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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SYT11 (ImmuneEditome ID:23208)

1. Gene summary of enriched editing regions for SYT11

check button Gene summary
Gene informationGene symbol

SYT11

Gene ID

23208

GeneSynonymsSYT12|sytXI
GeneCytomap

1q22

GeneTypeprotein-coding
GeneDescriptionsynaptotagmin-11|synaptotagmin 12|synaptotagmin XI
GeneModificationdate20230518
UniprotIDQ9BT88
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:155881779-155882052:+ENST00000368324.4ENSG00000132718.8SYT11UTR3AluSq2,(T)nchr1:155881779-155882052:+.alignment
chr1:155883229-155883509:+ENST00000368324.4ENSG00000132718.8SYT11UTR3AluJbchr1:155883229-155883509:+.alignment


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2. Tumor-specific enriched editing regions for SYT11


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000132718.8,SYT11PRADEAG3.5877e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000132718.8,SYT11COADPathEAG6.9968e-031.0714e-03-0.6045image
ENSG00000132718.8,SYT11KIRCPathEAG4.0378e-024.7705e-030.1875image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for SYT11


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for SYT11


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for SYT11


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000132718.8,SYT11BLCAEAGPlasma_cells8.9324e-030.4480image
chr1:155883229-155883509:+BRCAEERNeutrophils2.2774e-020.1688image
ENSG00000132718.8,SYT11BRCAEAGT_cells_CD4_naive1.1717e-020.1478image
ENSG00000132718.8,SYT11CESCEAGT_cells_gamma_delta3.9323e-020.4527image
ENSG00000132718.8,SYT11ESCAEAGNK_cells_activated2.1086e-020.2835image
ENSG00000132718.8,SYT11GBMEAGMonocytes4.0032e-040.2941image
ENSG00000132718.8,SYT11HNSCEAGMast_cells_activated5.5579e-030.3352image
ENSG00000132718.8,SYT11KIRCEAGPlasma_cells8.3585e-050.3023image
ENSG00000132718.8,SYT11KIRPEAGEosinophils5.4075e-060.4612image
ENSG00000132718.8,SYT11LGGEAGMast_cells_activated4.1695e-03-0.1603image
ENSG00000132718.8,SYT11LUADEAGDendritic_cells_activated2.9345e-030.3005image
chr1:155883229-155883509:+MESOEERB_cells_memory3.3026e-020.4665image
ENSG00000132718.8,SYT11MESOEAGEosinophils4.8088e-020.4164image
chr1:155881779-155882052:+OVEERT_cells_gamma_delta3.6804e-020.1695image
ENSG00000132718.8,SYT11OVEAGMacrophages_M21.7129e-03-0.2022image
ENSG00000132718.8,SYT11PAADEAGMacrophages_M04.3692e-040.4433image
chr1:155883229-155883509:+PRADEERMonocytes9.9533e-04-0.3702image
ENSG00000132718.8,SYT11PRADEAGMonocytes1.9852e-03-0.2944image
chr1:155883229-155883509:+SARCEERT_cells_CD4_memory_activated1.2732e-020.2483image
ENSG00000132718.8,SYT11SKCMEAGNK_cells_activated4.9939e-020.1432image
chr1:155881779-155882052:+STADEERNeutrophils6.0936e-030.2460image
ENSG00000132718.8,SYT11STADEAGT_cells_CD4_memory_activated1.1249e-030.2376image
ENSG00000132718.8,SYT11THCAEAGNeutrophils3.4306e-030.2872image
chr1:155883229-155883509:+UCECEERDendritic_cells_activated2.3342e-030.4624image
ENSG00000132718.8,SYT11UCECEAGDendritic_cells_activated1.5213e-030.4409image
ENSG00000132718.8,SYT11UCSEAGT_cells_CD83.4781e-020.4155image


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6. Enriched editing regions and immune gene sets for SYT11


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000132718.8,SYT11BRCAEAG1.8868e-05image1.0923e-03-0.1908image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000132718.8,SYT11BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.3416e-03-0.5116image
chr1:155883229-155883509:+BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER9.1620e-060.3222image
ENSG00000132718.8,SYT11BRCAGSVA_HALLMARK_UV_RESPONSE_DNEAG8.2925e-07-0.2846image
ENSG00000132718.8,SYT11ESCAGSVA_HALLMARK_COAGULATIONEAG3.9967e-02-0.2535image
ENSG00000132718.8,SYT11GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.9040e-070.4118image
ENSG00000132718.8,SYT11HNSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.6288e-04-0.4447image
ENSG00000132718.8,SYT11KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.4795e-09-0.4445image
ENSG00000132718.8,SYT11KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.3165e-03-0.3353image
ENSG00000132718.8,SYT11LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1009e-120.3851image
ENSG00000132718.8,SYT11LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG7.5269e-03-0.2712image
ENSG00000132718.8,SYT11LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.3644e-020.2137image
ENSG00000132718.8,SYT11MESOGSVA_HALLMARK_P53_PATHWAYEAG8.8521e-030.5328image
chr1:155883229-155883509:+MESOGSVA_HALLMARK_P53_PATHWAYEER1.2681e-020.5339image
chr1:155881779-155882052:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER4.6223e-02-0.1620image
ENSG00000132718.8,SYT11OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.3624e-09-0.3714image
ENSG00000132718.8,SYT11PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.3299e-02-0.2640image
chr1:155883229-155883509:+PCPGGSVA_HALLMARK_UV_RESPONSE_DNEER6.7640e-03-0.3143image
ENSG00000132718.8,SYT11PCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG1.1463e-03-0.3660image
chr1:155883229-155883509:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER2.0498e-05-0.4676image
ENSG00000132718.8,SYT11PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG2.4226e-07-0.4725image
chr1:155883229-155883509:+SARCGSVA_HALLMARK_APICAL_SURFACEEER5.5393e-030.2755image
ENSG00000132718.8,SYT11SARCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.9678e-020.1885image
chr1:155883229-155883509:+SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER1.9729e-04-0.2920image
ENSG00000132718.8,SYT11SKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0972e-03-0.2363image
chr1:155881779-155882052:+STADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.2497e-04-0.3390image
ENSG00000132718.8,SYT11STADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.5300e-04-0.2599image
ENSG00000132718.8,SYT11THCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG8.1553e-030.2606image
ENSG00000132718.8,SYT11UCECGSVA_HALLMARK_MYOGENESISEAG3.1509e-02-0.3077image
chr1:155883229-155883509:+UCECGSVA_HALLMARK_MYOGENESISEER2.2602e-02-0.3554image
ENSG00000132718.8,SYT11UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.4511e-03-0.5684image


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7. Enriched editing regions and drugs for SYT11


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000132718.8,SYT11BLCAGW.441756EAG2.8142e-02-0.3822image
chr1:155883229-155883509:+BRCADMOGEER3.3723e-050.3030image
ENSG00000132718.8,SYT11BRCADMOGEAG2.6067e-050.2447image
ENSG00000132718.8,SYT11CESCAMG.706EAG2.5367e-020.4982image
ENSG00000132718.8,SYT11ESCABIBW2992EAG2.1116e-02-0.2834image
ENSG00000132718.8,SYT11GBMCEP.701EAG2.8967e-090.4740image
ENSG00000132718.8,SYT11HNSCAP.24534EAG2.0472e-050.4951image
ENSG00000132718.8,SYT11KIRCEmbelinEAG3.0430e-080.4159image
ENSG00000132718.8,SYT11KIRPAZD6482EAG1.6850e-030.3283image
ENSG00000132718.8,SYT11LGGBortezomibEAG7.6965e-16-0.4313image
ENSG00000132718.8,SYT11LUADGSK269962AEAG2.2960e-030.3108image
ENSG00000132718.8,SYT11LUSCLapatinibEAG3.7772e-02-0.2102image
ENSG00000132718.8,SYT11MESOEmbelinEAG4.2638e-030.5730image
chr1:155883229-155883509:+MESOCyclopamineEER5.5578e-030.5828image
chr1:155881779-155882052:+OVAZD6244EER4.5633e-03-0.2289image
ENSG00000132718.8,SYT11OVBexaroteneEAG4.4354e-080.3456image
ENSG00000132718.8,SYT11PAADBIBW2992EAG8.1412e-03-0.3414image
chr1:155883229-155883509:+PCPGBMS.536924EER3.2266e-02-0.2526image
ENSG00000132718.8,SYT11PCPGGefitinibEAG1.9221e-02-0.2681image
chr1:155883229-155883509:+PRADBX.795EER1.9235e-040.4151image
ENSG00000132718.8,SYT11PRADBX.795EAG3.2030e-050.3888image
chr1:155883229-155883509:+SARCCamptothecinEER1.8476e-04-0.3655image
ENSG00000132718.8,SYT11SARCCytarabineEAG2.7448e-03-0.2842image
chr1:155883229-155883509:+SKCMGNF.2EER1.4974e-05-0.3369image
ENSG00000132718.8,SYT11SKCMGNF.2EAG5.4799e-05-0.2898image
chr1:155881779-155882052:+STADBIBW2992EER1.4353e-07-0.4564image
ENSG00000132718.8,SYT11STADAZD6482EAG7.0541e-050.2880image
ENSG00000132718.8,SYT11THCAEtoposideEAG1.2366e-030.3155image
ENSG00000132718.8,SYT11UCECLapatinibEAG2.3339e-03-0.4250image
chr1:155883229-155883509:+UCECLapatinibEER2.4688e-03-0.4602image
ENSG00000132718.8,SYT11UCSBX.795EAG5.6413e-030.5273image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType