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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PSD4 (ImmuneEditome ID:23550)

1. Gene summary of enriched editing regions for PSD4

check button Gene summary
Gene informationGene symbol

PSD4

Gene ID

23550

GeneSynonymsEFA6B|TIC
GeneCytomap

2q14.1

GeneTypeprotein-coding
GeneDescriptionPH and SEC7 domain-containing protein 4|ADP-ribosylation factor guanine nucleotide-exchange factor 6|SEC7 homolog|exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B|exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B|exchange factor for ARF6 B|pleckstrin homology and SEC7 domain-containing protein 4|telomeric of interleukin-1 cluster protein
GeneModificationdate20230329
UniprotIDQ8NDX1;B8ZZZ5;H7BZ06
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:113187641-113187844:+ENST00000418251.5ENSG00000125637.14PSD4ncRNA_intronicTigger18achr2:113187641-113187844:+.alignment
chr2:113191189-113191677:+ENST00000418251.5ENSG00000125637.14PSD4ncRNA_intronicAluSzchr2:113191189-113191677:+.alignment
chr2:113204988-113205663:+ENST00000441564.6ENSG00000125637.14PSD4UTR3AluSz,AluSxchr2:113204988-113205663:+.alignment


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2. Tumor-specific enriched editing regions for PSD4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr2:113204988-113205663:+COADEER6.0349e-03image
ENSG00000125637.14,PSD4COADEAG6.4760e-03image
chr2:113204988-113205663:+THCAEER4.2825e-06image
ENSG00000125637.14,PSD4THCAEAG6.2587e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr2:113204988-113205663:+DLBCEER2.6561e-033.5279e-029.8471e+05image
ENSG00000125637.14,PSD4DLBCEAG2.6561e-033.5279e-029.8471e+05image

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3. Enriched editing regions and immune related genes for PSD4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:113204988-113205663:+DLBCEERENSG00000135441,BLOC1S1-0.67675.5871e-036.8134e-05-0.5475imageNNBLOC1S1Macrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+DLBCEERENSG00000252965,Y_RNA-0.68545.8912e-031.5671e-04-0.5240imageNNNAMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+DLBCEERENSG00000103260,METRN-0.68096.2419e-033.2677e-05-0.5669imageNNNAMacrophages_M1GSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr2:113204988-113205663:+DLBCEERENSG00000145907,G3BP10.67177.3065e-034.5749e-050.5581imageNNG3BP1Macrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+DLBCEERENSG00000164163,ABCE10.66028.0382e-032.6418e-040.5084imageNNABCE1T_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+DLBCEERENSG00000119969,HELLS0.66388.8340e-031.7653e-030.4441imageNNHELLSNK_cells_restingGSVA_HALLMARK_G2M_CHECKPOINT
chr2:113204988-113205663:+DLBCEERENSG00000135940,COX5B-0.65001.0059e-026.6329e-06-0.6051imageNNCOX5BMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+DLBCEERENSG00000175463,TBC1D10C-0.63771.0144e-021.0937e-03-0.4615imageNNNAMacrophages_M2GSVA_HALLMARK_ANDROGEN_RESPONSE
chr2:113204988-113205663:+DLBCEERENSG00000198060,MARCH50.64691.0824e-028.9646e-050.5399imageNNMARCH5Macrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+DLBCEERENSG00000205339,IPO70.63001.0945e-029.0773e-040.4680imageNNNANK_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for PSD4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000125637.14,PSD4
DLBCEAGMEXENSG00000067829.14chrX153790194:153790292:153790563:153790575:153790795:153790851:153794245:153794325-0.73453.0322e-029.0513e-06-0.5980imageNAUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAGNAMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000125637.14,PSD4
DLBCEAGMEXENSG00000152726.14chr1050125112:50125241:50125368:50125449:50127582:50127795:50129418:501300390.67674.0042e-021.4557e-040.5364imageNADAR;DDX42;DDX54;EIF4A3;ELAVL1;EWSR1;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPC;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;KHDRBS1;KHSRP;PRPF8;RBFOX2;RBM10;RBM22;SAFB2;SRSF1;SRSF3;SRSF7;TAF15;TARDBP;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1NAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000125637.14,PSD4
DLBCEAGMEXENSG00000138744.10chr475910655:75911353:75914867:75914985:75917759:75917773:75918760:75918789-0.56644.2035e-022.4083e-04-0.5686imageNADAR;AUH;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LIN28B;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;ZC3H7BNAGSVA_HALLMARK_MITOTIC_SPINDLE
chr2:113204988-113205663:+
DLBCEERMEXENSG00000067829.14chrX153790194:153790292:153790563:153790575:153790795:153790851:153794245:153794325-0.73453.3070e-029.0513e-06-0.5980imageNNNAMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000125637.14,PSD4
ESCAEAGESENSG00000151876.8chr541934136:41934308:41939440:41939616:41941191:41941568-0.39932.5830e-021.9363e-06-0.4341imageNADAR;BUD13;CELF2;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28B;LSM11;MOV10;NOP56;NOP58;PRPF8;PTBP1;RANGAP1;RBM10;RBM22;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7BNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000125637.14,PSD4
THYMEAGMEXENSG00000073578.12chr5240443:240476:250991:251043:254392:254506:256333:2566820.39581.4714e-023.8165e-050.4034imageNAUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RBM6;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAGNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000125637.14,PSD4
THYMEAGMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664846:49665483:496656130.36131.8935e-023.2568e-050.4066imageNADAR;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAGIRF3Macrophages_M1GSVA_HALLMARK_ANGIOGENESIS
ENSG00000125637.14,PSD4
THYMEAGESENSG00000176261.11chr132627507:32627544:32633644:32634110:32650432:326509030.37981.3062e-021.5630e-050.4316imageNADAR;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM6;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZC3H7BNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr2:113204988-113205663:+
THYMEERMEXENSG00000126456.11chr1949663420:49663514:49664442:49664673:49664673:49664866:49665630:496657050.37171.4679e-021.1461e-050.4293imageNNIRF3Macrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000125637.14,PSD4
THYMEAGMEXENSG00000197958.8chr9127449280:127449362:127449609:127450679:127450730:127450804:127451280:127451373-0.46081.6806e-039.0549e-06-0.4317imageNADAR;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAGNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for PSD4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:113204988-113205663:+ACCEERT_cells_CD4_naive3.4608e-02-0.3157image
ENSG00000125637.14,PSD4ACCEAGT_cells_CD4_naive3.4608e-02-0.3157image
chr2:113204988-113205663:+BLCAEERT_cells_gamma_delta1.6977e-02-0.1631image
ENSG00000125637.14,PSD4BLCAEAGT_cells_CD81.1691e-020.1713image
chr2:113204988-113205663:+BRCAEERT_cells_follicular_helper1.0026e-02-0.0919image
ENSG00000125637.14,PSD4BRCAEAGT_cells_follicular_helper2.5347e-02-0.0793image
chr2:113204988-113205663:+CESCEERMacrophages_M11.2044e-020.1664image
ENSG00000125637.14,PSD4CESCEAGMacrophages_M19.9612e-030.1707image
chr2:113204988-113205663:+CHOLEERDendritic_cells_resting3.0633e-020.3713image
ENSG00000125637.14,PSD4CHOLEAGDendritic_cells_resting3.0633e-020.3713image
chr2:113204988-113205663:+COADEERDendritic_cells_activated4.1114e-020.1537image
chr2:113204988-113205663:+ESCAEERB_cells_naive3.9605e-020.1993image
chr2:113204988-113205663:+HNSCEERMacrophages_M19.2736e-040.1815image
ENSG00000125637.14,PSD4HNSCEAGMacrophages_M11.3396e-030.1756image
chr2:113204988-113205663:+KIRCEERPlasma_cells4.1742e-020.1755image
ENSG00000125637.14,PSD4KIRCEAGPlasma_cells3.8806e-020.1774image
chr2:113187641-113187844:+LAMLEERB_cells_memory1.1957e-020.3032image
chr2:113204988-113205663:+LIHCEERMast_cells_resting2.9071e-020.1430image
ENSG00000125637.14,PSD4LIHCEAGMast_cells_resting3.4680e-020.1384image
chr2:113204988-113205663:+LUSCEERT_cells_CD4_memory_activated2.8638e-030.2048image
ENSG00000125637.14,PSD4LUSCEAGT_cells_CD4_memory_activated1.5484e-030.2156image
chr2:113204988-113205663:+MESOEERNK_cells_resting1.0959e-020.4578image
ENSG00000125637.14,PSD4MESOEAGNK_cells_resting1.0959e-020.4578image
chr2:113204988-113205663:+OVEERT_cells_CD84.6400e-040.2346image
ENSG00000125637.14,PSD4OVEAGT_cells_CD82.0266e-030.2070image
chr2:113204988-113205663:+PRADEERT_cells_CD4_memory_resting6.7126e-040.1549image
ENSG00000125637.14,PSD4PRADEAGT_cells_CD4_memory_resting2.3478e-040.1671image
chr2:113204988-113205663:+SKCMEERT_cells_CD4_memory_resting8.0232e-030.3783image
ENSG00000125637.14,PSD4SKCMEAGT_cells_CD4_memory_resting8.4856e-030.3758image
chr2:113204988-113205663:+STADEERDendritic_cells_activated3.1999e-020.1474image
ENSG00000125637.14,PSD4STADEAGB_cells_memory1.9359e-020.1555image
chr2:113204988-113205663:+THCAEERT_cells_CD4_memory_activated2.9989e-050.2056image
ENSG00000125637.14,PSD4THCAEAGT_cells_CD4_memory_activated2.4140e-050.2077image
chr2:113204988-113205663:+THYMEERT_cells_gamma_delta2.3398e-060.4563image
ENSG00000125637.14,PSD4THYMEAGT_cells_gamma_delta2.3398e-060.4563image
chr2:113204988-113205663:+UCECEERT_cells_CD4_naive2.4511e-020.1867image
ENSG00000125637.14,PSD4UCECEAGT_cells_CD4_naive2.3506e-020.1880image
chr2:113204988-113205663:+UCSEERT_cells_follicular_helper4.5686e-020.4404image
ENSG00000125637.14,PSD4UCSEAGT_cells_follicular_helper4.5686e-020.4404image


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6. Enriched editing regions and immune gene sets for PSD4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr2:113204988-113205663:+PRADEER2.0548e-020.10588.3916e-070.22282.0531e-020.10585.9888e-040.1563image
ENSG00000125637.14,PSD4PRADEAG4.3645e-020.09212.1768e-060.21423.6294e-020.09561.2979e-030.1464image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000125637.14,PSD4ACCGSVA_HALLMARK_APOPTOSISEAG8.5047e-040.4799image
chr2:113204988-113205663:+ACCGSVA_HALLMARK_APOPTOSISEER8.5047e-040.4799image
chr2:113204988-113205663:+BLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER8.5607e-030.1793image
ENSG00000125637.14,PSD4BLCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG5.8507e-030.1870image
ENSG00000125637.14,PSD4BRCAGSVA_HALLMARK_APOPTOSISEAG4.8987e-070.1773image
chr2:113204988-113205663:+BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.5054e-070.1862image
ENSG00000125637.14,PSD4CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.0190e-040.2550image
chr2:113204988-113205663:+CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER9.9984e-050.2554image
chr2:113204988-113205663:+CHOLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.7390e-020.4054image
ENSG00000125637.14,PSD4CHOLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.7390e-020.4054image
chr2:113204988-113205663:+COADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.7971e-02-0.1489image
ENSG00000125637.14,PSD4COADGSVA_HALLMARK_P53_PATHWAYEAG8.8781e-03-0.1940image
ENSG00000125637.14,PSD4DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.7262e-040.4976image
chr2:113204988-113205663:+DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.7262e-040.4976image
chr2:113204988-113205663:+ESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.4861e-020.2042image
chr2:113204988-113205663:+HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.8491e-050.2194image
ENSG00000125637.14,PSD4HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.4583e-040.2002image
chr2:113204988-113205663:+KIRPGSVA_HALLMARK_G2M_CHECKPOINTEER2.8335e-020.2172image
ENSG00000125637.14,PSD4KIRPGSVA_HALLMARK_G2M_CHECKPOINTEAG3.3353e-020.2099image
chr2:113191189-113191677:+LAMLGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.0719e-020.2912image
chr2:113187641-113187844:+LAMLGSVA_HALLMARK_MYC_TARGETS_V1EER1.7853e-020.2865image
ENSG00000125637.14,PSD4LAMLGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.6921e-020.2396image
chr2:113204988-113205663:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER4.0985e-040.2296image
ENSG00000125637.14,PSD4LIHCGSVA_HALLMARK_HEME_METABOLISMEAG1.7282e-030.2042image
chr2:113204988-113205663:+LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.4090e-030.1958image
ENSG00000125637.14,PSD4LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.6820e-030.2047image
ENSG00000125637.14,PSD4OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG6.1894e-060.2994image
chr2:113204988-113205663:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.1261e-050.2701image
chr2:113204988-113205663:+PAADGSVA_HALLMARK_ANGIOGENESISEER4.5032e-040.2957image
ENSG00000125637.14,PSD4PAADGSVA_HALLMARK_ANGIOGENESISEAG4.9412e-040.2938image
ENSG00000125637.14,PSD4PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.3126e-070.2227image
chr2:113204988-113205663:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1633e-070.2392image
ENSG00000125637.14,PSD4READGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.3782e-040.4316image
chr2:113204988-113205663:+READGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.3782e-040.4316image
chr2:113204988-113205663:+SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.8739e-02-0.3381image
ENSG00000125637.14,PSD4SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.9012e-02-0.3374image
ENSG00000125637.14,PSD4STADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.5822e-020.1483image
chr2:113204988-113205663:+STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.5350e-020.1663image
ENSG00000125637.14,PSD4THCAGSVA_HALLMARK_APOPTOSISEAG1.9205e-080.2740image
chr2:113204988-113205663:+THCAGSVA_HALLMARK_APOPTOSISEER7.8147e-090.2815image
ENSG00000125637.14,PSD4THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG8.6466e-060.4326image
chr2:113204988-113205663:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER8.6466e-060.4326image
ENSG00000125637.14,PSD4UCECGSVA_HALLMARK_MYC_TARGETS_V2EAG2.9890e-02-0.1804image
chr2:113204988-113205663:+UCECGSVA_HALLMARK_MYC_TARGETS_V2EER2.7087e-02-0.1836image
chr2:113204988-113205663:+UCSGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.8404e-020.4780image
ENSG00000125637.14,PSD4UCSGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.8404e-020.4780image


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7. Enriched editing regions and drugs for PSD4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000125637.14,PSD4ACCAS601245EAG1.7308e-04-0.5313image
chr2:113204988-113205663:+ACCAS601245EER1.7308e-04-0.5313image
ENSG00000125637.14,PSD4BLCAErlotinibEAG1.8635e-020.1600image
chr2:113204988-113205663:+BLCAErlotinibEER6.3674e-030.1860image
ENSG00000125637.14,PSD4BRCADMOGEAG8.8749e-04-0.1177image
chr2:113204988-113205663:+BRCAJNK.Inhibitor.VIIIEER1.3050e-04-0.1362image
ENSG00000125637.14,PSD4CESCIPA.3EAG1.0580e-03-0.2160image
chr2:113204988-113205663:+CESCEmbelinEER1.0366e-03-0.2163image
chr2:113204988-113205663:+CHOLAZ628EER1.9011e-020.4002image
ENSG00000125637.14,PSD4CHOLAZ628EAG1.9011e-020.4002image
chr2:113204988-113205663:+COADAZD8055EER7.1535e-03-0.2015image
ENSG00000125637.14,PSD4COADAZD8055EAG6.8440e-03-0.2004image
ENSG00000125637.14,PSD4DLBCGNF.2EAG3.1788e-030.4214image
chr2:113204988-113205663:+DLBCGNF.2EER3.1788e-030.4214image
ENSG00000125637.14,PSD4ESCAJNK.Inhibitor.VIIIEAG4.1892e-020.1918image
chr2:113204988-113205663:+ESCAMidostaurinEER2.6668e-020.2143image
ENSG00000125637.14,PSD4HNSCAZD.2281EAG4.5092e-06-0.2490image
chr2:113204988-113205663:+HNSCAZD.2281EER2.2657e-06-0.2569image
chr2:113204988-113205663:+KIRCAZD8055EER2.1258e-02-0.1981image
ENSG00000125637.14,PSD4KIRCAZD8055EAG1.9461e-02-0.2002image
chr2:113204988-113205663:+KIRPMethotrexateEER3.5781e-04-0.3467image
ENSG00000125637.14,PSD4KIRPMethotrexateEAG3.2134e-04-0.3476image
ENSG00000125637.14,PSD4LAMLA.770041EAG1.9214e-02-0.2350image
chr2:113191189-113191677:+LAMLCGP.60474EER1.8494e-02-0.2696image
chr2:113187641-113187844:+LAMLCamptothecinEER5.0271e-03-0.3365image
chr2:113204988-113205663:+LIHCEtoposideEER1.5177e-040.2457image
ENSG00000125637.14,PSD4LIHCEtoposideEAG2.2467e-040.2395image
chr2:113204988-113205663:+LUADAS601245EER2.1737e-030.1868image
ENSG00000125637.14,PSD4LUADAS601245EAG3.9452e-020.1252image
ENSG00000125637.14,PSD4LUSCGDC0941EAG4.0570e-03-0.1961image
chr2:113204988-113205663:+LUSCAZD.2281EER3.8728e-03-0.1990image
ENSG00000125637.14,PSD4MESOJNK.Inhibitor.VIIIEAG7.4026e-03-0.4790image
chr2:113204988-113205663:+MESOJNK.Inhibitor.VIIIEER7.4026e-03-0.4790image
ENSG00000125637.14,PSD4OVBexaroteneEAG2.2101e-040.2466image
chr2:113204988-113205663:+OVBexaroteneEER2.9858e-030.1998image
ENSG00000125637.14,PSD4PAADBicalutamideEAG2.4460e-02-0.1936image
chr2:113204988-113205663:+PAADBicalutamideEER2.2617e-02-0.1961image
ENSG00000125637.14,PSD4PCPGCCT018159EAG1.4541e-020.4826image
chr2:113204988-113205663:+PCPGCCT018159EER1.4541e-020.4826image
chr2:113204988-113205663:+PRADJNK.Inhibitor.VIIIEER2.4533e-09-0.2682image
ENSG00000125637.14,PSD4PRADJNK.Inhibitor.VIIIEAG8.6353e-10-0.2752image
chr2:113204988-113205663:+READAP.24534EER2.9835e-03-0.3429image
ENSG00000125637.14,PSD4READAP.24534EAG2.9835e-03-0.3429image
ENSG00000125637.14,PSD4SKCMGemcitabineEAG1.7280e-02-0.3422image
chr2:113204988-113205663:+SKCMGemcitabineEER1.7155e-02-0.3426image
chr2:113204988-113205663:+STADKU.55933EER3.7281e-03-0.1984image
ENSG00000125637.14,PSD4STADErlotinibEAG1.7980e-020.1576image
ENSG00000125637.14,PSD4TGCTGNF.2EAG2.2053e-020.4470image
chr2:113204988-113205663:+TGCTGNF.2EER2.2053e-020.4470image
chr2:113204988-113205663:+THCAMetforminEER5.5848e-090.2842image
ENSG00000125637.14,PSD4THCAAICAREAG8.2160e-09-0.2808image
chr2:113204988-113205663:+THYMKIN001.135EER1.5056e-05-0.4220image
ENSG00000125637.14,PSD4THYMKIN001.135EAG1.5056e-05-0.4220image
ENSG00000125637.14,PSD4UCECBIRB.0796EAG2.7255e-030.2472image
chr2:113204988-113205663:+UCECBIRB.0796EER3.2544e-030.2428image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType