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	1. Gene summary of enriched editing regions
	2. Tumor-specific enriched editing regions
	Comparison of enriched editing regions between tumor and normal.
	Correlation of enriched editing regions with tumor stages.
	Associations of enriched editing regions with cancer survival.
	3. Enriched editing regions and immune related genes
	4. Enriched editing regions and immune related splicing
	5. Enriched editing regions and immune infiltration
	6. Enriched editing regions and immune gene sets
	Correlation of enriched editing regions with epithelial-mesenchymal transition.
	Correlations of enriched editing regions with hypoxic.
	Associations of enriched editing regions with hallmark gene sets from MSigDB.
	7. Enriched editing regions and drugs
	Correlations between enriched editing regions and drug sensitivity.
	Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ABCF1 (ImmuneEditome ID:23)

1. Gene summary of enriched editing regions for ABCF1

Gene summary

Gene information	Gene symbol	ABCF1
	Gene ID	23
	GeneSynonyms	ABC27\|ABC50
	GeneCytomap	6p21.33
	GeneType	protein-coding
	GeneDescription	ATP-binding cassette sub-family F member 1\|ATP-binding cassette 50 (TNF-alpha stimulated)\|ATP-binding cassette, sub-family F (GCN20), member 1\|TNF-alpha-stimulated ABC protein\|TNFalpha-inducible ATP-binding protein
	GeneModificationdate	20230409
	UniprotID	Q8NE71;A0A0G2JJB9;A0A0G2JIC2;Q2L6I2;F5GYK6;Q5STZ8
	PubMed ID

UCSC image.

Locations of each EERs.

EER	ENST	ENSG	GeneName	Region	Repeat	dsRNA structure
chr6:30587465-30589231:+	ENST00000326195.11	ENSG00000204574.11	ABCF1	intronic	L1ME4a,AluSp,AluSc8,AluSz,AluSg	chr6:30587465-30589231:+.alignment
chr6:30587465-30589231:+	ENST00000376545.6	ENSG00000204574.11	ABCF1	intronic	L1ME4a,AluSp,AluSc8,AluSz,AluSg	chr6:30587465-30589231:+.alignment
chr6:30587465-30589231:+	ENST00000475993.1	ENSG00000204574.11	ABCF1	intronic	L1ME4a,AluSp,AluSc8,AluSz,AluSg	chr6:30587465-30589231:+.alignment
chr6:30591588-30593731:+	ENST00000475993.1	ENSG00000204574.11	ABCF1	intronic	(TA)n,AluSz,AluJr,AluSx3,AluSx,MIR	chr6:30591588-30593731:+.alignment
chr6:30596562-30596944:+	ENST00000475993.1	ENSG00000204574.11	ABCF1	UTR3	AluY,AluSc	chr6:30596562-30596944:+.alignment

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2. Tumor-specific enriched editing regions for ABCF1

Comparison of enriched editing regions between tumor and normal.

* P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes.

ID_events

cancer

Type

Boxplot

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Correlation of enriched editing regions with tumor stages.

* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.

* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.

ID_events

cancer

Type

StageType

AnovaP

Boxplot

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Associations of enriched editing regions with cancer survival.

* Pkm<0.05 and Pcox<0.05.

* EER: enriched editing region, EAG: EER-associated genes.

ID_events

cancer

TypeID

Pkm

Pcox_continuous

HR_continuous

KMPlot

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3. Enriched editing regions and immune related genes for ABCF1

Enriched editing regions and immune related genes.

* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).

* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.

ID_events

cancer

Type

Gene

beta

FDR

PearsonP

PearsonR

CorrelationPlot

RBP

RBPtargets

ImmuneGene

ImmuneFraction

HallMark

chr6:30591588-30593731:+

TGCT

EER

ENSG00000104129,DNAJC17

0.4065

4.7947e-04

4.3516e-06

0.4152

ADAR;AUH;BUD13;CELF2;CSTF2T;DDX42;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28A;LIN28B;NONO;NOP58;NUMA1;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM22;RBM27;RNF219;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TNRC6A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184

B_cells_naive

GSVA_HALLMARK_MITOTIC_SPINDLE

chr6:30591588-30593731:+

TGCT

EER

ENSG00000147813,NAPRT

0.3815

1.3558e-03

7.2564e-06

0.4064

AUH;BUD13;CSTF2T;DDX42;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;NONO;NOP58;NUMA1;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM22;RBM27;RNF219;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184

T_cells_regulatory_(Tregs)

GSVA_HALLMARK_MITOTIC_SPINDLE

More results

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4. Enriched editing regions and immune related splicing for ABCF1

Enriched editing regions and immune related splicing.

* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).

* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.

ID_events

cancer

Type

SplicingType

SplicingGene

SplicingChr

SplicingPosition

beta

FDR

PearsonP

PearsonR

CorrelationPlot

RBP

RBPtargets

ImmuneGene

ImmuneFraction

HallMark

ENSG00000204574.11,ABCF1

ESCA

EAG

ENSG00000062716.6

chr17

59837854:59838397:59839767:59840003

0.3679

2.6838e-02

1.1921e-06

0.4038

ACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184

NK_cells_resting

GSVA_HALLMARK_DNA_REPAIR

chr6:30591588-30593731:+

TGCT

EER

ENSG00000174444.10

chr15

66500292:66500376:66500055:66500169:66500055:66500172

0.1111

2.9422e-02

9.5287e-06

0.4413

ADAR;AUH;BUD13;CELF2;CSTF2T;DDX42;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28A;LIN28B;MSI2;NONO;NOP58;NPM1;NUMA1;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM22;RBM27;RNF219;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184

T_cells_gamma_delta

ENSG00000204574.11,ABCF1

TGCT

EAG

ENSG00000013306.11

chr17

44323477:44323719:44324710:44324822

-0.3234

1.2890e-02

3.6997e-06

-0.4440

ACIN1;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;EIF4A3;EIF4G1;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184

T_cells_gamma_delta

GSVA_HALLMARK_MITOTIC_SPINDLE

ENSG00000204574.11,ABCF1

TGCT

EAG

MEX

ENSG00000063046.13

chr12

53034645:53034709:53037408:53037622:53039237:53039343:53039629:53039702

-0.4011

4.4861e-03

6.3867e-06

-0.4086

ACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184

T_cells_CD4_memory_resting

GSVA_HALLMARK_MITOTIC_SPINDLE

chr6:30591588-30593731:+

TGCT

EER

MEX

ENSG00000117419.10

chr1

44247985:44248038:44284834:44284907:44339044:44339322:44352849:44352925

0.4086

4.3625e-03

5.2153e-07

0.4496

ADAR;BUD13;CELF2;CSTF2T;DDX42;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28A;LIN28B;MSI2;NONO;NOP58;NPM1;NUMA1;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM22;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184

T_cells_gamma_delta

GSVA_HALLMARK_MITOTIC_SPINDLE

chr6:30591588-30593731:+

TGCT

EER

ENSG00000010322.11

chr3

52480183:52480295:52480878:52481109:52484512:52484637

0.3043

3.7801e-02

4.9836e-06

0.4328

NISCH

Neutrophils

GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

chr6:30591588-30593731:+

TGCT

EER

ENSG00000010322.11

chr3

52484512:52484637:52480138:52480295:52480138:52481109

-0.3043

3.7801e-02

4.9836e-06

-0.4328

NISCH

Neutrophils

GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

chr6:30591588-30593731:+

TGCT

EER

MEX

ENSG00000063046.13

chr12

53034645:53034709:53037408:53037622:53039234:53039343:53039629:53039702

-0.4019

5.0407e-03

6.0061e-06

-0.4097

T_cells_CD4_memory_resting

GSVA_HALLMARK_MITOTIC_SPINDLE

chr6:30591588-30593731:+

TGCT

EER

MEX

ENSG00000124783.8

chr6

7298746:7298823:7301309:7301491:7301521:7301572:7303549:7303633

0.3250

4.0122e-02

8.9435e-06

0.4026

T_cells_gamma_delta

GSVA_HALLMARK_MITOTIC_SPINDLE

ENSG00000204574.11,ABCF1

TGCT

EAG

MEX

ENSG00000124783.8

chr6

7298746:7298823:7301309:7301491:7301521:7301572:7303549:7303633

0.3240

3.8906e-02

9.5297e-06

0.4015

ACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;EIF4A3;EIF4G1;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDC2;YTHDF1;YWHAG;ZNF184

T_cells_gamma_delta

GSVA_HALLMARK_MITOTIC_SPINDLE

More results

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5. Enriched editing regions and immune infiltration for ABCF1

Associations of enriched editing regions with immune infiltration.

* P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.

ID_events	cancer	TypeID	ImmuneCell	P	R	CorrelationPlot
chr6:30591588-30593731:+	BLCA	EER	Dendritic_cells_activated	1.4134e-02	-0.1576
ENSG00000204574.11,ABCF1	BLCA	EAG	Macrophages_M1	9.6446e-03	0.1654
chr6:30591588-30593731:+	BRCA	EER	T_cells_CD4_memory_activated	1.5611e-02	-0.0990
ENSG00000204574.11,ABCF1	BRCA	EAG	T_cells_CD4_memory_activated	1.2312e-02	-0.1021
chr6:30591588-30593731:+	CESC	EER	T_cells_gamma_delta	3.6804e-04	0.2663
ENSG00000204574.11,ABCF1	CESC	EAG	T_cells_gamma_delta	4.1017e-04	0.2635
ENSG00000204574.11,ABCF1	COAD	EAG	Dendritic_cells_activated	6.3489e-05	0.4087
ENSG00000204574.11,ABCF1	DLBC	EAG	NK_cells_resting	7.3655e-03	0.4647
chr6:30591588-30593731:+	ESCA	EER	T_cells_follicular_helper	2.1579e-03	0.2647
ENSG00000204574.11,ABCF1	ESCA	EAG	T_cells_follicular_helper	3.7823e-03	0.2476
chr6:30591588-30593731:+	HNSC	EER	Neutrophils	7.7444e-04	-0.2108
ENSG00000204574.11,ABCF1	HNSC	EAG	Neutrophils	7.6015e-04	-0.2108
chr6:30591588-30593731:+	KIRC	EER	Neutrophils	3.8411e-02	0.2117
ENSG00000204574.11,ABCF1	KIRC	EAG	Neutrophils	2.9882e-02	0.2184
ENSG00000204574.11,ABCF1	KIRP	EAG	Dendritic_cells_resting	3.0071e-02	0.2341
ENSG00000204574.11,ABCF1	LGG	EAG	T_cells_regulatory_(Tregs)	3.9960e-02	0.2220
chr6:30591588-30593731:+	LIHC	EER	T_cells_regulatory_(Tregs)	9.2485e-04	0.2986
ENSG00000204574.11,ABCF1	LIHC	EAG	T_cells_regulatory_(Tregs)	9.2779e-04	0.2985
chr6:30591588-30593731:+	LUAD	EER	Neutrophils	5.1474e-03	-0.1906
ENSG00000204574.11,ABCF1	LUAD	EAG	Neutrophils	5.9323e-03	-0.1871
chr6:30591588-30593731:+	LUSC	EER	Dendritic_cells_resting	9.4205e-03	0.1709
ENSG00000204574.11,ABCF1	LUSC	EAG	Dendritic_cells_resting	9.2739e-03	0.1708
chr6:30591588-30593731:+	OV	EER	B_cells_memory	3.8651e-03	0.2205
ENSG00000204574.11,ABCF1	OV	EAG	B_cells_memory	8.0866e-03	0.2013
ENSG00000204574.11,ABCF1	PAAD	EAG	Plasma_cells	1.5755e-02	0.3748
chr6:30591588-30593731:+	PCPG	EER	B_cells_naive	2.2372e-02	-0.3326
ENSG00000204574.11,ABCF1	PCPG	EAG	B_cells_naive	2.5014e-02	-0.3233
chr6:30591588-30593731:+	PRAD	EER	T_cells_follicular_helper	2.5075e-02	-0.1381
ENSG00000204574.11,ABCF1	PRAD	EAG	Neutrophils	2.6023e-02	-0.1370
ENSG00000204574.11,ABCF1	READ	EAG	Dendritic_cells_resting	5.8731e-03	0.4834
chr6:30591588-30593731:+	STAD	EER	Dendritic_cells_activated	3.2984e-02	-0.1323
chr6:30591588-30593731:+	TGCT	EER	B_cells_memory	1.4579e-02	0.2283
ENSG00000204574.11,ABCF1	TGCT	EAG	B_cells_memory	1.4758e-02	0.2279
ENSG00000204574.11,ABCF1	THCA	EAG	Dendritic_cells_resting	4.7570e-02	0.2222
chr6:30591588-30593731:+	UCEC	EER	T_cells_CD8	3.4322e-03	0.2858
ENSG00000204574.11,ABCF1	UCEC	EAG	T_cells_CD8	3.1447e-03	0.2869
chr6:30591588-30593731:+	UCS	EER	NK_cells_resting	2.6587e-02	0.3381
ENSG00000204574.11,ABCF1	UCS	EAG	NK_cells_resting	2.5023e-02	0.3415
ENSG00000204574.11,ABCF1	UVM	EAG	NK_cells_activated	4.4798e-02	-0.3231

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6. Enriched editing regions and immune gene sets for ABCF1

Correlation of enriched editing regions with epithelial-mesenchymal transition.

* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).

* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the EERs/EAGs significantly edited between Epi and Mes group.

ID_events

cancer

Type

E2M_P

Boxplot

CorP

CorR

CorrelationPlot

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Correlations of enriched editing regions with hypoxic.

* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.

* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.

ID_events

cancer

Type

Buffa_P

Buffa_R

Ragnum_P

Ragnum_R

Winter_P

Winter_R

HALLMARK_P

HALLMARK_R

CorrelationPlot

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Associations of enriched editing regions with hallmark gene sets from MSigDB.

* P<0.05 and Informative number >=20.

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.

ID_events	cancer	HallmarkType	Type	P	R	CorrelationPlot
ENSG00000204574.11,ABCF1	BLCA	GSVA_HALLMARK_COAGULATION	EAG	1.2146e-02	0.1603
chr6:30591588-30593731:+	BLCA	GSVA_HALLMARK_APICAL_SURFACE	EER	1.7250e-02	0.1530
ENSG00000204574.11,ABCF1	BRCA	GSVA_HALLMARK_G2M_CHECKPOINT	EAG	6.3176e-03	-0.1114
chr6:30591588-30593731:+	BRCA	GSVA_HALLMARK_SPERMATOGENESIS	EER	6.6008e-03	-0.1111
ENSG00000204574.11,ABCF1	CESC	GSVA_HALLMARK_ANDROGEN_RESPONSE	EAG	5.8078e-03	-0.2071
chr6:30591588-30593731:+	CESC	GSVA_HALLMARK_ANDROGEN_RESPONSE	EER	7.9252e-03	-0.2001
ENSG00000204574.11,ABCF1	COAD	GSVA_HALLMARK_PEROXISOME	EAG	2.7835e-07	-0.5103
ENSG00000204574.11,ABCF1	ESCA	GSVA_HALLMARK_PROTEIN_SECRETION	EAG	9.0688e-03	-0.2238
chr6:30591588-30593731:+	ESCA	GSVA_HALLMARK_PROTEIN_SECRETION	EER	3.2254e-02	-0.1865
ENSG00000204574.11,ABCF1	KIRC	GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION	EAG	3.1433e-03	-0.2940
chr6:30591588-30593731:+	KIRC	GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION	EER	1.6220e-03	-0.3175
ENSG00000204574.11,ABCF1	KIRP	GSVA_HALLMARK_DNA_REPAIR	EAG	3.2893e-02	0.2303
ENSG00000204574.11,ABCF1	LIHC	GSVA_HALLMARK_PROTEIN_SECRETION	EAG	2.3751e-04	-0.3295
chr6:30591588-30593731:+	LIHC	GSVA_HALLMARK_PROTEIN_SECRETION	EER	2.0471e-04	-0.3327
ENSG00000204574.11,ABCF1	LUSC	GSVA_HALLMARK_PEROXISOME	EAG	3.3816e-02	0.1397
chr6:30591588-30593731:+	LUSC	GSVA_HALLMARK_PEROXISOME	EER	4.5902e-02	0.1318
chr6:30591588-30593731:+	OV	GSVA_HALLMARK_INFLAMMATORY_RESPONSE	EER	3.4527e-02	-0.1622
ENSG00000204574.11,ABCF1	OV	GSVA_HALLMARK_INFLAMMATORY_RESPONSE	EAG	4.2511e-02	-0.1549
ENSG00000204574.11,ABCF1	PAAD	GSVA_HALLMARK_UV_RESPONSE_DN	EAG	1.9562e-02	-0.3633
ENSG00000204574.11,ABCF1	PRAD	GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION	EAG	2.0007e-03	0.1894
chr6:30591588-30593731:+	PRAD	GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION	EER	9.1478e-04	0.2033
chr6:30591588-30593731:+	SKCM	GSVA_HALLMARK_MITOTIC_SPINDLE	EER	3.4643e-03	-0.1697
ENSG00000204574.11,ABCF1	SKCM	GSVA_HALLMARK_HEDGEHOG_SIGNALING	EAG	3.1476e-03	-0.1705
ENSG00000204574.11,ABCF1	STAD	GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE	EAG	5.9342e-03	0.1696
chr6:30587465-30589231:+	STAD	GSVA_HALLMARK_KRAS_SIGNALING_UP	EER	2.1133e-02	0.4883
chr6:30591588-30593731:+	STAD	GSVA_HALLMARK_NOTCH_SIGNALING	EER	1.7495e-02	0.1473
ENSG00000204574.11,ABCF1	TGCT	GSVA_HALLMARK_MITOTIC_SPINDLE	EAG	2.0603e-03	-0.2857
chr6:30591588-30593731:+	TGCT	GSVA_HALLMARK_MITOTIC_SPINDLE	EER	1.9880e-03	-0.2866
ENSG00000204574.11,ABCF1	THYM	GSVA_HALLMARK_FATTY_ACID_METABOLISM	EAG	5.5794e-04	-0.4430
ENSG00000204574.11,ABCF1	UCEC	GSVA_HALLMARK_HEME_METABOLISM	EAG	2.7880e-02	-0.2157
chr6:30591588-30593731:+	UCEC	GSVA_HALLMARK_HEME_METABOLISM	EER	2.7088e-02	-0.2178
chr6:30591588-30593731:+	UCS	GSVA_HALLMARK_HYPOXIA	EER	4.2529e-02	0.3108
ENSG00000204574.11,ABCF1	UCS	GSVA_HALLMARK_HYPOXIA	EAG	4.1543e-02	0.3122

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7. Enriched editing regions and drugs for ABCF1

Correlations between enriched editing regions and drug sensitivity.

* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.

* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).

* EER: enriched editing region, EAG: EER-associated genes.

* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.

ID_events	cancer	Drug	Type	P	R	CorrelationPlot
ENSG00000204574.11,ABCF1	BLCA	AICAR	EAG	3.3802e-04	-0.2276
chr6:30591588-30593731:+	BLCA	AICAR	EER	8.3801e-04	-0.2133
ENSG00000204574.11,ABCF1	BRCA	Bryostatin.1	EAG	3.1516e-03	-0.1203
chr6:30591588-30593731:+	BRCA	Bryostatin.1	EER	3.5037e-03	-0.1194
ENSG00000204574.11,ABCF1	CESC	Cyclopamine	EAG	2.1934e-02	-0.1736
chr6:30591588-30593731:+	CESC	BMS.509744	EER	2.1758e-02	-0.1734
ENSG00000204574.11,ABCF1	COAD	CCT007093	EAG	7.7043e-08	-0.5302
ENSG00000204574.11,ABCF1	DLBC	GW843682X	EAG	1.1514e-02	0.4410
ENSG00000204574.11,ABCF1	ESCA	Gefitinib	EAG	9.0398e-04	-0.2834
chr6:30591588-30593731:+	ESCA	Gefitinib	EER	5.3414e-04	-0.2985
ENSG00000204574.11,ABCF1	GBM	Erlotinib	EAG	3.0744e-02	0.3657
chr6:30591588-30593731:+	HNSC	GNF.2	EER	2.3021e-02	-0.1440
ENSG00000204574.11,ABCF1	HNSC	GNF.2	EAG	2.2788e-02	-0.1440
ENSG00000204574.11,ABCF1	KIRC	GNF.2	EAG	1.1845e-03	0.3213
chr6:30591588-30593731:+	KIRC	GNF.2	EER	7.4882e-04	0.3383
ENSG00000204574.11,ABCF1	KIRP	JW.7.52.1	EAG	4.7445e-02	-0.2144
ENSG00000204574.11,ABCF1	LGG	AMG.706	EAG	5.4338e-03	-0.2973
chr6:30591588-30593731:+	LIHC	Imatinib	EER	4.4858e-02	0.1835
ENSG00000204574.11,ABCF1	LIHC	Imatinib	EAG	4.8241e-02	0.1807
chr6:30591588-30593731:+	LUAD	GDC0941	EER	3.5889e-02	-0.1435
ENSG00000204574.11,ABCF1	LUAD	GDC0941	EAG	2.0906e-02	-0.1574
ENSG00000204574.11,ABCF1	LUSC	Dasatinib	EAG	4.6643e-02	-0.1310
chr6:30591588-30593731:+	LUSC	Dasatinib	EER	4.7321e-02	-0.1309
chr6:30591588-30593731:+	OV	BX.795	EER	4.2967e-02	0.1554
ENSG00000204574.11,ABCF1	PAAD	AZ628	EAG	3.1364e-02	-0.3593
chr6:30591588-30593731:+	PCPG	KU.55933	EER	6.4446e-04	0.4797
ENSG00000204574.11,ABCF1	PCPG	KU.55933	EAG	7.4306e-04	0.4703
chr6:30591588-30593731:+	PRAD	BMS.754807	EER	2.8997e-04	-0.2217
ENSG00000204574.11,ABCF1	PRAD	BMS.754807	EAG	4.9720e-04	-0.2129
ENSG00000204574.11,ABCF1	READ	Bleomycin	EAG	4.7164e-02	-0.3592
ENSG00000204574.11,ABCF1	SARC	BI.2536	EAG	2.6151e-02	0.2130
chr6:30591588-30593731:+	SKCM	Imatinib	EER	3.2852e-04	0.2077
ENSG00000204574.11,ABCF1	SKCM	Imatinib	EAG	2.4193e-04	0.2111
chr6:30587465-30589231:+	STAD	CEP.701	EER	2.7527e-02	-0.4694
chr6:30591588-30593731:+	STAD	EHT.1864	EER	3.0614e-02	-0.1341
ENSG00000204574.11,ABCF1	STAD	KU.55933	EAG	2.2161e-02	-0.1413
chr6:30591588-30593731:+	TGCT	GDC.0449	EER	1.9567e-04	-0.3420
ENSG00000204574.11,ABCF1	TGCT	GDC.0449	EAG	1.9743e-04	-0.3418
chr6:30591588-30593731:+	UCEC	AP.24534	EER	1.8670e-02	-0.2314
ENSG00000204574.11,ABCF1	UCEC	AP.24534	EAG	2.1969e-02	-0.2245
chr6:30591588-30593731:+	UCS	Gefitinib	EER	1.7392e-02	-0.3610
ENSG00000204574.11,ABCF1	UCS	Gefitinib	EAG	1.6764e-02	-0.3629

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EAGs targeted by drugs from DrugBank database.

* EAG: EER-associated genes.

EER

ENST

UniprotID

DrugBankID

Drug

DrugType