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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: AVL9 (ImmuneEditome ID:23080)

1. Gene summary of enriched editing regions for AVL9

check button Gene summary
Gene informationGene symbol

AVL9

Gene ID

23080

GeneSynonymsKIAA0241
GeneCytomap

7p14.3

GeneTypeprotein-coding
GeneDescriptionlate secretory pathway protein AVL9 homolog|AVL9 homolog (S. cerevisiase)
GeneModificationdate20230329
UniprotIDQ8NBF6;B8ZZW5;H7C0I1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:32503177-32505524:+ENST00000459629.1ENSG00000105778.16AVL9ncRNA_intronicL1ME2,MIR3,AluSz,(AC)n,AluSx,AluSq4chr7:32503177-32505524:+.alignment
chr7:32503177-32505524:+ENST00000485228.1ENSG00000105778.16AVL9ncRNA_intronicL1ME2,MIR3,AluSz,(AC)n,AluSx,AluSq4chr7:32503177-32505524:+.alignment
chr7:32519299-32520952:+ENST00000459629.1ENSG00000105778.16AVL9ncRNA_intronicMSTA,THE1A,AluSg4,MER4B-intchr7:32519299-32520952:+.alignment
chr7:32519299-32520952:+ENST00000485228.1ENSG00000105778.16AVL9ncRNA_intronicMSTA,THE1A,AluSg4,MER4B-intchr7:32519299-32520952:+.alignment
chr7:32523567-32524484:+ENST00000459629.1ENSG00000105778.16AVL9ncRNA_intronicAluSz,MER4B-int,AluY,AluSx1chr7:32523567-32524484:+.alignment
chr7:32523567-32524484:+ENST00000485228.1ENSG00000105778.16AVL9ncRNA_intronicAluSz,MER4B-int,AluY,AluSx1chr7:32523567-32524484:+.alignment
chr7:32541805-32542557:+ENST00000485228.1ENSG00000105778.16AVL9ncRNA_intronicAluSz,AluSxchr7:32541805-32542557:+.alignment
chr7:32549279-32549889:+ENST00000485228.1ENSG00000105778.16AVL9ncRNA_intronicAluJb,AluSx3chr7:32549279-32549889:+.alignment
chr7:32562615-32563315:+ENST00000318709.7ENSG00000105778.16AVL9intronicMER2,AluJo,AluSx1chr7:32562615-32563315:+.alignment
chr7:32562615-32563315:+ENST00000409301.4ENSG00000105778.16AVL9intronicMER2,AluJo,AluSx1chr7:32562615-32563315:+.alignment
chr7:32562615-32563315:+ENST00000446718.1ENSG00000105778.16AVL9intronicMER2,AluJo,AluSx1chr7:32562615-32563315:+.alignment


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2. Tumor-specific enriched editing regions for AVL9


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000105778.16,AVL9ESCAPathEAG1.3722e-021.6397e-020.2395image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr7:32503177-32505524:+ESCAEER1.1578e-027.9932e-033.8596e+02image
chr7:32541805-32542557:+ESCAEER4.5446e-021.7594e-022.3413e+02image
ENSG00000105778.16,AVL9ESCAEAG5.8836e-035.0837e-031.6601e+02image

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3. Enriched editing regions and immune related genes for AVL9


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for AVL9


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for AVL9


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000105778.16,AVL9BRCAEAGMacrophages_M13.8421e-020.3418image
chr7:32541805-32542557:+COADEERNK_cells_activated2.5277e-040.6922image
ENSG00000105778.16,AVL9COADEAGNK_cells_activated2.3000e-030.4578image
chr7:32503177-32505524:+ESCAEERB_cells_naive1.7825e-03-0.4627image
chr7:32519299-32520952:+ESCAEERMacrophages_M24.2832e-020.2520image
chr7:32562615-32563315:+ESCAEEREosinophils1.4133e-020.3520image
ENSG00000105778.16,AVL9ESCAEAGDendritic_cells_resting1.4229e-020.2321image
ENSG00000105778.16,AVL9KIRCEAGNK_cells_resting3.8067e-02-0.4666image
chr7:32519299-32520952:+LAMLEERT_cells_CD4_memory_resting4.4449e-02-0.2254image
ENSG00000105778.16,AVL9LAMLEAGT_cells_CD4_memory_activated8.1491e-030.2714image
chr7:32549279-32549889:+LUADEERT_cells_CD83.1063e-020.4712image
ENSG00000105778.16,AVL9LUSCEAGMacrophages_M02.5170e-02-0.3452image
ENSG00000105778.16,AVL9OVEAGDendritic_cells_activated2.1920e-020.2609image
chr7:32541805-32542557:+PRADEERNK_cells_activated7.1675e-030.5564image
ENSG00000105778.16,AVL9PRADEAGNK_cells_activated3.4642e-020.4006image
chr7:32503177-32505524:+STADEERT_cells_regulatory_(Tregs)2.7786e-02-0.1993image
chr7:32519299-32520952:+STADEERMonocytes4.3164e-02-0.1743image
chr7:32541805-32542557:+STADEERNK_cells_activated3.4929e-030.2154image
chr7:32549279-32549889:+STADEERB_cells_memory3.1552e-03-0.2335image
chr7:32562615-32563315:+STADEERMacrophages_M04.5503e-02-0.2964image
ENSG00000105778.16,AVL9STADEAGMacrophages_M21.0817e-020.1727image


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6. Enriched editing regions and immune gene sets for AVL9


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr7:32549279-32549889:+STADEER1.2511e-020.19832.2256e-020.18182.0814e-020.18386.2843e-030.2165image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000105778.16,AVL9BLCAGSVA_HALLMARK_ANGIOGENESISEAG2.6886e-030.5848image
ENSG00000105778.16,AVL9BRCAGSVA_HALLMARK_ANGIOGENESISEAG3.4713e-040.5566image
ENSG00000105778.16,AVL9COADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.1041e-030.4094image
chr7:32541805-32542557:+COADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.5720e-020.4640image
chr7:32562615-32563315:+ESCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.3901e-030.4041image
chr7:32503177-32505524:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.4514e-02-0.3232image
ENSG00000105778.16,AVL9ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.8856e-020.2226image
ENSG00000105778.16,AVL9KIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG3.2771e-02-0.4786image
ENSG00000105778.16,AVL9LAMLGSVA_HALLMARK_P53_PATHWAYEAG2.8000e-020.2267image
chr7:32519299-32520952:+LAMLGSVA_HALLMARK_P53_PATHWAYEER2.9754e-020.2432image
ENSG00000105778.16,AVL9LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.9144e-020.2737image
ENSG00000105778.16,AVL9LUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.3927e-03-0.4773image
chr7:32519299-32520952:+STADGSVA_HALLMARK_HYPOXIAEER3.3616e-040.3041image
chr7:32562615-32563315:+STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4907e-020.3569image
chr7:32549279-32549889:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER4.2209e-030.2265image
chr7:32503177-32505524:+STADGSVA_HALLMARK_HYPOXIAEER4.1216e-020.1851image
chr7:32541805-32542557:+STADGSVA_HALLMARK_APICAL_SURFACEEER5.5198e-040.2536image
ENSG00000105778.16,AVL9STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.4631e-050.2772image


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7. Enriched editing regions and drugs for AVL9


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000105778.16,AVL9BLCAAG.014699EAG1.8623e-02-0.4763image
ENSG00000105778.16,AVL9BRCABosutinibEAG1.3070e-020.4043image
chr7:32541805-32542557:+COADMG.132EER1.6249e-020.4953image
chr7:32562615-32563315:+ESCAElesclomolEER7.4051e-03-0.3818image
chr7:32503177-32505524:+ESCAErlotinibEER1.4611e-03-0.4703image
ENSG00000105778.16,AVL9ESCADocetaxelEAG1.8633e-03-0.2921image
chr7:32541805-32542557:+ESCACHIR.99021EER1.8984e-03-0.3196image
ENSG00000105778.16,AVL9KIRCBX.795EAG3.6281e-030.6188image
ENSG00000105778.16,AVL9LAMLAG.014699EAG4.3713e-020.2085image
chr7:32519299-32520952:+LAMLFTI.277EER4.2954e-02-0.2269image
ENSG00000105778.16,AVL9LUADJNK.Inhibitor.VIIIEAG7.5823e-040.3854image
chr7:32549279-32549889:+LUADAxitinibEER9.5872e-03-0.5513image
ENSG00000105778.16,AVL9LUSCGDC.0449EAG2.2195e-04-0.5402image
ENSG00000105778.16,AVL9OVGefitinibEAG1.5010e-020.2763image
chr7:32519299-32520952:+STADDocetaxelEER1.5973e-03-0.2691image
chr7:32562615-32563315:+STADABT.888EER9.0472e-03-0.3807image
chr7:32549279-32549889:+STADAICAREER3.1706e-030.2334image
chr7:32503177-32505524:+STADBAY.61.3606EER2.7815e-030.2686image
chr7:32541805-32542557:+STADJW.7.52.1EER1.8231e-04-0.2740image
ENSG00000105778.16,AVL9STADGSK269962AEAG3.3528e-05-0.2783image
ENSG00000105778.16,AVL9TGCTBMS.754807EAG2.1021e-020.3358image
chr7:32562615-32563315:+TGCTEmbelinEER1.7649e-020.3484image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType