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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GGA2 (ImmuneEditome ID:23062)

1. Gene summary of enriched editing regions for GGA2

check button Gene summary
Gene informationGene symbol

GGA2

Gene ID

23062

GeneSynonymsVEAR
GeneCytomap

16p12.2

GeneTypeprotein-coding
GeneDescriptionADP-ribosylation factor-binding protein GGA2|VHS domain and ear domain of gamma-adaptin|VHS domain and ear domain-containing protein|gamma-adaptin-related protein 2|golgi-localized, gamma ear-containing, ARF-binding protein 2
GeneModificationdate20230329
UniprotIDQ9UJY4;H3BMN6;I3L2C4;H3BPF4;H3BMM6;H3BPI3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:23465156-23465968:-ENST00000567468.4ENSG00000103365.14GGA2exonicAluSx,AluJochr16:23465156-23465968:-.alignment
chr16:23471749-23473604:-ENST00000309859.7ENSG00000103365.14GGA2intronicAluJr,AluJb,AluSz,L1ME4a,AluY,AluSx1chr16:23471749-23473604:-.alignment
chr16:23471749-23473604:-ENST00000567468.4ENSG00000103365.14GGA2intronicAluJr,AluJb,AluSz,L1ME4a,AluY,AluSx1chr16:23471749-23473604:-.alignment
chr16:23507668-23508294:-ENST00000566547.1ENSG00000103365.14GGA2ncRNA_intronicAluSz,AluSx3,AluSxchr16:23507668-23508294:-.alignment
chr16:23507668-23508294:-ENST00000568799.1ENSG00000103365.14GGA2ncRNA_intronicAluSz,AluSx3,AluSxchr16:23507668-23508294:-.alignment
chr16:23511850-23513588:-ENST00000569300.4ENSG00000103365.14GGA2intronicAluJb,(T)n,MER39,MER102c,LTR37A,LTR32,AluSx1chr16:23511850-23513588:-.alignment
chr16:23514158-23515524:-ENST00000569300.4ENSG00000103365.14GGA2intronicMER39,AluSx,AluJb,(AT)n,FLAM_A,AluSx1,MER5Achr16:23514158-23515524:-.alignment


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2. Tumor-specific enriched editing regions for GGA2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr16:23465156-23465968:-BRCAEER5.2109e-16image
ENSG00000103365.14,GGA2BRCAEAG1.5988e-02image
chr16:23465156-23465968:-KIRCEER2.0727e-06image
ENSG00000103365.14,GGA2LUADEAG2.7449e-03image
ENSG00000103365.14,GGA2LUSCEAG3.9723e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr16:23465156-23465968:-BRCAPathEER2.8646e-023.0889e-020.0710image
ENSG00000103365.14,GGA2BRCAPathEAG2.9628e-021.0928e-020.0802image
ENSG00000103365.14,GGA2KICHPathEAG1.7681e-023.8256e-020.2855image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000103365.14,GGA2KIRPEAG9.6023e-044.4171e-042.9473e+05image

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3. Enriched editing regions and immune related genes for GGA2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr16:23465156-23465968:-OVEERENSG00000135441,BLOC1S10.39861.9525e-069.1693e-100.4022imageNELAVL1;HNRNPA1;HNRNPC;SRSF1;SRSF3;SRSF7;U2AF2BLOC1S1T_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr16:23465156-23465968:-OVEERENSG00000182117,NOP100.39513.1196e-063.2528e-100.4119imageNELAVL1;HNRNPA1;HNRNPC;SRSF1;SRSF3;SRSF7;SRSF9;U2AF2NAT_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr16:23465156-23465968:-OVEERENSG00000136925,TSTD2-0.38963.6029e-067.5215e-10-0.4041imageNDHX9;ELAVL1;HNRNPA1;HNRNPC;SRSF1;SRSF3;SRSF7;SRSF9;U2AF2NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr16:23465156-23465968:-OVEERENSG00000168894,RNF1810.38465.9834e-065.5319e-100.4070imageNELAVL1;HNRNPA1;SRSF1;SRSF3;SRSF7;SRSF9;U2AF2NAT_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr16:23465156-23465968:-OVEERENSG00000118680,MYL12B0.34538.5811e-058.5850e-100.4028imageNELAVL1;HNRNPA1;HNRNPC;SRSF1;SRSF3;SRSF7;SRSF9;U2AF2NAMacrophages_M1GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr16:23465156-23465968:-OVEERENSG00000225973,PIGBOS10.28831.4473e-035.2609e-110.4284imageNDHX9;HNRNPA1;HNRNPC;SRSF1;SRSF9;U2AF2NAB_cells_memoryGSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for GGA2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000103365.14,GGA2
LIHCEAGIRENSG00000007202.10chr1728616888:28616999:28617231:286173180.26282.9340e-046.6407e-140.4015imageNACIN1;ADAR;AIFM1;ALKBH5;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_gamma_deltaGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000103365.14,GGA2
LIHCEAGIRENSG00000123415.10chr1254182071:54182170:54182503:54182623-0.30702.9797e-065.4189e-14-0.4034imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000103365.14,GGA2
OVEAGMEXENSG00000197070.9chr9137613614:137613769:137614031:137614898:137614922:137615000:137615073:137615360-0.38651.4499e-062.8152e-11-0.4033imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_HEME_METABOLISM
ENSG00000103365.14,GGA2
OVEAGMEXENSG00000197070.9chr9137613614:137613769:137614031:137614898:137614898:137615000:137615073:137615360-0.38541.5730e-062.4571e-11-0.4044imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_HEME_METABOLISM
ENSG00000103365.14,GGA2
OVEAGA3ENSG00000159110.15chr2133260596:33260727:33262792:33262855:33262560:33262855-0.38042.1655e-062.8981e-11-0.4031imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZC3H7B;ZNF184IFNAR2Macrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000103365.14,GGA2
OVEAGMEXENSG00000111640.10chr126536919:6537010:6537100:6537189:6537583:6537996:6538100:6538117-0.38052.2591e-063.6257e-11-0.4013imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_HEME_METABOLISM
ENSG00000103365.14,GGA2
OVEAGIRENSG00000121281.8chr1650312035:50314062:50314291:503144060.29861.4040e-045.1740e-110.4240imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAB_cells_memoryGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr16:23465156-23465968:-
OVEERIRENSG00000196547.10chr1590919634:90919865:90920998:90921194-0.33101.8507e-049.0535e-14-0.4797imageNDHX9;ELAVL1;HNRNPA1;HNRNPC;SRSF1;SRSF3;SRSF7;SRSF9;U2AF2NAB_cells_memoryGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr16:23465156-23465968:-
OVEERMEXENSG00000059378.8chr7140034234:140034331:140037714:140037961:140046883:140047007:140054661:1400547630.31861.0679e-034.4285e-100.4091imageNDHX9;ELAVL1;HNRNPA1;HNRNPC;METTL3;SRSF1;SRSF3;SRSF7;SRSF9;U2AF2NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000103365.14,GGA2
OVEAGMEXENSG00000119977.16chr1095663695:95664300:95680471:95680575:95682715:95682804:95683100:956831800.40182.7458e-079.8977e-130.4294imageNACIN1;ADAR;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184TCTN3B_cells_memoryGSVA_HALLMARK_HEME_METABOLISM

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5. Enriched editing regions and immune infiltration for GGA2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr16:23465156-23465968:-ACCEERB_cells_memory8.6191e-030.4434image
ENSG00000103365.14,GGA2BLCAEAGNK_cells_resting3.8862e-020.1318image
chr16:23465156-23465968:-BRCAEERB_cells_naive2.4557e-05-0.1385image
chr16:23511850-23513588:-BRCAEERMacrophages_M01.0643e-020.2695image
chr16:23514158-23515524:-BRCAEERMacrophages_M14.8319e-020.3103image
ENSG00000103365.14,GGA2BRCAEAGB_cells_naive1.6626e-04-0.1184image
ENSG00000103365.14,GGA2CESCEAGT_cells_CD4_memory_resting2.8871e-03-0.2076image
ENSG00000103365.14,GGA2CHOLEAGB_cells_memory8.1827e-060.7001image
ENSG00000103365.14,GGA2COADEAGEosinophils2.3831e-090.5152image
ENSG00000103365.14,GGA2DLBCEAGMast_cells_resting1.5704e-020.4236image
chr16:23465156-23465968:-ESCAEERNK_cells_resting4.1482e-020.1947image
ENSG00000103365.14,GGA2ESCAEAGNeutrophils1.0987e-020.2106image
ENSG00000103365.14,GGA2GBMEAGT_cells_CD4_naive1.0709e-050.4062image
ENSG00000103365.14,GGA2HNSCEAGDendritic_cells_resting3.6923e-020.1148image
ENSG00000103365.14,GGA2KICHEAGT_cells_CD4_memory_activated7.6624e-050.5160image
chr16:23465156-23465968:-KIRCEERT_cells_CD82.0327e-030.1665image
ENSG00000103365.14,GGA2KIRCEAGDendritic_cells_resting7.4502e-030.1399image
ENSG00000103365.14,GGA2KIRPEAGT_cells_regulatory_(Tregs)2.2525e-020.1488image
ENSG00000103365.14,GGA2LAMLEAGMacrophages_M06.5753e-050.4285image
ENSG00000103365.14,GGA2LGGEAGT_cells_CD4_naive1.5648e-040.1799image
ENSG00000103365.14,GGA2LIHCEAGT_cells_gamma_delta1.1997e-030.1784image
ENSG00000103365.14,GGA2LUADEAGT_cells_CD4_memory_activated2.6144e-040.1711image
ENSG00000103365.14,GGA2LUSCEAGPlasma_cells8.9114e-04-0.1709image
ENSG00000103365.14,GGA2MESOEAGB_cells_naive4.4381e-02-0.2428image
chr16:23465156-23465968:-OVEERT_cells_gamma_delta1.9198e-040.2517image
ENSG00000103365.14,GGA2OVEAGB_cells_memory2.1939e-040.2308image
ENSG00000103365.14,GGA2PAADEAGDendritic_cells_activated2.5094e-020.1823image
chr16:23465156-23465968:-PCPGEERNK_cells_resting9.8081e-030.1959image
ENSG00000103365.14,GGA2PRADEAGT_cells_CD4_memory_activated4.7224e-030.1619image
ENSG00000103365.14,GGA2SARCEAGEosinophils3.3893e-020.1548image
ENSG00000103365.14,GGA2SKCMEAGT_cells_regulatory_(Tregs)5.1925e-03-0.1427image
chr16:23465156-23465968:-STADEERMonocytes1.3455e-020.1470image
chr16:23471749-23473604:-STADEERB_cells_naive6.2813e-03-0.4198image
chr16:23511850-23513588:-STADEERB_cells_memory1.8630e-02-0.3284image
ENSG00000103365.14,GGA2STADEAGNK_cells_activated1.5667e-030.1769image
ENSG00000103365.14,GGA2TGCTEAGNK_cells_activated1.2806e-03-0.2838image
ENSG00000103365.14,GGA2THCAEAGNK_cells_activated3.3292e-030.1359image
chr16:23511850-23513588:-THYMEERT_cells_CD83.8836e-03-0.5369image
ENSG00000103365.14,GGA2THYMEAGMacrophages_M08.5478e-030.2463image
ENSG00000103365.14,GGA2UCECEAGT_cells_follicular_helper2.3437e-02-0.2122image
ENSG00000103365.14,GGA2UVMEAGMonocytes2.9140e-030.4048image


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6. Enriched editing regions and immune gene sets for GGA2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000103365.14,GGA2KIRPEAG5.2966e-04image3.0792e-02-0.1409image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000103365.14,GGA2LGGEAG4.7046e-03-0.13501.3382e-06-0.22881.2361e-02-0.11968.8509e-04-0.1585image
ENSG00000103365.14,GGA2PCPGEAG5.6052e-08-0.39332.9201e-02-0.16358.7706e-07-0.35881.4957e-05-0.3183image
ENSG00000103365.14,GGA2TGCTEAG2.3464e-03-0.26873.7524e-02-0.18558.4789e-03-0.23367.0479e-03-0.2390image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr16:23465156-23465968:-ACCGSVA_HALLMARK_MYOGENESISEER1.7103e-02-0.4063image
ENSG00000103365.14,GGA2ACCGSVA_HALLMARK_APICAL_SURFACEEAG3.5183e-03-0.3803image
ENSG00000103365.14,GGA2BLCAGSVA_HALLMARK_MYC_TARGETS_V2EAG2.7450e-040.2300image
chr16:23465156-23465968:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1732e-050.1394image
ENSG00000103365.14,GGA2BRCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.8538e-05-0.1345image
chr16:23511850-23513588:-BRCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.0091e-030.3232image
ENSG00000103365.14,GGA2CESCGSVA_HALLMARK_UV_RESPONSE_DNEAG4.3368e-04-0.2441image
ENSG00000103365.14,GGA2CHOLGSVA_HALLMARK_HEME_METABOLISMEAG1.0919e-04-0.6307image
ENSG00000103365.14,GGA2COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.9196e-06-0.3983image
ENSG00000103365.14,GGA2DLBCGSVA_HALLMARK_UV_RESPONSE_DNEAG8.8147e-03-0.4554image
ENSG00000103365.14,GGA2ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2812e-03-0.2649image
chr16:23465156-23465968:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2176e-020.2383image
ENSG00000103365.14,GGA2GBMGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG3.2270e-04-0.3367image
ENSG00000103365.14,GGA2HNSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG7.5324e-04-0.1843image
ENSG00000103365.14,GGA2KICHGSVA_HALLMARK_MYC_TARGETS_V2EAG8.4804e-030.3580image
chr16:23465156-23465968:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5461e-040.1860image
ENSG00000103365.14,GGA2KIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.0189e-020.1135image
ENSG00000103365.14,GGA2KIRPGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.4689e-03-0.2064image
ENSG00000103365.14,GGA2LAMLGSVA_HALLMARK_DNA_REPAIREAG4.5400e-02-0.2230image
ENSG00000103365.14,GGA2LGGGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG8.7545e-21-0.4269image
ENSG00000103365.14,GGA2LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3643e-07-0.2864image
ENSG00000103365.14,GGA2LUADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.0879e-04-0.1691image
ENSG00000103365.14,GGA2LUSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.1378e-03-0.1581image
ENSG00000103365.14,GGA2MESOGSVA_HALLMARK_KRAS_SIGNALING_DNEAG9.9545e-030.3083image
chr16:23465156-23465968:-OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER7.7834e-06-0.2996image
ENSG00000103365.14,GGA2OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.5896e-06-0.2841image
ENSG00000103365.14,GGA2PAADGSVA_HALLMARK_SPERMATOGENESISEAG6.3790e-03-0.2211image
ENSG00000103365.14,GGA2PCPGGSVA_HALLMARK_HEME_METABOLISMEAG2.3681e-08-0.4034image
chr16:23465156-23465968:-PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER7.1652e-03-0.2038image
ENSG00000103365.14,GGA2PRADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.5071e-03-0.1627image
ENSG00000103365.14,GGA2READGSVA_HALLMARK_KRAS_SIGNALING_UPEAG2.5833e-02-0.3151image
ENSG00000103365.14,GGA2SARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.3572e-04-0.2502image
ENSG00000103365.14,GGA2SKCMGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG4.2883e-05-0.2077image
chr16:23471749-23473604:-STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.0473e-030.4394image
chr16:23511850-23513588:-STADGSVA_HALLMARK_DNA_REPAIREER1.4973e-020.3389image
chr16:23465156-23465968:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.1978e-03-0.1750image
chr16:23514158-23515524:-STADGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.8344e-020.3464image
ENSG00000103365.14,GGA2STADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.1960e-05-0.2359image
ENSG00000103365.14,GGA2TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.8462e-08-0.4659image
ENSG00000103365.14,GGA2THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.6150e-020.0972image
chr16:23511850-23513588:-THYMGSVA_HALLMARK_MTORC1_SIGNALINGEER1.0572e-020.4838image
ENSG00000103365.14,GGA2UCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0638e-05-0.3995image
ENSG00000103365.14,GGA2UCSGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.1392e-03-0.5139image
ENSG00000103365.14,GGA2UVMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.7755e-030.4066image


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7. Enriched editing regions and drugs for GGA2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr16:23465156-23465968:-ACCAZD8055EER2.3103e-020.3887image
ENSG00000103365.14,GGA2ACCMetforminEAG8.5572e-030.3451image
ENSG00000103365.14,GGA2BLCAAZD6482EAG4.5233e-050.2570image
chr16:23465156-23465968:-BRCAAxitinibEER3.2309e-060.1527image
chr16:23514158-23515524:-BRCABMS.754807EER1.6952e-02-0.3710image
ENSG00000103365.14,GGA2BRCAAZD6482EAG2.5366e-060.1479image
chr16:23511850-23513588:-BRCAEHT.1864EER1.8335e-020.2496image
ENSG00000103365.14,GGA2CESCCCT007093EAG2.0543e-040.2571image
ENSG00000103365.14,GGA2CHOLLapatinibEAG7.3606e-060.7026image
ENSG00000103365.14,GGA2COADAZ628EAG1.0273e-050.3938image
ENSG00000103365.14,GGA2DLBCGW843682XEAG1.1343e-02-0.4419image
ENSG00000103365.14,GGA2ESCAA.770041EAG1.0739e-020.2113image
chr16:23465156-23465968:-ESCABMS.708163EER3.9236e-02-0.1969image
ENSG00000103365.14,GGA2GBMElesclomolEAG7.6301e-05-0.3680image
ENSG00000103365.14,GGA2HNSCErlotinibEAG1.1141e-04-0.2108image
ENSG00000103365.14,GGA2KICHGemcitabineEAG4.6352e-08-0.6680image
chr16:23465156-23465968:-KIRCGDC.0449EER1.0063e-05-0.2369image
ENSG00000103365.14,GGA2KIRCJNK.9LEAG5.8795e-030.1439image
ENSG00000103365.14,GGA2KIRPCMKEAG3.7237e-05-0.2656image
ENSG00000103365.14,GGA2LGGAP.24534EAG2.0472e-150.3674image
ENSG00000103365.14,GGA2LIHCDoxorubicinEAG5.1242e-060.2491image
ENSG00000103365.14,GGA2LUADAS601245EAG2.7682e-050.1960image
ENSG00000103365.14,GGA2LUSCAS601245EAG1.0824e-040.1986image
ENSG00000103365.14,GGA2MESOAMG.706EAG3.4224e-03-0.3477image
chr16:23465156-23465968:-OVBexaroteneEER1.7669e-060.3192image
ENSG00000103365.14,GGA2OVAZD6482EAG5.9905e-070.3089image
ENSG00000103365.14,GGA2PAADABT.263EAG3.6844e-040.2918image
ENSG00000103365.14,GGA2PCPGEmbelinEAG2.6967e-080.4019image
chr16:23465156-23465968:-PCPGBleomycinEER1.7245e-060.3544image
ENSG00000103365.14,GGA2PRADLenalidomideEAG2.0191e-05-0.2422image
ENSG00000103365.14,GGA2READGW843682XEAG2.0321e-02-0.3273image
ENSG00000103365.14,GGA2SARCA.770041EAG1.0924e-07-0.3756image
ENSG00000103365.14,GGA2SKCMCGP.60474EAG1.0903e-030.1665image
chr16:23511850-23513588:-STADBIBW2992EER1.6696e-03-0.4293image
chr16:23465156-23465968:-STADEpothilone.BEER8.2222e-030.1571image
chr16:23471749-23473604:-STADATRAEER4.7760e-030.4322image
ENSG00000103365.14,GGA2STADBexaroteneEAG2.5365e-020.1256image
chr16:23514158-23515524:-STADCCT018159EER4.7342e-02-0.2940image
ENSG00000103365.14,GGA2TGCTFTI.277EAG1.2941e-040.3345image
ENSG00000103365.14,GGA2THCADMOGEAG1.0724e-040.1787image
chr16:23511850-23513588:-THYMBryostatin.1EER3.4718e-030.5424image
ENSG00000103365.14,GGA2THYMBAY.61.3606EAG2.1005e-040.3419image
ENSG00000103365.14,GGA2UCECAZD6482EAG5.0131e-100.5413image
ENSG00000103365.14,GGA2UCSLapatinibEAG2.8163e-040.5635image
ENSG00000103365.14,GGA2UVMMidostaurinEAG2.9493e-02-0.3021image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType