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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CLASP2 (ImmuneEditome ID:23122)

1. Gene summary of enriched editing regions for CLASP2

check button Gene summary
Gene informationGene symbol

CLASP2

Gene ID

23122

GeneSynonyms-
GeneCytomap

3p22.3

GeneTypeprotein-coding
GeneDescriptionCLIP-associating protein 2|CLIP-associating protein CLASP2|multiple asters (Mast)-like homolog 2|protein Orbit homolog 2
GeneModificationdate20230517
UniprotIDB3KR06;O75122;E7ERI8;E7ENG2;A0A804HJG7;E7EW49;D6RBU8;A0A0U1RQI6;E3W994;J3KR49;C9J668;H7C4M5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:33505639-33506696:-ENST00000359576.8ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33505639-33506696:-ENST00000399362.7ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33505639-33506696:-ENST00000461133.6ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33505639-33506696:-ENST00000468888.5ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33505639-33506696:-ENST00000476251.1ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33505639-33506696:-ENST00000480013.4ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33505639-33506696:-ENST00000487553.4ENSG00000163539.14CLASP2intronicL1MC5a,L1M4,AluSg4,AluJochr3:33505639-33506696:-.alignment
chr3:33540286-33540537:-ENST00000494261.1ENSG00000163539.14CLASP2ncRNA_intronicAluJr4chr3:33540286-33540537:-.alignment
chr3:33541700-33541932:-ENST00000494261.1ENSG00000163539.14CLASP2ncRNA_intronicL1PA12chr3:33541700-33541932:-.alignment
chr3:33545673-33545896:-ENST00000359576.8ENSG00000163539.14CLASP2intronicAluSzchr3:33545673-33545896:-.alignment
chr3:33545673-33545896:-ENST00000399362.7ENSG00000163539.14CLASP2intronicAluSzchr3:33545673-33545896:-.alignment
chr3:33545673-33545896:-ENST00000461133.6ENSG00000163539.14CLASP2intronicAluSzchr3:33545673-33545896:-.alignment
chr3:33545673-33545896:-ENST00000468888.5ENSG00000163539.14CLASP2intronicAluSzchr3:33545673-33545896:-.alignment
chr3:33545673-33545896:-ENST00000480013.4ENSG00000163539.14CLASP2intronicAluSzchr3:33545673-33545896:-.alignment
chr3:33545673-33545896:-ENST00000480385.1ENSG00000163539.14CLASP2intronicAluSzchr3:33545673-33545896:-.alignment
chr3:33547837-33548526:-ENST00000359576.8ENSG00000163539.14CLASP2intronicAluJb,L1M4,AluSc8chr3:33547837-33548526:-.alignment
chr3:33547837-33548526:-ENST00000399362.7ENSG00000163539.14CLASP2intronicAluJb,L1M4,AluSc8chr3:33547837-33548526:-.alignment
chr3:33547837-33548526:-ENST00000461133.6ENSG00000163539.14CLASP2intronicAluJb,L1M4,AluSc8chr3:33547837-33548526:-.alignment
chr3:33547837-33548526:-ENST00000468888.5ENSG00000163539.14CLASP2intronicAluJb,L1M4,AluSc8chr3:33547837-33548526:-.alignment
chr3:33547837-33548526:-ENST00000480013.4ENSG00000163539.14CLASP2intronicAluJb,L1M4,AluSc8chr3:33547837-33548526:-.alignment
chr3:33547837-33548526:-ENST00000480385.1ENSG00000163539.14CLASP2intronicAluJb,L1M4,AluSc8chr3:33547837-33548526:-.alignment
chr3:33549766-33550333:-ENST00000359576.8ENSG00000163539.14CLASP2intronicAluSx1,HAL1,AluJbchr3:33549766-33550333:-.alignment
chr3:33549766-33550333:-ENST00000399362.7ENSG00000163539.14CLASP2intronicAluSx1,HAL1,AluJbchr3:33549766-33550333:-.alignment
chr3:33549766-33550333:-ENST00000461133.6ENSG00000163539.14CLASP2intronicAluSx1,HAL1,AluJbchr3:33549766-33550333:-.alignment
chr3:33549766-33550333:-ENST00000468888.5ENSG00000163539.14CLASP2intronicAluSx1,HAL1,AluJbchr3:33549766-33550333:-.alignment
chr3:33549766-33550333:-ENST00000480013.4ENSG00000163539.14CLASP2intronicAluSx1,HAL1,AluJbchr3:33549766-33550333:-.alignment
chr3:33549766-33550333:-ENST00000480385.1ENSG00000163539.14CLASP2intronicAluSx1,HAL1,AluJbchr3:33549766-33550333:-.alignment
chr3:33608800-33609285:-ENST00000313350.9ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000333778.9ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000359576.8ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000399362.7ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000461133.6ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000468888.5ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000480013.4ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment
chr3:33608800-33609285:-ENST00000487200.4ENSG00000163539.14CLASP2intronicAluSz,AluSqchr3:33608800-33609285:-.alignment


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2. Tumor-specific enriched editing regions for CLASP2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000163539.14,CLASP2ESCACliEAG1.0129e-029.4587e-03-0.4517image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CLASP2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for CLASP2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for CLASP2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:33545673-33545896:-BRCAEERNeutrophils4.2074e-02-0.4368image
chr3:33549766-33550333:-ESCAEERB_cells_naive4.6187e-03-0.3348image
ENSG00000163539.14,CLASP2ESCAEAGMacrophages_M06.3674e-030.2725image
chr3:33549766-33550333:-LAMLEERT_cells_CD85.2227e-050.3931image
ENSG00000163539.14,CLASP2LAMLEAGB_cells_naive2.0259e-030.2725image
ENSG00000163539.14,CLASP2LGGEAGMacrophages_M13.2300e-030.1629image
chr3:33547837-33548526:-OVEERMacrophages_M11.5281e-020.3199image
chr3:33549766-33550333:-OVEERT_cells_CD4_memory_activated3.3415e-020.3289image
ENSG00000163539.14,CLASP2OVEAGMacrophages_M01.0424e-02-0.2798image
chr3:33545673-33545896:-PCPGEERB_cells_naive3.0915e-020.4832image
ENSG00000163539.14,CLASP2PCPGEAGT_cells_follicular_helper2.5566e-02-0.4548image
chr3:33540286-33540537:-STADEERMacrophages_M24.6221e-02-0.4395image
chr3:33547837-33548526:-STADEERDendritic_cells_resting1.0781e-020.2721image
chr3:33549766-33550333:-STADEERT_cells_CD4_memory_activated9.8904e-030.2009image
ENSG00000163539.14,CLASP2STADEAGB_cells_memory4.3992e-03-0.2052image


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6. Enriched editing regions and immune gene sets for CLASP2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000163539.14,CLASP2BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.4720e-050.5847image
chr3:33545673-33545896:-BRCAGSVA_HALLMARK_P53_PATHWAYEER7.8221e-040.6624image
chr3:33549766-33550333:-ESCAGSVA_HALLMARK_HYPOXIAEER2.9124e-050.4775image
ENSG00000163539.14,CLASP2ESCAGSVA_HALLMARK_HYPOXIAEAG9.3435e-050.3825image
ENSG00000163539.14,CLASP2GBMGSVA_HALLMARK_UV_RESPONSE_UPEAG2.0612e-020.3115image
ENSG00000163539.14,CLASP2LAMLGSVA_HALLMARK_E2F_TARGETSEAG2.4567e-04-0.3212image
chr3:33549766-33550333:-LAMLGSVA_HALLMARK_E2F_TARGETSEER1.0809e-05-0.4244image
ENSG00000163539.14,CLASP2LGGGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG4.9481e-060.2502image
chr3:33549766-33550333:-LGGGSVA_HALLMARK_MYOGENESISEER7.4553e-030.2082image
ENSG00000163539.14,CLASP2OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.7114e-03-0.3073image
chr3:33547837-33548526:-OVGSVA_HALLMARK_P53_PATHWAYEER3.8997e-050.5165image
chr3:33549766-33550333:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.8776e-030.4362image
chr3:33549766-33550333:-STADGSVA_HALLMARK_UV_RESPONSE_UPEER4.0069e-030.2236image
ENSG00000163539.14,CLASP2STADGSVA_HALLMARK_MYC_TARGETS_V1EAG2.8172e-020.1588image
chr3:33540286-33540537:-STADGSVA_HALLMARK_MYC_TARGETS_V2EER4.2397e-020.4466image
chr3:33608800-33609285:-STADGSVA_HALLMARK_MYC_TARGETS_V2EER3.5648e-020.2652image
chr3:33547837-33548526:-STADGSVA_HALLMARK_UV_RESPONSE_UPEER3.3623e-030.3111image


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7. Enriched editing regions and drugs for CLASP2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000163539.14,CLASP2BRCAAZD.0530EAG2.1171e-03-0.4464image
chr3:33545673-33545896:-BRCADocetaxelEER1.0231e-02-0.5354image
chr3:33549766-33550333:-ESCABexaroteneEER5.6530e-04-0.4018image
ENSG00000163539.14,CLASP2ESCACGP.60474EAG1.1240e-03-0.3227image
ENSG00000163539.14,CLASP2GBMErlotinibEAG1.2712e-03-0.4236image
ENSG00000163539.14,CLASP2LAMLLFM.A13EAG5.1565e-04-0.3050image
chr3:33549766-33550333:-LAMLJNK.9LEER1.5174e-04-0.3699image
ENSG00000163539.14,CLASP2LGGCGP.60474EAG8.3360e-03-0.1461image
chr3:33549766-33550333:-LGGABT.263EER5.5971e-030.2154image
ENSG00000163539.14,CLASP2OVBexaroteneEAG1.2060e-040.4096image
chr3:33547837-33548526:-OVLapatinibEER7.9192e-03-0.3484image
chr3:33549766-33550333:-OVATRAEER1.1267e-030.4852image
ENSG00000163539.14,CLASP2PCPGCHIR.99021EAG3.1304e-02-0.4403image
chr3:33549766-33550333:-STADAZD.0530EER2.8403e-02-0.1750image
ENSG00000163539.14,CLASP2STADErlotinibEAG3.0201e-02-0.1573image
chr3:33540286-33540537:-STADAZD6244EER3.2410e-04-0.7086image
chr3:33547837-33548526:-STADA.443654EER1.0249e-02-0.2739image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType