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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ARHGAP8 (ImmuneEditome ID:23779)

1. Gene summary of enriched editing regions for ARHGAP8

check button Gene summary
Gene informationGene symbol

ARHGAP8

Gene ID

23779

GeneSynonymsBPGAP1|PP610
GeneCytomap

22q13.31

GeneTypeprotein-coding
GeneDescriptionrho GTPase-activating protein 8|BCH domain-containing Cdc42GAP-like protein|BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1|rho-type GTPase-activating protein 8
GeneModificationdate20230329
UniprotIDP85298;B1AHF8;F8WCV8;B1AHC2;F8W6F4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr22:44762150-44763989:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicLTR37A,AluJr,AluSz6,MER21C,AluSx1,AluYj4chr22:44762150-44763989:+.alignment
chr22:44769942-44770534:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicAluSx1,AluSg,LTR8Achr22:44769942-44770534:+.alignment
chr22:44769942-44770534:+ENST00000469872.1ENSG00000241484.8ARHGAP8ncRNA_intronicAluSx1,AluSg,LTR8Achr22:44769942-44770534:+.alignment
chr22:44772912-44773866:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicL1M5,AluSz6,AluJbchr22:44772912-44773866:+.alignment
chr22:44772912-44773866:+ENST00000469872.1ENSG00000241484.8ARHGAP8ncRNA_intronicL1M5,AluSz6,AluJbchr22:44772912-44773866:+.alignment
chr22:44780228-44782343:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicL1ME4b,AluJb,FRAM,L1MB5,AluSq2,AluSz,AluSx1,MIRchr22:44780228-44782343:+.alignment
chr22:44780228-44782343:+ENST00000469872.1ENSG00000241484.8ARHGAP8ncRNA_intronicL1ME4b,AluJb,FRAM,L1MB5,AluSq2,AluSz,AluSx1,MIRchr22:44780228-44782343:+.alignment
chr22:44786784-44787511:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicAluJb,AluSz,(TTTGT)nchr22:44786784-44787511:+.alignment
chr22:44786784-44787511:+ENST00000495219.1ENSG00000241484.8ARHGAP8ncRNA_intronicAluJb,AluSz,(TTTGT)nchr22:44786784-44787511:+.alignment
chr22:44811697-44812545:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicAluSz,L3,AluScchr22:44811697-44812545:+.alignment
chr22:44811697-44812545:+ENST00000498310.1ENSG00000241484.8ARHGAP8ncRNA_intronicAluSz,L3,AluScchr22:44811697-44812545:+.alignment
chr22:44829047-44829252:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_intronicAluSxchr22:44829047-44829252:+.alignment
chr22:44850661-44856040:+ENST00000460809.4ENSG00000241484.8ARHGAP8ncRNA_exonicAluSz6,MER34B-int,AluJb,AluJr,(TATT)n,AluSz,(GAAA)n,AluSc8,AluSp,AluSx1,MER34A1,MER31-int,MSTA,(TTTTG)n,MER67Bchr22:44850661-44856040:+.alignment
chr22:44858419-44859499:+ENST00000336963.7ENSG00000241484.8ARHGAP8intronic(GTTG)n,AluSq2,MSTA,MER58Achr22:44858419-44859499:+.alignment
chr22:44858419-44859499:+ENST00000356099.9ENSG00000241484.8ARHGAP8intronic(GTTG)n,AluSq2,MSTA,MER58Achr22:44858419-44859499:+.alignment
chr22:44858419-44859499:+ENST00000389772.7ENSG00000241484.8ARHGAP8intronic(GTTG)n,AluSq2,MSTA,MER58Achr22:44858419-44859499:+.alignment
chr22:44858419-44859499:+ENST00000389774.5ENSG00000241484.8ARHGAP8intronic(GTTG)n,AluSq2,MSTA,MER58Achr22:44858419-44859499:+.alignment


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2. Tumor-specific enriched editing regions for ARHGAP8


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr22:44858419-44859499:+BRCAEER4.4385e-04image
ENSG00000241484.8,ARHGAP8KIRCEAG1.2022e-03image
chr22:44858419-44859499:+THCAEER3.7756e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr22:44858419-44859499:+KIRPPathEER2.1593e-029.6636e-030.2414image
ENSG00000241484.8,ARHGAP8LUADPathEAG2.0895e-021.7418e-02-0.1379image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr22:44850661-44856040:+CESCEER8.3883e-031.0692e-021.7419e+03image
chr22:44858419-44859499:+PRADEER4.2452e-034.8741e-029.7501e+06image
ENSG00000241484.8,ARHGAP8PRADEAG1.8274e-032.9673e-022.4162e+05image

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3. Enriched editing regions and immune related genes for ARHGAP8


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr22:44850661-44856040:+ESCAEERENSG00000241484,ARHGAP8-0.54311.1257e-074.8753e-12-0.5288imageNNNAB_cells_memoryGSVA_HALLMARK_HYPOXIA
chr22:44850661-44856040:+OVEERENSG00000005022,SLC25A50.33601.1317e-043.6852e-140.4893imageNNNAMast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr22:44850661-44856040:+OVEERENSG00000232119,MCTS10.33151.6463e-044.3746e-110.4327imageNNMCTS1Macrophages_M0GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr22:44850661-44856040:+OVEERENSG00000119185,ITGB1BP10.29271.2525e-035.9911e-100.4089imageNNITGB1BP1NK_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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4. Enriched editing regions and immune related splicing for ARHGAP8


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000241484.8,ARHGAP8
ESCAEAGIRENSG00000138468.11chr3101332769:101332862:101337508:101337631-0.33371.3844e-026.5667e-07-0.4155imageNACIN1;ADAR;AIFM1;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FTO;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;IGF2BP3;KHDRBS2;MOV10;MSI1;NOP56;NOP58;NUMA1;PTBP1;RBFOX2;RBM10;SRSF1;SRSF10;SRSF3;TAF15;TARDBP;TROVE2;U2AF2;UPF1;VIM;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000241484.8,ARHGAP8
ESCAEAGIRENSG00000104892.12chr1945350340:45350551:45350640:45350747-0.40487.5564e-041.1378e-06-0.4059imageNADAR;AIFM1;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FTO;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MOV10;NOP56;NOP58;NUMA1;PTBP1;RBFOX2;SRSF1;TAF15;TARDBP;TROVE2;U2AF2;VIM;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000241484.8,ARHGAP8
ESCAEAGIRENSG00000104892.12chr1945350340:45350431:45350513:45350551-0.38482.6883e-035.6649e-07-0.4079imageNADAR;AIFM1;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FTO;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MOV10;NOP56;NOP58;NUMA1;PTBP1;RBFOX2;SRSF1;TAF15;TARDBP;TROVE2;U2AF2;VIM;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000241484.8,ARHGAP8
ESCAEAGIRENSG00000104892.12chr1945350340:45351017:45351285:45351515-0.41608.5148e-042.6286e-07-0.4133imageNADAR;AIFM1;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FTO;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MOV10;NOP56;NOP58;NUMA1;PTBP1;RBFOX2;SRSF1;TAF15;TARDBP;TROVE2;U2AF2;VIM;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr22:44850661-44856040:+
ESCAEERESENSG00000148700.9chr10110130362:110130486:110132304:110132400:110133325:110133348-0.44275.8014e-042.8009e-07-0.4072imageNNADD3T_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000241484.8,ARHGAP8
ESCAEAGIRENSG00000184083.7chrX54173788:54174146:54182499:54182778-0.28434.4686e-022.0198e-06-0.4334imageNACIN1;ADAR;AIFM1;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FTO;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LIN28A;MOV10;MSI1;NOP56;NOP58;NUMA1;PTBP1;QKI;RBFOX2;RBM10;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARDBP;TIAL1;TROVE2;U2AF2;UPF1;VIM;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000241484.8,ARHGAP8
ESCAEAGIRENSG00000104892.12chr1945350340:45350747:45350953:45351017-0.38431.0098e-034.3333e-06-0.4024imageNADAR;AIFM1;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FTO;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;MOV10;NOP56;NOP58;NUMA1;PTBP1;RBFOX2;SRSF1;TAF15;TARDBP;TROVE2;U2AF2;VIM;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr22:44850661-44856040:+
OVEERIRENSG00000197070.9chr9137611450:137613006:137613412:137613510-0.38969.5955e-063.5480e-11-0.4346imageNNNAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr22:44850661-44856040:+
OVEERIRENSG00000167792.7chr1167606953:67607616:67608395:67608457-0.26566.7507e-031.4293e-10-0.4268imageNNNAMacrophages_M1GSVA_HALLMARK_MTORC1_SIGNALING
chr22:44858419-44859499:+
OVEERIRENSG00000117480.11chr146409100:46410854:46411611:46411651-0.39926.0510e-071.6046e-10-0.4081imageNNNAMacrophages_M1GSVA_HALLMARK_MTORC1_SIGNALING

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5. Enriched editing regions and immune infiltration for ARHGAP8


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr22:44858419-44859499:+BLCAEERT_cells_follicular_helper4.6930e-02-0.1425image
ENSG00000241484.8,ARHGAP8BLCAEAGT_cells_follicular_helper4.4034e-02-0.1422image
chr22:44850661-44856040:+BRCAEERT_cells_regulatory_(Tregs)1.1591e-030.1260image
chr22:44858419-44859499:+BRCAEERDendritic_cells_activated5.2068e-050.1363image
ENSG00000241484.8,ARHGAP8BRCAEAGT_cells_CD4_memory_resting2.2748e-02-0.0740image
chr22:44858419-44859499:+COADEERNK_cells_activated2.3587e-02-0.1646image
chr22:44850661-44856040:+ESCAEERMonocytes1.1955e-02-0.2061image
chr22:44858419-44859499:+ESCAEERMonocytes3.4254e-02-0.1778image
ENSG00000241484.8,ARHGAP8ESCAEAGMonocytes9.2632e-03-0.2111image
chr22:44850661-44856040:+HNSCEERB_cells_naive4.3635e-020.3840image
ENSG00000241484.8,ARHGAP8HNSCEAGMonocytes4.2002e-02-0.1786image
chr22:44858419-44859499:+KICHEERMacrophages_M01.9595e-02-0.3292image
ENSG00000241484.8,ARHGAP8KICHEAGMacrophages_M18.2848e-030.3624image
chr22:44850661-44856040:+KIRCEERT_cells_CD4_memory_resting2.0222e-020.4365image
chr22:44858419-44859499:+KIRCEERNeutrophils3.8739e-02-0.2392image
chr22:44850661-44856040:+KIRPEERNK_cells_activated5.1470e-03-0.4101image
chr22:44858419-44859499:+KIRPEERT_cells_CD4_memory_activated1.0138e-060.4105image
ENSG00000241484.8,ARHGAP8KIRPEAGT_cells_CD4_memory_activated4.4200e-050.3392image
chr22:44850661-44856040:+LUADEEREosinophils2.4587e-020.1986image
chr22:44858419-44859499:+LUADEERT_cells_CD4_memory_activated2.4614e-020.1350image
chr22:44850661-44856040:+LUSCEERNeutrophils1.0985e-060.4415image
ENSG00000241484.8,ARHGAP8LUSCEAGMast_cells_activated4.6490e-020.1137image
chr22:44850661-44856040:+OVEERT_cells_CD4_memory_activated5.6491e-030.1895image
chr22:44858419-44859499:+OVEERMacrophages_M03.3051e-03-0.1929image
ENSG00000241484.8,ARHGAP8OVEAGMacrophages_M22.2432e-020.1421image
chr22:44850661-44856040:+PAADEERNK_cells_resting1.4243e-020.4051image
chr22:44858419-44859499:+PAADEERNeutrophils7.2195e-030.2712image
ENSG00000241484.8,ARHGAP8PAADEAGNeutrophils2.7852e-030.2932image
chr22:44850661-44856040:+PRADEERMast_cells_resting1.1509e-02-0.1880image
chr22:44858419-44859499:+PRADEERT_cells_regulatory_(Tregs)4.4875e-020.1084image
chr22:44850661-44856040:+READEERB_cells_naive1.2560e-020.5117image
chr22:44858419-44859499:+SKCMEERDendritic_cells_resting1.1727e-02-0.4213image
ENSG00000241484.8,ARHGAP8SKCMEAGNK_cells_resting2.6357e-020.3510image
chr22:44786784-44787511:+STADEERT_cells_CD81.1499e-02-0.4877image
chr22:44858419-44859499:+STADEERMacrophages_M14.3620e-03-0.1780image
ENSG00000241484.8,ARHGAP8TGCTEAGNeutrophils1.7741e-030.4085image
chr22:44850661-44856040:+THCAEERMast_cells_activated1.2264e-040.4139image
chr22:44858419-44859499:+UCECEERDendritic_cells_activated7.5805e-040.3164image
ENSG00000241484.8,ARHGAP8UCECEAGDendritic_cells_activated8.1420e-040.3029image


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6. Enriched editing regions and immune gene sets for ARHGAP8


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000241484.8,ARHGAP8UCECEAG1.2582e-030.29232.5739e-030.27391.2399e-030.29261.2075e-020.2294image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr22:44858419-44859499:+BLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.5896e-020.1504image
ENSG00000241484.8,ARHGAP8BLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.7143e-020.1471image
chr22:44850661-44856040:+BLCAGSVA_HALLMARK_APICAL_JUNCTIONEER8.0168e-030.3862image
ENSG00000241484.8,ARHGAP8BRCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0059e-050.1430image
chr22:44850661-44856040:+BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.7039e-040.1456image
chr22:44858419-44859499:+BRCAGSVA_HALLMARK_UV_RESPONSE_UPEER5.1496e-080.1827image
chr22:44858419-44859499:+CESCGSVA_HALLMARK_G2M_CHECKPOINTEER4.2711e-03-0.2305image
ENSG00000241484.8,ARHGAP8CESCGSVA_HALLMARK_G2M_CHECKPOINTEAG4.0406e-02-0.1612image
chr22:44850661-44856040:+CESCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.7143e-02-0.3331image
ENSG00000241484.8,ARHGAP8COADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG6.1104e-040.2420image
chr22:44858419-44859499:+COADGSVA_HALLMARK_PROTEIN_SECRETIONEER3.8714e-040.2555image
chr22:44850661-44856040:+COADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.0588e-050.4274image
chr22:44850661-44856040:+ESCAGSVA_HALLMARK_HYPOXIAEER1.0767e-040.3130image
ENSG00000241484.8,ARHGAP8ESCAGSVA_HALLMARK_HYPOXIAEAG1.2660e-030.2600image
chr22:44858419-44859499:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6169e-030.2622image
chr22:44858419-44859499:+KICHGSVA_HALLMARK_MTORC1_SIGNALINGEER2.0440e-020.3270image
ENSG00000241484.8,ARHGAP8KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.5029e-020.2930image
chr22:44850661-44856040:+KIRCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.6719e-020.4483image
chr22:44858419-44859499:+KIRPGSVA_HALLMARK_UV_RESPONSE_UPEER1.1347e-020.2198image
ENSG00000241484.8,ARHGAP8KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.3548e-03-0.2304image
chr22:44858419-44859499:+LUADGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER3.2796e-040.2143image
ENSG00000241484.8,ARHGAP8LUADGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG5.7107e-030.1595image
chr22:44850661-44856040:+LUSCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.4762e-030.2969image
chr22:44858419-44859499:+LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEER3.8985e-020.1219image
ENSG00000241484.8,ARHGAP8LUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.8596e-02-0.1343image
chr22:44858419-44859499:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.6761e-090.3693image
chr22:44850661-44856040:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.2383e-060.3183image
ENSG00000241484.8,ARHGAP8OVGSVA_HALLMARK_ADIPOGENESISEAG3.6676e-030.1803image
ENSG00000241484.8,ARHGAP8PAADGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.1119e-030.2900image
chr22:44850661-44856040:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER4.9198e-020.3302image
chr22:44858419-44859499:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER3.4450e-040.3560image
chr22:44858419-44859499:+PRADGSVA_HALLMARK_UV_RESPONSE_UPEER3.9796e-060.2461image
ENSG00000241484.8,ARHGAP8PRADGSVA_HALLMARK_UV_RESPONSE_UPEAG7.1345e-050.2044image
chr22:44850661-44856040:+PRADGSVA_HALLMARK_HEME_METABOLISMEER8.1290e-060.3257image
chr22:44858419-44859499:+READGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER4.7938e-020.2543image
chr22:44850661-44856040:+READGSVA_HALLMARK_HYPOXIAEER2.3357e-020.4708image
ENSG00000241484.8,ARHGAP8READGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.3422e-020.3100image
ENSG00000241484.8,ARHGAP8SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.7147e-02-0.3307image
chr22:44858419-44859499:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.1499e-030.1913image
chr22:44786784-44787511:+STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.8576e-020.4294image
chr22:44829047-44829252:+STADGSVA_HALLMARK_PEROXISOMEEER1.2153e-020.4136image
ENSG00000241484.8,ARHGAP8STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.9419e-03-0.1630image
chr22:44850661-44856040:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.5119e-03-0.1748image
ENSG00000241484.8,ARHGAP8TGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4047e-030.4166image
ENSG00000241484.8,ARHGAP8THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.4305e-070.2834image
chr22:44858419-44859499:+THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2523e-070.3018image
chr22:44850661-44856040:+THCAGSVA_HALLMARK_GLYCOLYSISEER3.8463e-030.3177image
ENSG00000241484.8,ARHGAP8UCECGSVA_HALLMARK_MYC_TARGETS_V1EAG9.9789e-050.3491image
chr22:44850661-44856040:+UCECGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.1240e-020.4235image
chr22:44858419-44859499:+UCECGSVA_HALLMARK_MYC_TARGETS_V1EER1.6597e-030.2965image


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7. Enriched editing regions and drugs for ARHGAP8


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr22:44858419-44859499:+BLCAGDC.0449EER1.6907e-02-0.1709image
chr22:44850661-44856040:+BLCABIRB.0796EER9.9364e-030.3764image
ENSG00000241484.8,ARHGAP8BRCAA.770041EAG1.0754e-03-0.1062image
chr22:44850661-44856040:+BRCAGSK269962AEER1.6844e-03-0.1220image
chr22:44858419-44859499:+BRCACCT007093EER2.2678e-050.1426image
chr22:44858419-44859499:+CESCBAY.61.3606EER1.7320e-030.2521image
chr22:44850661-44856040:+CESCAZ628EER1.3267e-020.4146image
ENSG00000241484.8,ARHGAP8COADBIBW2992EAG1.1977e-030.2292image
chr22:44858419-44859499:+COADMidostaurinEER3.1294e-03-0.2138image
chr22:44850661-44856040:+COADBIBW2992EER1.7683e-050.4449image
chr22:44850661-44856040:+ESCAJNJ.26854165EER2.7103e-04-0.2961image
chr22:44858419-44859499:+ESCAAZD.2281EER1.9114e-04-0.3092image
ENSG00000241484.8,ARHGAP8ESCAJNJ.26854165EAG6.5315e-05-0.3201image
chr22:44850661-44856040:+HNSCAMG.706EER4.3880e-030.5220image
ENSG00000241484.8,ARHGAP8HNSCGW.441756EAG2.3197e-030.2649image
chr22:44850661-44856040:+KICHBMS.754807EER1.0902e-02-0.4251image
ENSG00000241484.8,ARHGAP8KICHCMKEAG6.1408e-030.3751image
chr22:44858419-44859499:+KICHGSK269962AEER5.3070e-030.3885image
chr22:44858419-44859499:+KIRCJW.7.52.1EER2.0630e-020.2669image
chr22:44850661-44856040:+KIRCImatinibEER4.3552e-02-0.3842image
ENSG00000241484.8,ARHGAP8KIRCCGP.082996EAG1.9815e-020.2585image
ENSG00000241484.8,ARHGAP8KIRPAZD6482EAG7.3759e-080.4372image
chr22:44858419-44859499:+KIRPCCT007093EER1.0423e-070.4430image
chr22:44850661-44856040:+KIRPAG.014699EER6.3005e-030.4012image
ENSG00000241484.8,ARHGAP8LUADBMS.708163EAG5.2087e-03-0.1612image
chr22:44858419-44859499:+LUADAZD7762EER3.9950e-03-0.1724image
chr22:44850661-44856040:+LUSCAUY922EER1.1116e-03-0.3042image
chr22:44858419-44859499:+LUSCGW.441756EER3.3924e-02-0.1252image
ENSG00000241484.8,ARHGAP8LUSCFH535EAG1.9297e-030.1763image
chr22:44850661-44856040:+OVBMS.509744EER1.2470e-05-0.2951image
chr22:44858419-44859499:+OVBAY.61.3606EER3.4773e-040.2338image
ENSG00000241484.8,ARHGAP8OVBAY.61.3606EAG8.0444e-030.1647image
chr22:44858419-44859499:+PAADAUY922EER1.1994e-02-0.2542image
ENSG00000241484.8,ARHGAP8PAADMetforminEAG1.7812e-020.2342image
chr22:44850661-44856040:+PAADCytarabineEER7.9689e-030.4353image
chr22:44858419-44859499:+PRADBMS.536924EER4.9984e-04-0.1872image
chr22:44850661-44856040:+PRADBryostatin.1EER1.8663e-030.2303image
ENSG00000241484.8,ARHGAP8PRADBIBW2992EAG2.2538e-020.1183image
chr22:44850661-44856040:+READBexaroteneEER5.5207e-03-0.5594image
chr22:44858419-44859499:+READLapatinibEER5.7939e-030.3493image
ENSG00000241484.8,ARHGAP8READAZ628EAG1.5447e-020.3039image
chr22:44858419-44859499:+SKCMCHIR.99021EER1.5178e-02-0.4072image
ENSG00000241484.8,ARHGAP8SKCMCHIR.99021EAG2.5868e-02-0.3521image
chr22:44786784-44787511:+STADBleomycinEER7.1186e-030.5148image
chr22:44858419-44859499:+STADKU.55933EER2.1971e-02-0.1434image
ENSG00000241484.8,ARHGAP8STADBMS.509744EAG5.0993e-04-0.1959image
chr22:44850661-44856040:+STADBMS.509744EER2.5553e-04-0.2180image
chr22:44762150-44763989:+STADBX.795EER4.5351e-02-0.3405image
ENSG00000241484.8,ARHGAP8TGCTBMS.536924EAG2.4872e-03-0.3964image
chr22:44850661-44856040:+THCADoxorubicinEER2.1675e-020.2548image
ENSG00000241484.8,ARHGAP8THCAABT.263EAG2.6666e-030.1692image
chr22:44858419-44859499:+THCACCT007093EER1.9807e-040.2150image
chr22:44858419-44859499:+UCECBI.D1870EER1.3946e-03-0.3010image
ENSG00000241484.8,ARHGAP8UCECBI.D1870EAG3.0522e-04-0.3254image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType