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	1. Gene summary of enriched editing regions
	2. Tumor-specific enriched editing regions
	Comparison of enriched editing regions between tumor and normal.
	Correlation of enriched editing regions with tumor stages.
	Associations of enriched editing regions with cancer survival.
	3. Enriched editing regions and immune related genes
	4. Enriched editing regions and immune related splicing
	5. Enriched editing regions and immune infiltration
	6. Enriched editing regions and immune gene sets
	Correlation of enriched editing regions with epithelial-mesenchymal transition.
	Correlations of enriched editing regions with hypoxic.
	Associations of enriched editing regions with hallmark gene sets from MSigDB.
	7. Enriched editing regions and drugs
	Correlations between enriched editing regions and drug sensitivity.
	Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ARHGAP26 (ImmuneEditome ID:23092)

1. Gene summary of enriched editing regions for ARHGAP26

Gene summary

Gene information	Gene symbol	ARHGAP26
	Gene ID	23092
	GeneSynonyms	GRAF\|GRAF1\|OPHN1L\|OPHN1L1
	GeneCytomap	5q31.3
	GeneType	protein-coding
	GeneDescription	rho GTPase-activating protein 26\|GTPase regulator associated with focal adhesion kinase pp125(FAK)\|oligophrenin-1-like protein
	GeneModificationdate	20230329
	UniprotID	Q9UNA1;A0A2R8Y5C0;H7C3P8;A0A2R8YGB3;H7C1J1;H7BZZ0;A0A0S2Z536;A0A2R8YDK5;C9J6V4
	PubMed ID

UCSC image.

Locations of each EERs.

EER	ENST	ENSG	GeneName	Region	Repeat	dsRNA structure
chr5:142875899-142876714:+	ENST00000475287.1	ENSG00000145819.14	ARHGAP26	ncRNA_intronic	AluJr,AluJb,MIRb	chr5:142875899-142876714:+.alignment
chr5:143047939-143048852:+	ENST00000469131.4	ENSG00000145819.14	ARHGAP26	ncRNA_intronic	AluSz,AluSg	chr5:143047939-143048852:+.alignment
chr5:143167198-143167410:+	ENST00000486650.1	ENSG00000145819.14	ARHGAP26	ncRNA_intronic	AluSz	chr5:143167198-143167410:+.alignment
chr5:143211203-143211848:+	ENST00000486650.1	ENSG00000145819.14	ARHGAP26	ncRNA_intronic	(TTAT)n,MER53,AluJo	chr5:143211203-143211848:+.alignment
chr5:143225225-143226485:+	ENST00000486650.1	ENSG00000145819.14	ARHGAP26	ncRNA_exonic	AluY,AluSz	chr5:143225225-143226485:+.alignment

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2. Tumor-specific enriched editing regions for ARHGAP26

Comparison of enriched editing regions between tumor and normal.

* P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes.

ID_events	cancer	Type	P	Boxplot
chr5:143225225-143226485:+	COAD	EER	1.5160e-02
ENSG00000145819.14,ARHGAP26	COAD	EAG	1.7950e-02
ENSG00000145819.14,ARHGAP26	KIRP	EAG	4.9242e-02
chr5:143225225-143226485:+	LUAD	EER	2.3202e-02
ENSG00000145819.14,ARHGAP26	LUAD	EAG	3.0234e-02
chr5:143225225-143226485:+	THCA	EER	4.5316e-02

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Correlation of enriched editing regions with tumor stages.

* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.

* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.

ID_events

cancer

Type

StageType

AnovaP

Boxplot

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Associations of enriched editing regions with cancer survival.

* Pkm<0.05 and Pcox<0.05.

* EER: enriched editing region, EAG: EER-associated genes.

ID_events	cancer	TypeID	Pkm	Pcox_continuous	HR_continuous	KMPlot
chr5:143211203-143211848:+	KIRC	EER	4.8210e-03	3.2225e-02	3.1896e-04

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3. Enriched editing regions and immune related genes for ARHGAP26

Enriched editing regions and immune related genes.

* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).

* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.

ID_events

cancer

Type

Gene

beta

FDR

PearsonP

PearsonR

CorrelationPlot

RBP

RBPtargets

ImmuneGene

ImmuneFraction

HallMark

chr5:143225225-143226485:+

COAD

EER

ENSG00000188493,C19orf54

0.2430

1.3033e-02

2.7954e-10

0.4107

T_cells_follicular_helper

GSVA_HALLMARK_PROTEIN_SECRETION

chr5:143225225-143226485:+

COAD

EER

ENSG00000250067,YJEFN3

0.2292

1.9521e-02

7.5160e-16

0.5102

YJEFN3

Dendritic_cells_activated

GSVA_HALLMARK_PROTEIN_SECRETION

chr5:143225225-143226485:+

COAD

EER

ENSG00000175048,ZDHHC14

0.2028

4.8269e-02

6.5355e-12

0.4433

Dendritic_cells_activated

GSVA_HALLMARK_PEROXISOME

chr5:143225225-143226485:+

ESCA

EER

ENSG00000137486,ARRB1

-0.4350

1.5978e-04

3.8443e-07

-0.4162

ARRB1

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_BILE_ACID_METABOLISM

chr5:143225225-143226485:+

ESCA

EER

ENSG00000140968,IRF8

-0.4237

1.7734e-04

7.8824e-07

-0.4058

IRF8

T_cells_CD4_memory_resting

GSVA_HALLMARK_KRAS_SIGNALING_DN

chr5:143225225-143226485:+

ESCA

EER

ENSG00000205744,DENND1C

-0.4010

5.9702e-04

1.0350e-07

-0.4342

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_ALLOGRAFT_REJECTION

chr5:143225225-143226485:+

ESCA

EER

ENSG00000248994,RP11-259O2.1

0.3849

7.1907e-04

5.8373e-07

0.4102

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

chr5:143225225-143226485:+

ESCA

EER

ENSG00000181031,RPH3AL

-0.3908

1.5124e-03

3.3959e-07

-0.4179

RPH3AL

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_BILE_ACID_METABOLISM

chr5:143225225-143226485:+

ESCA

EER

ENSG00000133101,CCNA1

0.3854

1.6027e-03

1.6524e-10

0.5101

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_HYPOXIA

chr5:143225225-143226485:+

ESCA

EER

ENSG00000196083,IL1RAP

0.3830

1.9600e-03

5.7161e-07

0.4105

IL1RAP

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

More results

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4. Enriched editing regions and immune related splicing for ARHGAP26

Enriched editing regions and immune related splicing.

* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).

* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.

ID_events

cancer

Type

SplicingType

SplicingGene

SplicingChr

SplicingPosition

beta

FDR

PearsonP

PearsonR

CorrelationPlot

RBP

RBPtargets

ImmuneGene

ImmuneFraction

HallMark

chr5:143225225-143226485:+

COAD

EER

ENSG00000067066.12

chr2

230506302:230506445:230507992:230508031

0.2427

4.7425e-02

5.7065e-10

0.4067

SP100

Mast_cells_activated

GSVA_HALLMARK_UV_RESPONSE_UP

chr5:143225225-143226485:+

COAD

EER

ENSG00000142798.12

chr1

21852087:21852233:21852699:21852832

0.2391

4.8121e-02

9.7191e-13

0.4664

HSPG2

T_cells_CD4_naive

GSVA_HALLMARK_HEME_METABOLISM

chr5:143225225-143226485:+

COAD

EER

ENSG00000213928.4

chr14

24165846:24165962:24164062:24164955:24164062:24165183

-0.2420

4.8367e-02

4.4313e-14

-0.4849

IRF9

Mast_cells_activated

GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

chr5:143225225-143226485:+

COAD

EER

ENSG00000132199.14

chr18

690548:690631:691067:691095

0.2496

3.6622e-02

1.7353e-11

0.4361

Eosinophils

GSVA_HALLMARK_ADIPOGENESIS

ENSG00000145819.14,ARHGAP26

ESCA

EAG

ENSG00000140274.9

chr15

45114320:45114752:45115798:45115856

0.2843

4.6830e-02

2.3503e-05

0.4074

DKC1;ELAVL1;FBL;TAF15;U2AF2

B_cells_naive

GSVA_HALLMARK_PANCREAS_BETA_CELLS

chr5:143225225-143226485:+

ESCA

EER

ENSG00000165792.13

chr14

20996526:20996711:20996784:20997005

-0.3640

2.3856e-02

4.0654e-07

-0.4154

B_cells_naive

GSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE

chr5:143225225-143226485:+

ESCA

EER

ENSG00000140274.9

chr15

45114320:45114752:45115798:45115856

0.3100

1.6347e-02

2.0577e-05

0.4120

B_cells_naive

GSVA_HALLMARK_PANCREAS_BETA_CELLS

chr5:143225225-143226485:+

ESCA

EER

ENSG00000036054.8

chr3

100310402:100310542:100311832:100311877:100316098:100316187

0.3514

2.9629e-02

1.0487e-06

0.4016

B_cells_naive

GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

chr5:143225225-143226485:+

ESCA

EER

ENSG00000066230.6

chr5

474882:479965:481564:481635

0.3137

3.6697e-02

7.3242e-06

0.4013

SLC9A3

T_cells_CD4_memory_resting

GSVA_HALLMARK_PANCREAS_BETA_CELLS

chr5:143225225-143226485:+

ESCA

EER

ENSG00000024526.12

chr1

68481439:68481612:68482045:68482897:68483949:68484090

-0.3226

4.5681e-02

9.3853e-07

-0.4286

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_HYPOXIA

More results

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5. Enriched editing regions and immune infiltration for ARHGAP26

Associations of enriched editing regions with immune infiltration.

* P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.

ID_events	cancer	TypeID	ImmuneCell	P	R	CorrelationPlot
chr5:143225225-143226485:+	BLCA	EER	Macrophages_M2	4.5559e-03	0.4198
ENSG00000145819.14,ARHGAP26	BLCA	EAG	Macrophages_M2	8.5252e-03	0.3834
chr5:143225225-143226485:+	BRCA	EER	Mast_cells_resting	1.2031e-02	0.1407
ENSG00000145819.14,ARHGAP26	BRCA	EAG	Mast_cells_resting	9.1033e-03	0.1442
chr5:143225225-143226485:+	CESC	EER	Monocytes	2.6920e-02	-0.2270
ENSG00000145819.14,ARHGAP26	CESC	EAG	Monocytes	4.6985e-02	-0.2002
chr5:143225225-143226485:+	COAD	EER	Plasma_cells	2.7311e-04	-0.2442
ENSG00000145819.14,ARHGAP26	COAD	EAG	Plasma_cells	3.2548e-04	-0.2391
chr5:143225225-143226485:+	ESCA	EER	T_cells_regulatory_(Tregs)	1.2620e-03	-0.2718
ENSG00000145819.14,ARHGAP26	ESCA	EAG	B_cells_naive	7.4395e-03	-0.2261
chr5:143225225-143226485:+	GBM	EER	Eosinophils	1.4386e-02	-0.2349
ENSG00000145819.14,ARHGAP26	GBM	EAG	Eosinophils	1.4387e-02	-0.2349
chr5:143225225-143226485:+	HNSC	EER	Macrophages_M2	3.6700e-02	0.2124
ENSG00000145819.14,ARHGAP26	HNSC	EAG	Macrophages_M2	4.2257e-02	0.2056
chr5:143225225-143226485:+	KIRP	EER	NK_cells_resting	3.1078e-02	0.1792
ENSG00000145819.14,ARHGAP26	KIRP	EAG	T_cells_gamma_delta	3.2904e-02	-0.1761
chr5:143211203-143211848:+	LAML	EER	Dendritic_cells_resting	1.3471e-02	0.3741
ENSG00000145819.14,ARHGAP26	LAML	EAG	B_cells_memory	7.1061e-03	0.3006
chr5:143225225-143226485:+	LGG	EER	Monocytes	2.5092e-02	-0.1154
ENSG00000145819.14,ARHGAP26	LGG	EAG	Monocytes	2.0423e-02	-0.1194
chr5:143225225-143226485:+	LUAD	EER	T_cells_CD4_memory_resting	1.7651e-02	-0.1482
ENSG00000145819.14,ARHGAP26	OV	EAG	Macrophages_M0	2.6900e-02	0.1391
chr5:143225225-143226485:+	PAAD	EER	Dendritic_cells_resting	2.0115e-03	-0.2804
ENSG00000145819.14,ARHGAP26	PAAD	EAG	Dendritic_cells_resting	9.8436e-03	-0.2348
chr5:143225225-143226485:+	PCPG	EER	Dendritic_cells_activated	1.2104e-02	0.2452
ENSG00000145819.14,ARHGAP26	PCPG	EAG	Dendritic_cells_activated	1.0921e-02	0.2486
chr5:143225225-143226485:+	PRAD	EER	NK_cells_activated	8.4804e-03	0.2291
ENSG00000145819.14,ARHGAP26	PRAD	EAG	NK_cells_activated	1.6511e-02	0.2023
chr5:143225225-143226485:+	READ	EER	Monocytes	3.4864e-02	0.2424
ENSG00000145819.14,ARHGAP26	READ	EAG	Monocytes	3.4139e-02	0.2418
ENSG00000145819.14,ARHGAP26	SARC	EAG	T_cells_CD8	3.2848e-02	0.3152
chr5:143225225-143226485:+	SKCM	EER	Dendritic_cells_resting	4.1166e-02	0.1883
ENSG00000145819.14,ARHGAP26	SKCM	EAG	Dendritic_cells_resting	3.0404e-02	0.1961
chr5:142875899-142876714:+	STAD	EER	Macrophages_M1	3.0267e-03	0.3596
chr5:143047939-143048852:+	STAD	EER	NK_cells_resting	1.9034e-02	0.2296
chr5:143211203-143211848:+	STAD	EER	Macrophages_M2	1.6955e-02	0.2714
chr5:143225225-143226485:+	STAD	EER	T_cells_CD4_memory_resting	1.0359e-02	-0.1355
ENSG00000145819.14,ARHGAP26	STAD	EAG	T_cells_CD4_memory_resting	8.9684e-03	-0.1379
ENSG00000145819.14,ARHGAP26	THCA	EAG	Monocytes	3.3230e-02	-0.1946
chr5:143225225-143226485:+	THYM	EER	Monocytes	1.5946e-04	0.5091
ENSG00000145819.14,ARHGAP26	THYM	EAG	Monocytes	1.3973e-04	0.5129
chr5:143225225-143226485:+	UCEC	EER	T_cells_gamma_delta	1.0658e-03	0.3883
ENSG00000145819.14,ARHGAP26	UCEC	EAG	T_cells_gamma_delta	7.1014e-04	0.3925

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6. Enriched editing regions and immune gene sets for ARHGAP26

Correlation of enriched editing regions with epithelial-mesenchymal transition.

* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).

* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the EERs/EAGs significantly edited between Epi and Mes group.

ID_events

cancer

Type

E2M_P

Boxplot

CorP

CorR

CorrelationPlot

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Correlations of enriched editing regions with hypoxic.

* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.

* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.

ID_events	cancer	Type	Buffa_P	Buffa_R	Ragnum_P	Ragnum_R	Winter_P	Winter_R	HALLMARK_P	HALLMARK_R	CorrelationPlot
chr5:143225225-143226485:+	OV	EER	2.4804e-02	0.1414	5.5746e-03	0.1741	5.2936e-04	0.2168	6.3998e-03	0.1713
ENSG00000145819.14,ARHGAP26	OV	EAG	4.1849e-02	0.1280	4.5165e-03	0.1780	4.6529e-04	0.2185	6.1007e-03	0.1720

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Associations of enriched editing regions with hallmark gene sets from MSigDB.

* P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.

ID_events	cancer	HallmarkType	Type	P	R	CorrelationPlot
chr5:143225225-143226485:+	BRCA	GSVA_HALLMARK_ANGIOGENESIS	EER	4.0708e-02	0.1148
ENSG00000145819.14,ARHGAP26	BRCA	GSVA_HALLMARK_ANGIOGENESIS	EAG	1.1386e-02	0.1400
chr5:143225225-143226485:+	COAD	GSVA_HALLMARK_BILE_ACID_METABOLISM	EER	1.0411e-05	-0.2937
ENSG00000145819.14,ARHGAP26	COAD	GSVA_HALLMARK_BILE_ACID_METABOLISM	EAG	6.4226e-04	-0.2274
chr5:143225225-143226485:+	ESCA	GSVA_HALLMARK_BILE_ACID_METABOLISM	EER	2.2071e-04	-0.3095
chr5:143211203-143211848:+	ESCA	GSVA_HALLMARK_NOTCH_SIGNALING	EER	2.6055e-02	0.3474
ENSG00000145819.14,ARHGAP26	ESCA	GSVA_HALLMARK_HYPOXIA	EAG	1.3352e-03	0.2695
ENSG00000145819.14,ARHGAP26	HNSC	GSVA_HALLMARK_COMPLEMENT	EAG	3.3232e-03	0.2938
chr5:143225225-143226485:+	HNSC	GSVA_HALLMARK_XENOBIOTIC_METABOLISM	EER	1.7840e-03	0.3132
ENSG00000145819.14,ARHGAP26	KIRC	GSVA_HALLMARK_DNA_REPAIR	EAG	2.9563e-02	0.1218
chr5:143225225-143226485:+	KIRC	GSVA_HALLMARK_DNA_REPAIR	EER	2.0266e-02	0.1306
ENSG00000145819.14,ARHGAP26	KIRP	GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING	EAG	1.7181e-02	0.1963
chr5:143211203-143211848:+	LAML	GSVA_HALLMARK_MYC_TARGETS_V1	EER	8.0104e-04	0.4922
ENSG00000145819.14,ARHGAP26	LAML	GSVA_HALLMARK_PROTEIN_SECRETION	EAG	1.5075e-02	-0.2726
ENSG00000145819.14,ARHGAP26	LGG	GSVA_HALLMARK_TGF_BETA_SIGNALING	EAG	8.6519e-03	-0.1350
chr5:143225225-143226485:+	LGG	GSVA_HALLMARK_TGF_BETA_SIGNALING	EER	8.8007e-03	-0.1348
ENSG00000145819.14,ARHGAP26	LUAD	GSVA_HALLMARK_COAGULATION	EAG	2.7773e-02	0.1360
chr5:143225225-143226485:+	LUAD	GSVA_HALLMARK_HYPOXIA	EER	4.7717e-02	0.1239
ENSG00000145819.14,ARHGAP26	LUSC	GSVA_HALLMARK_MYC_TARGETS_V2	EAG	3.8629e-02	-0.1816
ENSG00000145819.14,ARHGAP26	OV	GSVA_HALLMARK_DNA_REPAIR	EAG	2.3902e-04	0.2290
chr5:143225225-143226485:+	OV	GSVA_HALLMARK_DNA_REPAIR	EER	4.8931e-05	0.2529
ENSG00000145819.14,ARHGAP26	PAAD	GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING	EAG	1.3590e-03	0.2892
chr5:143225225-143226485:+	PAAD	GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING	EER	4.8092e-04	0.3152
chr5:143225225-143226485:+	PCPG	GSVA_HALLMARK_PANCREAS_BETA_CELLS	EER	4.9885e-02	0.1928
ENSG00000145819.14,ARHGAP26	PRAD	GSVA_HALLMARK_BILE_ACID_METABOLISM	EAG	3.1812e-02	0.1816
ENSG00000145819.14,ARHGAP26	READ	GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY	EAG	8.4543e-03	-0.2981
chr5:143225225-143226485:+	READ	GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY	EER	1.1380e-03	-0.3663
ENSG00000145819.14,ARHGAP26	SARC	GSVA_HALLMARK_ANGIOGENESIS	EAG	1.4340e-02	0.3588
chr5:143211203-143211848:+	STAD	GSVA_HALLMARK_UV_RESPONSE_UP	EER	1.3865e-03	0.3581
ENSG00000145819.14,ARHGAP26	STAD	GSVA_HALLMARK_DNA_REPAIR	EAG	2.3836e-05	0.2213
chr5:143225225-143226485:+	STAD	GSVA_HALLMARK_DNA_REPAIR	EER	7.7975e-04	0.1770
chr5:143225225-143226485:+	THYM	GSVA_HALLMARK_MITOTIC_SPINDLE	EER	2.7261e-02	-0.3123
ENSG00000145819.14,ARHGAP26	THYM	GSVA_HALLMARK_MITOTIC_SPINDLE	EAG	3.1281e-02	-0.3050

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7. Enriched editing regions and drugs for ARHGAP26

Correlations between enriched editing regions and drug sensitivity.

* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.

* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.

ID_events	cancer	Drug	Type	P	R	CorrelationPlot
ENSG00000145819.14,ARHGAP26	BLCA	ABT.263	EAG	1.2145e-02	-0.3669
chr5:143225225-143226485:+	BLCA	ABT.888	EER	3.3251e-03	-0.4330
ENSG00000145819.14,ARHGAP26	CESC	ABT.888	EAG	2.4433e-02	-0.2261
chr5:143225225-143226485:+	CESC	Bortezomib	EER	1.4434e-02	-0.2503
ENSG00000145819.14,ARHGAP26	COAD	ABT.888	EAG	4.3908e-02	-0.1354
chr5:143225225-143226485:+	COAD	ABT.888	EER	1.8142e-02	-0.1599
chr5:143225225-143226485:+	ESCA	Docetaxel	EER	2.4367e-04	-0.3075
ENSG00000145819.14,ARHGAP26	ESCA	Docetaxel	EAG	5.9562e-04	-0.2876
chr5:143211203-143211848:+	ESCA	AZ628	EER	6.7260e-04	-0.5093
ENSG00000145819.14,ARHGAP26	GBM	BMS.754807	EAG	6.3758e-03	-0.2610
chr5:143225225-143226485:+	GBM	BMS.754807	EER	6.3758e-03	-0.2610
ENSG00000145819.14,ARHGAP26	HNSC	CI.1040	EAG	8.5452e-03	-0.2643
chr5:143225225-143226485:+	HNSC	BAY.61.3606	EER	2.0043e-03	0.3100
ENSG00000145819.14,ARHGAP26	KIRC	AP.24534	EAG	8.2056e-03	0.1478
chr5:143225225-143226485:+	KIRC	AP.24534	EER	6.7620e-03	0.1521
ENSG00000145819.14,ARHGAP26	KIRP	Midostaurin	EAG	2.7553e-02	-0.1818
chr5:143225225-143226485:+	KIRP	Gemcitabine	EER	2.7546e-02	-0.1830
chr5:143211203-143211848:+	LAML	Docetaxel	EER	5.4240e-03	-0.4169
ENSG00000145819.14,ARHGAP26	LAML	BI.2536	EAG	2.0132e-04	-0.4065
ENSG00000145819.14,ARHGAP26	LGG	DMOG	EAG	3.1914e-03	0.1515
chr5:143225225-143226485:+	LGG	DMOG	EER	4.6775e-03	0.1454
chr5:143225225-143226485:+	LIHC	AZD6482	EER	1.0179e-02	0.5140
ENSG00000145819.14,ARHGAP26	LIHC	AZD6482	EAG	1.0179e-02	0.5140
ENSG00000145819.14,ARHGAP26	LUAD	Lenalidomide	EAG	7.9402e-03	0.1637
chr5:143225225-143226485:+	LUAD	Lenalidomide	EER	6.3908e-03	0.1700
chr5:143225225-143226485:+	OV	Lenalidomide	EER	7.4274e-04	0.2116
ENSG00000145819.14,ARHGAP26	OV	Lenalidomide	EAG	2.9382e-03	0.1866
ENSG00000145819.14,ARHGAP26	PAAD	BIBW2992	EAG	6.5766e-04	0.3067
chr5:143225225-143226485:+	PAAD	BIBW2992	EER	3.1981e-04	0.3244
chr5:143225225-143226485:+	PCPG	ABT.263	EER	2.8198e-02	0.2153
ENSG00000145819.14,ARHGAP26	PCPG	ABT.263	EAG	1.8923e-02	0.2298
chr5:143225225-143226485:+	PRAD	Erlotinib	EER	7.6228e-03	0.2322
ENSG00000145819.14,ARHGAP26	PRAD	CHIR.99021	EAG	6.2614e-04	0.2856
chr5:143225225-143226485:+	READ	GW.441756	EER	1.6338e-04	-0.4193
ENSG00000145819.14,ARHGAP26	READ	GW.441756	EAG	1.6527e-04	-0.4164
chr5:143225225-143226485:+	SARC	AZD7762	EER	1.9062e-02	-0.3521
ENSG00000145819.14,ARHGAP26	SARC	AZD7762	EAG	4.2412e-03	-0.4139
chr5:143225225-143226485:+	SKCM	BAY.61.3606	EER	2.3573e-03	0.2774
ENSG00000145819.14,ARHGAP26	SKCM	BAY.61.3606	EAG	2.8644e-03	0.2678
chr5:142875899-142876714:+	STAD	AG.014699	EER	9.4219e-04	0.3978
chr5:143211203-143211848:+	STAD	GW.441756	EER	2.6623e-03	-0.3378
chr5:143047939-143048852:+	STAD	Gemcitabine	EER	2.6534e-04	-0.3504
ENSG00000145819.14,ARHGAP26	STAD	A.770041	EAG	3.7669e-07	-0.2650
chr5:143225225-143226485:+	STAD	A.770041	EER	3.2160e-06	-0.2439
ENSG00000145819.14,ARHGAP26	THCA	Embelin	EAG	1.2692e-02	0.2269
chr5:143225225-143226485:+	THCA	Embelin	EER	1.0887e-02	0.2336
ENSG00000145819.14,ARHGAP26	THYM	AZ628	EAG	2.0412e-02	-0.3271
chr5:143225225-143226485:+	THYM	AZ628	EER	1.6404e-02	-0.3379
ENSG00000145819.14,ARHGAP26	UCEC	GSK269962A	EAG	5.5927e-04	-0.3994
chr5:143225225-143226485:+	UCEC	BMS.754807	EER	7.2565e-05	-0.4622

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EAGs targeted by drugs from DrugBank database.

* EAG: EER-associated genes.

EER

ENST

UniprotID

DrugBankID

Drug

DrugType