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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CABIN1 (ImmuneEditome ID:23523)

1. Gene summary of enriched editing regions for CABIN1

check button Gene summary
Gene informationGene symbol

CABIN1

Gene ID

23523

GeneSynonymsCAIN|KB-318B8.7|PPP3IN
GeneCytomap

22q11.23

GeneTypeprotein-coding
GeneDescriptioncalcineurin-binding protein cabin-1|calcineurin binding protein cabin 1|calcineurin inhibitor
GeneModificationdate20230517
UniprotIDB5MEB3;Q9Y6J0;A0A024R1E5;C9JT60;C9J068;A0A087WWW8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr22:24015097-24015843:+ENST00000263119.8ENSG00000099991.15CABIN1intronicAluSx1,AluYk3,AluSz,L1MC4achr22:24015097-24015843:+.alignment
chr22:24015097-24015843:+ENST00000398319.5ENSG00000099991.15CABIN1intronicAluSx1,AluYk3,AluSz,L1MC4achr22:24015097-24015843:+.alignment
chr22:24015097-24015843:+ENST00000405822.5ENSG00000099991.15CABIN1intronicAluSx1,AluYk3,AluSz,L1MC4achr22:24015097-24015843:+.alignment
chr22:24015097-24015843:+ENST00000445422.4ENSG00000099991.15CABIN1intronicAluSx1,AluYk3,AluSz,L1MC4achr22:24015097-24015843:+.alignment
chr22:24015097-24015843:+ENST00000454754.4ENSG00000099991.15CABIN1intronicAluSx1,AluYk3,AluSz,L1MC4achr22:24015097-24015843:+.alignment
chr22:24015097-24015843:+ENST00000617531.3ENSG00000099991.15CABIN1intronicAluSx1,AluYk3,AluSz,L1MC4achr22:24015097-24015843:+.alignment
chr22:24042003-24042550:+ENST00000263119.8ENSG00000099991.15CABIN1intronicAluJb,AluJrchr22:24042003-24042550:+.alignment
chr22:24042003-24042550:+ENST00000398319.5ENSG00000099991.15CABIN1intronicAluJb,AluJrchr22:24042003-24042550:+.alignment
chr22:24042003-24042550:+ENST00000405822.5ENSG00000099991.15CABIN1intronicAluJb,AluJrchr22:24042003-24042550:+.alignment
chr22:24042003-24042550:+ENST00000445422.4ENSG00000099991.15CABIN1intronicAluJb,AluJrchr22:24042003-24042550:+.alignment
chr22:24042003-24042550:+ENST00000454754.4ENSG00000099991.15CABIN1intronicAluJb,AluJrchr22:24042003-24042550:+.alignment
chr22:24042003-24042550:+ENST00000617531.3ENSG00000099991.15CABIN1intronicAluJb,AluJrchr22:24042003-24042550:+.alignment
chr22:24109261-24110113:+ENST00000467937.1ENSG00000099991.15CABIN1ncRNA_intronicMIR3,AluJo,AluSxchr22:24109261-24110113:+.alignment
chr22:24173531-24174352:+ENST00000263119.8ENSG00000099991.15CABIN1intronicMIRb,AluJb,AluSc,(T)n,Charlie30a,AluSxchr22:24173531-24174352:+.alignment
chr22:24173531-24174352:+ENST00000337989.10ENSG00000099991.15CABIN1intronicMIRb,AluJb,AluSc,(T)n,Charlie30a,AluSxchr22:24173531-24174352:+.alignment
chr22:24173531-24174352:+ENST00000398319.5ENSG00000099991.15CABIN1intronicMIRb,AluJb,AluSc,(T)n,Charlie30a,AluSxchr22:24173531-24174352:+.alignment
chr22:24173531-24174352:+ENST00000405822.5ENSG00000099991.15CABIN1intronicMIRb,AluJb,AluSc,(T)n,Charlie30a,AluSxchr22:24173531-24174352:+.alignment
chr22:24173531-24174352:+ENST00000617531.3ENSG00000099991.15CABIN1intronicMIRb,AluJb,AluSc,(T)n,Charlie30a,AluSxchr22:24173531-24174352:+.alignment
chr22:24173531-24174352:+ENST00000620406.1ENSG00000099991.15CABIN1intronicMIRb,AluJb,AluSc,(T)n,Charlie30a,AluSxchr22:24173531-24174352:+.alignment


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2. Tumor-specific enriched editing regions for CABIN1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr22:24109261-24110113:+ESCAEER2.7761e-029.0384e-031.1938e+02image

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3. Enriched editing regions and immune related genes for CABIN1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for CABIN1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for CABIN1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000099991.15,CABIN1BLCAEAGT_cells_CD4_naive3.6995e-020.3489image
chr22:24109261-24110113:+BRCAEERT_cells_CD4_memory_resting4.5820e-02-0.2283image
chr22:24173531-24174352:+BRCAEERMacrophages_M22.5491e-020.2497image
ENSG00000099991.15,CABIN1BRCAEAGMacrophages_M21.1514e-020.2031image
ENSG00000099991.15,CABIN1ESCAEAGB_cells_naive7.5912e-03-0.2812image
ENSG00000099991.15,CABIN1GBMEAGNK_cells_resting1.6187e-020.3876image
chr22:24109261-24110113:+KIRCEERDendritic_cells_activated8.7116e-040.4946image
ENSG00000099991.15,CABIN1KIRCEAGDendritic_cells_activated9.8792e-050.4545image
chr22:24042003-24042550:+LAMLEERMonocytes2.8815e-020.3261image
chr22:24173531-24174352:+LAMLEERMonocytes3.3401e-020.2151image
ENSG00000099991.15,CABIN1LAMLEAGMacrophages_M12.4138e-030.2639image
ENSG00000099991.15,CABIN1LGGEAGB_cells_memory3.2061e-020.2547image
chr22:24109261-24110113:+LUADEERMonocytes1.8132e-020.4686image
chr22:24173531-24174352:+LUADEERT_cells_CD4_memory_resting8.8615e-03-0.2744image
ENSG00000099991.15,CABIN1LUADEAGT_cells_CD82.0088e-030.3038image
ENSG00000099991.15,CABIN1OVEAGNeutrophils3.8070e-020.3102image
ENSG00000099991.15,CABIN1SKCMEAGT_cells_regulatory_(Tregs)1.1966e-02-0.3054image
chr22:24173531-24174352:+STADEERNeutrophils7.8500e-030.3088image
ENSG00000099991.15,CABIN1STADEAGNK_cells_activated4.1649e-020.1655image
ENSG00000099991.15,CABIN1THCAEAGDendritic_cells_resting6.6397e-040.5041image


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6. Enriched editing regions and immune gene sets for CABIN1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr22:24173531-24174352:+LUADEER9.6593e-040.34212.3312e-030.31701.9092e-030.32296.4779e-040.3528image
ENSG00000099991.15,CABIN1LUADEAG2.5189e-040.35662.1280e-030.30221.2095e-030.31765.7342e-040.3368image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr22:24109261-24110113:+BRCAGSVA_HALLMARK_PEROXISOMEEER3.9563e-040.3938image
ENSG00000099991.15,CABIN1BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.5614e-030.2528image
chr22:24109261-24110113:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER9.6682e-03-0.3051image
ENSG00000099991.15,CABIN1ESCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG7.8737e-04-0.3495image
ENSG00000099991.15,CABIN1GBMGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG8.5353e-030.4207image
chr22:24173531-24174352:+KIRCGSVA_HALLMARK_MYC_TARGETS_V2EER5.9901e-03-0.4079image
chr22:24042003-24042550:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.3173e-020.3669image
chr22:24109261-24110113:+LAMLGSVA_HALLMARK_KRAS_SIGNALING_UPEER2.8819e-020.2578image
chr22:24173531-24174352:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.9714e-020.2197image
ENSG00000099991.15,CABIN1LAMLGSVA_HALLMARK_P53_PATHWAYEAG2.5080e-02-0.1965image
ENSG00000099991.15,CABIN1LGGGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.7213e-02-0.2622image
ENSG00000099991.15,CABIN1LUADGSVA_HALLMARK_G2M_CHECKPOINTEAG1.7116e-040.3655image
chr22:24109261-24110113:+LUADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.6108e-030.5975image
chr22:24173531-24174352:+LUADGSVA_HALLMARK_G2M_CHECKPOINTEER3.6699e-040.3674image
ENSG00000099991.15,CABIN1OVGSVA_HALLMARK_HEME_METABOLISMEAG7.6328e-030.3926image
ENSG00000099991.15,CABIN1STADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.1643e-020.1655image
chr22:24042003-24042550:+STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER8.5735e-040.4796image
chr22:24109261-24110113:+STADGSVA_HALLMARK_GLYCOLYSISEER4.5864e-020.2313image
ENSG00000099991.15,CABIN1TGCTGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.8670e-030.5929image
ENSG00000099991.15,CABIN1THCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.8053e-030.4498image


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7. Enriched editing regions and drugs for CABIN1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000099991.15,CABIN1BLCAFH535EAG8.0432e-030.4348image
chr22:24109261-24110113:+BRCAAZD6482EER3.5636e-020.2414image
ENSG00000099991.15,CABIN1BRCABI.D1870EAG2.4817e-02-0.1808image
chr22:24109261-24110113:+ESCACI.1040EER3.7317e-030.3399image
chr22:24173531-24174352:+ESCADMOGEER1.0936e-02-0.3801image
ENSG00000099991.15,CABIN1ESCAImatinibEAG2.1740e-03-0.3208image
ENSG00000099991.15,CABIN1GBMKIN001.135EAG5.7266e-03-0.4398image
ENSG00000099991.15,CABIN1KIRCGW843682XEAG1.7160e-030.3733image
chr22:24109261-24110113:+KIRCJNK.9LEER9.3655e-030.3963image
chr22:24173531-24174352:+KIRCLFM.A13EER7.0890e-03-0.4003image
chr22:24042003-24042550:+LAMLLenalidomideEER7.2067e-030.3952image
chr22:24109261-24110113:+LAMLAZD.2281EER4.8373e-030.3285image
chr22:24173531-24174352:+LAMLImatinibEER1.9215e-020.2362image
ENSG00000099991.15,CABIN1LAMLLFM.A13EAG3.5758e-030.2538image
ENSG00000099991.15,CABIN1LGGMidostaurinEAG3.6348e-020.2489image
ENSG00000099991.15,CABIN1LUADATRAEAG2.1797e-030.3016image
chr22:24109261-24110113:+LUADEpothilone.BEER1.3793e-030.6042image
chr22:24173531-24174352:+LUADATRAEER1.9639e-020.2456image
ENSG00000099991.15,CABIN1LUSCGemcitabineEAG2.6379e-02-0.2891image
ENSG00000099991.15,CABIN1OVJNK.9LEAG2.3556e-03-0.4422image
ENSG00000099991.15,CABIN1SKCMGNF.2EAG2.9605e-02-0.2660image
ENSG00000099991.15,CABIN1STADLapatinibEAG3.1652e-03-0.2402image
chr22:24042003-24042550:+STADBIBW2992EER8.8307e-06-0.6095image
chr22:24173531-24174352:+STADBryostatin.1EER2.9924e-02-0.2543image
ENSG00000099991.15,CABIN1TGCTAS601245EAG9.3321e-050.7242image
ENSG00000099991.15,CABIN1THCADasatinibEAG1.6278e-03-0.4714image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType