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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ICMT (ImmuneEditome ID:23463)

1. Gene summary of enriched editing regions for ICMT

check button Gene summary
Gene informationGene symbol

ICMT

Gene ID

23463

GeneSynonymsHSTE14|MST098|MSTP098|PCCMT|PCMT|PPMT
GeneCytomap

1p36.31

GeneTypeprotein-coding
GeneDescriptionprotein-S-isoprenylcysteine O-methyltransferase|prenylated protein carboxyl methyltransferase|prenylcysteine carboxyl methyltransferase
GeneModificationdate20230517
UniprotIDO60725;Q7Z750;A0A024R4F6;K7EQW0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:6222106-6223428:-ENST00000495791.1ENSG00000116237.14ICMTncRNA_exonicAluSz,AluSx3chr1:6222106-6223428:-.alignment


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2. Tumor-specific enriched editing regions for ICMT


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:6222106-6223428:-BRCAEER6.9602e-29image
ENSG00000116237.14,ICMTBRCAEAG6.9602e-29image
chr1:6222106-6223428:-COADEER1.3057e-03image
ENSG00000116237.14,ICMTCOADEAG1.3282e-03image
chr1:6222106-6223428:-HNSCEER1.6844e-14image
ENSG00000116237.14,ICMTHNSCEAG1.6844e-14image
chr1:6222106-6223428:-KIRCEER1.3457e-09image
ENSG00000116237.14,ICMTKIRCEAG1.3457e-09image
chr1:6222106-6223428:-KIRPEER8.8549e-03image
ENSG00000116237.14,ICMTKIRPEAG8.8549e-03image
chr1:6222106-6223428:-LIHCEER8.4472e-04image
ENSG00000116237.14,ICMTLIHCEAG8.4472e-04image
chr1:6222106-6223428:-LUADEER1.5194e-08image
ENSG00000116237.14,ICMTLUADEAG1.5194e-08image
chr1:6222106-6223428:-LUSCEER1.7267e-05image
ENSG00000116237.14,ICMTLUSCEAG1.7267e-05image
chr1:6222106-6223428:-STADEER8.7050e-04image
ENSG00000116237.14,ICMTSTADEAG8.7045e-04image
chr1:6222106-6223428:-THCAEER4.5342e-03image
ENSG00000116237.14,ICMTTHCAEAG4.5342e-03image
chr1:6222106-6223428:-UCECEER1.5748e-06image
ENSG00000116237.14,ICMTUCECEAG1.4788e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000116237.14,ICMTKIRCPathEAG7.8687e-042.6882e-040.1581image
chr1:6222106-6223428:-KIRCPathEER7.8687e-042.6882e-040.1581image
ENSG00000116237.14,ICMTTHCAPathEAG1.1527e-032.8966e-040.1618image
chr1:6222106-6223428:-THCAPathEER1.1527e-032.8966e-040.1618image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ICMT


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:6222106-6223428:-BLCAEERENSG00000156587,UBE2L60.57007.1370e-318.9216e-330.5466imageNELAVL3;FBL;FUSNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000204267,TAP20.56423.1987e-301.3158e-290.5225imageNFBL;FUSTAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000168394,TAP10.55881.7020e-298.3842e-280.5078imageNFBL;FUSTAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000117228,GBP10.55525.3499e-294.9261e-180.4130imageNNGBP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000025708,TYMP0.54305.0483e-287.6893e-230.4634imageNFBL;FUSTYMPT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000115267,IFIH10.53813.3862e-272.3413e-230.4683imageNFBL;FUSIFIH1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000240065,PSMB90.53764.0893e-273.6452e-270.5024imageNFBL;FUSPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000234745,HLA-B0.53755.8856e-275.1962e-280.5095imageNFBL;FUSHLA-BT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000134470,IL15RA0.52983.4234e-261.5786e-230.4699imageNFBL;FUSIL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:6222106-6223428:-BLCAEERENSG00000068079,IFI350.52581.0982e-256.2841e-250.4828imageNFBL;FUSIFI35T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for ICMT


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000116237.14,ICMT
ACCEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.61252.7697e-022.7277e-08-0.5922imageNACIN1;ADAR;AIFM1;AUH;BUD13;CAPRIN1;CBX7;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RBM6;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YTHDF2;YWHAG;ZNF184PRKCSHT_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000116237.14,ICMT
BLCAEAGIRENSG00000016864.12chr352694488:52695302:52695420:52695554-0.42984.0193e-151.0625e-17-0.4092imageNACIN1;ADAR;AIFM1;AUH;BUD13;CBX7;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000116237.14,ICMT
BLCAEAGIRENSG00000111679.12chr126951261:6951520:6951608:6951731-0.30822.6043e-091.8341e-14-0.4029imageNAIFM1;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX54;DHX9;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LARP7;LIN28A;LSM11;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF1;U2AF2;UPF1;ZNF184PTPN6Dendritic_cells_activatedGSVA_HALLMARK_COMPLEMENT
chr1:6222106-6223428:-
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.66057.2851e-456.1899e-50-0.6516imageNELAVL3;FBL;FUSPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000116237.14,ICMT
BLCAEAGIRENSG00000076928.13chr1941897314:41898113:41898441:41898587-0.40671.0356e-144.4986e-19-0.4436imageNADAR;AIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZFP36;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000116237.14,ICMT
BLCAEAGIRENSG00000016864.12chr352694488:52695587:52695927:52696040-0.42042.1520e-147.6271e-18-0.4109imageNACIN1;ADAR;AIFM1;AUH;BUD13;CBX7;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMacrophages_M1GSVA_HALLMARK_HEME_METABOLISM
ENSG00000116237.14,ICMT
BLCAEAGESENSG00000083457.7chr173720306:3720402:3723287:3723383:3723687:37237440.42672.4172e-146.4861e-200.4337imageNACIN1;ADAR;AIFM1;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZNF184ITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000116237.14,ICMT
BLCAEAGIRENSG00000121281.8chr1650312035:50314062:50314291:50314406-0.29221.2700e-081.5450e-13-0.4055imageNACIN1;ADAR;AIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YTHDF2;YWHAG;ZNF184NAMacrophages_M1GSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr1:6222106-6223428:-
BLCAEERIRENSG00000184922.9chr1745238563:45238638:45238954:45239054-0.32701.9673e-102.1341e-15-0.4211imageNFBL;FUSNAT_cells_CD4_memory_activatedGSVA_HALLMARK_IL2_STAT5_SIGNALING
ENSG00000116237.14,ICMT
BLCAEAGIRENSG00000139278.5chr1275495576:75498720:75498823:75503853-0.40931.0820e-131.0082e-19-0.4326imageNADAR;DKC1;EIF4A3;ELAVL1;ELAVL3;FMR1;FUS;HNRNPC;HNRNPL;IGF2BP1;IGF2BP2;KHDRBS2;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;PTBP1;RBFOX2;RBM47;RBM5;SAFB2;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;U2AF1;UPF1;YTHDC1NADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

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5. Enriched editing regions and immune infiltration for ICMT


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:6222106-6223428:-BLCAEERMacrophages_M12.2749e-160.3934image
ENSG00000116237.14,ICMTBLCAEAGMacrophages_M12.2749e-160.3934image
chr1:6222106-6223428:-BRCAEERMacrophages_M11.3035e-090.1833image
ENSG00000116237.14,ICMTBRCAEAGMacrophages_M11.3035e-090.1833image
chr1:6222106-6223428:-CESCEERB_cells_naive6.9229e-04-0.1945image
ENSG00000116237.14,ICMTCESCEAGB_cells_naive6.9229e-04-0.1945image
chr1:6222106-6223428:-CHOLEERT_cells_CD4_naive4.1107e-020.3470image
ENSG00000116237.14,ICMTCHOLEAGT_cells_CD4_naive4.1107e-020.3470image
chr1:6222106-6223428:-COADEERMacrophages_M12.4618e-050.2541image
ENSG00000116237.14,ICMTCOADEAGMacrophages_M11.9113e-050.2574image
chr1:6222106-6223428:-DLBCEERMacrophages_M23.4681e-030.4360image
ENSG00000116237.14,ICMTDLBCEAGMacrophages_M23.4681e-030.4360image
chr1:6222106-6223428:-ESCAEERT_cells_regulatory_(Tregs)9.6419e-04-0.2585image
ENSG00000116237.14,ICMTESCAEAGT_cells_regulatory_(Tregs)9.6469e-04-0.2585image
chr1:6222106-6223428:-GBMEERT_cells_follicular_helper1.4501e-03-0.2520image
ENSG00000116237.14,ICMTGBMEAGT_cells_follicular_helper1.4501e-03-0.2520image
chr1:6222106-6223428:-HNSCEERT_cells_regulatory_(Tregs)3.5136e-06-0.2074image
ENSG00000116237.14,ICMTHNSCEAGT_cells_regulatory_(Tregs)3.5136e-06-0.2074image
chr1:6222106-6223428:-KICHEEREosinophils5.7749e-040.4155image
ENSG00000116237.14,ICMTKICHEAGEosinophils5.7749e-040.4155image
chr1:6222106-6223428:-KIRCEERMast_cells_resting5.9544e-04-0.1754image
ENSG00000116237.14,ICMTKIRCEAGMast_cells_resting5.9544e-04-0.1754image
chr1:6222106-6223428:-KIRPEERT_cells_CD4_memory_resting4.9760e-03-0.1668image
ENSG00000116237.14,ICMTKIRPEAGT_cells_CD4_memory_resting4.9760e-03-0.1668image
chr1:6222106-6223428:-LGGEERT_cells_CD4_memory_activated8.0993e-040.1466image
ENSG00000116237.14,ICMTLGGEAGT_cells_CD4_memory_activated8.0993e-040.1466image
chr1:6222106-6223428:-LIHCEERPlasma_cells1.5768e-040.2059image
ENSG00000116237.14,ICMTLIHCEAGPlasma_cells1.5768e-040.2059image
chr1:6222106-6223428:-LUADEERT_cells_CD4_memory_activated4.4031e-090.2566image
ENSG00000116237.14,ICMTLUADEAGT_cells_CD4_memory_activated4.4031e-090.2566image
chr1:6222106-6223428:-LUSCEERMacrophages_M14.5829e-090.2591image
ENSG00000116237.14,ICMTLUSCEAGMacrophages_M14.5829e-090.2591image
chr1:6222106-6223428:-MESOEERMacrophages_M05.8556e-03-0.3036image
ENSG00000116237.14,ICMTMESOEAGMacrophages_M05.8556e-03-0.3036image
chr1:6222106-6223428:-OVEERMacrophages_M13.6699e-060.2680image
ENSG00000116237.14,ICMTOVEAGMacrophages_M13.6770e-060.2680image
chr1:6222106-6223428:-PAADEERNK_cells_resting1.7478e-050.3167image
ENSG00000116237.14,ICMTPAADEAGNK_cells_resting1.7478e-050.3167image
chr1:6222106-6223428:-PCPGEERT_cells_CD4_memory_resting3.9232e-04-0.2614image
ENSG00000116237.14,ICMTPCPGEAGT_cells_CD4_memory_resting3.9232e-04-0.2614image
chr1:6222106-6223428:-PRADEERDendritic_cells_activated2.4822e-050.1879image
ENSG00000116237.14,ICMTPRADEAGDendritic_cells_activated3.0591e-050.1858image
chr1:6222106-6223428:-READEERT_cells_CD4_naive4.6207e-02-0.2073image
ENSG00000116237.14,ICMTREADEAGT_cells_CD4_naive4.6207e-02-0.2073image
chr1:6222106-6223428:-SARCEERT_cells_CD4_memory_activated3.0201e-060.2882image
ENSG00000116237.14,ICMTSARCEAGT_cells_CD4_memory_activated3.0201e-060.2882image
chr1:6222106-6223428:-SKCMEERT_cells_CD83.0233e-140.3415image
ENSG00000116237.14,ICMTSKCMEAGT_cells_CD83.0233e-140.3415image
chr1:6222106-6223428:-STADEERMast_cells_activated1.1988e-03-0.1687image
ENSG00000116237.14,ICMTSTADEAGMast_cells_activated1.1986e-03-0.1687image
chr1:6222106-6223428:-TGCTEERMacrophages_M21.0992e-04-0.3116image
ENSG00000116237.14,ICMTTGCTEAGMacrophages_M21.0992e-04-0.3116image
chr1:6222106-6223428:-THCAEERT_cells_regulatory_(Tregs)1.6542e-100.2810image
ENSG00000116237.14,ICMTTHCAEAGT_cells_regulatory_(Tregs)1.6542e-100.2810image
chr1:6222106-6223428:-THYMEERT_cells_gamma_delta2.6667e-050.3941image
ENSG00000116237.14,ICMTTHYMEAGT_cells_gamma_delta2.6667e-050.3941image
chr1:6222106-6223428:-UCECEERDendritic_cells_activated1.2203e-020.1941image
ENSG00000116237.14,ICMTUCECEAGDendritic_cells_activated8.0293e-030.2051image
chr1:6222106-6223428:-UVMEERT_cells_CD4_memory_resting5.6973e-03-0.3084image
ENSG00000116237.14,ICMTUVMEAGT_cells_CD4_memory_resting5.6973e-03-0.3084image


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6. Enriched editing regions and immune gene sets for ICMT


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr1:6222106-6223428:-BLCAEER3.9450e-02image1.9400e-130.3554image
ENSG00000116237.14,ICMTBLCAEAG3.9450e-02image1.9400e-130.3554image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000116237.14,ICMTBLCAEAG5.3516e-090.28554.9102e-040.17291.9006e-080.27542.4349e-140.3676image
chr1:6222106-6223428:-BLCAEER5.3516e-090.28554.9102e-040.17291.9006e-080.27542.4349e-140.3676image
ENSG00000116237.14,ICMTHNSCEAG1.9129e-040.16744.0815e-05-0.18396.5452e-060.20176.0487e-080.2412image
chr1:6222106-6223428:-HNSCEER1.9129e-040.16744.0815e-05-0.18396.5452e-060.20176.0487e-080.2412image
ENSG00000116237.14,ICMTLUADEAG8.3516e-100.26803.7352e-090.25786.1500e-090.25438.4503e-060.1962image
chr1:6222106-6223428:-LUADEER8.3516e-100.26803.7352e-090.25786.1500e-090.25438.4503e-060.1962image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr1:6222106-6223428:-ACCGSVA_HALLMARK_MYC_TARGETS_V1EER1.6021e-04-0.4198image
ENSG00000116237.14,ICMTACCGSVA_HALLMARK_MYC_TARGETS_V1EAG1.6021e-04-0.4198image
chr1:6222106-6223428:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.8430e-380.5856image
ENSG00000116237.14,ICMTBLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.8430e-380.5856image
ENSG00000116237.14,ICMTBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2780e-530.4441image
chr1:6222106-6223428:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2780e-530.4441image
ENSG00000116237.14,ICMTCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.1251e-230.5291image
chr1:6222106-6223428:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.1251e-230.5291image
ENSG00000116237.14,ICMTCOADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3029e-100.3789image
chr1:6222106-6223428:-COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.7300e-100.3766image
ENSG00000116237.14,ICMTDLBCGSVA_HALLMARK_APICAL_SURFACEEAG1.7850e-020.3596image
chr1:6222106-6223428:-DLBCGSVA_HALLMARK_APICAL_SURFACEEER1.7850e-020.3596image
ENSG00000116237.14,ICMTESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.8446e-080.4150image
chr1:6222106-6223428:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.8414e-080.4150image
ENSG00000116237.14,ICMTGBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3209e-040.3004image
chr1:6222106-6223428:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3209e-040.3004image
ENSG00000116237.14,ICMTHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.1986e-240.4333image
chr1:6222106-6223428:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.1986e-240.4333image
ENSG00000116237.14,ICMTKICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.9527e-02-0.2560image
chr1:6222106-6223428:-KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.9527e-02-0.2560image
chr1:6222106-6223428:-KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER7.5835e-09-0.2909image
ENSG00000116237.14,ICMTKIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.5835e-09-0.2909image
ENSG00000116237.14,ICMTKIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.5478e-05-0.2542image
chr1:6222106-6223428:-KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.5478e-05-0.2542image
chr1:6222106-6223428:-LGGGSVA_HALLMARK_P53_PATHWAYEER4.6023e-060.1996image
ENSG00000116237.14,ICMTLGGGSVA_HALLMARK_P53_PATHWAYEAG4.6023e-060.1996image
chr1:6222106-6223428:-LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0604e-060.2641image
ENSG00000116237.14,ICMTLIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0604e-060.2641image
ENSG00000116237.14,ICMTLUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4448e-170.3662image
chr1:6222106-6223428:-LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4448e-170.3662image
chr1:6222106-6223428:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.4742e-260.4476image
ENSG00000116237.14,ICMTLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.4742e-260.4476image
chr1:6222106-6223428:-MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.7119e-040.3797image
ENSG00000116237.14,ICMTMESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.7119e-040.3797image
chr1:6222106-6223428:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0268e-150.4479image
ENSG00000116237.14,ICMTOVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0224e-150.4479image
chr1:6222106-6223428:-PAADGSVA_HALLMARK_P53_PATHWAYEER1.4665e-060.3528image
ENSG00000116237.14,ICMTPAADGSVA_HALLMARK_P53_PATHWAYEAG1.4665e-060.3528image
chr1:6222106-6223428:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0036e-040.2738image
ENSG00000116237.14,ICMTPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0036e-040.2738image
ENSG00000116237.14,ICMTPRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9535e-140.3305image
chr1:6222106-6223428:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.9935e-140.3304image
ENSG00000116237.14,ICMTREADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.0231e-070.4970image
chr1:6222106-6223428:-READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.0231e-070.4970image
ENSG00000116237.14,ICMTSARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9354e-090.3654image
chr1:6222106-6223428:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9354e-090.3654image
chr1:6222106-6223428:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.6055e-240.4419image
ENSG00000116237.14,ICMTSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.6055e-240.4419image
ENSG00000116237.14,ICMTSTADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9783e-070.2678image
chr1:6222106-6223428:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9773e-070.2678image
chr1:6222106-6223428:-TGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2788e-060.3706image
ENSG00000116237.14,ICMTTGCTGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2788e-060.3706image
chr1:6222106-6223428:-THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.9560e-120.3057image
ENSG00000116237.14,ICMTTHCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.9560e-120.3057image
ENSG00000116237.14,ICMTTHYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2565e-05-0.4085image
chr1:6222106-6223428:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2565e-05-0.4085image
chr1:6222106-6223428:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.7415e-100.4520image
ENSG00000116237.14,ICMTUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.4177e-100.4524image
ENSG00000116237.14,ICMTUCSGSVA_HALLMARK_UV_RESPONSE_UPEAG8.6392e-050.5002image
chr1:6222106-6223428:-UCSGSVA_HALLMARK_UV_RESPONSE_UPEER8.6392e-050.5002image
chr1:6222106-6223428:-UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER7.5636e-050.4303image
ENSG00000116237.14,ICMTUVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.5636e-050.4303image


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7. Enriched editing regions and drugs for ICMT


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr1:6222106-6223428:-ACCEpothilone.BEER2.0997e-040.4129image
ENSG00000116237.14,ICMTACCEpothilone.BEAG2.0997e-040.4129image
chr1:6222106-6223428:-BLCACGP.60474EER9.4307e-22-0.4527image
ENSG00000116237.14,ICMTBLCACGP.60474EAG9.4307e-22-0.4527image
chr1:6222106-6223428:-BRCAAxitinibEER3.5187e-120.2097image
ENSG00000116237.14,ICMTBRCAAxitinibEAG3.5187e-120.2097image
chr1:6222106-6223428:-CESCFH535EER6.2605e-130.3990image
ENSG00000116237.14,ICMTCESCFH535EAG6.2605e-130.3990image
chr1:6222106-6223428:-CHOLJNK.Inhibitor.VIIIEER2.7998e-020.3715image
ENSG00000116237.14,ICMTCHOLJNK.Inhibitor.VIIIEAG2.7998e-020.3715image
ENSG00000116237.14,ICMTCOADGefitinibEAG1.8982e-05-0.2575image
chr1:6222106-6223428:-COADGefitinibEER1.6917e-05-0.2590image
chr1:6222106-6223428:-DLBCGefitinibEER6.4326e-030.4092image
ENSG00000116237.14,ICMTDLBCGefitinibEAG6.4326e-030.4092image
chr1:6222106-6223428:-ESCAAxitinibEER2.0486e-020.1837image
ENSG00000116237.14,ICMTESCAAxitinibEAG2.0489e-020.1836image
ENSG00000116237.14,ICMTGBMBMS.754807EAG1.8852e-040.2938image
chr1:6222106-6223428:-GBMBMS.754807EER1.8852e-040.2938image
ENSG00000116237.14,ICMTHNSCCI.1040EAG4.0676e-21-0.4076image
chr1:6222106-6223428:-HNSCCI.1040EER4.0676e-21-0.4076image
chr1:6222106-6223428:-KICHCytarabineEER2.5047e-04-0.4394image
ENSG00000116237.14,ICMTKICHCytarabineEAG2.5047e-04-0.4394image
ENSG00000116237.14,ICMTKIRCBicalutamideEAG3.7086e-060.2348image
chr1:6222106-6223428:-KIRCBicalutamideEER3.7086e-060.2348image
chr1:6222106-6223428:-KIRPEpothilone.BEER9.9426e-070.2865image
ENSG00000116237.14,ICMTKIRPEpothilone.BEAG9.9426e-070.2865image
chr1:6222106-6223428:-LAMLKIN001.135EER3.0149e-020.3521image
ENSG00000116237.14,ICMTLAMLKIN001.135EAG3.0149e-020.3521image
ENSG00000116237.14,ICMTLGGBexaroteneEAG3.4315e-05-0.1808image
chr1:6222106-6223428:-LGGBexaroteneEER3.4315e-05-0.1808image
ENSG00000116237.14,ICMTLIHCBMS.754807EAG1.9303e-040.2038image
chr1:6222106-6223428:-LIHCBMS.754807EER1.9303e-040.2038image
ENSG00000116237.14,ICMTLUADJW.7.52.1EAG1.3583e-08-0.2486image
chr1:6222106-6223428:-LUADJW.7.52.1EER1.3583e-08-0.2486image
chr1:6222106-6223428:-LUSCGemcitabineEER6.6666e-10-0.2724image
ENSG00000116237.14,ICMTLUSCGemcitabineEAG6.6666e-10-0.2724image
chr1:6222106-6223428:-MESOCGP.082996EER2.7843e-03-0.3281image
ENSG00000116237.14,ICMTMESOCGP.082996EAG2.7843e-03-0.3281image
ENSG00000116237.14,ICMTOVCHIR.99021EAG7.2622e-090.3315image
chr1:6222106-6223428:-OVCHIR.99021EER7.2733e-090.3315image
chr1:6222106-6223428:-PAADATRAEER7.3924e-040.2564image
ENSG00000116237.14,ICMTPAADATRAEAG7.3924e-040.2564image
ENSG00000116237.14,ICMTPCPGFTI.277EAG1.0866e-030.2416image
chr1:6222106-6223428:-PCPGFTI.277EER1.0866e-030.2416image
chr1:6222106-6223428:-PRADCytarabineEER2.2470e-090.2641image
ENSG00000116237.14,ICMTPRADCytarabineEAG2.4663e-090.2634image
ENSG00000116237.14,ICMTREADJNK.9LEAG5.3632e-04-0.3522image
chr1:6222106-6223428:-READJNK.9LEER5.3632e-04-0.3522image
ENSG00000116237.14,ICMTSARCAG.014699EAG2.0398e-100.3853image
chr1:6222106-6223428:-SARCAG.014699EER2.0398e-100.3853image
chr1:6222106-6223428:-SKCMEpothilone.BEER1.5152e-080.2579image
ENSG00000116237.14,ICMTSKCMEpothilone.BEAG1.5152e-080.2579image
ENSG00000116237.14,ICMTSTADGefitinibEAG6.7465e-04-0.1774image
chr1:6222106-6223428:-STADGefitinibEER6.7431e-04-0.1774image
chr1:6222106-6223428:-TGCTCI.1040EER2.7247e-06-0.3734image
ENSG00000116237.14,ICMTTGCTCI.1040EAG2.7247e-06-0.3734image
chr1:6222106-6223428:-THCAAG.014699EER9.9087e-170.3602image
ENSG00000116237.14,ICMTTHCAAG.014699EAG9.9087e-170.3602image
ENSG00000116237.14,ICMTTHYMBAY.61.3606EAG1.6408e-060.4442image
chr1:6222106-6223428:-THYMBAY.61.3606EER1.6408e-060.4442image
ENSG00000116237.14,ICMTUCECFH535EAG6.4317e-060.3421image
chr1:6222106-6223428:-UCECFH535EER5.6416e-060.3441image
ENSG00000116237.14,ICMTUCSCGP.60474EAG3.4000e-04-0.4618image
chr1:6222106-6223428:-UCSCGP.60474EER3.4000e-04-0.4618image
ENSG00000116237.14,ICMTUVMJNJ.26854165EAG1.4439e-06-0.5116image
chr1:6222106-6223428:-UVMJNJ.26854165EER1.4439e-06-0.5116image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType