850.49011.5634e-182.0085e-230.4774imageNACIN1;ALYREF;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;METTL3;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1WARST_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000180776.14,ZDHHC20
BLCAEAGESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.42402.0955e-131.1641e-220.4668imageNACIN1;ADAR;AIFM1;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28B;MBNL1;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;SF3B4;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;U2AF1;U2AF2;UPF1;YTHDF1;ZNF184ITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr13:21374272-21375145:-
BLCAEERIRENSG00000139278.5chr1275495576:75498720:75498823:75503853-0.35631.0079e-095.6464e-17-0.4087imageNEIF4A3;ELAVL1;FMR1;FUS;IGF2BP1;IGF2BP2;LIN28B;MOV10;NOP56;PTBP1;SRSF1;SRSF3;SRSF9;U2AF1;UPF1NADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000180776.14,ZDHHC20
BLCAEAGIRENSG00000139725.3chr12121777757:121779662:121780871:121781006-0.38788.0767e-131.5327e-16-0.4208imageNACIN1;ADAR;AIFM1;ALYREF;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MBNL2;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;SF3B4;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184NAMacrophages_M1GSVA_HALLMARK_COMPLEMENT
chr13:21374272-21375145:-
BLCAEERESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.44391.1757e-147.4260e-250.4908imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SF3B4;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1ITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr13:21374272-21375145:-
BLCAEERIRENSG00000139725.3chr12121777757:121779662:121780871:121781006-0.39543.1622e-136.9698e-17-0.4285imageNACIN1;ALYREF;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;METTL3;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TARDBP;TRA2A;U2AF1;U2AF2;UPF1NAMacrophages_M1GSVA_HALLMARK_COMPLEMENT
ENSG00000180776.14,ZDHHC20
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.63128.4102e-372.6423e-41-0.6093imageNACIN1;ADAR;AIFM1;ALYREF;BCCIP;BUD13;CAPRIN1;CBX7;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LARP7;LIN28A;LIN28B;MBNL1;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;SF3B4;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000180776.14,ZDHHC20
BLCAEAGMEXENSG00000140105.13chr14100342397:100342571:100343274:100343387:100369086:100369258:100376259:1003762850.49492.0617e-191.1866e-230.4769imageNACIN1;ADAR;AIFM1;ALYREF;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LARP7;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;SF3B4;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZC3H7B;ZNF184WARST_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000180776.14,ZDHHC20
BLCAEAGIRENSG00000139278.5chr1275495576:75498720:75498823:75503853-0.35431.2577e-092.7655e-17-0.4095imageNADAR;DKC1;EIF4A3;ELAVL1;ELAVL3;FMR1;FUS;HNRNPC;HNRNPL;IGF2BP1;IGF2BP2;KHDRBS2;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;PTBP1;RBFOX2;RBM47;RBM5;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;U2AF1;UPF1;YTHDC1NADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

More results



Top

5. Enriched editing regions and immune infiltration for ZDHHC20


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr13:21374272-21375145:-ACCEERT_cells_CD4_memory_activated2.9950e-020.2829image
ENSG00000180776.14,ZDHHC20ACCEAGT_cells_CD4_memory_activated2.0768e-020.3005image
chr13:21374272-21375145:-BLCAEERMacrophages_M18.9659e-190.4292image
ENSG00000180776.14,ZDHHC20BLCAEAGMacrophages_M11.8189e-170.4107image
chr13:21374272-21375145:-BRCAEERB_cells_naive5.6821e-08-0.1664image
ENSG00000180776.14,ZDHHC20BRCAEAGB_cells_naive6.2475e-08-0.1657image
chr13:21374272-21375145:-CESCEERMacrophages_M11.3965e-040.2230image
ENSG00000180776.14,ZDHHC20CESCEAGMacrophages_M13.7469e-040.2079image
chr13:21374272-21375145:-CHOLEERT_cells_regulatory_(Tregs)6.2495e-050.6556image
ENSG00000180776.14,ZDHHC20CHOLEAGT_cells_regulatory_(Tregs)1.3235e-020.4333image
chr13:21374272-21375145:-COADEERMacrophages_M13.9331e-070.3001image
ENSG00000180776.14,ZDHHC20COADEAGMacrophages_M12.4723e-060.2796image
chr13:21374272-21375145:-DLBCEERMacrophages_M23.4548e-030.5336image
ENSG00000180776.14,ZDHHC20DLBCEAGMacrophages_M21.6611e-020.4487image
chr13:21374272-21375145:-ESCAEERDendritic_cells_resting5.3774e-04-0.2698image
chr13:21441410-21442679:-ESCAEERB_cells_naive2.6584e-02-0.2527image
ENSG00000180776.14,ZDHHC20ESCAEAGDendritic_cells_resting7.2126e-04-0.2638image
chr13:21374272-21375145:-GBMEERMacrophages_M01.8833e-08-0.4193image
ENSG00000180776.14,ZDHHC20GBMEAGMacrophages_M01.6701e-08-0.4207image
chr13:21374272-21375145:-HNSCEERMacrophages_M11.5846e-090.2724image
ENSG00000180776.14,ZDHHC20HNSCEAGMacrophages_M12.1819e-060.2149image
chr13:21374272-21375145:-KIRCEERMacrophages_M21.5321e-04-0.1948image
ENSG00000180776.14,ZDHHC20KIRCEAGMacrophages_M21.7377e-04-0.1929image
chr13:21374272-21375145:-KIRPEERB_cells_memory1.7810e-030.2054image
ENSG00000180776.14,ZDHHC20KIRPEAGB_cells_memory1.7810e-030.2054image
chr13:21400799-21401271:-LAMLEERNK_cells_activated8.9989e-030.3588image
chr13:21449779-21451959:-LAMLEERT_cells_CD4_memory_activated4.0148e-02-0.2942image
ENSG00000180776.14,ZDHHC20LAMLEAGMacrophages_M24.6801e-02-0.1626image
chr13:21374272-21375145:-LGGEERMacrophages_M11.8071e-050.1886image
ENSG00000180776.14,ZDHHC20LGGEAGMacrophages_M13.0747e-050.1833image
chr13:21374272-21375145:-LIHCEERMacrophages_M12.5964e-080.3386image
ENSG00000180776.14,ZDHHC20LIHCEAGMacrophages_M12.5964e-080.3386image
chr13:21374272-21375145:-LUADEERT_cells_CD4_memory_activated5.3130e-050.1780image
ENSG00000180776.14,ZDHHC20LUADEAGT_cells_CD4_memory_activated1.3830e-040.1678image
chr13:21374272-21375145:-LUSCEERT_cells_CD4_memory_activated5.5432e-110.2882image
ENSG00000180776.14,ZDHHC20LUSCEAGT_cells_CD4_memory_activated7.0957e-110.2867image
chr13:21374272-21375145:-MESOEERT_cells_follicular_helper1.4244e-030.3595image
ENSG00000180776.14,ZDHHC20MESOEAGT_cells_follicular_helper1.4244e-030.3595image
chr13:21374272-21375145:-OVEERT_cells_follicular_helper1.8442e-050.2482image
ENSG00000180776.14,ZDHHC20OVEAGT_cells_follicular_helper1.1829e-050.2533image
chr13:21374272-21375145:-PAADEERB_cells_naive6.0867e-03-0.2078image
ENSG00000180776.14,ZDHHC20PAADEAGB_cells_naive5.7929e-03-0.2084image
chr13:21374272-21375145:-PCPGEERT_cells_CD89.2371e-050.3032image
ENSG00000180776.14,ZDHHC20PCPGEAGT_cells_CD89.2371e-050.3032image
chr13:21374272-21375145:-PRADEERT_cells_regulatory_(Tregs)1.9081e-050.1962image
ENSG00000180776.14,ZDHHC20PRADEAGT_cells_regulatory_(Tregs)1.0001e-030.1504image
chr13:21374272-21375145:-READEERDendritic_cells_resting3.1440e-02-0.2221image
ENSG00000180776.14,ZDHHC20READEAGDendritic_cells_resting2.4843e-02-0.2302image
chr13:21374272-21375145:-SARCEERMacrophages_M02.0918e-03-0.2002image
ENSG00000180776.14,ZDHHC20SARCEAGMacrophages_M02.1151e-03-0.2000image
chr13:21374272-21375145:-SKCMEERT_cells_CD81.9800e-080.2645image
ENSG00000180776.14,ZDHHC20SKCMEAGT_cells_CD87.0898e-090.2721image
chr13:21374272-21375145:-STADEERT_cells_CD4_memory_activated2.5652e-080.2826image
chr13:21379905-21380693:-STADEERT_cells_regulatory_(Tregs)5.7028e-03-0.5945image
chr13:21395169-21397539:-STADEERDendritic_cells_activated1.3569e-02-0.2380image
chr13:21444061-21445029:-STADEERT_cells_gamma_delta1.1973e-020.4261image
ENSG00000180776.14,ZDHHC20STADEAGT_cells_CD4_memory_activated1.7276e-080.2860image
chr13:21374272-21375145:-TGCTEERMacrophages_M21.2433e-04-0.3176image
ENSG00000180776.14,ZDHHC20TGCTEAGMacrophages_M21.2433e-04-0.3176image
chr13:21374272-21375145:-THCAEERT_cells_regulatory_(Tregs)2.3125e-050.1905image
ENSG00000180776.14,ZDHHC20THCAEAGT_cells_regulatory_(Tregs)1.1818e-050.1967image
chr13:21374272-21375145:-THYMEERNK_cells_resting3.4711e-060.4718image
ENSG00000180776.14,ZDHHC20THYMEAGNK_cells_resting1.6368e-050.4373image
chr13:21374272-21375145:-UCECEERT_cells_CD4_memory_resting4.0284e-03-0.2305image
ENSG00000180776.14,ZDHHC20UCECEAGT_cells_CD4_memory_resting3.2862e-03-0.2304image


Top

6. Enriched editing regions and immune gene sets for ZDHHC20


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000180776.14,ZDHHC20BLCAEAG1.6521e-080.27963.9346e-030.14501.3710e-070.26167.8831e-090.2856image
chr13:21374272-21375145:-BLCAEER1.1822e-080.28483.0735e-030.15017.4183e-080.26933.5994e-090.2943image
chr13:21374272-21375145:-HNSCEER3.6677e-020.09593.5003e-04-0.16344.6007e-020.09161.8256e-030.1427image
ENSG00000180776.14,ZDHHC20LUADEAG1.8039e-050.18841.5778e-050.18974.1521e-060.20201.4460e-030.1406image
chr13:21374272-21375145:-LUADEER1.1809e-050.19261.2092e-050.19241.9413e-060.20891.4163e-030.1410image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000180776.14,ZDHHC20ACCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.4802e-020.2920image
chr13:21374272-21375145:-ACCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.3030e-020.2780image
ENSG00000180776.14,ZDHHC20BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.8323e-280.5167image
chr13:21374272-21375145:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.5173e-290.5272image
chr13:21374272-21375145:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7175e-480.4296image
ENSG00000180776.14,ZDHHC20BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0143e-470.4248image
chr13:21374272-21375145:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4711e-170.4721image
ENSG00000180776.14,ZDHHC20CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0669e-160.4622image
chr13:21374272-21375145:-CHOLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2925e-020.4414image
ENSG00000180776.14,ZDHHC20CHOLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4490e-020.4282image
chr13:21374272-21375145:-COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.5982e-090.3464image
ENSG00000180776.14,ZDHHC20COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6057e-080.3278image
ENSG00000180776.14,ZDHHC20DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.9325e-02-0.4394image
chr13:21374272-21375145:-DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1409e-03-0.5826image
ENSG00000180776.14,ZDHHC20ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0688e-100.4809image
chr13:21426659-21426923:-ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.2509e-020.3265image
chr13:21374272-21375145:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3356e-100.4731image
chr13:21441410-21442679:-ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.3791e-02-0.2796image
chr13:21374272-21375145:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.5736e-120.4992image
ENSG00000180776.14,ZDHHC20GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.7997e-120.4979image
chr13:21374272-21375145:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1390e-360.5304image
ENSG00000180776.14,ZDHHC20HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2067e-240.4456image
chr13:21374272-21375145:-KICHGSVA_HALLMARK_PROTEIN_SECRETIONEER3.9822e-02-0.2731image
ENSG00000180776.14,ZDHHC20KICHGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.9822e-02-0.2731image
ENSG00000180776.14,ZDHHC20KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.5776e-050.2032image
chr13:21374272-21375145:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.5222e-050.2035image
ENSG00000180776.14,ZDHHC20KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.8518e-07-0.3252image
chr13:21374272-21375145:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER4.8518e-07-0.3252image
chr13:21400799-21401271:-LAMLGSVA_HALLMARK_MYC_TARGETS_V1EER5.2405e-03-0.3817image
chr13:21374272-21375145:-LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEER3.1761e-02-0.1760image
chr13:21374272-21375145:-LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.4358e-180.3721image
ENSG00000180776.14,ZDHHC20LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.7990e-170.3596image
ENSG00000180776.14,ZDHHC20LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.4043e-120.4163image
chr13:21374272-21375145:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.4043e-120.4163image
chr13:21374272-21375145:-LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.1233e-130.3107image
ENSG00000180776.14,ZDHHC20LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4470e-120.3064image
chr13:21374272-21375145:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2772e-220.4193image
ENSG00000180776.14,ZDHHC20LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5909e-220.4184image
ENSG00000180776.14,ZDHHC20MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6767e-030.3545image
chr13:21374272-21375145:-MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6767e-030.3545image
chr13:21441410-21442679:-OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.7119e-020.3241image
chr13:21374272-21375145:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.6028e-230.5353image
ENSG00000180776.14,ZDHHC20OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.4822e-230.5382image
chr13:21374272-21375145:-PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0988e-050.3173image
ENSG00000180776.14,ZDHHC20PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.7831e-050.3190image
chr13:21374272-21375145:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.5482e-060.3469image
ENSG00000180776.14,ZDHHC20PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.5482e-060.3469image
chr13:21374272-21375145:-PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER5.4308e-07-0.2291image
ENSG00000180776.14,ZDHHC20PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.9371e-09-0.2707image
chr13:21374272-21375145:-READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.9442e-030.2946image
ENSG00000180776.14,ZDHHC20READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.1144e-060.4425image
ENSG00000180776.14,ZDHHC20SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.0943e-120.4266image
chr13:21374272-21375145:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.4337e-120.4283image
chr13:21374272-21375145:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.8568e-110.3065image
ENSG00000180776.14,ZDHHC20SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2685e-110.3057image
chr13:21395169-21397539:-STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.4973e-030.2726image
chr13:21441410-21442679:-STADGSVA_HALLMARK_HYPOXIAEER1.6301e-040.2993image
chr13:21444061-21445029:-STADGSVA_HALLMARK_P53_PATHWAYEER1.5025e-030.5231image
chr13:21374272-21375145:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5811e-250.4988image
ENSG00000180776.14,ZDHHC20STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.9888e-250.5012image
chr13:21379905-21380693:-STADGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER6.7956e-030.5845image
chr13:21374272-21375145:-TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.3986e-07-0.4138image
ENSG00000180776.14,ZDHHC20TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.3986e-07-0.4138image
chr13:21374272-21375145:-THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.1436e-110.2973image
ENSG00000180776.14,ZDHHC20THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.0732e-100.2866image
ENSG00000180776.14,ZDHHC20THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0826e-06-0.4878image
chr13:21374272-21375145:-THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.3964e-050.4340image
chr13:21374272-21375145:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.4903e-080.4265image
ENSG00000180776.14,ZDHHC20UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.9675e-080.4198image
chr13:21374272-21375145:-UCSGSVA_HALLMARK_P53_PATHWAYEER9.2520e-040.4541image
ENSG00000180776.14,ZDHHC20UCSGSVA_HALLMARK_P53_PATHWAYEAG6.1898e-040.4632image
ENSG00000180776.14,ZDHHC20UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.3487e-020.3413image
chr13:21374272-21375145:-UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.3487e-020.3413image


Top

7. Enriched editing regions and drugs for ZDHHC20


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000180776.14,ZDHHC20ACCEHT.1864EAG1.1064e-020.3286image
chr13:21374272-21375145:-ACCEHT.1864EER1.5086e-020.3150image
chr13:21374272-21375145:-BLCACGP.60474EER3.8231e-20-0.4442image
ENSG00000180776.14,ZDHHC20BLCACGP.60474EAG1.2063e-18-0.4242image
ENSG00000180776.14,ZDHHC20BRCACGP.082996EAG1.1059e-08-0.1748image
chr13:21374272-21375145:-BRCACGP.082996EER6.3585e-09-0.1778image
ENSG00000180776.14,ZDHHC20CESCAZD6244EAG3.4677e-10-0.3584image
chr13:21374272-21375145:-CESCAZD.2281EER1.0127e-08-0.3301image
chr13:21374272-21375145:-CHOLCHIR.99021EER2.7750e-020.3953image
ENSG00000180776.14,ZDHHC20CHOLErlotinibEAG4.2459e-02-0.3608image
ENSG00000180776.14,ZDHHC20COADCisplatinEAG3.2536e-06-0.2764image
chr13:21374272-21375145:-COADCisplatinEER1.3613e-06-0.2865image
ENSG00000180776.14,ZDHHC20DLBCA.770041EAG3.3746e-03-0.5347image
chr13:21374272-21375145:-DLBCBMS.536924EER2.4366e-04-0.6402image
chr13:21374272-21375145:-ESCAGDC.0449EER1.4197e-03-0.2502image
ENSG00000180776.14,ZDHHC20ESCAGDC.0449EAG2.6235e-03-0.2363image
chr13:21426659-21426923:-ESCALapatinibEER1.0462e-020.4105image
chr13:21395169-21397539:-ESCACMKEER1.3551e-02-0.4024image
ENSG00000180776.14,ZDHHC20GBMBIBW2992EAG3.4523e-12-0.5062image
chr13:21374272-21375145:-GBMBIBW2992EER3.9634e-12-0.5050image
ENSG00000180776.14,ZDHHC20HNSCAZD6244EAG2.8657e-15-0.3513image
chr13:21374272-21375145:-HNSCCGP.60474EER2.9408e-14-0.3393image
chr13:21374272-21375145:-KICHLapatinibEER1.2568e-020.3286image
ENSG00000180776.14,ZDHHC20KICHLapatinibEAG1.2568e-020.3286image
chr13:21374272-21375145:-KIRCBMS.536924EER3.1001e-04-0.1862image
ENSG00000180776.14,ZDHHC20KIRCBexaroteneEAG3.5505e-040.1837image
chr13:21374272-21375145:-KIRPAZD6482EER4.2209e-070.3268image
ENSG00000180776.14,ZDHHC20KIRPAZD6482EAG4.2209e-070.3268image
chr13:21400799-21401271:-LAMLAZD6244EER1.0806e-02-0.3507image
chr13:21374272-21375145:-LAMLAZD6482EER2.9154e-020.1788image
chr13:21449779-21451959:-LAMLEHT.1864EER2.2762e-02-0.3248image
chr13:21374272-21375145:-LGGKU.55933EER3.6749e-14-0.3272image
ENSG00000180776.14,ZDHHC20LGGKU.55933EAG1.3077e-15-0.3440image
ENSG00000180776.14,ZDHHC20LIHCBMS.754807EAG3.1721e-110.3995image
chr13:21374272-21375145:-LIHCBMS.754807EER3.1721e-110.3995image
chr13:21374272-21375145:-LUADFTI.277EER5.0686e-09-0.2552image
ENSG00000180776.14,ZDHHC20LUADFTI.277EAG9.1305e-09-0.2507image
chr13:21374272-21375145:-LUSCGemcitabineEER5.6860e-09-0.2573image
ENSG00000180776.14,ZDHHC20LUSCGemcitabineEAG5.7618e-09-0.2572image
ENSG00000180776.14,ZDHHC20MESOBMS.536924EAG2.8808e-04-0.4047image
chr13:21374272-21375145:-MESOBMS.536924EER2.8808e-04-0.4047image
chr13:21441410-21442679:-OVA.443654EER3.3908e-020.3450image
chr13:21374272-21375145:-OVBIBW2992EER1.3180e-08-0.3255image
ENSG00000180776.14,ZDHHC20OVBIBW2992EAG1.8345e-08-0.3219image
chr13:21374272-21375145:-PAADDMOGEER3.1738e-030.2264image
ENSG00000180776.14,ZDHHC20PAADDMOGEAG2.6655e-030.2297image
chr13:21374272-21375145:-PCPGBosutinibEER2.5939e-040.2841image
ENSG00000180776.14,ZDHHC20PCPGBosutinibEAG2.5939e-040.2841image
chr13:21374272-21375145:-PRADGNF.2EER1.0706e-09-0.2774image
ENSG00000180776.14,ZDHHC20PRADGNF.2EAG1.3171e-15-0.3560image
chr13:21374272-21375145:-READCyclopamineEER4.0395e-04-0.3593image
ENSG00000180776.14,ZDHHC20READBMS.754807EAG6.8788e-04-0.3422image
ENSG00000180776.14,ZDHHC20SARCAG.014699EAG2.7582e-090.3763image
chr13:21374272-21375145:-SARCAG.014699EER2.4550e-090.3774image
chr13:21374272-21375145:-SKCMAZD6244EER1.5002e-08-0.2667image
ENSG00000180776.14,ZDHHC20SKCMAZD6244EAG2.8674e-09-0.2789image
chr13:21395169-21397539:-STADCytarabineEER4.4195e-02-0.1949image
chr13:21441410-21442679:-STADATRAEER9.0415e-040.2648image
chr13:21444061-21445029:-STADCEP.701EER5.8177e-03-0.4631image
chr13:21374272-21375145:-STADCI.1040EER1.4098e-08-0.2877image
ENSG00000180776.14,ZDHHC20STADCI.1040EAG1.1059e-08-0.2897image
chr13:21379905-21380693:-STADBortezomibEER4.3615e-02-0.4554image
chr13:21374272-21375145:-TGCTKIN001.135EER4.4483e-060.3756image
ENSG00000180776.14,ZDHHC20TGCTKIN001.135EAG4.4483e-060.3756image
ENSG00000180776.14,ZDHHC20THCAEmbelinEAG5.6062e-190.3876image
chr13:21374272-21375145:-THCAEmbelinEER3.0523e-180.3807image
ENSG00000180776.14,ZDHHC20THYMEmbelinEAG1.3599e-090.5854image
chr13:21374272-21375145:-THYMEmbelinEER1.3183e-070.5271image
ENSG00000180776.14,ZDHHC20UCECCGP.60474EAG5.5546e-08-0.4122image
chr13:21374272-21375145:-UCECCGP.60474EER2.1061e-05-0.3355image
chr13:21374272-21375145:-UCSBryostatin.1EER7.6321e-05-0.5297image
ENSG00000180776.14,ZDHHC20UCSBryostatin.1EAG2.2401e-05-0.5564image
ENSG00000180776.14,ZDHHC20UVMCisplatinEAG4.9918e-02-0.3161image
chr13:21374272-21375145:-UVMCisplatinEER4.9918e-02-0.3161image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType